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Found 76 hits Enz. Inhib. hit(s) with Target = 'Prolyl endopeptidase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50005864
PNG
(CHEMBL3236270)
Show SMILES CC(C)c1ccc(C(=O)c2ccco2)c(SCCCCCCCCN(C)[11CH3])n1
Show InChI InChI=1S/C23H34N2O2S/c1-18(2)20-14-13-19(22(26)21-12-11-16-27-21)23(24-20)28-17-10-8-6-5-7-9-15-25(3)4/h11-14,16,18H,5-10,15,17H2,1-4H3/i3-1
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0.950n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Competitive inhibition of rat brain prolyl oligopeptidase


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50038881
PNG
(CHEMBL294803 | Y-29794 | [2-(8-Dimethylamino-octyl...)
Show SMILES CC(C)c1ccc(C(=O)c2cccs2)c(SCCCCCCCCN(C)C)n1
Show InChI InChI=1S/C23H34N2OS2/c1-18(2)20-14-13-19(22(26)21-12-11-17-27-21)23(24-20)28-16-10-8-6-5-7-9-15-25(3)4/h11-14,17-18H,5-10,15-16H2,1-4H3
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0.950n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of POP in rat brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50316818
PNG
(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCSC1
Show InChI InChI=1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17-,18+,19-,20-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
inhibition of rat cortex POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50316819
PNG
((S)-1-(4-(4-chlorobenzylamino)-4-oxobutanoyl)pyrro...)
Show SMILES OC(=O)[C@@H]1CCCN1C(=O)CCC(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C16H19ClN2O4/c17-12-5-3-11(4-6-12)10-18-14(20)7-8-15(21)19-9-1-2-13(19)16(22)23/h3-6,13H,1-2,7-10H2,(H,18,20)(H,22,23)/t13-/m0/s1
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12n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
inhibition of rat cortex POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051495
PNG
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50274983
PNG
(2-{3-[(2S)-4,4-Difluoro-2-(pyrrolidinocarbonyl)pyr...)
Show SMILES FC1(F)C[C@H](N(C1)C(=O)CCN1C(=O)c2ccccc2C1=O)C(=O)N1CCCC1
Show InChI InChI=1S/C20H21F2N3O4/c21-20(22)11-15(19(29)23-8-3-4-9-23)25(12-20)16(26)7-10-24-17(27)13-5-1-2-6-14(13)18(24)28/h1-2,5-6,15H,3-4,7-12H2/t15-/m0/s1
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n/an/a 0.810n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051495
PNG
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1
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n/an/a 0.830n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of POP in rat brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50274985
PNG
(1-{3-Oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)
Show SMILES O=C(CCn1c2ccccc2nc(-c2ccccc2)c1=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C26H28N4O3/c31-23(29-17-8-13-22(29)25(32)28-15-6-7-16-28)14-18-30-21-12-5-4-11-20(21)27-24(26(30)33)19-9-2-1-3-10-19/h1-5,9-12,22H,6-8,13-18H2/t22-/m0/s1
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n/an/a 0.880n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051520
PNG
(CHEMBL305681 | [(2S,3aS,7aS)-2-(Pyrrolidine-1-carb...)
Show SMILES FC(F)(F)c1cccc(c1)[C@H]1C[C@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C24H29F3N2O2/c25-24(26,27)17-8-5-7-15(12-17)18-14-19(18)22(30)29-20-9-2-1-6-16(20)13-21(29)23(31)28-10-3-4-11-28/h5,7-8,12,16,18-21H,1-4,6,9-11,13-14H2/t16-,18+,19+,20-,21-/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051511
PNG
(CHEMBL80684 | [(1R,2S)-2-(4-Fluoro-phenyl)-cyclopr...)
Show SMILES Fc1ccc(cc1)[C@H]1C[C@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H29FN2O2/c24-17-9-7-15(8-10-17)18-14-19(18)22(27)26-20-6-2-1-5-16(20)13-21(26)23(28)25-11-3-4-12-25/h7-10,16,18-21H,1-6,11-14H2/t16-,18+,19+,20-,21-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50316823
PNG
(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H30N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,8-9,17-21H,4-7,10-15H2/t17-,18-,19+,20-,21-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
inhibition of rat cortex POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051523
PNG
(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H30N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,8-9,17-21H,4-7,10-15H2/t17-,18+,19+,20-,21-/m0/s1
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Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051515
PNG
(CHEMBL80698 | [(2S,3aS,7aS)-2-(Pyrrolidine-1-carbo...)
