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Found 23 hits Enz. Inhib. hit(s) with Target = 'Poly(ADP-ribose) glycohydrolase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM205479
PNG
(PDD00017273 (4))
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnc(C)s3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1
Show InChI InChI=1S/C23H26N6O4S2/c1-14-9-16(27(4)25-14)12-28-20-6-5-18(35(32,33)26-23(3)7-8-23)10-19(20)21(30)29(22(28)31)13-17-11-24-15(2)34-17/h5-6,9-11,26H,7-8,12-13H2,1-4H3
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n/an/a 26n/an/an/an/an/an/a



University of Manchester



Assay Description
Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM205480
PNG
(PDD00017238 (5))
Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3n(-c3ncns3)c2=O)S(=O)(=O)NC2(C)CC2)s1
Show InChI InChI=1S/C19H20N6O3S3/c1-11-16(29-12(2)22-11)9-24-14-5-4-13(31(27,28)23-19(3)6-7-19)8-15(14)25(18(24)26)17-20-10-21-30-17/h4-5,8,10,23H,6-7,9H2,1-3H3
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n/an/a 40n/an/an/an/an/an/a



University of Manchester



Assay Description
Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350107
PNG
(CHEMBL1230692)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)O[P@](O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O12P2/c16-13-9-14(19-4-18-13)21(5-20-9)15-12(25)11(24)8(32-15)3-31-35(28,29)33-34(26,27)30-2-6-10(23)7(22)1-17-6/h4-8,10-12,15,17,22-25H,1-3H2,(H,26,27)(H,28,29)(H2,16,18,19)/t6-,7+,8-,10-,11-,12-,15-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350093
PNG
(CHEMBL1813879)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2cc3ccccc3cc2Br)c(Cl)c1
Show InChI InChI=1S/C23H13BrCl3NO3/c24-17-7-12-3-1-2-4-13(12)8-21(17)31-20-6-5-15(11-18(20)26)28-23(30)16-9-14(25)10-19(27)22(16)29/h1-11,29H,(H,28,30)
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350095
PNG
(CHEMBL1813881)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C23H14Cl3NO3/c24-15-10-18(22(28)20(26)11-15)23(29)27-16-6-8-21(19(25)12-16)30-17-7-5-13-3-1-2-4-14(13)9-17/h1-12,28H,(H,27,29)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350102
PNG
(CHEMBL1813893)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H14Cl2F3NO3/c25-15-10-18(22(31)20(26)11-15)23(32)30-16-6-8-21(19(12-16)24(27,28)29)33-17-7-5-13-3-1-2-4-14(13)9-17/h1-12,31H,(H,30,32)
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50084659
PNG
(3-Bromo-5-chloro-N-[5-chloro-2-(1-chloro-naphthale...)
Show SMILES Oc1c(Br)cc(Cl)cc1C(=O)Nc1cc(Cl)ccc1Oc1ccc2ccccc2c1Cl
Show InChI InChI=1S/C23H13BrCl3NO3/c24-17-10-14(26)9-16(22(17)29)23(30)28-18-11-13(25)6-8-19(18)31-20-7-5-12-3-1-2-4-15(12)21(20)27/h1-11,29H,(H,28,30)
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350103
PNG
(CHEMBL1814045)
Show SMILES Cc1cc(NC(=O)c2cc(Cl)cc(Cl)c2O)ccc1Oc1ccc2ccccc2c1
Show InChI InChI=1S/C24H17Cl2NO3/c1-14-10-18(27-24(29)20-12-17(25)13-21(26)23(20)28)7-9-22(14)30-19-8-6-15-4-2-3-5-16(15)11-19/h2-13,28H,1H3,(H,27,29)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350104
PNG
(CHEMBL1814046)
Show SMILES Cc1ccc(Oc2ccc(NC(=O)c3cc(Cl)cc(Cl)c3O)cc2Cl)cc1
Show InChI InChI=1S/C20H14Cl3NO3/c1-11-2-5-14(6-3-11)27-18-7-4-13(10-16(18)22)24-20(26)15-8-12(21)9-17(23)19(15)25/h2-10,25H,1H3,(H,24,26)
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350094
PNG
(CHEMBL1813880)
Show SMILES CC(C)c1ccc(C)c(Oc2ccc(Cl)cc2NC(=O)c2cc(Cl)cc(Br)c2O)c1Br
Show InChI InChI=1S/C23H19Br2Cl2NO3/c1-11(2)15-6-4-12(3)22(20(15)25)31-19-7-5-13(26)10-18(19)28-23(30)16-8-14(27)9-17(24)21(16)29/h4-11,29H,1-3H3,(H,28,30)
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350101
PNG
(CHEMBL1813892)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(F)c1
Show InChI InChI=1S/C23H14Cl2FNO3/c24-15-10-18(22(28)19(25)11-15)23(29)27-16-6-8-21(20(26)12-16)30-17-7-5-13-3-1-2-4-14(13)9-17/h1-12,28H,(H,27,29)
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350100
PNG
(CHEMBL1813891)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C23H15Cl2NO3/c24-16-12-20(22(27)21(25)13-16)23(28)26-17-6-9-18(10-7-17)29-19-8-5-14-3-1-2-4-15(14)11-19/h1-13,27H,(H,26,28)
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n/an/a 4.20E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM205482
PNG
(PDD00031705 (7))
Show SMILES CN(C1(C)CC1)S(=O)(=O)c1ccc2n(Cc3sc(C)nc3C)c(=O)n(-c3ncns3)c2c1
Show InChI InChI=1S/C20H22N6O3S3/c1-12-17(30-13(2)23-12)10-25-15-6-5-14(32(28,29)24(4)20(3)7-8-20)9-16(15)26(19(25)27)18-21-11-22-31-18/h5-6,9,11H,7-8,10H2,1-4H3
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n/an/a>6.00E+4n/an/an/an/an/an/a



