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Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Polyphenol oxidase (PPO)' AND taxid = 936046   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polyphenol oxidase (PPO)


(Agaricus bisporus (Mushroom))
BDBM173587
PNG
((2E)-3-(3,5-dihydroxyphenyl)-1-(3-hydroxynaphthale...)
Show SMILES Oc1cc(O)cc(\C=C\C(=O)c2cc3ccccc3cc2O)c1
Show InChI InChI=1S/C19H14O4/c20-15-7-12(8-16(21)11-15)5-6-18(22)17-9-13-3-1-2-4-14(13)10-19(17)23/h1-11,20-21,23H/b6-5+
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
3.80E+3n/a 1.04E+4n/an/an/an/an/an/a



University of Technology Sydney



Assay Description
The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...


Bioorg Chem 63: 116-22 (2015)

More data for this
Ligand-Target Pair
Polyphenol oxidase (PPO)


(Agaricus bisporus (Mushroom))
BDBM173584
PNG
((2E)-3-(2,4-dihydroxyphenyl)-1-(3-hydroxynaphthale...)
Show SMILES Oc1ccc(\C=C\C(=O)c2cc3ccccc3cc2O)c(O)c1
Show InChI InChI=1S/C19H14O4/c20-15-7-5-12(18(22)11-15)6-8-17(21)16-9-13-3-1-2-4-14(13)10-19(16)23/h1-11,20,22-23H/b8-6+
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
4.50E+3n/a 1.44E+4n/an/an/an/an/an/a



University of Technology Sydney



Assay Description
The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...


Bioorg Chem 63: 116-22 (2015)

More data for this
Ligand-Target Pair
Polyphenol oxidase (PPO)


(Agaricus bisporus (Mushroom))
BDBM173583
PNG
((2E)-3-(2,5-dihydroxyphenyl)-1-(3-hydroxynaphthale...)
Show SMILES Oc1ccc(O)c(\C=C\C(=O)c2cc3ccccc3cc2O)c1
Show InChI InChI=1S/C19H14O4/c20-15-6-8-17(21)14(9-15)5-7-18(22)16-10-12-3-1-2-4-13(12)11-19(16)23/h1-11,20-21,23H/b7-5+
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
1.08E+4n/a 2.04E+4n/an/an/an/an/an/a



University of Technology Sydney



Assay Description
The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...


Bioorg Chem 63: 116-22 (2015)

More data for this
Ligand-Target Pair
Polyphenol oxidase (PPO)


(Agaricus bisporus (Mushroom))
BDBM173585
PNG
((2E)-1-(3-hydroxynaphthalen-2-yl)-3-(2-hydroxy-4-n...)
Show SMILES Oc1cc(ccc1\C=C\C(=O)c1cc2ccccc2cc1O)[N+]([O-])=O
Show InChI InChI=1S/C19H13NO5/c21-17(8-6-12-5-7-15(20(24)25)11-18(12)22)16-9-13-3-1-2-4-14(13)10-19(16)23/h1-11,22-23H/b8-6+
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
1.12E+4n/a 2.29E+4n/an/an/an/an/an/a



University of Technology Sydney



Assay Description
The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...


Bioorg Chem 63: 116-22 (2015)

More data for this
Ligand-Target Pair
Polyphenol oxidase (PPO)


(Agaricus bisporus (Mushroom))
BDBM173586
PNG
((2E)-1-(3-hydroxynaphthalen-2-yl)-3-(4-hydroxy-3-n...)
Show SMILES Oc1ccc(\C=C\C(=O)c2cc3ccccc3cc2O)cc1[N+]([O-])=O
Show InChI InChI=1S/C19H13NO5/c21-17(7-5-12-6-8-18(22)16(9-12)20(24)25)15-10-13-3-1-2-4-14(13)11-19(15)23/h1-11,22-23H/b7-5+
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
1.19E+4n/a 2.56E+4n/an/an/an/an/an/a



University of Technology Sydney



Assay Description
The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...


Bioorg Chem 63: 116-22 (2015)

More data for this
Ligand-Target Pair
Polyphenol oxidase (PPO)


(Agaricus bisporus (Mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
UniProtKB/TrEMBL

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Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.22E+4n/a 2.75E+4n/an/an/an/an/an/a



University of Technology Sydney



Assay Description
The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...


Bioorg Chem 63: 116-22 (2015)

More data for this
Ligand-Target Pair