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Found 204 hits Enz. Inhib. hit(s) with Target = 'Prolyl endopeptidase' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl endopeptidase


(Sus scrofa)
BDBM50155838
PNG
((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
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0.0200n/an/an/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Sus scrofa)
BDBM50155838
PNG
((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
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0.0230n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of pig POP


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Sus scrofa)
BDBM50155839
PNG
((S)-1-[(R)-2-(4-Phenyl-butyryl)-cyclopent-2-enecar...)
Show SMILES O=C(CCCc1ccccc1)C1=CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C21H24N2O2/c22-15-17-10-6-14-23(17)21(25)19-12-5-11-18(19)20(24)13-4-9-16-7-2-1-3-8-16/h1-3,7-8,11,17,19H,4-6,9-10,12-14H2/t17-,19+/m0/s1
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0.0300n/an/an/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50051495
PNG
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1
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0.0600n/an/an/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50155838
PNG
((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of porcine prolyl oligopeptidase using Z-Gly-Pro-AMC as substrate after 60 mins by double-reciprocal plot analysis


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Sus scrofa)
BDBM50155836
PNG
((R)-5-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC=C1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H24N2O4/c23-13-18(24)17-10-5-11-22(17)20(26)16-9-4-8-15(16)19(25)21-12-14-6-2-1-3-7-14/h1-3,6-8,16-17,23H,4-5,9-13H2,(H,21,25)/t16-,17+/m1/s1
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0.150n/an/an/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170682
PNG
((S)-1-((S)-1-(3-((S)-2-(cyclopentanecarbonyl)pyrro...)
Show SMILES O=C(C1CCCC1)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C28H34N4O4/c29-18-22-11-4-14-30(22)28(36)24-13-6-16-32(24)27(35)21-10-3-9-20(17-21)26(34)31-15-5-12-23(31)25(33)19-7-1-2-8-19/h3,9-10,17,19,22-24H,1-2,4-8,11-16H2/t22-,23-,24-/m0/s1
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0.360n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of pig brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50005880
PNG
(CHEMBL3236273)
Show SMILES Ic1ccc(CCCC(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C#N)cc1
Show InChI InChI=1S/C20H24IN3O2/c21-16-10-8-15(9-11-16)4-1-7-19(25)24-13-3-6-18(24)20(26)23-12-2-5-17(23)14-22/h8-11,17-18H,1-7,12-13H2/t17-,18-/m0/s1
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4.20n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of porcine prolyl oligopeptidase using Z-Gly-Pro-AMC as substrate after 60 mins by double-reciprocal plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50005872
PNG
(CHEMBL3236272)
Show SMILES Ic1ccc(CCCC(=O)N2CCC[C@H]2C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C19H25IN2O2/c20-16-10-8-15(9-11-16)5-3-7-18(23)22-14-4-6-17(22)19(24)21-12-1-2-13-21/h8-11,17H,1-7,12-14H2/t17-/m0/s1
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22n/an/an/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of porcine prolyl oligopeptidase using Z-Gly-Pro-AMC as substrate after 60 mins by double-reciprocal plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50316825
PNG
(2-(2,3-dihydro-1H-inden-2-yl)-1-((R)-4-((R)-4-(dim...)
Show SMILES COC(OC)[C@@H]1CSCN1C(=O)[C@@H]1CSCN1C(=O)CC1Cc2ccccc2C1
Show InChI InChI=1S/C21H28N2O4S2/c1-26-21(27-2)18-11-29-13-23(18)20(25)17-10-28-12-22(17)19(24)9-14-7-15-5-3-4-6-16(15)8-14/h3-6,14,17-18,21H,7-13H2,1-2H3/t17-,18-/m0/s1
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2.90E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of pig POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50051495
PNG
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of pig brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50155839
PNG
((S)-1-[(R)-2-(4-Phenyl-butyryl)-cyclopent-2-enecar...)
Show SMILES O=C(CCCc1ccccc1)C1=CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C21H24N2O2/c22-15-17-10-6-14-23(17)21(25)19-12-5-11-18(19)20(24)13-4-9-16-7-2-1-3-8-16/h1-3,7-8,11,17,19H,4-6,9-10,12-14H2/t17-,19+/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50051495
PNG
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50155838
PNG
((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Sus scrofa)
BDBM50051495
PNG
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50155838
PNG
((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
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n/an/a 0.220n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Sus scrofa)
BDBM50170689
PNG
(1-{(S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-c...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CCCc1ccccc1
Show InChI InChI=1S/C21H28N2O4/c24-15-19(25)17-10-5-14-23(17)21(27)18-11-6-13-22(18)20(26)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18,24H,4-6,9-15H2/t17-,18-/m0/s1
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n/an/a 0.220n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50155836
PNG
((R)-5-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC=C1C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H24N2O4/c23-13-18(24)17-10-5-11-22(17)20(26)16-9-4-8-15(16)19(25)21-12-14-6-2-1-3-7-14/h1-3,6-8,16-17,23H,4-5,9-13H2,(H,21,25)/t16-,17+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134170
PNG
(1-((S)-2-Cyclopentanecarbonyl-pyrrolidin-1-yl)-5-{...)
Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)CO
Show InChI InChI=1S/C28H43N3O6/c1-28(2,16-24(34)29-13-6-11-21(29)26(36)19-8-3-4-9-19)17-25(35)30-14-7-12-22(30)27(37)31-15-5-10-20(31)23(33)18-32/h19-22,32H,3-18H2,1-2H3/t20-,21-,22-/m0/s1
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n/an/a 0.320n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134170
PNG
(1-((S)-2-Cyclopentanecarbonyl-pyrrolidin-1-yl)-5-{...)
Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)CO
Show InChI InChI=1S/C28H43N3O6/c1-28(2,16-24(34)29-13-6-11-21(29)26(36)19-8-3-4-9-19)17-25(35)30-14-7-12-22(30)27(37)31-15-5-10-20(31)23(33)18-32/h19-22,32H,3-18H2,1-2H3/t20-,21-,22-/m0/s1
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n/an/a 0.320n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50038879
PNG
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
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n/an/a 0.330n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Sus scrofa)
BDBM50038879
PNG
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
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n/an/a 0.330n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pigbrain expressed


