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Compile Data Set for Download or QSAR

Found 102 hits Enz. Inhib. hit(s) with Target = 'Proprotein convertase subtilisin/kexin type 9 (PCSK9)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM50280216
PNG
(Borinic acid derivative | CHEMBL31523 | Phenyl but...)
Show SMILES CCCCB(O)c1ccccc1
Show InChI InChI=1S/C10H15BO/c1-2-3-9-11(12)10-7-5-4-6-8-10/h4-8,12H,2-3,9H2,1H3
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Article
1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of subtilisin


Citation and Details
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM50067889
PNG
(CHEMBL81556 | Diphenyl Borinic acid)
Show SMILES OB(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C12H11BO/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,14H
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Article
3.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of subtilisin


Citation and Details
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM50014066
PNG
(2-Acetylamino-3-(4-oxiranylmethoxy-phenyl)-propion...)
Show SMILES CCOC(=O)[C@H](Cc1ccc(OCC2CO2)cc1)NC(C)=O
Show InChI InChI=1S/C16H21NO5/c1-3-20-16(19)15(17-11(2)18)8-12-4-6-13(7-5-12)21-9-14-10-22-14/h4-7,14-15H,3,8-10H2,1-2H3,(H,17,18)/t14?,15-/m0/s1
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PubMed
2.00E+5n/an/an/an/an/an/an/an/a



State University

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was tested against subtilisin


J Med Chem 33: 1620-34 (1990)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM26996
PNG
(CHEMBL21485 | PhB(OH)2 | Phenylboronic acid, 22 | ...)
Show SMILES OB(O)c1ccccc1
Show InChI InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H
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Article
4.70E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of subtilisin


Citation and Details
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200316
PNG
(US9227956, 1)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn2cccnc12
Show InChI InChI=1/C24H24N6O/c1-17-5-2-12-26-22(17)30(20-6-3-11-25-15-20)24(31)19-9-7-18(8-10-19)21-16-28-29-14-4-13-27-23(21)29/h2,4-5,7-10,12-14,16,20,25H,3,6,11,15H2,1H3/t20-/s2
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US Patent
n/an/a 440n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200332
PNG
(US9227956, 16)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
Show InChI InChI=1/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/s2
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n/an/a 520n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200354
PNG
(US9227956, 38 | US9227956, 39)
Show SMILES CC(C)OC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C29H35N9O4/c1-18(2)41-29(40)42-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/s2
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n/an/a 592n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200325
PNG
(US9227956, 10)
Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C23H24ClN5O3/c1-28-20(23(31)32-2)18(14-27-28)15-7-9-16(10-8-15)22(30)29(17-5-3-11-25-13-17)21-19(24)6-4-12-26-21/h4,6-10,12,14,17,25H,3,5,11,13H2,1-2H3/t17-/s2
PDB

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n/an/a 640n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200317
PNG
(US9227956, 2)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn2cccnc12
Show InChI InChI=1/C23H21ClN6O/c24-20-5-2-11-27-22(20)30(18-4-1-10-25-14-18)23(31)17-8-6-16(7-9-17)19-15-28-29-13-3-12-26-21(19)29/h2-3,5-9,11-13,15,18,25H,1,4,10,14H2/t18-/s2
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n/an/a 690n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200332
PNG
(US9227956, 16)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
Show InChI InChI=1/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/s2
PDB

UniProtKB/SwissProt

antibodypedia
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US Patent
n/an/a 800n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200328
PNG
(US9227956, 13)
Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C24H27N5O3/c1-16-6-4-13-26-22(16)29(19-7-5-12-25-14-19)23(30)18-10-8-17(9-11-18)20-15-27-28(2)21(20)24(31)32-3/h4,6,8-11,13,15,19,25H,5,7,12,14H2,1-3H3/t19-/s2
PDB

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US Patent
n/an/a 800n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200318
PNG
(US9227956, 3)
Show SMILES Cc1cnc2n(nnc2c1)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C23H22ClN7O/c1-15-12-20-22(27-13-15)31(29-28-20)17-8-6-16(7-9-17)23(32)30(18-4-2-10-25-14-18)21-19(24)5-3-11-26-21/h3,5-9,11-13,18,25H,2,4,10,14H2,1H3/t18-/s2
PDB

UniProtKB/SwissProt

antibodypedia
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US Patent
n/an/a 800n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200325
PNG
(US9227956, 10)
Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C23H24ClN5O3/c1-28-20(23(31)32-2)18(14-27-28)15-7-9-16(10-8-15)22(30)29(17-5-3-11-25-13-17)21-19(24)6-4-12-26-21/h4,6-10,12,14,17,25H,3,5,11,13H2,1-2H3/t17-/s2
PDB

