BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 145 hits Enz. Inhib. hit(s) with Target = 'Prokineticin Receptor 1 (PKR1)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM26335
PNG
(3-[2-({5-[(4-ethylphenyl)methyl]-1-[(4-methoxyphen...)
Show SMILES CCc1ccc(Cn2c(=O)nc(NCCN=C(N)N)n(Cc3ccc(OC)cc3)c2=O)cc1
Show InChI InChI=1S/C23H29N7O3/c1-3-16-4-6-17(7-5-16)15-30-22(31)28-21(27-13-12-26-20(24)25)29(23(30)32)14-18-8-10-19(33-2)11-9-18/h4-11H,3,12-15H2,1-2H3,(H4,24,25,26)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
22 -45.5n/an/an/an/an/a7.437



University of Ferrara



Assay Description
Nonspecific binding was determined in the presence of 1 uM Bv8. Displacement curves were determined in triplicate. The inhibition constant (Ki) of th...


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM26336
PNG
(6-[(2-aminoethyl)amino]-3-[(4-ethylphenyl)methyl]-...)
Show SMILES CCc1ccc(Cn2c(=O)nc(NCCN)n(Cc3ccc(OC)cc3)c2=O)cc1
Show InChI InChI=1S/C22H27N5O3/c1-3-16-4-6-17(7-5-16)15-27-21(28)25-20(24-13-12-23)26(22(27)29)14-18-8-10-19(30-2)11-9-18/h4-11H,3,12-15,23H2,1-2H3,(H,24,25,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
440 -37.7n/an/an/an/an/a7.437



University of Ferrara



Assay Description
Nonspecific binding was determined in the presence of 1 uM Bv8. Displacement curves were determined in triplicate. The inhibition constant (Ki) of th...


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM26337
PNG
(6-{[2-(4,5-dihydro-1H-imidazol-2-ylamino)ethyl]ami...)
Show SMILES CCc1ccc(Cn2c(=O)nc(NCCN=C3NCCN3)n(Cc3ccc(OC)cc3)c2=O)cc1
Show InChI InChI=1S/C25H31N7O3/c1-3-18-4-6-19(7-5-18)17-32-24(33)30-23(29-15-14-28-22-26-12-13-27-22)31(25(32)34)16-20-8-10-21(35-2)11-9-20/h4-11H,3,12-17H2,1-2H3,(H2,26,27,28)(H,29,30,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
4.72E+3 -31.6n/an/an/an/an/a7.437



University of Ferrara



Assay Description
Nonspecific binding was determined in the presence of 1 uM Bv8. Displacement curves were determined in triplicate. The inhibition constant (Ki) of th...