Show SMILES O=C([C@@H]1C[C@@H]1c1cccs1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C21H28N2O2S/c24-20(16-13-15(16)19-8-5-11-26-19)23-17-7-2-1-6-14(17)12-18(23)21(25)22-9-3-4-10-22/h5,8,11,14-18H,1-4,6-7,9-10,12-13H2/t14-,15-,16+,17-,18-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051504
PNG
(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(th...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCSC1
Show InChI InChI=1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17+,18+,19-,20-/m0/s1
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Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051506
PNG
(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccccc1)N1C2CCC(C2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C21H26N2O2/c24-20(18-13-17(18)14-6-2-1-3-7-14)23-16-9-8-15(12-16)19(23)21(25)22-10-4-5-11-22/h1-3,6-7,15-19H,4-5,8-13H2/t15?,16?,17-,18-,19+/m1/s1
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Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051516
PNG
(CHEMBL79213 | [(2S,3aS,7aS)-2-(Pyrrolidine-1-carbo...)
Show SMILES Cc1ccc(cc1)[C@H]1C[C@H]1C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C24H32N2O2/c1-16-8-10-17(11-9-16)19-15-20(19)23(27)26-21-7-3-2-6-18(21)14-22(26)24(28)25-12-4-5-13-25/h8-11,18-22H,2-7,12-15H2,1H3/t18-,19+,20+,21-,22-/m0/s1
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Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051508
PNG
(CHEMBL75968 | [(2S,3aS,7aS)-2-(Isoxazolidine-2-car...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCO1
Show InChI InChI=1S/C22H28N2O3/c25-21(18-14-17(18)15-7-2-1-3-8-15)24-19-10-5-4-9-16(19)13-20(24)22(26)23-11-6-12-27-23/h1-3,7-8,16-20H,4-6,9-14H2/t16-,17+,18+,19-,20-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50316829
PNG
(CHEMBL1087103 | isoxazolidin-2-yl((2S,3aS,7aS)-1-(...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCO1
Show InChI InChI=1S/C22H28N2O3/c25-21(18-14-17(18)15-7-2-1-3-8-15)24-19-10-5-4-9-16(19)13-20(24)22(26)23-11-6-12-27-23/h1-3,7-8,16-20H,4-6,9-14H2/t16-,17-,18+,19-,20-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
inhibition of rat cortex POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50316830
PNG
(((2S,3aS,7aS)-2-(1H-pyrrole-1-carbonyl)octahydro-1...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)n1cccc1
Show InChI InChI=1S/C23H26N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,6-9,12-13,17-21H,4-5,10-11,14-15H2/t17-,18-,19+,20-,21-/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
inhibition of rat cortex POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051489
PNG
(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)n1cccc1
Show InChI InChI=1S/C23H26N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,6-9,12-13,17-21H,4-5,10-11,14-15H2/t17-,18+,19+,20-,21-/m0/s1
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Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50316831
PNG
((2,5-dihydro-1H-pyrrol-1-yl)((2S,3aS,7aS)-1-((1R,2...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CC=CC1
Show InChI InChI=1S/C23H28N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,6-9,17-21H,4-5,10-15H2/t17-,18-,19+,20-,21-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
inhibition of rat cortex POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051483
PNG
(CHEMBL80865 | [(2S,3aS,7aS)-2-(2,5-Dihydro-pyrrole...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CC=CC1
Show InChI InChI=1S/C23H28N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,6-9,17-21H,4-5,10-15H2/t17-,18+,19+,20-,21-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50316832
PNG
((2,3-dihydro-1H-pyrrol-1-yl)((2S,3aS,7aS)-1-((1R,2...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCC=C1
Show InChI InChI=1S/C23H28N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,6,8-9,12,17-21H,4-5,7,10-11,13-15H2/t17-,18-,19+,20-,21-/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
inhibition of rat cortex POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051544
PNG
(CHEMBL311848 | [(2S,3aS,7aS)-2-(2,3-Dihydro-pyrrol...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCC=C1
Show InChI InChI=1S/C23H28N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,6,8-9,12,17-21H,4-5,7,10-11,13-15H2/t17-,18+,19+,20-,21-/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50274959
PNG
((S)-2-(3-oxo-3-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Show SMILES O=C(CCN1C(=O)c2ccccc2C1=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C20H23N3O4/c24-17(22-12-5-8-16(22)20(27)21-10-3-4-11-21)9-13-23-18(25)14-6-1-2-7-15(14)19(23)26/h1-2,6-7,16H,3-5,8-13H2/t16-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051513
PNG
(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(thiazolidin...)
Show SMILES O=C([C@@H]1C2CCC(CC2)N1C(=O)[C@@H]1C[C@@H]1c1ccccc1)N1CCSC1
Show InChI InChI=1S/C21H26N2O2S/c24-20(18-12-17(18)14-4-2-1-3-5-14)23-16-8-6-15(7-9-16)19(23)21(25)22-10-11-26-13-22/h1-5,15-19H,6-13H2/t15?,16?,17-,18-,19+/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051496
PNG
(CHEMBL310228 | [(S)-3-(Pyrrolidine-1-carbonyl)-2-a...)