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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200321
PNG
(US9227956, 6)
Show SMILES CCOC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C24H26ClN5O3/c1-3-33-24(32)21-19(15-28-29(21)2)16-8-10-17(11-9-16)23(31)30(18-6-4-12-26-14-18)22-20(25)7-5-13-27-22/h5,7-11,13,15,18,26H,3-4,6,12,14H2,1-2H3/t18-/s2
PDB

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antibodypedia
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AffyNet 
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200320
PNG
(US9227956, 5)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cn1)-n1nnc2cccnc12
Show InChI InChI=1/C21H19ClN8O/c22-16-5-2-10-24-19(16)29(14-4-1-9-23-12-14)21(31)18-8-7-15(13-26-18)30-20-17(27-28-30)6-3-11-25-20/h2-3,5-8,10-11,13-14,23H,1,4,9,12H2/t14-/s2
PDB

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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200321
PNG
(US9227956, 6)
Show SMILES CCOC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C24H26ClN5O3/c1-3-33-24(32)21-19(15-28-29(21)2)16-8-10-17(11-9-16)23(31)30(18-6-4-12-26-14-18)22-20(25)7-5-13-27-22/h5,7-11,13,15,18,26H,3-4,6,12,14H2,1-2H3/t18-/s2
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200317
PNG
(US9227956, 2)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn2cccnc12
Show InChI InChI=1/C23H21ClN6O/c24-20-5-2-11-27-22(20)30(18-4-1-10-25-14-18)23(31)17-8-6-16(7-9-17)19-15-28-29-13-3-12-26-21(19)29/h2-3,5-9,11-13,15,18,25H,1,4,10,14H2/t18-/s2
PDB

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AffyNet 
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200327
PNG
(US9227956, 12)
Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12
Show InChI InChI=1/C25H26N6O3/c1-29-13-10-17-9-12-27-23(21(17)29)31(19-4-3-11-26-14-19)24(32)18-7-5-16(6-8-18)20-15-28-30(2)22(20)25(33)34/h5-10,12-13,15,19,26H,3-4,11,14H2,1-2H3,(H,33,34)/t19-/s2
PDB

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n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200324
PNG
(US9227956, 9)
Show SMILES Cc1cnc2n(nnc2c1)-c1ccc(nc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C22H21ClN8O/c1-14-10-19-21(27-11-14)31(29-28-19)16-6-7-18(26-13-16)22(32)30(15-4-2-8-24-12-15)20-17(23)5-3-9-25-20/h3,5-7,9-11,13,15,24H,2,4,8,12H2,1H3/t15-/s2
PDB

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n/an/a 1.80E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200326
PNG
(US9227956, 11)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccccc12
Show InChI InChI=1/C31H33N5O6/c1-4-40-31(39)42-20(2)41-30(38)27-26(19-34-35(27)3)22-11-13-23(14-12-22)29(37)36(24-9-7-16-32-18-24)28-25-10-6-5-8-21(25)15-17-33-28/h5-6,8,10-15,17,19-20,24,32H,4,7,9,16,18H2,1-3H3/t20?,24-/s2
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200354
PNG
(US9227956, 38 | US9227956, 39)
Show SMILES CC(C)OC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C29H35N9O4/c1-18(2)41-29(40)42-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/s2
PDB

UniProtKB/SwissProt

antibodypedia
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US Patent
n/an/a 2.19E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200328
PNG
(US9227956, 13)
Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C24H27N5O3/c1-16-6-4-13-26-22(16)29(19-7-5-12-25-14-19)23(30)18-10-8-17(9-11-18)20-15-27-28(2)21(20)24(31)32-3/h4,6,8-11,13,15,19,25H,5,7,12,14H2,1-3H3/t19-/s2
PDB

UniProtKB/SwissProt

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n/an/a 2.30E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200341
PNG
(US9227956, 25)
Show SMILES Cn1ncc(c1C(=O)NO)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C22H23ClN6O3/c1-28-19(21(30)27-32)17(13-26-28)14-6-8-15(9-7-14)22(31)29(16-4-2-10-24-12-16)20-18(23)5-3-11-25-20/h3,5-9,11,13,16,24,32H,2,4,10,12H2,1H3,(H,27,30)/t16-/s2
PDB