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294596
PNG
(1-(2-(5-(4-chlorobenzyl)-1-(4-methoxybenzyl)-4,6-d...)
Show SMILES COc1ccc(Cn2c(NCCN=C(N)N)nc(=O)n(Cc3ccc(Cl)cc3)c2=O)cc1
Show InChI InChI=1S/C21H24ClN7O3/c1-32-17-8-4-15(5-9-17)12-28-19(26-11-10-25-18(23)24)27-20(30)29(21(28)31)13-14-2-6-16(22)7-3-14/h2-9H,10-13H2,1H3,(H4,23,24,25)(H,26,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294589
PNG
(1-(2-(1,5-bis(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-t...)
Show SMILES COc1ccc(Cn2c(NCCN=C(N)N)nc(=O)n(Cc3ccc(OC)cc3)c2=O)cc1
Show InChI InChI=1S/C22H27N7O4/c1-32-17-7-3-15(4-8-17)13-28-20(26-12-11-25-19(23)24)27-21(30)29(22(28)31)14-16-5-9-18(33-2)10-6-16/h3-10H,11-14H2,1-2H3,(H4,23,24,25)(H,26,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294586
PNG
(1-(2-(5-(3,4-dichlorobenzyl)-1-(4-methoxybenzyl)-4...)
Show SMILES COc1ccc(Cn2c(NCCN=C(N)N)nc(=O)n(Cc3ccc(Cl)c(Cl)c3)c2=O)cc1
Show InChI InChI=1S/C21H23Cl2N7O3/c1-33-15-5-2-13(3-6-15)11-29-19(27-9-8-26-18(24)25)28-20(31)30(21(29)32)12-14-4-7-16(22)17(23)10-14/h2-7,10H,8-9,11-12H2,1H3,(H4,24,25,26)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294601
PNG
(1-(2-(1-(4-hydroxybenzyl)-5-(4-methoxybenzyl)-4,6-...)
Show SMILES COc1ccc(Cn2c(=O)nc(NCCN=C(N)N)n(Cc3ccc(O)cc3)c2=O)cc1
Show InChI InChI=1S/C21H25N7O4/c1-32-17-8-4-15(5-9-17)13-28-20(30)26-19(25-11-10-24-18(22)23)27(21(28)31)12-14-2-6-16(29)7-3-14/h2-9,29H,10-13H2,1H3,(H4,22,23,24)(H,25,26,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294585
PNG
(1-(2-(5-(4-fluorobenzyl)-1-(4-methoxybenzyl)-4,6-d...)
Show SMILES COc1ccc(Cn2c(NCCN=C(N)N)nc(=O)n(Cc3ccc(F)cc3)c2=O)cc1
Show InChI InChI=1S/C21H24FN7O3/c1-32-17-8-4-15(5-9-17)12-28-19(26-11-10-25-18(23)24)27-20(30)29(21(28)31)13-14-2-6-16(22)7-3-14/h2-9H,10-13H2,1H3,(H4,23,24,25)(H,26,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294604
PNG
(1-(2-(5-(3,4-dichlorobenzyl)-1-(4-(difluoromethoxy...)
Show SMILES NC(N)=NCCNc1nc(=O)n(Cc2ccc(Cl)c(Cl)c2)c(=O)n1Cc1ccc(OC(F)F)cc1
Show InChI InChI=1S/C21H21Cl2F2N7O3/c22-15-6-3-13(9-16(15)23)11-32-20(33)30-19(29-8-7-28-18(26)27)31(21(32)34)10-12-1-4-14(5-2-12)35-17(24)25/h1-6,9,17H,7-8,10-11H2,(H4,26,27,28)(H,29,30,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250600
PNG
(US9475795, 79)
Show SMILES COc1cc(Cl)ccc1CC1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H26ClN3O3S/c1-13-19(14(2)22(3)21-13)27(24,25)23-9-7-15(8-10-23)11-16-5-6-17(20)12-18(16)26-4/h5-6,12,15H,7-11H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 50n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294603
PNG
(1-(2-(5-(4-methoxybenzyl)-1-((6-methoxypyridin-3-y...)
Show SMILES COc1ccc(Cn2c(=O)nc(NCCN=C(N)N)n(Cc3ccc(OC)nc3)c2=O)cc1
Show InChI InChI=1S/C21H26N8O4/c1-32-16-6-3-14(4-7-16)12-29-20(30)27-19(25-10-9-24-18(22)23)28(21(29)31)13-15-5-8-17(33-2)26-11-15/h3-8,11H,9-10,12-13H2,1-2H3,(H4,22,23,24)(H,25,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250620
PNG
(US9475795, 99)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C)c1ccc(Cl)cc1
Show InChI InChI=1/C19H26ClN3O3S/c1-13-19(14(2)22(3)21-13)27(24,25)23-11-9-16(10-12-23)18(26-4)15-5-7-17(20)8-6-15/h5-8,16,18H,9-12H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 60n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250599
PNG
(US9475795, 78)
Show SMILES COc1cc(Cl)ccc1CC1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H24ClN3O3S/c1-12-18(13(2)21-20-12)26(23,24)22-8-6-14(7-9-22)10-15-4-5-16(19)11-17(15)25-3/h4-5,11,14H,6-10H2,1-3H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250617
PNG
(US9475795, 96 | US9475795, 97 | US9475795, 98)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
Show InChI InChI=1/C18H24ClN3O3S/c1-12-18(13(2)21-20-12)26(23,24)22-10-8-15(9-11-22)17(25-3)14-4-6-16(19)7-5-14/h4-7,15,17H,8-11H2,1-3H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250612
