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Found 139 hits Enz. Inhib. hit(s) with Target = 'Probable G-protein coupled receptor 88' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065698
PNG
(CHEMBL3400251)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)CC(C)C)C(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1/C29H34N2O2/c1-20(2)17-24(30)19-31(29(32)28-18-27(28)23-7-5-4-6-8-23)25-13-9-21(10-14-25)22-11-15-26(33-3)16-12-22/h4-16,20,24,27-28H,17-19,30H2,1-3H3/t24-,27-,28+/s2
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n/an/an/an/a 330n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065699
PNG
(CHEMBL3400250)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1C
Show InChI InChI=1/C29H34N2O/c1-20(2)17-24(30)19-31(29(32)28-18-27(28)22-10-5-4-6-11-22)25-15-13-23(14-16-25)26-12-8-7-9-21(26)3/h4-16,20,24,27-28H,17-19,30H2,1-3H3/t24-,27-,28+/s2
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n/an/an/an/a 3.40E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065700
PNG
(CHEMBL3400249)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1cccc(C)c1
Show InChI InChI=1/C29H34N2O/c1-20(2)16-25(30)19-31(29(32)28-18-27(28)23-9-5-4-6-10-23)26-14-12-22(13-15-26)24-11-7-8-21(3)17-24/h4-15,17,20,25,27-28H,16,18-19,30H2,1-3H3/t25-,27-,28+/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065701
PNG
(CHEMBL3400248)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1/C29H34N2O/c1-20(2)17-25(30)19-31(29(32)28-18-27(28)24-7-5-4-6-8-24)26-15-13-23(14-16-26)22-11-9-21(3)10-12-22/h4-16,20,25,27-28H,17-19,30H2,1-3H3/t25-,27-,28+/s2
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n/an/an/an/a 360n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065702
PNG
(CHEMBL3400247)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)C1=CCCCC1
Show InChI InChI=1/C28H36N2O/c1-20(2)17-24(29)19-30(28(31)27-18-26(27)23-11-7-4-8-12-23)25-15-13-22(14-16-25)21-9-5-3-6-10-21/h4,7-9,11-16,20,24,26-27H,3,5-6,10,17-19,29H2,1-2H3/t24-,26-,27+/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065703
PNG
(CHEMBL3400246)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)C1=CCCCCC1
Show InChI InChI=1/C29H38N2O/c1-21(2)18-25(30)20-31(29(32)28-19-27(28)24-12-8-5-9-13-24)26-16-14-23(15-17-26)22-10-6-3-4-7-11-22/h5,8-10,12-17,21,25,27-28H,3-4,6-7,11,18-20,30H2,1-2H3/t25-,27-,28+/s2
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n/an/an/an/a 2.10E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065704
PNG
(CHEMBL3400245)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)C1=CCCC1
Show InChI InChI=1/C27H34N2O/c1-19(2)16-23(28)18-29(24-14-12-21(13-15-24)20-8-6-7-9-20)27(30)26-17-25(26)22-10-4-3-5-11-22/h3-5,8,10-15,19,23,25-26H,6-7,9,16-18,28H2,1-2H3/t23-,25-,26+/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065705
PNG
(CHEMBL3400244)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccoc1
Show InChI InChI=1/C26H30N2O2/c1-18(2)14-22(27)16-28(23-10-8-19(9-11-23)21-12-13-30-17-21)26(29)25-15-24(25)20-6-4-3-5-7-20/h3-13,17-18,22,24-25H,14-16,27H2,1-2H3/t22-,24-,25+/s2
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n/an/an/an/a 2.00E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065706
PNG
(CHEMBL3400243)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1cccs1
Show InChI InChI=1/C26H30N2OS/c1-18(2)15-21(27)17-28(22-12-10-20(11-13-22)25-9-6-14-30-25)26(29)24-16-23(24)19-7-4-3-5-8-19/h3-14,18,21,23-24H,15-17,27H2,1-2H3/t21-,23-,24+/s2
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n/an/an/an/a 1.50E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065707
PNG
(CHEMBL3400242)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccsc1
Show InChI InChI=1/C26H30N2OS/c1-18(2)14-22(27)16-28(23-10-8-19(9-11-23)21-12-13-30-17-21)26(29)25-15-24(25)20-6-4-3-5-7-20/h3-13,17-18,22,24-25H,14-16,27H2,1-2H3/t22-,24-,25+/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065708
PNG
(CHEMBL3400241)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1/C27H31N3O/c1-19(2)16-23(28)18-30(27(31)26-17-25(26)22-6-4-3-5-7-22)24-10-8-20(9-11-24)21-12-14-29-15-13-21/h3-15,19,23,25-26H,16-18,28H2,1-2H3/t23-,25-,26+/s2