J Med Chem 45: 4581-4 (2002)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Sus scrofa)
BDBM50134160
PNG
(2-Hydroxy-1-[(S)-1-((S)-1-{3-[(S)-2-(pyrrolidine-1...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C28H36N4O6/c33-18-24(34)21-9-4-14-30(21)28(38)23-11-6-16-32(23)26(36)20-8-3-7-19(17-20)25(35)31-15-5-10-22(31)27(37)29-12-1-2-13-29/h3,7-8,17,21-23,33H,1-2,4-6,9-16,18H2/t21-,22-,23-/m0/s1
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n/an/a 0.390n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50118910
PNG
(2-Hydroxy-1-[1-(1-{3-[2-(pyrrolidine-1-carbonyl)-p...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCCC1C(=O)N1CCCC1
Show InChI InChI=1S/C28H36N4O6/c33-18-24(34)21-9-4-14-30(21)28(38)23-11-6-16-32(23)26(36)20-8-3-7-19(17-20)25(35)31-15-5-10-22(31)27(37)29-12-1-2-13-29/h3,7-8,17,21-23,33H,1-2,4-6,9-16,18H2/t21-,22?,23-/m0/s1
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n/an/a 0.390n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pig brain ;value ranges from (1.1-2.2)


J Med Chem 45: 4581-4 (2002)