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n/an/a 2.97E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200333
PNG
(US9227956, 17)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn(C)c1-c1nn[nH]n1
Show InChI InChI=1/C23H25N9O/c1-15-5-3-12-25-22(15)32(18-6-4-11-24-13-18)23(33)17-9-7-16(8-10-17)19-14-26-31(2)20(19)21-27-29-30-28-21/h3,5,7-10,12,14,18,24H,4,6,11,13H2,1-2H3,(H,27,28,29,30)/t18-/s2
PDB

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n/an/a 3.05E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200330
PNG
(US9227956, 15a)
Show SMILES CCOC(=O)O[C@@H](C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17-,20+/s2
PDB

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n/an/a 3.10E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200316
PNG
(US9227956, 1)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn2cccnc12
Show InChI InChI=1/C24H24N6O/c1-17-5-2-12-26-22(17)30(20-6-3-11-25-15-20)24(31)19-9-7-18(8-10-19)21-16-28-29-14-4-13-27-23(21)29/h2,4-5,7-10,12-14,16,20,25H,3,6,11,15H2,1H3/t20-/s2
PDB

UniProtKB/SwissProt

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n/an/a 3.20E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200366
PNG
(US9227956, 50 | US9227956, 51)
Show SMILES CC(C)C(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C29H35N9O3/c1-18(2)29(40)41-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/s2
PDB

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n/an/a 3.56E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200323
PNG
(US9227956, 8)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17?,20-/s2
PDB

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n/an/a 3.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200319
PNG
(US9227956, 4)
Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccccc12
Show InChI InChI=1/C26H25N5O3/c1-30-23(26(33)34)22(16-29-30)18-8-10-19(11-9-18)25(32)31(20-6-4-13-27-15-20)24-21-7-3-2-5-17(21)12-14-28-24/h2-3,5,7-12,14,16,20,27H,4,6,13,15H2,1H3,(H,33,34)/t20-/s2
PDB

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n/an/a 3.80E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/s2
PDB

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n/an/a 4.39E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200329
PNG
(US9227956, 14)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12
Show InChI InChI=1/C30H34N6O6/c1-5-40-30(39)42-19(2)41-29(38)26-24(18-33-35(26)4)20-8-10-22(11-9-20)28(37)36(23-7-6-14-31-17-23)27-25-21(12-15-32-27)13-16-34(25)3/h8-13,15-16,18-19,23,31H,5-7,14,17H2,1-4H3/t19?,23-/s2
PDB

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n/an/a 4.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200362
PNG
(US9227956, 46 | US9227956, 47)
Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/s2
PDB

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n/an/a 4.67E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200331
PNG
(US9227956, 15b)
Show SMILES CCOC(=O)O[C@H](C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17-,20-/s2
PDB

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n/an/a 5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200350
PNG
(US9227956, 34 | US9227956, 35)
Show SMILES CCOC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C30H37N9O4/c1-6-42-30(41)43-29(19(2)3)39-35-26(34-36-39)25-24(18-33-37(25)5)21-11-13-22(14-12-21)28(40)38(23-10-8-15-31-17-23)27-20(4)9-7-16-32-27/h7,9,11-14,16,18-19,23,29,31H,6,8,10,15,17H2,1-5H3/t23-,29?/s2
PDB

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n/an/a 5.22E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200352
PNG
(US9227956, 36 | US9227956, 37)
Show SMILES CCOC(=O)OC(n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C)C(C)(C)C
Show InChI InChI=1/C31H39N9O4/c1-7-43-30(42)44-29(31(3,4)5)40-36-26(35-37-40)25-24(19-34-38(25)6)21-12-14-22(15-13-21)28(41)39(23-11-9-16-32-18-23)27-20(2)10-8-17-33-27/h8,10,12-15,17,19,23,29,32H,7,9,11,16,18H2,1-6H3/t23-,29?/s2
PDB

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n/an/a 5.43E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200334
PNG
(US9227956, 18)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn(C)c1-c1noc(=O)[nH]1
Show InChI InChI=1/C24H25N7O3/c1-15-5-3-12-26-22(15)31(18-6-4-11-25-13-18)23(32)17-9-7-16(8-10-17)19-14-27-30(2)20(19)21-28-24(33)34-29-21/h3,5,7-10,12,14,18,25H,4,6,11,13H2,1-2H3,(H,28,29,33)/t18-/s2
PDB