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n/an/an/an/a 1.30E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065709
PNG
(CHEMBL3400240)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1/C27H31N3O/c1-19(2)15-23(28)18-30(27(31)26-16-25(26)21-7-4-3-5-8-21)24-12-10-20(11-13-24)22-9-6-14-29-17-22/h3-14,17,19,23,25-26H,15-16,18,28H2,1-2H3/t23-,25-,26+/s2
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n/an/an/an/a 1.00E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065710
PNG
(CHEMBL3400239)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccccc1-c1ccccc1
Show InChI InChI=1/C28H32N2O/c1-20(2)17-23(29)19-30(28(31)26-18-25(26)22-13-7-4-8-14-22)27-16-10-9-15-24(27)21-11-5-3-6-12-21/h3-16,20,23,25-26H,17-19,29H2,1-2H3/t23-,25-,26+/s2
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n/an/an/an/a 6.20E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065711
PNG
(CHEMBL3400238)
Show SMILES CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1/C28H32N2O/c1-20(2)16-24(29)19-30(28(31)27-18-26(27)22-12-7-4-8-13-22)25-15-9-14-23(17-25)21-10-5-3-6-11-21/h3-15,17,20,24,26-27H,16,18-19,29H2,1-2H3/t24-,26-,27+/s2
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n/an/an/an/a 2.30E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065712
PNG
(CHEMBL3400237)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1csc(C)n1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C26H31N3OS/c1-4-17(2)24(27)15-29(26(30)23-14-22(23)25-16-31-18(3)28-25)21-12-10-20(11-13-21)19-8-6-5-7-9-19/h5-13,16-17,22-24H,4,14-15,27H2,1-3H3/t17-,22+,23+,24+/s2
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n/an/an/an/a 1.50E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065713
PNG
(CHEMBL3400236)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)c(C)s1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C27H33N3OS/c1-5-17(2)25(28)16-30(22-13-11-21(12-14-22)20-9-7-6-8-10-20)27(31)24-15-23(24)26-29-18(3)19(4)32-26/h6-14,17,23-25H,5,15-16,28H2,1-4H3/t17-,23+,24+,25+/s2
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n/an/an/an/a 3.60E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065714
PNG
(CHEMBL3400235)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncc(C)s1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C26H31N3OS/c1-4-17(2)24(27)16-29(26(30)23-14-22(23)25-28-15-18(3)31-25)21-12-10-20(11-13-21)19-8-6-5-7-9-19/h5-13,15,17,22-24H,4,14,16,27H2,1-3H3/t17-,22+,23+,24+/s2
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n/an/an/an/a 1.30E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065715
PNG
(CHEMBL3400234)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)cs1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C26H31N3OS/c1-4-17(2)24(27)15-29(26(30)23-14-22(23)25-28-18(3)16-31-25)21-12-10-20(11-13-21)19-8-6-5-7-9-19/h5-13,16-17,22-24H,4,14-15,27H2,1-3H3/t17-,22+,23+,24+/s2
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n/an/an/an/a 730n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065716
PNG
(CHEMBL3400233)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccoc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C26H30N2O2/c1-3-18(2)25(27)16-28(26(29)24-15-23(24)21-13-14-30-17-21)22-11-9-20(10-12-22)19-7-5-4-6-8-19/h4-14,17-18,23-25H,3,15-16,27H2,1-2H3/t18-,23-,24+,25+/s2
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n/an/an/an/a 580n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065717
PNG
(CHEMBL3400232)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccsc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C26H30N2OS/c1-3-18(2)25(27)16-28(26(29)24-15-23(24)21-13-14-30-17-21)22-11-9-20(10-12-22)19-7-5-4-6-8-19/h4-14,17-18,23-25H,3,15-16,27H2,1-2H3/t18-,23-,24+,25+/s2
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n/an/an/an/a 450n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065718
PNG
(CHEMBL3400231)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccs1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C26H30N2OS/c1-3-18(2)24(27)17-28(26(29)23-16-22(23)25-10-7-15-30-25)21-13-11-20(12-14-21)19-8-5-4-6-9-19/h4-15,18,22-24H,3,16-17,27H2,1-2H3/t18-,22+,23+,24+/s2
