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Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with Target = 'Prolyl 4-hydroxylase alpha-1 subunit' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl 4-hydroxylase alpha-1 subunit


(Rattus norvegicus)
BDBM26106
PNG
(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Show SMILES OC(=O)CNC(=O)C(O)=O
Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
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PubMed
540n/an/an/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of prolyl 4-hydroxylase


J Med Chem 35: 2652-8 (1992)

More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase alpha-1 subunit


(Rattus norvegicus)
BDBM26114
PNG
(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Show SMILES OC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)
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PubMed
800n/an/an/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl 4-hydroxylase


J Med Chem 35: 2652-8 (1992)

More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase alpha-1 subunit


(Rattus norvegicus)
BDBM26106
PNG
(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Show SMILES OC(=O)CNC(=O)C(O)=O
Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
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PubMed
n/an/a 2.89E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of prolyl 4-hydroxylase


J Med Chem 35: 2652-8 (1992)

More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase alpha-1 subunit


(Rattus norvegicus)
BDBM26114
PNG
(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Show SMILES OC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)
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PubMed
n/an/a 5.18E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of prolyl 4-hydroxylase


J Med Chem 35: 2652-8 (1992)

More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase alpha-1 subunit


(Rattus norvegicus)
BDBM50000866
PNG
(2-(Oxalyl-amino)-propionic acid (0.25H2O) | CHEMBL...)
Show SMILES C[C@H](NC(=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C5H7NO5/c1-2(4(8)9)6-3(7)5(10)11/h2H,1H3,(H,6,7)(H,8,9)(H,10,11)/t2-/m0/s1
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n/an/a 3.82E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of prolyl 4-hydroxylase


J Med Chem 35: 2652-8 (1992)

More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase alpha-1 subunit


(Rattus norvegicus)
BDBM50000865
PNG
(2-(Oxalyl-amino)-propionic acid | CHEMBL314979)
Show SMILES CC(NC(=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C5H7NO5/c1-2(4(8)9)6-3(7)5(10)11/h2H,1H3,(H,6,7)(H,8,9)(H,10,11)
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PubMed
n/an/a 9.07E+4n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of prolyl 4-hydroxylase


J Med Chem 35: 2652-8 (1992)

More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase alpha-1 subunit


(Rattus norvegicus)
BDBM50000864
PNG
(CHEMBL314175 | N-(2-Methanesulfonylamino-2-oxo-eth...)
Show SMILES CS(=O)(=O)NC(=O)CNC(=O)C(O)=O
Show InChI InChI=1S/C5H8N2O6S/c1-14(12,13)7-3(8)2-6-4(9)5(10)11/h2H2,1H3,(H,6,9)(H,7,8)(H,10,11)
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n/an/a 4.14E+5n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of prolyl 4-hydroxylase


J Med Chem 35: 2652-8 (1992)

More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase alpha-1 subunit


(Rattus norvegicus)
BDBM50000863
PNG
(2-(Oxalyl-amino)-propionic acid | CHEMBL88472)
Show SMILES C[C@@H](NC(=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C5H7NO5/c1-2(4(8)9)6-3(7)5(10)11/h2H,1H3,(H,6,7)(H,8,9)(H,10,11)/t2-/m1/s1
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PubMed
n/an/a 6.21E+5n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of prolyl 4-hydroxylase at 50 ug/mL


J Med Chem 35: 2652-8 (1992)

More data for this
Ligand-Target Pair