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n/an/a 5.61E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200342
PNG
(US9227956, 26)
Show SMILES Cn1ncc(c1-c1nn[nH]n1)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C22H22ClN9O/c1-31-19(20-27-29-30-28-20)17(13-26-31)14-6-8-15(9-7-14)22(33)32(16-4-2-10-24-12-16)21-18(23)5-3-11-25-21/h3,5-9,11,13,16,24H,2,4,10,12H2,1H3,(H,27,28,29,30)/t16-/s2
PDB

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n/an/a 5.75E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200338
PNG
(US9227956, 22)
Show SMILES Cn1ncc(c1C(=O)NS(=O)(=O)C(F)(F)F)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C23H22ClF3N6O4S/c1-32-19(21(34)31-38(36,37)23(25,26)27)17(13-30-32)14-6-8-15(9-7-14)22(35)33(16-4-2-10-28-12-16)20-18(24)5-3-11-29-20/h3,5-9,11,13,16,28H,2,4,10,12H2,1H3,(H,31,34)/t16-/s2
PDB

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n/an/a 5.80E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200350
PNG
(US9227956, 34 | US9227956, 35)
Show SMILES CCOC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C30H37N9O4/c1-6-42-30(41)43-29(19(2)3)39-35-26(34-36-39)25-24(18-33-37(25)5)21-11-13-22(14-12-21)28(40)38(23-10-8-15-31-17-23)27-20(4)9-7-16-32-27/h7,9,11-14,16,18-19,23,29,31H,6,8,10,15,17H2,1-5H3/t23-,29?/s2
PDB

UniProtKB/SwissProt

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n/an/a 6.20E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200348
PNG
(US9227956, 32 | US9227956, 33)
Show SMILES CCOC(=O)OC(CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C29H35N9O4/c1-5-24(42-29(40)41-6-2)38-34-26(33-35-38)25-23(18-32-36(25)4)20-11-13-21(14-12-20)28(39)37(22-10-8-15-30-17-22)27-19(3)9-7-16-31-27/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/s2
PDB

UniProtKB/SwissProt

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n/an/a 7.26E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200330
PNG
(US9227956, 15a)
Show SMILES CCOC(=O)O[C@@H](C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17-,20+/s2
PDB

UniProtKB/SwissProt

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n/an/a 7.30E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200358
PNG
(US9227956, 42 | US9227956, 43)
Show SMILES CC(C)OC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C31H39N9O4/c1-19(2)30(44-31(42)43-20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/s2
PDB

UniProtKB/SwissProt

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n/an/a 7.38E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200364
PNG
(US9227956, 48 | US9227956, 49)
Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/s2
PDB

UniProtKB/SwissProt

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n/an/a 7.68E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200366
PNG
(US9227956, 50 | US9227956, 51)
Show SMILES CC(C)C(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C29H35N9O3/c1-18(2)29(40)41-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/s2
PDB

UniProtKB/SwissProt

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n/an/a 8.03E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200323
PNG
(US9227956, 8)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17?,20-/s2
PDB

UniProtKB/SwissProt

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n/an/a 9.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200368
PNG
(US9227956, 52 | US9227956, 53)
Show SMILES CCC(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C30H37N9O3/c1-6-25(42-30(41)19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/s2
PDB

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n/an/a 1.07E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200331
PNG
(US9227956, 15b)
Show SMILES CCOC(=O)O[C@H](C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl
Show InChI InChI=1/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17-,20-/s2
PDB

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n/an/a 1.07E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200326
PNG
(US9227956, 11)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccccc12
Show InChI InChI=1/C31H33N5O6/c1-4-40-31(39)42-20(2)41-30(38)27-26(19-34-35(27)3)22-11-13-23(14-12-22)29(37)36(24-9-7-16-32-18-24)28-25-10-6-5-8-21(25)15-17-33-28/h5-6,8,10-15,17,19-20,24,32H,4,7,9,16,18H2,1-3H3/t20?,24-/s2
PDB

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n/an/a 1.17E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200354
PNG
(US9227956, 38 | US9227956, 39)
Show SMILES CC(C)OC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C29H35N9O4/c1-18(2)41-29(40)42-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/s2
PDB

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n/an/a 1.18E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9)


(Homo sapiens (Human))
BDBM200370
PNG
(US9227956, 54 | US9227956, 55)
Show SMILES CC(C)C(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C
Show InChI InChI=1/C31H39N9O3/c1-19(2)30(43-31(42)20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/s2
PDB

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n/an/a 1.28E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...


US Patent US9227956 (2016)

More data for this
Ligand-Target Pair
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