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n/an/an/an/a 360n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065719
PNG
(CHEMBL3400230)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nccs1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C25H29N3OS/c1-3-17(2)23(26)16-28(25(29)22-15-21(22)24-27-13-14-30-24)20-11-9-19(10-12-20)18-7-5-4-6-8-18/h4-14,17,21-23H,3,15-16,26H2,1-2H3/t17-,21+,22+,23+/s2
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n/an/an/an/a 210n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065720
PNG
(CHEMBL3400229)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cncnc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C26H30N4O/c1-3-18(2)25(27)16-30(26(31)24-13-23(24)21-14-28-17-29-15-21)22-11-9-20(10-12-22)19-7-5-4-6-8-19/h4-12,14-15,17-18,23-25H,3,13,16,27H2,1-2H3/t18-,23-,24+,25+/s2
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n/an/an/an/a 1.90E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065721
PNG
(CHEMBL3400228)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C26H30N4O/c1-3-18(2)24(27)17-30(26(31)23-16-22(23)25-28-14-7-15-29-25)21-12-10-20(11-13-21)19-8-5-4-6-9-19/h4-15,18,22-24H,3,16-17,27H2,1-2H3/t18-,22+,23+,24+/s2
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n/an/an/an/a 130n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065722
PNG
(CHEMBL3400227)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccncc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C27H31N3O/c1-3-19(2)26(28)18-30(27(31)25-17-24(25)22-13-15-29-16-14-22)23-11-9-21(10-12-23)20-7-5-4-6-8-20/h4-16,19,24-26H,3,17-18,28H2,1-2H3/t19-,24-,25+,26+/s2
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n/an/an/an/a 1.50E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065723
PNG
(CHEMBL3400226)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccnc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C27H31N3O/c1-3-19(2)26(28)18-30(27(31)25-16-24(25)22-10-7-15-29-17-22)23-13-11-21(12-14-23)20-8-5-4-6-9-20/h4-15,17,19,24-26H,3,16,18,28H2,1-2H3/t19-,24-,25+,26+/s2
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n/an/an/an/a 1.50E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065724
PNG
(CHEMBL3400225)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C27H31N3O/c1-3-19(2)25(28)18-30(27(31)24-17-23(24)26-11-7-8-16-29-26)22-14-12-21(13-15-22)20-9-5-4-6-10-20/h4-16,19,23-25H,3,17-18,28H2,1-2H3/t19-,23+,24+,25+/s2
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n/an/an/an/a 130n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065725
PNG
(CHEMBL3400224)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1c(F)cccc1F)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H30F2N2O/c1-3-18(2)26(31)17-32(21-14-12-20(13-15-21)19-8-5-4-6-9-19)28(33)23-16-22(23)27-24(29)10-7-11-25(27)30/h4-15,18,22-23,26H,3,16-17,31H2,1-2H3/t18-,22+,23+,26+/s2
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n/an/an/an/a 1.10E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065726
PNG
(CHEMBL3400223)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1F)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H30F2N2O/c1-3-18(2)27(31)17-32(22-12-9-20(10-13-22)19-7-5-4-6-8-19)28(33)25-16-24(25)23-14-11-21(29)15-26(23)30/h4-15,18,24-25,27H,3,16-17,31H2,1-2H3/t18-,24-,25+,27+/s2
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n/an/an/an/a 1.30E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065727
PNG
(CHEMBL3400222)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)c(F)c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H30F2N2O/c1-3-18(2)27(31)17-32(22-12-9-20(10-13-22)19-7-5-4-6-8-19)28(33)24-16-23(24)21-11-14-25(29)26(30)15-21/h4-15,18,23-24,27H,3,16-17,31H2,1-2H3/t18-,23-,24+,27+/s2
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n/an/an/an/a 720n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065728
PNG
