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Found 18 hits Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] glycohydrolase' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50350107
PNG
(CHEMBL1230692)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)O[P@](O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O12P2/c16-13-9-14(19-4-18-13)21(5-20-9)15-12(25)11(24)8(32-15)3-31-35(28,29)33-34(26,27)30-2-6-10(23)7(22)1-17-6/h4-8,10-12,15,17,22-25H,1-3H2,(H,26,27)(H,28,29)(H2,16,18,19)/t6-,7+,8-,10-,11-,12-,15-/m1/s1
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n/an/a 330n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit bovine thymus polyadenosine diphosphoribose glycohydrolase (bPARG)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370277
PNG
(CHEMBL610722)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]4NC[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12
Show InChI InChI=1S/C15H23N9O12P2/c16-12-8-13(20-4-19-12)24(15(21-8)22-23-17)14-11(28)10(27)7(35-14)3-34-38(31,32)36-37(29,30)33-2-5-9(26)6(25)1-18-5/h4-7,9-11,14,18,25-28H,1-3H2,(H,29,30)(H,31,32)(H2,16,19,20)/t5-,6+,7-,9-,10-,11-,14?/m1/s1
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n/an/a 390n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit bovine thymus polyadenosine diphosphoribose glycohydrolase (bPARG)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370277
PNG
(CHEMBL610722)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]4NC[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12
Show InChI InChI=1S/C15H23N9O12P2/c16-12-8-13(20-4-19-12)24(15(21-8)22-23-17)14-11(28)10(27)7(35-14)3-34-38(31,32)36-37(29,30)33-2-5-9(26)6(25)1-18-5/h4-7,9-11,14,18,25-28H,1-3H2,(H,29,30)(H,31,32)(H2,16,19,20)/t5-,6+,7-,9-,10-,11-,14?/m1/s1
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n/an/a 440n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50350107
PNG
(CHEMBL1230692)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)O[P@](O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O12P2/c16-13-9-14(19-4-18-13)21(5-20-9)15-12(25)11(24)8(32-15)3-31-35(28,29)33-34(26,27)30-2-6-10(23)7(22)1-17-6/h4-8,10-12,15,17,22-25H,1-3H2,(H,26,27)(H,28,29)(H2,16,18,19)/t6-,7+,8-,10-,11-,12-,15-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50350107
PNG
(CHEMBL1230692)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)O[P@](O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O12P2/c16-13-9-14(19-4-18-13)21(5-20-9)15-12(25)11(24)8(32-15)3-31-35(28,29)33-34(26,27)30-2-6-10(23)7(22)1-17-6/h4-8,10-12,15,17,22-25H,1-3H2,(H,26,27)(H,28,29)(H2,16,18,19)/t6-,7+,8-,10-,11-,12-,15-/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370276
PNG
(CHEMBL608370)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OCC2C[C@@H](O)CN2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O11P2/c16-13-10-14(19-5-18-13)21(6-20-10)15-12(24)11(23)9(31-15)4-30-34(27,28)32-33(25,26)29-3-7-1-8(22)2-17-7/h5-9,11-12,15,17,22-24H,1-4H2,(H,25,26)(H,27,28)(H2,16,18,19)/t7?,8-,9-,11-,12-,15?/m1/s1
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n/an/a 3.07E+3n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit bovine thymus polyadenosine diphosphoribose glycohydrolase (bPARG)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370276
PNG
(CHEMBL608370)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OCC2C[C@@H](O)CN2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O11P2/c16-13-10-14(19-5-18-13)21(6-20-10)15-12(24)11(23)9(31-15)4-30-34(27,28)32-33(25,26)29-3-7-1-8(22)2-17-7/h5-9,11-12,15,17,22-24H,1-4H2,(H,25,26)(H,27,28)(H2,16,18,19)/t7?,8-,9-,11-,12-,15?/m1/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370280
PNG
(CHEMBL611597)
Show SMILES NCCCCCCNc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H38N8O12P2/c22-5-3-1-2-4-6-24-21-28-14-18(23)26-10-27-19(14)29(21)20-17(33)16(32)13(40-20)9-39-43(36,37)41-42(34,35)38-8-11-15(31)12(30)7-25-11/h10-13,15-17,20,25,30-33H,1-9,22H2,(H,24,28)(H,34,35)(H,36,37)(H2,23,26,27)/t11-,12+,13-,15-,16-,17-,20?/m1/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370283
PNG
(CHEMBL608371)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OCC2CCCN2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O10P2/c16-13-10-14(19-6-18-13)21(7-20-10)15-12(23)11(22)9(30-15)5-29-33(26,27)31-32(24,25)28-4-8-2-1-3-17-8/h6-9,11-12,15,17,22-23H,1-5H2,(H,24,25)(H,26,27)(H2,16,18,19)/t8?,9-,11-,12-,15?/m1/s1
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n/an/a 1.92E+4n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit bovine thymus polyadenosine diphosphoribose glycohydrolase (bPARG)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370283
PNG
