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Compile Data Set for Download or QSAR

Found 58 hits Enz. Inhib. hit(s) with Target = 'Progesterone receptor' AND taxid = 9986   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50026617
PNG
(17-Hydroxy-17-(2-iodo-vinyl)-13-methyl-1,2,6,7,8,9...)
Show SMILES CC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)\C=C\I
Show InChI InChI=1S/C20H27IO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h10-12,15-18,23H,2-9H2,1H3/b11-10+
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1.81n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-R5020 binding to rabbit uterine progesterone receptor


J Med Chem 28: 1695-9 (1985)

Checked by Author
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50026618
PNG
(17-Hydroxy-17-(2-iodo-vinyl)-13-methyl-1,2,6,7,8,9...)
Show SMILES CC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)\C=C/I
Show InChI InChI=1S/C20H27IO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h10-12,15-18,23H,2-9H2,1H3/b11-10-
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4.26n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-R5020 binding to rabbit uterine progesterone receptor


J Med Chem 28: 1695-9 (1985)

Checked by Author
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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10.4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-R5020 binding to rabbit uterine progesterone receptor


J Med Chem 28: 1695-9 (1985)

Checked by Author
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50026619
PNG
(17-Hydroxy-16-iodo-13-methyl-1,2,6,7,8,9,10,11,12,...)
Show SMILES CC12CCC3C(CCC4=CC(=O)CCC34)C1C[C@@H](I)C2O
Show InChI InChI=1S/C18H25IO2/c1-18-7-6-13-12-5-3-11(20)8-10(12)2-4-14(13)15(18)9-16(19)17(18)21/h8,12-17,21H,2-7,9H2,1H3/t12?,13?,14?,15?,16-,17?,18?/m1/s1
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39.8n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-R5020 binding to rabbit uterine progesterone receptor


J Med Chem 28: 1695-9 (1985)

Checked by Author
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50026616
PNG
(17-Hydroxy-17-(1-iodo-vinyl)-13-methyl-1,2,6,7,8,9...)
Show SMILES CC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C(I)=C
Show InChI InChI=1S/C20H27IO2/c1-12(21)20(23)10-8-18-17-5-3-13-11-14(22)4-6-15(13)16(17)7-9-19(18,20)2/h11,15-18,23H,1,3-10H2,2H3
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80.1n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-R5020 binding to rabbit uterine progesterone receptor


J Med Chem 28: 1695-9 (1985)

Checked by Author
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290345
PNG
(7-(3,4-Difluoro-benzyl)-1-(4-fluoro-phenyl)-4,5,6,...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3ccc(F)c(F)c3)c12
Show InChI InChI=1S/C21H17F3N2O/c22-15-5-7-16(8-6-15)26-21-14(2-1-3-17(21)20(12-27)25-26)10-13-4-9-18(23)19(24)11-13/h4-9,11-12,14H,1-3,10H2
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290353
PNG
(CHEMBL422241 | [1-[1-(4-Fluoro-phenyl)-7-naphthale...)
Show SMILES Fc1ccc(cc1)-n1nc(\C=N\c2ccccc2)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C31H26FN3/c32-25-16-18-27(19-17-25)35-31-24(20-23-10-6-9-22-8-4-5-14-28(22)23)11-7-15-29(31)30(34-35)21-33-26-12-2-1-3-13-26/h1-6,8-10,12-14,16-19,21,24H,7,11,15,20H2/b33-21+
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290364
PNG
(7-Benzyl-1-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-1H...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3ccccc3)c12
Show InChI InChI=1S/C21H19FN2O/c22-17-9-11-18(12-10-17)24-21-16(13-15-5-2-1-3-6-15)7-4-8-19(21)20(14-25)23-24/h1-3,5-6,9-12,14,16H,4,7-8,13H2
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n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290359
PNG
(1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5,6,...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C25H21FN2O/c26-20-11-13-21(14-12-20)28-25-19(8-4-10-23(25)24(16-29)27-28)15-18-7-3-6-17-5-1-2-9-22(17)18/h1-3,5-7,9,11-14,16,19H,4,8,10,15H2
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n/an/a 3.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290336
PNG
(Acetic acid acetoxy-[1-(4-fluoro-phenyl)-7-naphtha...)
Show SMILES CC(=O)OC(OC(C)=O)c1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H27FN2O4/c1-18(33)35-29(36-19(2)34)27-26-12-6-10-22(17-21-9-5-8-20-7-3-4-11-25(20)21)28(26)32(31-27)24-15-13-23(30)14-16-24/h3-5,7-9,11,13-16,22,29H,6,10,12,17H2,1-2H3
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n/an/a 5.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from rabbit PR by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Oryctolagus cuniculus)
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation counting


