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Found 6 hits Enz. Inhib. hit(s) with Target = 'Prolyl 4-hydroxylase subunit alpha-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl 4-hydroxylase subunit alpha-1


(Homo sapiens)
BDBM50042876
PNG
(CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic...)
Show SMILES OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O
Show InChI InChI=1S/C12H8N2O4/c15-11(16)7-1-3-9(13-5-7)10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
PDB

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Article
PubMed
140n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1


(Homo sapiens)
BDBM50092609
PNG
(CHEMBL3586252)
Show SMILES OC(=O)c1ccc(nc1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C12H8N2O4/c15-11(16)7-3-4-13-10(5-7)9-2-1-8(6-14-9)12(17)18/h1-6H,(H,15,16)(H,17,18)
PDB

UniProtKB/SwissProt

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PC sid
UniChem

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Article
PubMed
200n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1


(Homo sapiens)
BDBM26114
PNG
(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Show SMILES OC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)
PDB

UniProtKB/SwissProt

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CHEMBL
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PC sid
UniChem

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Article
PubMed
2.60E+3n/an/an/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1


(Homo sapiens)
BDBM50042876
PNG
(CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic...)
Show SMILES OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O
Show InChI InChI=1S/C12H8N2O4/c15-11(16)7-1-3-9(13-5-7)10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 840n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1


(Homo sapiens)
BDBM50092609
PNG
(CHEMBL3586252)
Show SMILES OC(=O)c1ccc(nc1)-c1cc(ccn1)C(O)=O
Show InChI InChI=1S/C12H8N2O4/c15-11(16)7-3-4-13-10(5-7)9-2-1-8(6-14-9)12(17)18/h1-6H,(H,15,16)(H,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1


(Homo sapiens)
BDBM26114
PNG
(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Show SMILES OC(=O)c1ccc(nc1)C(O)=O
Show InChI InChI=1S/C7H5NO4/c9-6(10)4-1-2-5(7(11)12)8-3-4/h1-3H,(H,9,10)(H,11,12)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



University of Wisconsin-Madison

Curated by ChEMBL


Assay Description
Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...


Citation and Details
More data for this
Ligand-Target Pair