(CHEMBL608371)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OCC2CCCN2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O10P2/c16-13-10-14(19-6-18-13)21(7-20-10)15-12(23)11(22)9(30-15)5-29-33(26,27)31-32(24,25)28-4-8-2-1-3-17-8/h6-9,11-12,15,17,22-23H,1-5H2,(H,24,25)(H,26,27)(H2,16,18,19)/t8?,9-,11-,12-,15?/m1/s1
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n/an/a 6.30E+4n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370282
PNG
(CHEMBL611596)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]4NC[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O)c(Sc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C21H27ClN6O12P2S/c22-9-1-3-10(4-2-9)43-21-27-14-18(23)25-8-26-19(14)28(21)20-17(32)16(31)13(39-20)7-38-42(35,36)40-41(33,34)37-6-11-15(30)12(29)5-24-11/h1-4,8,11-13,15-17,20,24,29-32H,5-7H2,(H,33,34)(H,35,36)(H2,23,25,26)/t11-,12+,13-,15-,16-,17-,20?/m1/s1
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n/an/a 1.20E+5n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370281
PNG
(CHEMBL611304)
Show SMILES Nc1nc(N=[N+]=[N-])nc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H23N9O12P2/c16-12-8-13(21-15(20-12)22-23-17)24(4-19-8)14-11(28)10(27)7(35-14)3-34-38(31,32)36-37(29,30)33-2-5-9(26)6(25)1-18-5/h4-7,9-11,14,18,25-28H,1-3H2,(H,29,30)(H,31,32)(H2,16,20,21)/t5-,6+,7-,9-,10-,11-,14?/m1/s1
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n/an/a 1.48E+5n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370281
PNG
(CHEMBL611304)
Show SMILES Nc1nc(N=[N+]=[N-])nc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H23N9O12P2/c16-12-8-13(21-15(20-12)22-23-17)24(4-19-8)14-11(28)10(27)7(35-14)3-34-38(31,32)36-37(29,30)33-2-5-9(26)6(25)1-18-5/h4-7,9-11,14,18,25-28H,1-3H2,(H,29,30)(H,31,32)(H2,16,20,21)/t5-,6+,7-,9-,10-,11-,14?/m1/s1
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n/an/a 2.90E+5n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit bovine thymus polyadenosine diphosphoribose glycohydrolase (bPARG)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370278
PNG
(CHEMBL608667)
Show SMILES CCCCCCNc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OCC2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H36N6O12P2/c1-2-3-4-5-6-22-19-15-20(25-10-24-19)27(11-26-15)21-18(31)17(30)14(38-21)9-37-41(34,35)39-40(32,33)36-8-12-16(29)13(28)7-23-12/h10-14,16-18,21,23,28-31H,2-9H2,1H3,(H,32,33)(H,34,35)(H,22,24,25)/t12?,13-,14+,16+,17+,18+,21?/m0/s1
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n/an/a 5.10E+5n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370284
PNG
(CHEMBL608972)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]4NC[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O)c(NCCCCCCNC(=O)C(F)(F)F)nc12
Show InChI InChI=1S/C23H37F3N8O13P2/c24-23(25,26)21(39)28-5-3-1-2-4-6-29-22-33-14-18(27)31-10-32-19(14)34(22)20-17(38)16(37)13(46-20)9-45-49(42,43)47-48(40,41)44-8-11-15(36)12(35)7-30-11/h10-13,15-17,20,30,35-38H,1-9H2,(H,28,39)(H,29,33)(H,40,41)(H,42,43)(H2,27,31,32)/t11-,12+,13-,15-,16-,17-,20?/m1/s1
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n/an/a 5.70E+5n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370279
PNG
(CHEMBL611306)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](COP(O)(=O)OP(O)(=O)OCC2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O13P2/c16-15-19-12-8(13(26)20-15)18-4-21(12)14-11(25)10(24)7(33-14)3-32-36(29,30)34-35(27,28)31-2-5-9(23)6(22)1-17-5/h4-7,9-11,14,17,22-25H,1-3H2,(H,27,28)(H,29,30)(H3,16,19,20,26)/t5?,6-,7+,9+,10+,11+,14?/m0/s1
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n/an/a 9.70E+5n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370279
PNG
(CHEMBL611306)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](COP(O)(=O)OP(O)(=O)OCC2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H24N6O13P2/c16-15-19-12-8(13(26)20-15)18-4-21(12)14-11(25)10(24)7(33-14)3-32-36(29,30)34-35(27,28)31-2-5-9(23)6(22)1-17-5/h4-7,9-11,14,17,22-25H,1-3H2,(H,27,28)(H,29,30)(H3,16,19,20,26)/t5?,6-,7+,9+,10+,11+,14?/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit bovine thymus polyadenosine diphosphoribose glycohydrolase (bPARG)


Citation and Details
More data for this
Ligand-Target Pair
Poly [ADP-ribose] glycohydrolase


(Bos taurus)
BDBM50370275
PNG
(CHEMBL608372)
Show SMILES O[C@H]1CNC(COP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(NCc4ccccc4)ncnc23)[C@H]1O
Show InChI InChI=1S/C22H30N6O12P2/c29-14-7-23-13(17(14)30)8-37-41(33,34)40-42(35,36)38-9-15-18(31)19(32)22(39-15)28-11-27-16-20(25-10-26-21(16)28)24-6-12-4-2-1-3-5-12/h1-5,10-11,13-15,17-19,22-23,29-32H,6-9H2,(H,33,34)(H,35,36)(H,24,25,26)/t13?,14-,15+,17+,18+,19+,22?/m0/s1
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Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
The compound was tested for its ability to inhibit bovine thymus polyadenosine diphosphoribose glycohydrolase (bPARG)


Citation and Details
More data for this
Ligand-Target Pair