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290361
PNG
(7-Naphthalen-1-ylmethyl-1-phenyl-4,5,6,7-tetrahydr...)
Show SMILES O=Cc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccccc1
Show InChI InChI=1S/C25H22N2O/c28-17-24-23-15-7-11-20(25(23)27(26-24)21-12-2-1-3-13-21)16-19-10-6-9-18-8-4-5-14-22(18)19/h1-6,8-10,12-14,17,20H,7,11,15-16H2
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290333
PNG
(7-(4-Fluoro-benzyl)-1-(4-fluoro-phenyl)-4,5,6,7-te...)
Show SMILES Fc1ccc(CC2CCCc3c(C=O)nn(c23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18F2N2O/c22-16-6-4-14(5-7-16)12-15-2-1-3-19-20(13-26)24-25(21(15)19)18-10-8-17(23)9-11-18/h4-11,13,15H,1-3,12H2
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n/an/a 6.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290356
PNG
(1-(4-Fluoro-phenyl)-7-(4-methyl-benzyl)-4,5,6,7-te...)
Show SMILES Cc1ccc(CC2CCCc3c(C=O)nn(c23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H21FN2O/c1-15-5-7-16(8-6-15)13-17-3-2-4-20-21(14-26)24-25(22(17)20)19-11-9-18(23)10-12-19/h5-12,14,17H,2-4,13H2,1H3
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n/an/a 7.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290334
PNG
(1-(4-Chloro-phenyl)-7-naphthalen-1-ylmethyl-4,5,6,...)
Show SMILES Clc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C25H21ClN2O/c26-20-11-13-21(14-12-20)28-25-19(8-4-10-23(25)24(16-29)27-28)15-18-7-3-6-17-5-1-2-9-22(17)18/h1-3,5-7,9,11-14,16,19H,4,8,10,15H2
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290362
PNG
(7-(2-Chloro-benzyl)-1-(4-fluoro-phenyl)-4,5,6,7-te...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3ccccc3Cl)c12
Show InChI InChI=1S/C21H18ClFN2O/c22-19-7-2-1-4-14(19)12-15-5-3-6-18-20(13-26)24-25(21(15)18)17-10-8-16(23)9-11-17/h1-2,4,7-11,13,15H,3,5-6,12H2
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n/an/a 10.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290358
PNG
(7-(4-Chloro-benzyl)-1-(4-fluoro-phenyl)-4,5,6,7-te...)
Show SMILES Fc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3ccc(Cl)cc3)c12
Show InChI InChI=1S/C21H18ClFN2O/c22-16-6-4-14(5-7-16)12-15-2-1-3-19-20(13-26)24-25(21(15)19)18-10-8-17(23)9-11-18/h4-11,13,15H,1-3,12H2
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n/an/a 11.9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290349
PNG
(1-(4-Methoxy-phenyl)-7-naphthalen-1-ylmethyl-4,5,6...)
Show SMILES COc1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C26H24N2O2/c1-30-22-14-12-21(13-15-22)28-26-20(9-5-11-24(26)25(17-29)27-28)16-19-8-4-7-18-6-2-3-10-23(18)19/h2-4,6-8,10,12-15,17,20H,5,9,11,16H2,1H3
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n/an/a 12.7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290338
PNG
(1-(4-Fluoro-phenyl)-7-(3-methoxy-benzyl)-octahydro...)
Show SMILES COc1cccc(CC2CCCC3C(NN(C23)c2ccc(F)cc2)C=O)c1
Show InChI InChI=1S/C22H25FN2O2/c1-27-19-6-2-4-15(13-19)12-16-5-3-7-20-21(14-26)24-25(22(16)20)18-10-8-17(23)9-11-18/h2,4,6,8-11,13-14,16,20-22,24H,3,5,7,12H2,1H3
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n/an/a 16.8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290354
PNG
(1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5,6,...)
Show SMILES Fc1ccc(cc1)-n1nc(C#N)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C25H20FN3/c26-20-11-13-21(14-12-20)29-25-19(8-4-10-23(25)24(16-27)28-29)15-18-7-3-6-17-5-1-2-9-22(17)18/h1-3,5-7,9,11-14,19H,4,8,10,15H2
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TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290375
PNG
(CHEMBL314154 | N-[1-[1-(4-Fluoro-phenyl)-7-naphtha...)
Show SMILES CN=NCc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN4/c1-28-29-17-25-24-11-5-9-20(16-19-8-4-7-18-6-2-3-10-23(18)19)26(24)31(30-25)22-14-12-21(27)13-15-22/h2-4,6-8,10,12-15,20H,5,9,11,16-17H2,1H3
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n/an/a 49n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290360
PNG
(CHEMBL315787 | [1-(4-Fluoro-phenyl)-7-naphthalen-1...)
Show SMILES OCc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H23FN2O/c26-20-11-13-21(14-12-20)28-25-19(8-4-10-23(25)24(16-29)27-28)15-18-7-3-6-17-5-1-2-9-22(17)18/h1-3,5-7,9,11-14,19,29H,4,8,10,15-16H2
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TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290372