PNG
(US9475795, 91)
Show SMILES COc1cc(Cl)ccc1CC1(F)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H25ClFN3O3S/c1-13-18(14(2)23(3)22-13)28(25,26)24-9-7-19(21,8-10-24)12-15-5-6-16(20)11-17(15)27-4/h5-6,11H,7-10,12H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250617
PNG
(US9475795, 96 | US9475795, 97 | US9475795, 98)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
Show InChI InChI=1/C18H24ClN3O3S/c1-12-18(13(2)21-20-12)26(23,24)22-10-8-15(9-11-22)17(25-3)14-4-6-16(19)7-5-14/h4-7,15,17H,8-11H2,1-3H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 160n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250611
PNG
(US9475795, 90)
Show SMILES COc1cc(Cl)ccc1CC1(F)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H23ClFN3O3S/c1-12-17(13(2)22-21-12)27(24,25)23-8-6-18(20,7-9-23)11-14-4-5-15(19)10-16(14)26-3/h4-5,10H,6-9,11H2,1-3H3,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 170n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250595
PNG
(US9475795, 74)
Show SMILES COc1cc(Cl)ccc1OC1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C18H24ClN3O4S/c1-12-18(13(2)21(3)20-12)27(23,24)22-9-7-15(8-10-22)26-16-6-5-14(19)11-17(16)25-4/h5-6,11,15H,7-10H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 170n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250609
PNG
(US9475795, 88)
Show SMILES COc1cc(Cl)ccc1CC1(O)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H26ClN3O4S/c1-13-18(14(2)22(3)21-13)28(25,26)23-9-7-19(24,8-10-23)12-15-5-6-16(20)11-17(15)27-4/h5-6,11,24H,7-10,12H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 200n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250594
PNG
(US9475795, 73)
Show SMILES COc1cc(Cl)ccc1OC1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C17H22ClN3O4S/c1-11-17(12(2)20-19-11)26(22,23)21-8-6-14(7-9-21)25-15-5-4-13(18)10-16(15)24-3/h4-5,10,14H,6-9H2,1-3H3,(H,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 200n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250561
PNG
(US9475795, 40)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C17H19ClF3N3O3S/c1-10-16(11(2)23-22-10)28(25,26)24-7-5-13(6-8-24)27-15-4-3-12(18)9-14(15)17(19,20)21/h3-4,9,13H,5-8H2,1-2H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 210n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250560
PNG
(US9475795, 39)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H21ClF3N3O3S/c1-11-17(12(2)24(3)23-11)29(26,27)25-8-6-14(7-9-25)28-16-5-4-13(19)10-15(16)18(20,21)22/h4-5,10,14H,6-9H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 210n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250544
PNG
(US9475795, 23)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc2ccccc2c1
Show InChI InChI=1S/C21H25N3O3S/c1-15-21(16(2)23(3)22-15)28(25,26)24-12-10-19(11-13-24)27-20-9-8-17-6-4-5-7-18(17)14-20/h4-9,14,19H,10-13H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 220n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250555
PNG
(US9475795, 34)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C#N
Show InChI InChI=1S/C17H19ClN4O3S/c1-11-17(12(2)21-20-11)26(23,24)22-7-5-15(6-8-22)25-16-4-3-14(18)9-13(16)10-19/h3-4,9,15H,5-8H2,1-2H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 240n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50121328
PNG
(CHEMBL3622090)
Show SMILES CNc1cc(ccn1)C(=O)N1CCCC(F)(C1)c1ncc(Cl)cc1C
Show InChI InChI=1/C18H20ClFN4O/c1-12-8-14(19)10-23-16(12)18(20)5-3-7-24(11-18)17(25)13-4-6-22-15(9-13)21-2/h4,6,8-10H,3,5,7,11H2,1-2H3,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 290n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in rat RBL2H3 cells assessed as inhibition of PK1-stimulated intracellular calcium release incubated for ...