(CHEMBL3400221)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)cc(F)c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H30F2N2O/c1-3-18(2)27(31)17-32(24-11-9-20(10-12-24)19-7-5-4-6-8-19)28(33)26-16-25(26)21-13-22(29)15-23(30)14-21/h4-15,18,25-27H,3,16-17,31H2,1-2H3/t18-,25-,26+,27+/s2
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n/an/an/an/a 960n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065729
PNG
(CHEMBL3400220)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)ccc1F)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H30F2N2O/c1-3-18(2)27(31)17-32(22-12-9-20(10-13-22)19-7-5-4-6-8-19)28(33)25-16-23(25)24-15-21(29)11-14-26(24)30/h4-15,18,23,25,27H,3,16-17,31H2,1-2H3/t18-,23-,25+,27+/s2
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n/an/an/an/a 770n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065730
PNG
(CHEMBL3400219)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1C1CCCCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H38N2O/c1-3-20(2)27(29)19-30(28(31)26-18-25(26)23-12-8-5-9-13-23)24-16-14-22(15-17-24)21-10-6-4-7-11-21/h4,6-7,10-11,14-17,20,23,25-27H,3,5,8-9,12-13,18-19,29H2,1-2H3/t20-,25-,26+,27+/s2
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n/an/an/an/a>2.50E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065731
PNG
(CHEMBL3400218)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(c1)C#N)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C29H31N3O/c1-3-20(2)28(31)19-32(25-14-12-23(13-15-25)22-9-5-4-6-10-22)29(33)27-17-26(27)24-11-7-8-21(16-24)18-30/h4-16,20,26-28H,3,17,19,31H2,1-2H3/t20-,26-,27+,28+/s2
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n/an/an/an/a 1.60E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065733
PNG
(CHEMBL3400217)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(cc1)C#N)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C29H31N3O/c1-3-20(2)28(31)19-32(25-15-13-23(14-16-25)22-7-5-4-6-8-22)29(33)27-17-26(27)24-11-9-21(18-30)10-12-24/h4-16,20,26-28H,3,17,19,31H2,1-2H3/t20-,26-,27+,28+/s2
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n/an/an/an/a>2.50E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065734
PNG
(CHEMBL3400216)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C)c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C29H34N2O/c1-4-21(3)28(30)19-31(25-15-13-23(14-16-25)22-10-6-5-7-11-22)29(32)27-18-26(27)24-12-8-9-20(2)17-24/h5-17,21,26-28H,4,18-19,30H2,1-3H3/t21-,26-,27+,28+/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065735
PNG
(CHEMBL3400215)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1F)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H31FN2O/c1-3-19(2)27(30)18-31(22-15-13-21(14-16-22)20-9-5-4-6-10-20)28(32)25-17-24(25)23-11-7-8-12-26(23)29/h4-16,19,24-25,27H,3,17-18,30H2,1-2H3/t19-,24-,25+,27+/s2
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n/an/an/an/a 650n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065736
PNG
(CHEMBL3400214)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H31FN2O/c1-3-19(2)27(30)18-31(24-14-12-21(13-15-24)20-8-5-4-6-9-20)28(32)26-17-25(26)22-10-7-11-23(29)16-22/h4-16,19,25-27H,3,17-18,30H2,1-2H3/t19-,25-,26+,27+/s2
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n/an/an/an/a 560n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065737
PNG
(CHEMBL3400213)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H31FN2O/c1-3-19(2)27(30)18-31(24-15-11-21(12-16-24)20-7-5-4-6-8-20)28(32)26-17-25(26)22-9-13-23(29)14-10-22/h4-16,19,25-27H,3,17-18,30H2,1-2H3/t19-,25-,26+,27+/s2
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n/an/an/an/a 600n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065738
PNG
(CHEMBL3400212)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(OC)c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C29H34N2O2/c1-4-20(2)28(30)19-31(24-15-13-22(14-16-24)21-9-6-5-7-10-21)29(32)27-18-26(27)23-11-8-12-25(17-23)33-3/h5-17,20,26-28H,4,18-19,30H2,1-3H3/t20-,26-,27+,28+/s2
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n/an/an/an/a 3.00E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065739
PNG