PNG
(1-(4-Fluoro-phenyl)-7-naphthalen-2-ylmethyl-octahy...)
Show SMILES Fc1ccc(cc1)N1NC(C=O)C2CCCC(Cc3ccc4ccccc4c3)C12
Show InChI InChI=1S/C25H25FN2O/c26-21-10-12-22(13-11-21)28-25-20(6-3-7-23(25)24(16-29)27-28)15-17-8-9-18-4-1-2-5-19(18)14-17/h1-2,4-5,8-14,16,20,23-25,27H,3,6-7,15H2
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n/an/a 56.4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290368
PNG
(1-(3-Chloro-phenyl)-7-naphthalen-1-ylmethyl-4,5,6,...)
Show SMILES Clc1cccc(c1)-n1nc(C=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C25H21ClN2O/c26-20-10-5-11-21(15-20)28-25-19(9-4-13-23(25)24(16-29)27-28)14-18-8-3-7-17-6-1-2-12-22(17)18/h1-3,5-8,10-12,15-16,19H,4,9,13-14H2
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TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290352
PNG
(Acetic acid 1-(4-fluoro-phenyl)-7-naphthalen-1-ylm...)
Show SMILES CC(=O)OCc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25FN2O2/c1-18(31)32-17-26-25-11-5-9-21(16-20-8-4-7-19-6-2-3-10-24(19)20)27(25)30(29-26)23-14-12-22(28)13-15-23/h2-4,6-8,10,12-15,21H,5,9,11,16-17H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290344
PNG
(CHEMBL420978 | Carbonic acid ethyl ester 1-(4-fluo...)
Show SMILES CCOC(=O)OCc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H27FN2O3/c1-2-33-28(32)34-18-26-25-12-6-10-21(17-20-9-5-8-19-7-3-4-11-24(19)20)27(25)31(30-26)23-15-13-22(29)14-16-23/h3-5,7-9,11,13-16,21H,2,6,10,12,17-18H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290363
PNG
(3-[1,3]Dioxolan-2-yl-1-(4-fluoro-phenyl)-7-naphtha...)
Show SMILES Fc1ccc(cc1)-n1nc(C2OCCO2)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C27H25FN2O2/c28-21-11-13-22(14-12-21)30-26-20(17-19-7-3-6-18-5-1-2-9-23(18)19)8-4-10-24(26)25(29-30)27-31-15-16-32-27/h1-3,5-7,9,11-14,20,27H,4,8,10,15-17H2
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TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50338693
PNG
(2-methyl-2-((3aR,4S,9bS)-8-nitro-3a,4,5,9b-tetrahy...)
Show SMILES CC(C)(CO)[C@H]1Nc2ccc(cc2[C@H]2C=CC[C@@H]12)[N+]([O-])=O
Show InChI InChI=1S/C16H20N2O3/c1-16(2,9-19)15-12-5-3-4-11(12)13-8-10(18(20)21)6-7-14(13)17-15/h3-4,6-8,11-12,15,17,19H,5,9H2,1-2H3/t11-,12+,15-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from rabbit PR by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290351
PNG
(1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-3-viny...)
Show SMILES Fc1ccc(cc1)-n1nc(C=C)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C26H23FN2/c1-2-25-24-12-6-10-20(17-19-9-5-8-18-7-3-4-11-23(18)19)26(24)29(28-25)22-15-13-21(27)14-16-22/h2-5,7-9,11,13-16,20H,1,6,10,12,17H2
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n/an/a 147n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290376
PNG
(1-(4-Fluoro-phenyl)-7-(4-methoxy-benzyl)-4,5,6,7-t...)
Show SMILES COc1ccc(CC2CCCc3c(C=O)nn(c23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H21FN2O2/c1-27-19-11-5-15(6-12-19)13-16-3-2-4-20-21(14-26)24-25(22(16)20)18-9-7-17(23)8-10-18/h5-12,14,16H,2-4,13H2,1H3
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n/an/a 163n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290374
PNG
(Benzoic acid 1-(4-fluoro-phenyl)-7-naphthalen-1-yl...)
Show SMILES Fc1ccc(cc1)-n1nc(COC(=O)c2ccccc2)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C32H27FN2O2/c33-26-16-18-27(19-17-26)35-31-25(20-24-12-6-11-22-8-4-5-14-28(22)24)13-7-15-29(31)30(34-35)21-37-32(36)23-9-2-1-3-10-23/h1-6,8-12,14,16-19,25H,7,13,15,20-21H2
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n/an/a 182n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290369
PNG
(1-[1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5...)
Show SMILES CC(O)c1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN2O/c1-17(30)25-24-11-5-9-20(16-19-8-4-7-18-6-2-3-10-23(18)19)26(24)29(28-25)22-14-12-21(27)13-15-22/h2-4,6-8,10,12-15,17,20,30H,5,9,11,16H2,1H3
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n/an/a 236n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM18161
PNG
((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
Show InChI InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
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n/an/a 440n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation counting


