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Found 23 hits Enz. Inhib. hit(s) with Target = 'Poly(ADP-ribose) glycohydrolase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50350107
PNG
(CHEMBL1230692)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)O[P@](O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O12P2/c16-13-9-14(19-4-18-13)21(5-20-9)15-12(25)11(24)8(32-15)3-31-35(28,29)33-34(26,27)30-2-6-10(23)7(22)1-17-6/h4-8,10-12,15,17,22-25H,1-3H2,(H,26,27)(H,28,29)(H2,16,18,19)/t6-,7+,8-,10-,11-,12-,15-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052832
PNG
(CHEMBL3318753)
Show SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1O
Show InChI InChI=1/C13H16O10/c14-3-7-9(18)11(10(19)13(21)22-7)23-12(20)4-1-5(15)8(17)6(16)2-4/h1-2,7,9-11,13-19,21H,3H2/t7-,9-,10-,11+,13?/s2
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n/an/a 950n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50053036
PNG
(CHEMBL3318737)
Show SMILES Oc1ccc(\C=N\NC(=O)c2ccc(cc2)C(=O)N\N=C\c2ccc(O)c(O)c2O)c(O)c1O
Show InChI InChI=1S/C22H18N4O8/c27-15-7-5-13(17(29)19(15)31)9-23-25-21(33)11-1-2-12(4-3-11)22(34)26-24-10-14-6-8-16(28)20(32)18(14)30/h1-10,27-32H,(H,25,33)(H,26,34)/b23-9+,24-10+
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n/an/a 1.00E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052838
PNG
(CHEMBL3318748)
Show SMILES Oc1ccc(\C=N\NC(=O)CC(=O)N\N=C\c2ccc(O)c(O)c2O)c(O)c1O
Show InChI InChI=1S/C17H16N4O8/c22-10-3-1-8(14(26)16(10)28)6-18-20-12(24)5-13(25)21-19-7-9-2-4-11(23)17(29)15(9)27/h1-4,6-7,22-23,26-29H,5H2,(H,20,24)(H,21,25)/b18-6+,19-7+
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n/an/a 1.60E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50053035
PNG
(CHEMBL3318738)
Show SMILES Oc1cc(\C=N\NC(=O)c2ccc(cc2)C(=O)N\N=C\c2cc(O)c(O)c(O)c2)cc(O)c1O
Show InChI InChI=1S/C22H18N4O8/c27-15-5-11(6-16(28)19(15)31)9-23-25-21(33)13-1-2-14(4-3-13)22(34)26-24-10-12-7-17(29)20(32)18(30)8-12/h1-10,27-32H,(H,25,33)(H,26,34)/b23-9+,24-10+
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n/an/a 2.10E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052839
PNG
(CHEMBL3318747)
Show SMILES Oc1cc(\C=N\NC(=O)C(=O)N\N=C\c2cc(O)c(O)c(O)c2)cc(O)c1O
Show InChI InChI=1S/C16H14N4O8/c21-9-1-7(2-10(22)13(9)25)5-17-19-15(27)16(28)20-18-6-8-3-11(23)14(26)12(24)4-8/h1-6,21-26H,(H,19,27)(H,20,28)/b17-5+,18-6+
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n/an/a 2.80E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052831
PNG
(CHEMBL3318754)
Show SMILES OC(=O)CCN1C(=S)S\C(C1=O)=C1/N(Cc2c(Cl)cccc2Cl)c2ccc(Br)cc2C1=O
Show InChI InChI=1S/C21H13BrCl2N2O4S2/c22-10-4-5-15-11(8-10)18(29)17(26(15)9-12-13(23)2-1-3-14(12)24)19-20(30)25(21(31)32-19)7-6-16(27)28/h1-5,8H,6-7,9H2,(H,27,28)/b19-17-
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n/an/a 2.90E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052840
PNG
(CHEMBL3318746)
Show SMILES Oc1ccc(\C=N\NC(=O)C(=O)N\N=C\c2ccc(O)c(O)c2O)c(O)c1O
Show InChI InChI=1S/C16H14N4O8/c21-9-3-1-7(11(23)13(9)25)5-17-19-15(27)16(28)20-18-6-8-2-4-10(22)14(26)12(8)24/h1-6,21-26H,(H,19,27)(H,20,28)/b17-5+,18-6+
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n/an/a 3.10E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052843
PNG
(CHEMBL3318743)
Show SMILES Oc1ccc(\C=N\NC(=O)c2cccc(c2)C(=O)N\N=C\c2ccc(O)c(O)c2O)c(O)c1O
Show InChI InChI=1S/C22H18N4O8/c27-15-6-4-13(17(29)19(15)31)9-23-25-21(33)11-2-1-3-12(8-11)22(34)26-24-10-14-5-7-16(28)20(32)18(14)30/h1-10,27-32H,(H,25,33)(H,26,34)/b23-9+,24-10+
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n/an/a 3.10E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052842
PNG
(CHEMBL3318744)
Show SMILES Oc1cc(\C=N\NC(=O)c2cccc(c2)C(=O)N\N=C\c2cc(O)c(O)c(O)c2)cc(O)c1O
Show InChI InChI=1S/C22H18N4O8/c27-15-4-11(5-16(28)19(15)31)9-23-25-21(33)13-2-1-3-14(8-13)22(34)26-24-10-12-6-17(29)20(32)18(30)7-12/h1-10,27-32H,(H,25,33)(H,26,34)/b23-9+,24-10+
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n/an/a 3.20E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052835
PNG
(CHEMBL3318751)
Show SMILES Oc1cc(\C=N\NC(=O)CCC(=O)N\N=C\c2cc(O)c(O)c(O)c2)cc(O)c1O