More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170712
PNG
((S)-1-[(S)-1-(5-Azepan-1-yl-3,3-dimethyl-5-oxo-pen...)
Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)CC(=O)N1CCCCCC1
Show InChI InChI=1S/C23H36N4O3/c1-23(2,15-20(28)25-11-5-3-4-6-12-25)16-21(29)27-14-8-10-19(27)22(30)26-13-7-9-18(26)17-24/h18-19H,3-16H2,1-2H3/t18-,19-/m0/s1
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n/an/a 0.390n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134160
PNG
(2-Hydroxy-1-[(S)-1-((S)-1-{3-[(S)-2-(pyrrolidine-1...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C28H36N4O6/c33-18-24(34)21-9-4-14-30(21)28(38)23-11-6-16-32(23)26(36)20-8-3-7-19(17-20)25(35)31-15-5-10-22(31)27(37)29-12-1-2-13-29/h3,7-8,17,21-23,33H,1-2,4-6,9-16,18H2/t21-,22-,23-/m0/s1
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n/an/a 0.390n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134150
PNG
((S)-1-{(S)-1-[5-((S)-2-Cyclopentanecarbonyl-pyrrol...)
Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C27H40N4O4/c1-27(2,16-23(32)30-14-6-11-21(30)25(34)19-8-3-4-9-19)17-24(33)31-15-7-12-22(31)26(35)29-13-5-10-20(29)18-28/h19-22H,3-17H2,1-2H3/t20-,21-,22-/m0/s1
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n/an/a 0.570n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134150
PNG
((S)-1-{(S)-1-[5-((S)-2-Cyclopentanecarbonyl-pyrrol...)
Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C27H40N4O4/c1-27(2,16-23(32)30-14-6-11-21(30)25(34)19-8-3-4-9-19)17-24(33)31-15-7-12-22(31)26(35)29-13-5-10-20(29)18-28/h19-22H,3-17H2,1-2H3/t20-,21-,22-/m0/s1
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n/an/a 0.570n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134168
PNG
(1-((R)-1-{(S)-1-[3-((R)-2-Cyclopentanecarbonyl-pyr...)
Show SMILES OCC(=O)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@@H]1C(=O)C1CCCC1
Show InChI InChI=1S/C29H37N3O6/c33-18-25(34)22-11-4-14-30(22)29(38)24-13-6-16-32(24)28(37)21-10-3-9-20(17-21)27(36)31-15-5-12-23(31)26(35)19-7-1-2-8-19/h3,9-10,17,19,22-24,33H,1-2,4-8,11-16,18H2/t22-,23-,24+/m1/s1
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n/an/a 0.610n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170693
PNG
(1-((S)-1-{(S)-1-[3-((S)-2-Cyclopentanecarbonyl-pyr...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)C1CCCC1
Show InChI InChI=1S/C29H37N3O6/c33-18-25(34)22-11-4-14-30(22)29(38)24-13-6-16-32(24)28(37)21-10-3-9-20(17-21)27(36)31-15-5-12-23(31)26(35)19-7-1-2-8-19/h3,9-10,17,19,22-24,33H,1-2,4-8,11-16,18H2/t22-,23-,24-/m0/s1
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n/an/a 0.610n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134161
PNG
((R)-1-{(S)-1-[3-((R)-2-Cyclohexanecarbonyl-pyrroli...)
Show SMILES O=C([C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N)C1CCCCC1
Show InChI InChI=1S/C29H36N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h4,10-11,18,20,23-25H,1-3,5-9,12-17H2/t23-,24-,25+/m1/s1
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n/an/a 0.720n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170686
PNG
((S)-1-{(S)-1-[3-((S)-2-Cyclohexanecarbonyl-pyrroli...)
Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)C1CCCCC1
Show InChI InChI=1S/C29H36N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h4,10-11,18,20,23-25H,1-3,5-9,12-17H2/t23-,24-,25-/m0/s1
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n/an/a 0.720n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170705
PNG
((S)-1-[(S)-1-(4-Azepan-1-yl-4-oxo-butyryl)-pyrroli...)
