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Found 14 hits Enz. Inhib. hit(s) with Target = 'Prolyl endopeptidase' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl endopeptidase


(Bos taurus)
BDBM50038879
PNG
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
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0.210n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Bos taurus)
BDBM50038879
PNG
((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
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0.350n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of POP in bovine serum using Z-Gly-Pro-NH-Mec fluorimetric substrate


J Med Chem 59: 4221-34 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Bos taurus)
BDBM50316839
PNG
((S)-benzyl 2-((S)-2-formylpyrrolidine-1-carbonyl)-...)
Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCC(=O)N1C(=O)OCc1ccccc1
Show InChI InChI=1S/C18H20N2O5/c21-11-14-7-4-10-19(14)17(23)15-8-9-16(22)20(15)18(24)25-12-13-5-2-1-3-6-13/h1-3,5-6,11,14-15H,4,7-10,12H2/t14-,15-/m0/s1
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3.40n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50316835
PNG
((S)-benzyl 2-(thiazolidine-3-carbonyl)pyrrolidine-...)
Show SMILES O=C(OCc1ccccc1)N1CCC[C@H]1C(=O)N1CCSC1
Show InChI InChI=1S/C16H20N2O3S/c19-15(17-9-10-22-12-17)14-7-4-8-18(14)16(20)21-11-13-5-2-1-3-6-13/h1-3,5-6,14H,4,7-12H2/t14-/m0/s1
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39n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50316834
PNG
((S)-2-(1-Oxo-1lambda*4*-thiazolidine-3-carbonyl)-p...)
Show SMILES O=C(OCc1ccccc1)N1CCC[C@H]1C(=O)N1CCS(=O)C1
Show InChI InChI=1S/C16H20N2O4S/c19-15(17-9-10-23(21)12-17)14-7-4-8-18(14)16(20)22-11-13-5-2-1-3-6-13/h1-3,5-6,14H,4,7-12H2/t14-,23?/m0/s1
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1.61E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50316820
PNG
((S)-benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1...)
Show SMILES O=C(OCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C17H22N2O3/c20-16(18-10-4-5-11-18)15-9-6-12-19(15)17(21)22-13-14-7-2-1-3-8-14/h1-3,7-8,15H,4-6,9-13H2/t15-/m0/s1
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2.10E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50316833
PNG
((S)-benzyl 2-(oxazolidine-3-carbonyl)pyrrolidine-1...)
Show SMILES O=C(OCc1ccccc1)N1CCC[C@H]1C(=O)N1CCOC1
Show InChI InChI=1S/C16H20N2O4/c19-15(17-9-10-21-12-17)14-7-4-8-18(14)16(20)22-11-13-5-2-1-3-6-13/h1-3,5-6,14H,4,7-12H2/t14-/m0/s1
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2.90E+3n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50316827
PNG
((S)-benzyl 2-(2-(2-chloroacetyl)pyrrolidin-1-yl)-2...)
Show SMILES ClCC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OCc1ccccc1
Show InChI InChI=1S/C16H19ClN2O4/c17-9-14(20)13-7-4-8-19(13)15(21)10-18-16(22)23-11-12-5-2-1-3-6-12/h1-3,5-6,13H,4,7-11H2,(H,18,22)/t13-/m0/s1
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7.00E+4n/an/an/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50316842
PNG
((S)-1-((S)-3-methyl-2-(4-phenylbutanamido)butanoyl...)
Show SMILES CC(C)[C@H](NC(=O)CCCc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C20H28N2O4/c1-14(2)18(19(24)22-13-7-11-16(22)20(25)26)21-17(23)12-6-10-15-8-4-3-5-9-15/h3-5,8-9,14,16,18H,6-7,10-13H2,1-2H3,(H,21,23)(H,25,26)/t16-,18-/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50051480
PNG
(4-Phenyl-1-[(R)-4-(pyrrolidine-1-carbonyl)-thiazol...)
Show SMILES O=C(CCCc1ccccc1)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C18H24N2O2S/c21-17(10-6-9-15-7-2-1-3-8-15)20-14-23-13-16(20)18(22)19-11-4-5-12-19/h1-3,7-8,16H,4-6,9-14H2/t16-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from bovine brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50051480
PNG
(4-Phenyl-1-[(R)-4-(pyrrolidine-1-carbonyl)-thiazol...)
Show SMILES O=C(CCCc1ccccc1)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C18H24N2O2S/c21-17(10-6-9-15-7-2-1-3-8-15)20-14-23-13-16(20)18(22)19-11-4-5-12-19/h1-3,7-8,16H,4-6,9-14H2/t16-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Institut de Recherche Servier

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from bovine brain


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50051539
PNG
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C19H26N2O2/c22-18(12-6-10-16-8-2-1-3-9-16)21-15-7-11-17(21)19(23)20-13-4-5-14-20/h1-3,8-9,17H,4-7,10-15H2/t17-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50316826
PNG
((S)-benzyl 2-((S)-2-(hydroxymethyl)pyrrolidine-1-c...)
Show SMILES OC[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1
Show InChI InChI=1S/C18H24N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,15-16,21H,4-5,8-13H2/t15-,16-/m0/s1
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n/an/a 4.20E+4n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Bos taurus)
BDBM50316838
PNG
((S)-4-phenyl-1-(2-(pyrrolidin-1-ylmethyl)pyrrolidi...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1CN1CCCC1
Show InChI InChI=1S/C19H28N2O/c22-19(12-6-10-17-8-2-1-3-9-17)21-15-7-11-18(21)16-20-13-4-5-14-20/h1-3,8-9,18H,4-7,10-16H2/t18-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain POP


Citation and Details
More data for this
Ligand-Target Pair