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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Proline-rich AKT1 substrate 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proline-rich AKT1 substrate 1


(Homo sapiens)
BDBM50327790
PNG
((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)
Show SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)Cc3ccc(F)cc3)c12
Show InChI InChI=1S/C20H23FN6O/c1-13-11-23-18-17(13)19(25-12-24-18)26-6-8-27(9-7-26)20(28)16(22)10-14-2-4-15(21)5-3-14/h2-5,11-12,16H,6-10,22H2,1H3,(H,23,24,25)/t16-/m1/s1
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PC sid
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Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Array BioPharma Inc

Curated by ChEMBL


Assay Description
Inhibition of PRAS40 phosphorylation at Thr246 in human LNCaP cells after 1.5 hrs


Citation and Details
More data for this
Ligand-Target Pair
Proline-rich AKT1 substrate 1


(Homo sapiens)
BDBM50327797
PNG
((R)-2-amino-3-(4-chlorophenyl)-1-(4-(quinazolin-4-...)
Show SMILES N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ncnc2ccccc12
Show InChI InChI=1S/C21H22ClN5O/c22-16-7-5-15(6-8-16)13-18(23)21(28)27-11-9-26(10-12-27)20-17-3-1-2-4-19(17)24-14-25-20/h1-8,14,18H,9-13,23H2/t18-/m1/s1
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PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Array BioPharma Inc

Curated by ChEMBL


Assay Description
Inhibition of PRAS40 phosphorylation at Thr246 in human LNCaP cells after 1.5 hrs


Citation and Details
More data for this
Ligand-Target Pair
Proline-rich AKT1 substrate 1


(Homo sapiens)
BDBM50327791
PNG
((R)-2-amino-2-(2,3-dihydro-1H-inden-2-yl)-1-(4-(5-...)
Show SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)C3Cc4ccccc4C3)c12
Show InChI InChI=1S/C22H26N6O/c1-14-12-24-20-18(14)21(26-13-25-20)27-6-8-28(9-7-27)22(29)19(23)17-10-15-4-2-3-5-16(15)11-17/h2-5,12-13,17,19H,6-11,23H2,1H3,(H,24,25,26)/t19-/m1/s1
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UniProtKB/SwissProt

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AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a



Array BioPharma Inc

Curated by ChEMBL


Assay Description
Inhibition of PRAS40 phosphorylation at Thr246 in human LNCaP cells after 1.5 hrs


Citation and Details
More data for this
Ligand-Target Pair