Show SMILES O=C(CCC(=O)N1CCCCCC1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C20H30N4O3/c21-15-16-7-5-13-23(16)20(27)17-8-6-14-24(17)19(26)10-9-18(25)22-11-3-1-2-4-12-22/h16-17H,1-14H2/t16-,17-/m0/s1
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n/an/a 0.760n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50176777
PNG
(4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl...)
Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12
Show InChI InChI=1S/C38H40N4O9S/c43-21-31(46)29-6-4-17-42(29)35(48)30-7-5-16-41(30)34(47)8-2-1-3-15-39-37(52)40-22-9-12-26-25(18-22)36(49)51-38(26)27-13-10-23(44)19-32(27)50-33-20-24(45)11-14-28(33)38/h9-14,18-20,29-30,43-45H,1-8,15-17,21H2,(H2,39,40,52)/t29-,30-/m0/s1
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n/an/a 0.830n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of pig brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50316822
PNG
(3-cyclohexyl-N-((S)-1-oxo-3-phenyl-1-((S)-2-(piper...)
Show SMILES O=C(CCC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCCCC1
Show InChI InChI=1S/C28H41N3O3/c32-26(17-16-22-11-4-1-5-12-22)29-24(21-23-13-6-2-7-14-23)27(33)31-20-10-15-25(31)28(34)30-18-8-3-9-19-30/h2,6-7,13-14,22,24-25H,1,3-5,8-12,15-21H2,(H,29,32)/t24-,25-/m0/s1
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n/an/a 1.05n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of pig brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50316821
PNG
(CHEMBL1096175 | N-((S)-3-methyl-1-oxo-1-((S)-2-(pi...)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(Oc2ccccc2)c1)C(=O)N1CCC[C@H]1C(=O)N1CCCCC1
Show InChI InChI=1S/C28H35N3O4/c1-20(2)25(28(34)31-18-10-15-24(31)27(33)30-16-7-4-8-17-30)29-26(32)21-11-9-14-23(19-21)35-22-12-5-3-6-13-22/h3,5-6,9,11-14,19-20,24-25H,4,7-8,10,15-18H2,1-2H3,(H,29,32)/t24-,25-/m0/s1
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n/an/a 1.05n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of pig brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134175
PNG
((R)-1-{(S)-1-[3-((R)-2-Cyclopentanecarbonyl-pyrrol...)
Show SMILES O=C(C1CCCC1)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N
Show InChI InChI=1S/C28H34N4O4/c29-18-22-11-4-14-30(22)28(36)24-13-6-16-32(24)27(35)21-10-3-9-20(17-21)26(34)31-15-5-12-23(31)25(33)19-7-1-2-8-19/h3,9-10,17,19,22-24H,1-2,4-8,11-16H2/t22-,23-,24+/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170682
PNG
((S)-1-((S)-1-(3-((S)-2-(cyclopentanecarbonyl)pyrro...)
Show SMILES O=C(C1CCCC1)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C28H34N4O4/c29-18-22-11-4-14-30(22)28(36)24-13-6-16-32(24)27(35)21-10-3-9-20(17-21)26(34)31-15-5-12-23(31)25(33)19-7-1-2-8-19/h3,9-10,17,19,22-24H,1-2,4-8,11-16H2/t22-,23-,24-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170683
PNG
((S)-1-[(S)-1-(5-Azepan-1-yl-5-oxo-pentanoyl)-pyrro...)
Show SMILES O=C(CCCC(=O)N1CCCCCC1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C21H32N4O3/c22-16-17-8-6-14-24(17)21(28)18-9-7-15-25(18)20(27)11-5-10-19(26)23-12-3-1-2-4-13-23/h17-18H,1-15H2/t17-,18-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50193665
PNG
(1-((2R,5S)-2-tert-butyl-5-(pyrrolidine-1-carbonyl)...)
Show SMILES CC(C)(C)[C@H]1CC[C@H](N1C(=O)CCCc1ccccc1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H34N2O2/c1-23(2,3)20-15-14-19(22(27)24-16-7-8-17-24)25(20)21(26)13-9-12-18-10-5-4-6-11-18/h4-6,10-11,19-20H,7-9,12-17H2,1-3H3/t19-,20+/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of pig brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170707
PNG
(1-((S)-1-{(S)-1-[3-((S)-2-Acetyl-pyrrolidine-1-car...)