University of Manchester



Assay Description
Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM205481
PNG
(PDD00031704 (6))
Show SMILES CN(C1(C)CC1)S(=O)(=O)c1ccc2n(Cc3cc(C)nn3C)c(=O)n(Cc3cnc(C)s3)c(=O)c2c1
Show InChI InChI=1S/C24H28N6O4S2/c1-15-10-17(27(4)26-15)13-29-21-7-6-19(36(33,34)28(5)24(3)8-9-24)11-20(21)22(31)30(23(29)32)14-18-12-25-16(2)35-18/h6-7,10-12H,8-9,13-14H2,1-5H3
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University of Manchester



Assay Description
Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM205478
PNG
(PDD00013907 (1))
Show SMILES CC(C)(C)NS(=O)(=O)c1ccc2C(=O)c3ccccc3C(=O)c2c1
Show InChI InChI=1S/C18H17NO4S/c1-18(2,3)19-24(22,23)11-8-9-14-15(10-11)17(21)13-7-5-4-6-12(13)16(14)20/h4-10,19H,1-3H3
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University of Manchester



Assay Description
Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350098
PNG
(CHEMBL1813885)
Show SMILES Oc1c(Cl)cccc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C23H15Cl2NO3/c24-19-7-3-6-18(22(19)27)23(28)26-16-9-11-21(20(25)13-16)29-17-10-8-14-4-1-2-5-15(14)12-17/h1-13,27H,(H,26,28)
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n/an/a 6.10E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350105
PNG
(CHEMBL1814047)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H12Cl3NO3/c20-11-8-14(18(24)16(22)9-11)19(25)23-12-6-7-17(15(21)10-12)26-13-4-2-1-3-5-13/h1-10,24H,(H,23,25)
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n/an/a 6.10E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350109
PNG
(CHEMBL1813887)
Show SMILES OC(=O)c1ccccc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C24H16ClNO4/c25-21-14-17(26-23(27)19-7-3-4-8-20(19)24(28)29)10-12-22(21)30-18-11-9-15-5-1-2-6-16(15)13-18/h1-14H,(H,26,27)(H,28,29)
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n/an/a 7.20E+4n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350097
PNG
(CHEMBL1813884)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C23H15Cl2NO3/c24-16-6-9-21(27)19(12-16)23(28)26-17-7-10-22(20(25)13-17)29-18-8-5-14-3-1-2-4-15(14)11-18/h1-13,27H,(H,26,28)
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n/an/a 1.17E+5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350099
PNG
(CHEMBL1813890)
Show SMILES CN(C(=O)c1cc(Cl)cc(Cl)c1O)c1ccc(Oc2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C24H16Cl3NO3/c1-28(24(30)19-11-16(25)12-21(27)23(19)29)17-7-9-22(20(26)13-17)31-18-8-6-14-4-2-3-5-15(14)10-18/h2-13,29H,1H3
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n/an/a 1.40E+5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350096
PNG
(CHEMBL1813883)
Show SMILES Oc1ccccc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C23H16ClNO3/c24-20-14-17(25-23(27)19-7-3-4-8-21(19)26)10-12-22(20)28-18-11-9-15-5-1-2-6-16(15)13-18/h1-14,26H,(H,25,27)
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n/an/a 5.00E+5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50350106
PNG
(CHEMBL1814051)
Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C13H8Cl3NO2/c14-7-2-1-3-9(4-7)17-13(19)10-5-8(15)6-11(16)12(10)18/h1-6,18H,(H,17,19)
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n/an/a 5.00E+5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM50106187
PNG
(Benzenecarboxamide | Benzoic acid amide | Benzoyla...)
Show SMILES NC(=O)c1ccccc1
Show InChI InChI=1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
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antibodypedia
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay


Citation and Details
More data for this
Ligand-Target Pair