Show InChI InChI=1S/C18H18N4O8/c23-11-3-9(4-12(24)17(11)29)7-19-21-15(27)1-2-16(28)22-20-8-10-5-13(25)18(30)14(26)6-10/h3-8,23-26,29-30H,1-2H2,(H,21,27)(H,22,28)/b19-7+,20-8+
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n/an/a 8.20E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052836
PNG
(CHEMBL3318750)
Show SMILES Oc1ccc(\C=N\NC(=O)CCC(=O)N\N=C\c2ccc(O)c(O)c2O)c(O)c1O
Show InChI InChI=1S/C18H18N4O8/c23-11-3-1-9(15(27)17(11)29)7-19-21-13(25)5-6-14(26)22-20-8-10-2-4-12(24)18(30)16(10)28/h1-4,7-8,23-24,27-30H,5-6H2,(H,21,25)(H,22,26)/b19-7+,20-8+
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n/an/a 9.80E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50053034
PNG
(CHEMBL3318739)
Show SMILES Oc1cc(O)c(\C=N\NC(=O)c2ccc(cc2)C(=O)N\N=C\c2c(O)cc(O)cc2O)c(O)c1
Show InChI InChI=1S/C22H18N4O8/c27-13-5-17(29)15(18(30)6-13)9-23-25-21(33)11-1-2-12(4-3-11)22(34)26-24-10-16-19(31)7-14(28)8-20(16)32/h1-10,27-32H,(H,25,33)(H,26,34)/b23-9+,24-10+
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n/an/a 9.90E+3n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052834
PNG
(CHEMBL3317464)
Show SMILES Oc1ccc(\C=N\NC(=O)CCCC(=O)N\N=C\c2ccc(O)c(O)c2O)c(O)c1O
Show InChI InChI=1S/C19H20N4O8/c24-12-6-4-10(16(28)18(12)30)8-20-22-14(26)2-1-3-15(27)23-21-9-11-5-7-13(25)19(31)17(11)29/h4-9,24-25,28-31H,1-3H2,(H,22,26)(H,23,27)/b20-8+,21-9+
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n/an/a 1.39E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50053033
PNG
(CHEMBL3318740)
Show SMILES Oc1cccc(\C=N\NC(=O)c2cccc(c2)C(=O)N\N=C\c2cccc(O)c2O)c1O
Show InChI InChI=1S/C22H18N4O6/c27-17-8-2-6-15(19(17)29)11-23-25-21(31)13-4-1-5-14(10-13)22(32)26-24-12-16-7-3-9-18(28)20(16)30/h1-12,27-30H,(H,25,31)(H,26,32)/b23-11+,24-12+
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n/an/a 1.48E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052837
PNG
(CHEMBL3318749)
Show SMILES Oc1cc(\C=N\NC(=O)CC(=O)N\N=C\c2cc(O)c(O)c(O)c2)cc(O)c1O
Show InChI InChI=1S/C17H16N4O8/c22-10-1-8(2-11(23)16(10)28)6-18-20-14(26)5-15(27)21-19-7-9-3-12(24)17(29)13(25)4-9/h1-4,6-7,22-25,28-29H,5H2,(H,20,26)(H,21,27)/b18-6+,19-7+
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n/an/a 1.54E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052841
PNG
(CHEMBL3318745)
Show SMILES Oc1cc(O)c(\C=N\NC(=O)c2cccc(c2)C(=O)N\N=C\c2c(O)cc(O)cc2O)c(O)c1
Show InChI InChI=1S/C22H18N4O8/c27-13-5-17(29)15(18(30)6-13)9-23-25-21(33)11-2-1-3-12(4-11)22(34)26-24-10-16-19(31)7-14(28)8-20(16)32/h1-10,27-32H,(H,25,33)(H,26,34)/b23-9+,24-10+
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n/an/a 1.88E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052844
PNG
(CHEMBL3318742)
Show SMILES Oc1ccc(\C=N\NC(=O)c2cccc(c2)C(=O)N\N=C\c2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C22H18N4O6/c27-17-6-4-13(8-19(17)29)11-23-25-21(31)15-2-1-3-16(10-15)22(32)26-24-12-14-5-7-18(28)20(30)9-14/h1-12,27-30H,(H,25,31)(H,26,32)/b23-11+,24-12+
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n/an/a 1.92E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50052833
PNG
(CHEMBL3318752)
Show SMILES Oc1cc(\C=N\NC(=O)CCCC(=O)N\N=C\c2cc(O)c(O)c(O)c2)cc(O)c1O
Show InChI InChI=1S/C19H20N4O8/c24-12-4-10(5-13(25)18(12)30)8-20-22-16(28)2-1-3-17(29)23-21-9-11-6-14(26)19(31)15(27)7-11/h4-9,24-27,30-31H,1-3H2,(H,22,28)(H,23,29)/b20-8+,21-9+
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n/an/a 2.74E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50053032
PNG
(CHEMBL3318741)
Show SMILES Oc1ccc(\C=N\NC(=O)c2cccc(c2)C(=O)N\N=C\c2ccc(O)cc2O)c(O)c1
Show InChI InChI=1S/C22H18N4O6/c27-17-6-4-15(19(29)9-17)11-23-25-21(31)13-2-1-3-14(8-13)22(32)26-24-12-16-5-7-18(28)10-20(16)30/h1-12,27-30H,(H,25,31)(H,26,32)/b23-11+,24-12+
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n/an/a 4.01E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50053039
PNG
(CHEMBL3318734)
Show SMILES Oc1cccc(\C=N\NC(=O)c2ccc(cc2)C(=O)N\N=C\c2cccc(O)c2O)c1O
Show InChI InChI=1S/C22H18N4O6/c27-17-5-1-3-15(19(17)29)11-23-25-21(31)13-7-9-14(10-8-13)22(32)26-24-12-16-4-2-6-18(28)20(16)30/h1-12,27-30H,(H,25,31)(H,26,32)/b23-11+,24-12+
PDB