Show SMILES FC(F)(F)c1cccc(c1)[C@H]1C[C@H]1C(=O)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H27F3N2O2/c24-23(25,26)16-5-3-4-15(12-16)18-13-19(18)21(29)28-17-8-6-14(7-9-17)20(28)22(30)27-10-1-2-11-27/h3-5,12,14,17-20H,1-2,6-11,13H2/t14?,17?,18-,19-,20+/m1/s1
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n/an/a 3.20n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051537
PNG
(CHEMBL80136 | [(1R,2S)-2-(4-Fluoro-phenyl)-cyclopr...)
Show SMILES Fc1ccc(cc1)[C@H]1C[C@H]1C(=O)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C22H27FN2O2/c23-16-7-3-14(4-8-16)18-13-19(18)21(26)25-17-9-5-15(6-10-17)20(25)22(27)24-11-1-2-12-24/h3-4,7-8,15,17-20H,1-2,5-6,9-13H2/t15?,17?,18-,19-,20+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051543
PNG
((2-Benzyl-cyclopropyl)-[(S)-3-(pyrrolidine-1-carbo...)
Show SMILES O=C([C@@H]1C2CCC(CC2)N1C(=O)C1CC1Cc1ccccc1)N1CCCC1
Show InChI InChI=1S/C23H30N2O2/c26-22(20-15-18(20)14-16-6-2-1-3-7-16)25-19-10-8-17(9-11-19)21(25)23(27)24-12-4-5-13-24/h1-3,6-7,17-21H,4-5,8-15H2/t17?,18?,19?,20?,21-/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051484
PNG
(CHEMBL307938 | [(S)-3-(Pyrrolidine-1-carbonyl)-2-a...)
Show SMILES O=C([C@@H]1C2CCC(CC2)N1C(=O)[C@@H]1C[C@@H]1c1cccs1)N1CCCC1
Show InChI InChI=1S/C20H26N2O2S/c23-19(16-12-15(16)17-4-3-11-25-17)22-14-7-5-13(6-8-14)18(22)20(24)21-9-1-2-10-21/h3-4,11,13-16,18H,1-2,5-10,12H2/t13?,14?,15-,16+,18-/m0/s1
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n/an/a 4.80n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051486
PNG
(((1R,2S)-2-Naphthalen-2-yl-cyclopropyl)-[(S)-3-(py...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccc2ccccc2c1)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C26H30N2O2/c29-25(23-16-22(23)20-8-7-17-5-1-2-6-19(17)15-20)28-21-11-9-18(10-12-21)24(28)26(30)27-13-3-4-14-27/h1-2,5-8,15,18,21-24H,3-4,9-14,16H2/t18?,21?,22-,23-,24+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051488
PNG
(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Show SMILES O=C([C@@H]1C[C@@H]1c1ccccc1)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C22H28N2O2/c25-21(19-14-18(19)15-6-2-1-3-7-15)24-17-10-8-16(9-11-17)20(24)22(26)23-12-4-5-13-23/h1-3,6-7,16-20H,4-5,8-14H2/t16?,17?,18-,19-,20+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50316841
PNG
(((S)-2-((1R,2R)-2-phenylcyclopropanecarbonyl)-2-az...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C22H28N2O2/c25-21(19-14-18(19)15-6-2-1-3-7-15)24-17-10-8-16(9-11-17)20(24)22(26)23-12-4-5-13-23/h1-3,6-7,16-20H,4-5,8-14H2/t16?,17?,18-,19+,20-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
inhibition of rat cortex POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051539
PNG
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C19H26N2O2/c22-18(12-6-10-16-8-2-1-3-9-16)21-15-7-11-17(21)19(23)20-13-4-5-14-20/h1-3,8-9,17H,4-7,10-15H2/t17-/m0/s1
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n/an/a 7.20n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of rat brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50240495
PNG
((R)-1-(4-(pyrrolidine-1-carbonyl)thiazolidin-3-yl)...)
Show SMILES CCCCCCCC(=O)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C16H28N2O2S/c1-2-3-4-5-6-9-15(19)18-13-21-12-14(18)16(20)17-10-7-8-11-17/h14H,2-13H2,1H3/t14-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50240495
PNG
((R)-1-(4-(pyrrolidine-1-carbonyl)thiazolidin-3-yl)...)
Show SMILES CCCCCCCC(=O)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C16H28N2O2S/c1-2-3-4-5-6-9-15(19)18-13-21-12-14(18)16(20)17-10-7-8-11-17/h14H,2-13H2,1H3/t14-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051491
PNG
(CHEMBL77149 | [(2S,3aS,7aS)-2-(3-Hydroxy-pyrrolidi...)
