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Found 22 hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2' AND taxid = 10141   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279434
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES Oc1cn(N=C2CCOc3ccc(Cl)cc23)c(=O)n1CCCCN1CCCCC1
Show InChI InChI=1S/C21H27ClN4O3/c22-16-6-7-19-17(14-16)18(8-13-29-19)23-26-15-20(27)25(21(26)28)12-5-4-11-24-9-2-1-3-10-24/h6-7,14-15,27H,1-5,8-13H2
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n/an/a 6.20n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279741
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C25H36N4O4/c1-2-3-16-32-20-9-10-23-21(18-20)22(11-17-33-23)26-29-19-24(30)28(25(29)31)15-8-7-14-27-12-5-4-6-13-27/h9-10,18-19,30H,2-8,11-17H2,1H3
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n/an/a 17n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279454
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C23H33N5O4/c1-3-14-31-18-5-6-21-19(16-18)20(7-15-32-21)24-28-17-22(29)27(23(28)30)9-4-8-26-12-10-25(2)11-13-26/h5-6,16-17,29H,3-4,7-15H2,1-2H3
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n/an/a 106n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 180n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279703
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C25H37N5O4/c1-3-4-16-33-20-7-8-23-21(18-20)22(9-17-34-23)26-30-19-24(31)29(25(30)32)11-6-5-10-28-14-12-27(2)13-15-28/h7-8,18-19,31H,3-6,9-17H2,1-2H3
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n/an/a 180n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279740
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C24H34N4O4/c1-2-15-31-19-8-9-22-20(17-19)21(10-16-32-22)25-28-18-23(29)27(24(28)30)14-7-6-13-26-11-4-3-5-12-26/h8-9,17-18,29H,2-7,10-16H2,1H3
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n/an/a 400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279739
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C23H32N4O4/c1-2-30-18-8-9-21-19(16-18)20(10-15-31-21)24-27-17-22(28)26(23(27)29)14-7-6-13-25-11-4-3-5-12-25/h8-9,16-17,28H,2-7,10-15H2,1H3
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n/an/a 450n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279719
PNG
(1-(2,3-dihydro-6-amidecarboxylchromen-4-ylideneami...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=C3CCOc4ccc(cc34)C(N)=O)c2=O)CC1
Show InChI InChI=1S/C22H30N6O4/c1-25-9-11-26(12-10-25)7-2-3-8-27-20(29)15-28(22(27)31)24-18-6-13-32-19-5-4-16(21(23)30)14-17(18)19/h4-5,14-15,29H,2-3,6-13H2,1H3,(H2,23,30)
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n/an/a 450n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279436
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C21H29N5O4/c1-23-9-11-24(12-10-23)7-3-8-25-20(27)15-26(21(25)28)22-18-6-13-30-19-5-4-16(29-2)14-17(18)19/h4-5,14-15,27H,3,6-13H2,1-2H3
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n/an/a 540n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279456
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCn2c(O)cn(N=C3CCOc4ccc(C)cc34)c2=O)CC1
Show InChI InChI=1S/C21H29N5O3/c1-16-4-5-19-17(14-16)18(6-13-29-19)22-26-15-20(27)25(21(26)28)8-3-7-24-11-9-23(2)10-12-24/h4-5,14-15,27H,3,6-13H2,1-2H3
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n/an/a 619n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279700
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C22H31N5O4/c1-24-10-12-25(13-11-24)8-3-4-9-26-21(28)16-27(22(26)29)23-19-7-14-31-20-6-5-17(30-2)15-18(19)20/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279471
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCn2c(O)cn(N=C3CCOc4ccc(Cl)cc34)c2=O)CC1
Show InChI InChI=1S/C20H26ClN5O3/c1-23-8-10-24(11-9-23)6-2-7-25-19(27)14-26(20(25)28)22-17-5-12-29-18-4-3-15(21)13-16(17)18/h3-4,13-14,27H,2,5-12H2,1H3
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n/an/a 3.87E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279453
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C22H31N5O4/c1-3-30-17-5-6-20-18(15-17)19(7-14-31-20)23-27-16-21(28)26(22(27)29)9-4-8-25-12-10-24(2)11-13-25/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a 4.34E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279717
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=C3CCOc4ccc(Cl)cc34)c2=O)CC1
Show InChI InChI=1S/C21H28ClN5O3/c1-24-9-11-25(12-10-24)7-2-3-8-26-20(28)15-27(21(26)29)23-18-6-13-30-19-5-4-16(22)14-17(18)19/h4-5,14-15,28H,2-3,6-13H2,1H3
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n/an/a 4.70E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279701
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C23H33N5O4/c1-3-31-18-6-7-21-19(16-18)20(8-15-32-21)24-28-17-22(29)27(23(28)30)10-5-4-9-26-13-11-25(2)12-14-26/h6-7,16-17,29H,3-5,8-15H2,1-2H3
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n/an/a 6.15E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279738
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C22H30N4O4/c1-29-17-7-8-20-18(15-17)19(9-14-30-20)23-26-16-21(27)25(22(26)28)13-6-5-12-24-10-3-2-4-11-24/h7-8,15-16,27H,2-6,9-14H2,1H3
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n/an/a 7.47E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279433
PNG
(1-(2,3-dihydro-6-hydroxychromen-4-ylideneamino)-3-...)
Show SMILES Oc1cn(N=C2CCOc3ccc(O)cc23)c(=O)n1CCCCN1CCCCC1
Show InChI InChI=1S/C21H28N4O4/c26-16-6-7-19-17(14-16)18(8-13-29-19)22-25-15-20(27)24(21(25)28)12-5-4-11-23-9-2-1-3-10-23/h6-7,14-15,26-27H,1-5,8-13H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279718
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=C3CCOc4ccc(C)cc34)c2=O)CC1
Show InChI InChI=1S/C22H31N5O3/c1-17-5-6-20-18(15-17)19(7-14-30-20)23-27-16-21(28)26(22(27)29)9-4-3-8-25-12-10-24(2)11-13-25/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279702
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C24H35N5O4/c1-3-15-32-19-6-7-22-20(17-19)21(8-16-33-22)25-29-18-23(30)28(24(29)31)10-5-4-9-27-13-11-26(2)12-14-27/h6-7,17-18,30H,3-5,8-16H2,1-2H3
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n/an/a 1.18E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279435
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES Cc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C22H30N4O3/c1-17-7-8-20-18(15-17)19(9-14-29-20)23-26-16-21(27)25(22(26)28)13-6-5-12-24-10-3-2-4-11-24/h7-8,15-16,27H,2-6,9-14H2,1H3
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n/an/a 2.20E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279455
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C24H35N5O4/c1-3-4-15-32-19-6-7-22-20(17-19)21(8-16-33-22)25-29-18-23(30)28(24(29)31)10-5-9-27-13-11-26(2)12-14-27/h6-7,17-18,30H,3-5,8-16H2,1-2H3
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n/an/a 3.97E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


Citation and Details
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Cavia porcellus)
BDBM50279716
PNG
(1-(2,3-dihydro-6-hydroxychromen-4-ylideneamino)-3-...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=C3CCOc4ccc(O)cc34)c2=O)CC1
Show InChI InChI=1S/C21H29N5O4/c1-23-9-11-24(12-10-23)7-2-3-8-25-20(28)15-26(21(25)29)22-18-6-13-30-19-5-4-16(27)14-17(18)19/h4-5,14-15,27-28H,2-3,6-13H2,1H3
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...


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