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n/an/a>7.50E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50053037
PNG
(CHEMBL3318736)
Show SMILES Oc1ccc(\C=N\NC(=O)c2ccc(cc2)C(=O)N\N=C\c2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C22H18N4O6/c27-17-7-1-13(9-19(17)29)11-23-25-21(31)15-3-5-16(6-4-15)22(32)26-24-12-14-2-8-18(28)20(30)10-14/h1-12,27-30H,(H,25,31)(H,26,32)/b23-11+,24-12+
PDB

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n/an/a>7.50E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair
Poly(ADP-ribose) glycohydrolase


(Rattus norvegicus)
BDBM50053038
PNG
(CHEMBL3318735)
Show SMILES Oc1ccc(\C=N\NC(=O)c2ccc(cc2)C(=O)N\N=C\c2ccc(O)cc2O)c(O)c1
Show InChI InChI=1S/C22H18N4O6/c27-17-7-5-15(19(29)9-17)11-23-25-21(31)13-1-2-14(4-3-13)22(32)26-24-12-16-6-8-18(28)10-20(16)30/h1-12,27-30H,(H,25,31)(H,26,32)/b23-11+,24-12+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>7.50E+4n/an/an/an/an/an/a



Kumamoto Health Science University

Curated by ChEMBL


Assay Description
Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay


Bioorg Med Chem Lett 24: 3802-6 (2014)

More data for this
Ligand-Target Pair