Show SMILES OC1CCN(C1)C(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C23H30N2O3/c26-17-10-11-24(14-17)23(28)21-12-16-8-4-5-9-20(16)25(21)22(27)19-13-18(19)15-6-2-1-3-7-15/h1-3,6-7,16-21,26H,4-5,8-14H2/t16-,17?,18+,19+,20-,21-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051481
PNG
(CHEMBL306957 | [(1R,2S)-2-(4-Methoxy-phenyl)-cyclo...)
Show SMILES COc1ccc(cc1)[C@H]1C[C@H]1C(=O)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H30N2O3/c1-28-18-10-6-15(7-11-18)19-14-20(19)22(26)25-17-8-4-16(5-9-17)21(25)23(27)24-12-2-3-13-24/h6-7,10-11,16-17,19-21H,2-5,8-9,12-14H2,1H3/t16?,17?,19-,20-,21+/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50289645
PNG
(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Show SMILES CCCCCCC(=O)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C15H26N2O2S/c1-2-3-4-5-8-14(18)17-12-20-11-13(17)15(19)16-9-6-7-10-16/h13H,2-12H2,1H3/t13-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50240498
PNG
((S)-1-(2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)o...)
Show SMILES CCCCCCCC(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C17H30N2O2/c1-2-3-4-5-6-11-16(20)19-14-9-10-15(19)17(21)18-12-7-8-13-18/h15H,2-14H2,1H3/t15-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of POP in rat brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50240498
PNG
((S)-1-(2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)o...)
Show SMILES CCCCCCCC(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C17H30N2O2/c1-2-3-4-5-6-11-16(20)19-14-9-10-15(19)17(21)18-12-7-8-13-18/h15H,2-14H2,1H3/t15-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051479
PNG
((3-Phenyl-cyclobutyl)-[(S)-3-(pyrrolidine-1-carbon...)
Show SMILES O=C(C1CC(C1)c1ccccc1)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H30N2O2/c26-22(19-14-18(15-19)16-6-2-1-3-7-16)25-20-10-8-17(9-11-20)21(25)23(27)24-12-4-5-13-24/h1-3,6-7,17-21H,4-5,8-15H2/t17?,18?,19?,20?,21-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051479
PNG
((3-Phenyl-cyclobutyl)-[(S)-3-(pyrrolidine-1-carbon...)
Show SMILES O=C(C1CC(C1)c1ccccc1)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H30N2O2/c26-22(19-14-18(15-19)16-6-2-1-3-7-16)25-20-10-8-17(9-11-20)21(25)23(27)24-12-4-5-13-24/h1-3,6-7,17-21H,4-5,8-15H2/t17?,18?,19?,20?,21-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051539
PNG
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C19H26N2O2/c22-18(12-6-10-16-8-2-1-3-9-16)21-15-7-11-17(21)19(23)20-13-4-5-14-20/h1-3,8-9,17H,4-7,10-15H2/t17-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051539
PNG
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C19H26N2O2/c22-18(12-6-10-16-8-2-1-3-9-16)21-15-7-11-17(21)19(23)20-13-4-5-14-20/h1-3,8-9,17H,4-7,10-15H2/t17-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051527
PNG
(((1S,2R)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Show SMILES O=C([C@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C23H30N2O2/c26-22(19-15-18(19)16-8-2-1-3-9-16)25-20-11-5-4-10-17(20)14-21(25)23(27)24-12-6-7-13-24/h1-3,8-9,17-21H,4-7,10-15H2/t17-,18-,19-,20-,21-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortex


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50289634
PNG
((E)-1-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidin-1...)
Show SMILES CCCCC\C=C\C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C17H28N2O2/c1-2-3-4-5-6-11-16(20)19-14-9-10-15(19)17(21)18-12-7-8-13-18/h6,11,15H,2-5,7-10,12-14H2,1H3/b11-6+/t15-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50289636
PNG
(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Show SMILES CCCCC(=O)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C13H22N2O2S/c1-2-3-6-12(16)15-10-18-9-11(15)13(17)14-7-4-5-8-14/h11H,2-10H2,1H3/t11-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50289643
PNG
(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Show SMILES CCCCCC(=O)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C14H24N2O2S/c1-2-3-4-7-13(17)16-11-19-10-12(16)14(18)15-8-5-6-9-15/h12H,2-11H2,1H3/t12-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50289637
PNG
(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Show SMILES CCCCCCCCCC(=O)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C18H32N2O2S/c1-2-3-4-5-6-7-8-11-17(21)20-15-23-14-16(20)18(22)19-12-9-10-13-19/h16H,2-15H2,1H3/t16-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)


Citation and Details
More data for this
Ligand-Target Pair
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