(CHEMBL3400150)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(OC)cc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C29H34N2O2/c1-4-20(2)28(30)19-31(24-14-10-22(11-15-24)21-8-6-5-7-9-21)29(32)27-18-26(27)23-12-16-25(33-3)17-13-23/h5-17,20,26-28H,4,18-19,30H2,1-3H3/t20-,26-,27+,28+/s2
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n/an/an/an/a>2.50E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065740
PNG
(CHEMBL3400211)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1Cl)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H31ClN2O/c1-3-19(2)27(30)18-31(22-15-13-21(14-16-22)20-9-5-4-6-10-20)28(32)25-17-24(25)23-11-7-8-12-26(23)29/h4-16,19,24-25,27H,3,17-18,30H2,1-2H3/t19-,24-,25+,27+/s2
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n/an/an/an/a>2.50E+4n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065741
PNG
(CHEMBL3400210)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H31ClN2O/c1-3-19(2)27(30)18-31(24-14-12-21(13-15-24)20-8-5-4-6-9-20)28(32)26-17-25(26)22-10-7-11-23(29)16-22/h4-16,19,25-27H,3,17-18,30H2,1-2H3/t19-,25-,26+,27+/s2
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n/an/an/an/a 2.20E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065742
PNG
(CHEMBL3400209)
Show SMILES CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(Cl)cc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C28H31ClN2O/c1-3-19(2)27(30)18-31(24-15-11-21(12-16-24)20-7-5-4-6-8-20)28(32)26-17-25(26)22-9-13-23(29)14-10-22/h4-16,19,25-27H,3,17-18,30H2,1-2H3/t19-,25-,26+,27+/s2
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PubMed
n/an/an/an/a 4.30E+3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065743
PNG
(CHEMBL3400208)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C30H34N2O/c33-30(29-21-28(29)26-13-5-2-6-14-26)32(20-19-31-22-23-9-7-8-10-23)27-17-15-25(16-18-27)24-11-3-1-4-12-24/h1-6,11-18,23,28-29,31H,7-10,19-22H2/t28-,29+/s2
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n/an/an/an/a 2.5n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065744
PNG
(CHEMBL3400207)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C31H36N2O/c34-31(30-22-29(30)27-14-8-3-9-15-27)33(21-20-32-23-24-10-4-1-5-11-24)28-18-16-26(17-19-28)25-12-6-2-7-13-25/h2-3,6-9,12-19,24,29-30,32H,1,4-5,10-11,20-23H2/t29-,30+/s2
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n/an/an/an/a 6.60n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065745
PNG
(CHEMBL3400206)
Show SMILES CCC(C)CNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C29H34N2O/c1-3-22(2)21-30-18-19-31(29(32)28-20-27(28)25-12-8-5-9-13-25)26-16-14-24(15-17-26)23-10-6-4-7-11-23/h4-17,22,27-28,30H,3,18-21H2,1-2H3/t22?,27-,28+/s2
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n/an/an/an/a 4.70n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065746
PNG
(CHEMBL3400205)
Show SMILES CC(C)CCNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C29H34N2O/c1-22(2)17-18-30-19-20-31(29(32)28-21-27(28)25-11-7-4-8-12-25)26-15-13-24(14-16-26)23-9-5-3-6-10-23/h3-16,22,27-28,30H,17-21H2,1-2H3/t27-,28+/s2
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n/an/an/an/a 5.10n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065747
PNG
(CHEMBL3400204)
Show SMILES CCC(CC)C(N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C30H36N2O/c1-3-22(4-2)29(31)19-20-32(30(33)28-21-27(28)25-13-9-6-10-14-25)26-17-15-24(16-18-26)23-11-7-5-8-12-23/h5-18,22,27-29H,3-4,19-21,31H2,1-2H3/t27-,28+,29?/s2
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n/an/an/an/a 2n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 88


(Homo sapiens)
BDBM50065748
PNG
(CHEMBL3400203)
Show SMILES CC(C)C[C@H](N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1/C29H34N2O/c1-21(2)19-25(30)17-18-31(29(32)28-20-27(28)24-11-7-4-8-12-24)26-15-13-23(14-16-26)22-9-5-3-6-10-22/h3-16,21,25,27-28H,17-20,30H2,1-2H3/t25-,27+,28-/s2
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n/an/an/an/a 3n/an/an/an/a



Lexicon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
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