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM18161
PNG
((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
Show InChI InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
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Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from rabbit PR by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290355
PNG
(CHEMBL82911 | N'-[1-[1-(4-Fluoro-phenyl)-7-naphtha...)
Show SMILES CN(C)\N=C\c1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C27H27FN4/c1-31(2)29-18-26-25-12-6-10-21(17-20-9-5-8-19-7-3-4-11-24(19)20)27(25)32(30-26)23-15-13-22(28)14-16-23/h3-5,7-9,11,13-16,18,21H,6,10,12,17H2,1-2H3/b29-18+
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n/an/a 547n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290343
PNG
(1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5,6,...)
Show SMILES Fc1ccc(cc1)-n1nc(CN=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C25H22FN3O/c26-20-11-13-21(14-12-20)29-25-19(8-4-10-23(25)24(28-29)16-27-30)15-18-7-3-6-17-5-1-2-9-22(17)18/h1-3,5-7,9,11-14,19H,4,8,10,15-16H2
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TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290371
PNG
(1-[1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5...)
Show SMILES CCC(O)c1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C27H27FN2O/c1-2-25(31)26-24-12-6-10-20(17-19-9-5-8-18-7-3-4-11-23(18)19)27(24)30(29-26)22-15-13-21(28)14-16-22/h3-5,7-9,11,13-16,20,25,31H,2,6,10,12,17H2,1H3
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n/an/a 690n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290337
PNG
(4-(3-Formyl-7-naphthalen-1-ylmethyl-4,5,6,7-tetrah...)
Show SMILES CCCCOC(=O)c1ccc(cc1)-n1nc(C=O)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C30H30N2O3/c1-2-3-18-35-30(34)22-14-16-25(17-15-22)32-29-24(11-7-13-27(29)28(20-33)31-32)19-23-10-6-9-21-8-4-5-12-26(21)23/h4-6,8-10,12,14-17,20,24H,2-3,7,11,13,18-19H2,1H3
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n/an/a 851n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290335
PNG
(7-(4-tert-Butyl-benzyl)-1-(4-fluoro-phenyl)-4,5,6,...)
Show SMILES CC(C)(C)c1ccc(CC2CCCc3c(C=O)nn(c23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C25H27FN2O/c1-25(2,3)19-9-7-17(8-10-19)15-18-5-4-6-22-23(16-29)27-28(24(18)22)21-13-11-20(26)12-14-21/h7-14,16,18H,4-6,15H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290340
PNG
(1-[1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5...)
Show SMILES CCC(=O)c1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C27H25FN2O/c1-2-25(31)26-24-12-6-10-20(17-19-9-5-8-18-7-3-4-11-23(18)19)27(24)30(29-26)22-15-13-21(28)14-16-22/h3-5,7-9,11,13-16,20H,2,6,10,12,17H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290350
PNG
(CHEMBL315817 | Diethyl-[1-(4-fluoro-phenyl)-7-naph...)
Show SMILES CCN(CC)Cc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H32FN3/c1-3-32(4-2)20-28-27-14-8-12-23(19-22-11-7-10-21-9-5-6-13-26(21)22)29(27)33(31-28)25-17-15-24(30)16-18-25/h5-7,9-11,13,15-18,23H,3-4,8,12,14,19-20H2,1-2H3
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n/an/a 1.38E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290370
PNG
(Benzyl-[1-(4-fluoro-phenyl)-7-naphthalen-1-ylmethy...)
Show SMILES Fc1ccc(cc1)-n1nc(CNCc2ccccc2)c2CCCC(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C32H30FN3/c33-27-16-18-28(19-17-27)36-32-26(20-25-12-6-11-24-10-4-5-14-29(24)25)13-7-15-30(32)31(35-36)22-34-21-23-8-2-1-3-9-23/h1-6,8-12,14,16-19,26,34H,7,13,15,20-22H2
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n/an/a 1.38E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