ACS Med Chem Lett 6: 834-5 (2015)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250626
PNG
(US9475795, 105 | US9475795, 106 | US9475795, 107)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(F)c1ccc(Cl)cc1
Show InChI InChI=1/C17H21ClFN3O2S/c1-11-17(12(2)21-20-11)25(23,24)22-9-7-14(8-10-22)16(19)13-3-5-15(18)6-4-13/h3-6,14,16H,7-10H2,1-2H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 310n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250552
PNG
(US9475795, 31)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C#N
Show InChI InChI=1S/C18H21ClN4O3S/c1-12-18(13(2)22(3)21-12)27(24,25)23-8-6-16(7-9-23)26-17-5-4-15(19)10-14(17)11-20/h4-5,10,16H,6-9H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 310n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294592
PNG
(1-(2-(5-(4-cyanobenzyl)-1-(4-methoxybenzyl)-4,6-di...)
Show SMILES COc1ccc(Cn2c(NCCN=C(N)N)nc(=O)n(Cc3ccc(cc3)C#N)c2=O)cc1
Show InChI InChI=1S/C22H24N8O3/c1-33-18-8-6-17(7-9-18)13-29-20(27-11-10-26-19(24)25)28-21(31)30(22(29)32)14-16-4-2-15(12-23)3-5-16/h2-9H,10-11,13-14H2,1H3,(H4,24,25,26)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 318n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50121324
PNG
(CHEMBL3622086)
Show SMILES CC(C)n1c(nc2ccccc12)C1CCCN(C1)C(=O)c1ccnc(c1)N(C)C
Show InChI InChI=1/C23H29N5O/c1-16(2)28-20-10-6-5-9-19(20)25-22(28)18-8-7-13-27(15-18)23(29)17-11-12-24-21(14-17)26(3)4/h5-6,9-12,14,16,18H,7-8,13,15H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 320n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in rat RBL2H3 cells assessed as inhibition of PK1-stimulated intracellular calcium release incubated for ...