Show SMILES CC(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)CO
Show InChI InChI=1S/C25H31N3O6/c1-16(30)19-8-3-11-26(19)23(32)17-6-2-7-18(14-17)24(33)28-13-5-10-21(28)25(34)27-12-4-9-20(27)22(31)15-29/h2,6-7,14,19-21,29H,3-5,8-13,15H2,1H3/t19-,20-,21-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134164
PNG
(1-((R)-1-{(S)-1-[3-((R)-2-Acetyl-pyrrolidine-1-car...)
Show SMILES CC(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C(=O)CO
Show InChI InChI=1S/C25H31N3O6/c1-16(30)19-8-3-11-26(19)23(32)17-6-2-7-18(14-17)24(33)28-13-5-10-21(28)25(34)27-12-4-9-20(27)22(31)15-29/h2,6-7,14,19-21,29H,3-5,8-13,15H2,1H3/t19-,20-,21+/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134167
PNG
((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C27H34N4O5/c32-18-21-9-4-14-29(21)27(36)23-11-6-16-31(23)25(34)20-8-3-7-19(17-20)24(33)30-15-5-10-22(30)26(35)28-12-1-2-13-28/h3,7-8,17-18,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50170692
PNG
((S)-1-{(S)-1-[3-((S)-2-Benzoyl-pyrrolidine-1-carbo...)
Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)c1ccccc1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C29H30N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h1-4,8-11,18,23-25H,5-7,12-17H2/t23-,24-,25-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50155834
PNG
(4-Phenyl-1-[5-(pyrrolidine-1-carbonyl)-cyclopent-1...)
Show SMILES O=C(CCCc1ccccc1)C1=CCCC1C(=O)N1CCCC1
Show InChI InChI=1S/C20H25NO2/c22-19(13-6-10-16-8-2-1-3-9-16)17-11-7-12-18(17)20(23)21-14-4-5-15-21/h1-3,8-9,11,18H,4-7,10,12-15H2
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n/an/a 1.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134159
PNG
((R)-1-{(S)-1-[3-((R)-2-Benzoyl-pyrrolidine-1-carbo...)
Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@@H]1C(=O)c1ccccc1)N1CCC[C@@H]1C#N
Show InChI InChI=1S/C29H30N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h1-4,8-11,18,23-25H,5-7,12-17H2/t23-,24-,25+/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50051539
PNG
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C19H26N2O2/c22-18(12-6-10-16-8-2-1-3-9-16)21-15-7-11-17(21)19(23)20-13-4-5-14-20/h1-3,8-9,17H,4-7,10-15H2/t17-/m0/s1
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PubMed
n/an/a 1.30n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of pig brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134167
PNG
((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C27H34N4O5/c32-18-21-9-4-14-29(21)27(36)23-11-6-16-31(23)25(34)20-8-3-7-19(17-20)24(33)30-15-5-10-22(30)26(35)28-12-1-2-13-28/h3,7-8,17-18,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50118908
PNG
(1-(1-{3-[2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCCC1C(=O)N1CCCC1
Show InChI InChI=1S/C27H34N4O5/c32-18-21-9-4-14-29(21)27(36)23-11-6-16-31(23)25(34)20-8-3-7-19(17-20)24(33)30-15-5-10-22(30)26(35)28-12-1-2-13-28/h3,7-8,17-18,21-23H,1-2,4-6,9-16H2/t21-,22?,23-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pigbrain expressed


J Med Chem 45: 4581-4 (2002)

More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Sus scrofa)
BDBM50134163
PNG
((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...)
Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)N1CCCC1
Show InChI InChI=1S/C27H33N5O4/c28-18-21-9-4-14-30(21)27(36)23-11-6-16-32(23)25(34)20-8-3-7-19(17-20)24(33)31-15-5-10-22(31)26(35)29-12-1-2-13-29/h3,7-8,17,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibition of prolyl oligopeptidase (POP) from pig brain


Citation and Details
More data for this
Ligand-Target Pair
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