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More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290347
PNG
(CHEMBL84715 | [1-(4-Fluoro-phenyl)-7-naphthalen-1-...)
Show SMILES COC(=O)Nc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C26H24FN3O2/c1-32-26(31)28-25-23-11-5-9-19(16-18-8-4-7-17-6-2-3-10-22(17)18)24(23)30(29-25)21-14-12-20(27)13-15-21/h2-4,6-8,10,12-15,19H,5,9,11,16H2,1H3,(H,28,29,31)
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n/an/a 1.57E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290373
PNG
(1-[1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5...)
Show SMILES CC(=O)c1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C26H23FN2O/c1-17(30)25-24-11-5-9-20(16-19-8-4-7-18-6-2-3-10-23(18)19)26(24)29(28-25)22-14-12-21(27)13-15-22/h2-4,6-8,10,12-15,20H,5,9,11,16H2,1H3
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n/an/a 1.76E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


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More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290366
PNG
(7-(3,4-Dimethoxy-benzyl)-1-(4-fluoro-phenyl)-4,5,6...)
Show SMILES COc1ccc(CC2CCCc3c(C=O)nn(c23)-c2ccc(F)cc2)cc1OC
Show InChI InChI=1S/C23H23FN2O3/c1-28-21-11-6-15(13-22(21)29-2)12-16-4-3-5-19-20(14-27)25-26(23(16)19)18-9-7-17(24)8-10-18/h6-11,13-14,16H,3-5,12H2,1-2H3
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n/an/a 1.89E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290341
PNG
(1-(4-Fluoro-phenyl)-7-(4-isopropyl-benzyl)-4,5,6,7...)
Show SMILES CC(C)c1ccc(CC2CCCc3c(C=O)nn(c23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C24H25FN2O/c1-16(2)18-8-6-17(7-9-18)14-19-4-3-5-22-23(15-28)26-27(24(19)22)21-12-10-20(25)11-13-21/h6-13,15-16,19H,3-5,14H2,1-2H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290342
PNG
(1-(4-Fluoro-phenyl)-7-naphthalen-1-ylmethyl-4,5,6,...)
Show SMILES CCN(CC)C(=O)c1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H30FN3O/c1-3-32(4-2)29(34)27-26-14-8-12-22(19-21-11-7-10-20-9-5-6-13-25(20)21)28(26)33(31-27)24-17-15-23(30)16-18-24/h5-7,9-11,13,15-18,22H,3-4,8,12,14,19H2,1-2H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50355936
PNG
(CHEMBL1910411)
Show SMILES CN(C)[C@H]1C[C@H](Nc2ccc(cc12)[N+]([O-])=O)C(C)(C)CO
Show InChI InChI=1S/C15H23N3O3/c1-15(2,9-19)14-8-13(17(3)4)11-7-10(18(20)21)5-6-12(11)16-14/h5-7,13-14,16,19H,8-9H2,1-4H3/t13-,14-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Kaken Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation counting


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More data for this
Ligand-Target Pair
Progesterone receptor


(Oryctolagus cuniculus)
BDBM50290346
PNG
(CHEMBL85913 | Octanoic acid 1-(4-fluoro-phenyl)-7-...)
Show SMILES CCCCCCCC(=O)OCc1nn(c2C(Cc3cccc4ccccc34)CCCc12)-c1ccc(F)cc1
Show InChI InChI=1S/C33H37FN2O2/c1-2-3-4-5-6-17-32(37)38-23-31-30-16-10-14-26(22-25-13-9-12-24-11-7-8-15-29(24)25)33(30)36(35-31)28-20-18-27(34)19-21-28/h7-9,11-13,15,18-21,26H,2-6,10,14,16-17,22-23H2,1H3
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n/an/a 4.01E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity determined by ability to displace [3H]-R5020 radioligand using uterine progesterone receptor obtained from estrogen-primed rabbit


Citation and Details
More data for this
Ligand-Target Pair
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