ACS Med Chem Lett 6: 834-5 (2015)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250549
PNG
(US9475795, 28)
Show SMILES CCc1nn(C)c(CC)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H25Cl2N3O3S/c1-4-16-19(17(5-2)23(3)22-16)28(25,26)24-10-8-14(9-11-24)27-18-7-6-13(20)12-15(18)21/h6-7,12,14H,4-5,8-11H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 320n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50121325
PNG
(CHEMBL3622087)
Show SMILES CCn1cc(cn1)C(=O)N1CCCC(C1)c1cc2ccccc2n1C(C)C
Show InChI InChI=1/C22H28N4O/c1-4-25-15-19(13-23-25)22(27)24-11-7-9-18(14-24)21-12-17-8-5-6-10-20(17)26(21)16(2)3/h5-6,8,10,12-13,15-16,18H,4,7,9,11,14H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 330n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in rat RBL2H3 cells assessed as inhibition of PK1-stimulated intracellular calcium release incubated for ...


ACS Med Chem Lett 6: 834-5 (2015)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294606
PNG
(1-(2-(5-benzyl-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5...)
Show SMILES COc1ccc(Cn2c(NCCN=C(N)N)nc(=O)n(Cc3ccccc3)c2=O)cc1
Show InChI InChI=1S/C21H25N7O3/c1-31-17-9-7-16(8-10-17)13-27-19(25-12-11-24-18(22)23)26-20(29)28(21(27)30)14-15-5-3-2-4-6-15/h2-10H,11-14H2,1H3,(H4,22,23,24)(H,25,26,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 336n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250632
PNG
(US9475795, 111)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(C(F)F)c1ccc(Cl)cc1
Show InChI InChI=1/C18H22ClF2N3O2S/c1-11-17(12(2)23-22-11)27(25,26)24-9-7-14(8-10-24)16(18(20)21)13-3-5-15(19)6-4-13/h3-6,14,16,18H,7-10H2,1-2H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 340n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250626
PNG
(US9475795, 105 | US9475795, 106 | US9475795, 107)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(F)c1ccc(Cl)cc1
Show InChI InChI=1/C17H21ClFN3O2S/c1-11-17(12(2)21-20-11)25(23,24)22-9-7-14(8-10-22)16(19)13-3-5-15(18)6-4-13/h3-6,14,16H,7-10H2,1-2H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 410n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250610
PNG
(US9475795, 89)
Show SMILES COc1cc(Cl)ccc1CC1(O)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H24ClN3O4S/c1-12-17(13(2)21-20-12)27(24,25)22-8-6-18(23,7-9-22)11-14-4-5-15(19)10-16(14)26-3/h4-5,10,23H,6-9,11H2,1-3H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 410n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250593
PNG
(US9475795, 72)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)c(F)c2)CC1
Show InChI InChI=1S/C18H23ClFN3O2S/c1-12-18(13(2)22(3)21-12)26(24,25)23-8-6-14(7-9-23)10-15-4-5-16(19)17(20)11-15/h4-5,11,14H,6-10H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 440n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250554
PNG
(US9475795, 33)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc2ccccc2c1
Show InChI InChI=1S/C20H23N3O3S/c1-14-20(15(2)22-21-14)27(24,25)23-11-9-18(10-12-23)26-19-8-7-16-5-3-4-6-17(16)13-19/h3-8,13,18H,9-12H2,1-2H3,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 440n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294591
PNG
(1-(2-(1-(4-methoxybenzyl)-5-(4-methoxyphenethyl)-4...)
Show SMILES COc1ccc(CCn2c(=O)nc(NCCN=C(N)N)n(Cc3ccc(OC)cc3)c2=O)cc1
Show InChI InChI=1S/C23H29N7O4/c1-33-18-7-3-16(4-8-18)11-14-29-22(31)28-21(27-13-12-26-20(24)25)30(23(29)32)15-17-5-9-19(34-2)10-6-17/h3-10H,11-15H2,1-2H3,(H4,24,25,26)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 461n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250623
PNG
(US9475795, 102)
Show SMILES CC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
Show InChI InChI=1/C18H24ClN3O2S/c1-12(15-4-6-17(19)7-5-15)16-8-10-22(11-9-16)25(23,24)18-13(2)20-21-14(18)3/h4-7,12,16H,8-11H2,1-3H3,(H,20,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 470n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250535
PNG
(US9475795, 14)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Br)cc1F
Show InChI InChI=1S/C17H21BrFN3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-14(7-9-22)25-16-5-4-13(18)10-15(16)19/h4-5,10,14H,6-9H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 470n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250551
PNG
(US9475795, 30)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1F
Show InChI InChI=1S/C17H21ClFN3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-14(7-9-22)25-16-5-4-13(18)10-15(16)19/h4-5,10,14H,6-9H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 510n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM50294598
PNG
(1-(2-(5-(3,4-dichlorobenzyl)-4,6-dioxo-1-(4-propox...)
Show SMILES CCCOc1ccc(Cn2c(NCCN=C(N)N)nc(=O)n(Cc3ccc(Cl)c(Cl)c3)c2=O)cc1
Show InChI InChI=1S/C23H27Cl2N7O3/c1-2-11-35-17-6-3-15(4-7-17)13-31-21(29-10-9-28-20(26)27)30-22(33)32(23(31)34)14-16-5-8-18(24)19(25)12-16/h3-8,12H,2,9-11,13-14H2,1H3,(H4,26,27,28)(H,29,30,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 515n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human PKR1 expressed in HEK293 cells assessed as inhibition of PK1-induced calcium mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250588
PNG
(US9475795, 67)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C17H22ClN3O2S/c1-12-17(13(2)20-19-12)24(22,23)21-9-7-15(8-10-21)11-14-3-5-16(18)6-4-14/h3-6,15H,7-11H2,1-2H3,(H,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 520n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250576
PNG
(US9475795, 55)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C18H24ClN3O2S/c1-13-18(14(2)21(3)20-13)25(23,24)22-10-8-16(9-11-22)12-15-4-6-17(19)7-5-15/h4-7,16H,8-12H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 520n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250526
PNG
(US9475795, 5)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C17H22ClN3O3S/c1-12-17(13(2)20(3)19-12)25(22,23)21-10-8-16(9-11-21)24-15-6-4-14(18)5-7-15/h4-7,16H,8-11H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 530n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250614
PNG
(US9475795, 93)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(C#N)c1ccc(Cl)cc1
Show InChI InChI=1/C18H21ClN4O2S/c1-12-18(13(2)22-21-12)26(24,25)23-9-7-15(8-10-23)17(11-20)14-3-5-16(19)6-4-14/h3-6,15,17H,7-10H2,1-2H3,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 610n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250584
PNG
(US9475795, 63)
Show SMILES CCOC(=O)C1(Cc2ccc(Br)cc2)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C21H28BrN3O4S/c1-5-29-20(26)21(14-17-6-8-18(22)9-7-17)10-12-25(13-11-21)30(27,28)19-15(2)23-24(4)16(19)3/h6-9H,5,10-14H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 640n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250602
PNG
(US9475795, 81)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(F)(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C18H22ClF2N3O2S/c1-12-17(13(2)23(3)22-12)27(25,26)24-8-6-18(21,7-9-24)11-14-4-5-15(19)10-16(14)20/h4-5,10H,6-9,11H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 670n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250583
PNG
(US9475795, 62)
Show SMILES CCOC(=O)C1(Cc2ccc(Br)cc2)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C20H26BrN3O4S/c1-4-28-19(25)20(13-16-5-7-17(21)8-6-16)9-11-24(12-10-20)29(26,27)18-14(2)22-23-15(18)3/h5-8H,4,9-13H2,1-3H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 680n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Prokineticin Receptor 1 (PKR1)


(Homo sapiens (human))
BDBM250616
PNG
(US9475795, 95)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)C(O)c1ccc(Cl)cc1
Show InChI InChI=1/C18H24ClN3O3S/c1-12-18(13(2)21(3)20-12)26(24,25)22-10-8-15(9-11-22)17(23)14-4-6-16(19)7-5-14/h4-7,15,17,23H,8-11H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
UniChem
AffyNet 
US Patent
n/an/a 710n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...


US Patent US9475795 (2016)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 145 total )  |  Next  |  Last  >>
Jump to: