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Found 16 hits Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 2' AND taxid = 9986   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331901
PNG
(CHEMBL1289341 | E-5-Bromo-3-[[4-(methylsulfonyl)ph...)
Show SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(Br)cc23)cc1
Show InChI InChI=1S/C16H12BrNO3S/c1-22(20,21)12-5-2-10(3-6-12)8-14-13-9-11(17)4-7-15(13)18-16(14)19/h2-9H,1H3,(H,18,19)/b14-8+
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n/an/a 100n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50044080
PNG
(2-Amino-5-[1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-...)
Show SMILES CC(C)(C)c1cc(C=C2SC(N)=NC2=O)cc(c1O)C(C)(C)C
Show InChI InChI=1S/C18H24N2O2S/c1-17(2,3)11-7-10(8-12(14(11)21)18(4,5)6)9-13-15(22)20-16(19)23-13/h7-9,21H,1-6H3,(H2,19,20,22)
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n/an/a 110n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331890
PNG
(CHEMBL1290661 | E-5-Fluoro-3-[[4-(sulfamoyl)phenyl...)
Show SMILES NS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(F)cc23)cc1
Show InChI InChI=1S/C15H11FN2O3S/c16-10-3-6-14-12(8-10)13(15(19)18-14)7-9-1-4-11(5-2-9)22(17,20)21/h1-8H,(H,18,19)(H2,17,20,21)/b13-7+
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n/an/a 180n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331900
PNG
(CHEMBL1289227 | E-6-Chloro-3-[[4-(methylsulfonyl)p...)
Show SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C16H12ClNO3S/c1-22(20,21)12-5-2-10(3-6-12)8-14-13-7-4-11(17)9-15(13)18-16(14)19/h2-9H,1H3,(H,18,19)/b14-8+
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n/an/a 2.39E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331902
PNG
(CHEMBL1289342 | E-5-Nitro-3-[[4-(Methylsulfonyl)ph...)
Show SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(cc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C16H12N2O5S/c1-24(22,23)12-5-2-10(3-6-12)8-14-13-9-11(18(20)21)4-7-15(13)17-16(14)19/h2-9H,1H3,(H,17,19)/b14-8+
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n/an/a 3.29E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331891
PNG
(CHEMBL1290662 | E-5-Chloro-3-[[4-(sulfamoyl)phenyl...)
Show SMILES NS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C15H11ClN2O3S/c16-10-3-6-14-12(8-10)13(15(19)18-14)7-9-1-4-11(5-2-9)22(17,20)21/h1-8H,(H,18,19)(H2,17,20,21)/b13-7+
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n/an/a 3.31E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331895
PNG
(CHEMBL1289105 | E-5-Nitro-3-[[4-(sulfamoyl)phenyl]...)
Show SMILES NS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(cc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C15H11N3O5S/c16-24(22,23)11-4-1-9(2-5-11)7-13-12-8-10(18(20)21)3-6-14(12)17-15(13)19/h1-8H,(H,17,19)(H2,16,22,23)/b13-7+
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n/an/a 3.72E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331898
PNG
(CHEMBL1289225 | E-5-Chloro-3-[[4-(methylsulfonyl)p...)
Show SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C16H12ClNO3S/c1-22(20,21)12-5-2-10(3-6-12)8-14-13-9-11(17)4-7-15(13)18-16(14)19/h2-9H,1H3,(H,18,19)/b14-8+
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n/an/a 3.82E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331896
PNG
(CHEMBL1289106 | E-3-[[4-(Methylsulfonyl)phenyl]met...)
Show SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C16H13NO3S/c1-21(19,20)12-8-6-11(7-9-12)10-14-13-4-2-3-5-15(13)17-16(14)18/h2-10H,1H3,(H,17,18)/b14-10+
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n/an/a 5.52E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331888
PNG
(5-Chloro-2-oxo-3-(thiophene-2-carbonyl)-2,3-dihydr...)
Show SMILES NC(=O)n1c(O)c(C(=O)c2cccs2)c2cc(Cl)ccc12
Show InChI InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)
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n/an/a 8.40E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331894
PNG
(CHEMBL1287841 | E-5-Bromo-3-[[4-(sulfamoyl)phenyl]...)
Show SMILES NS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(Br)cc23)cc1
Show InChI InChI=1S/C15H11BrN2O3S/c16-10-3-6-14-12(8-10)13(15(19)18-14)7-9-1-4-11(5-2-9)22(17,20)21/h1-8H,(H,18,19)(H2,17,20,21)/b13-7+
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n/an/a 2.09E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331889
PNG
(CHEMBL1290660 | E-3-[[4-(Sulfamoyl)phenyl]methylen...)
Show SMILES NS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H12N2O3S/c16-21(19,20)11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)17-15(13)18/h1-9H,(H,17,18)(H2,16,19,20)/b13-9+
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n/an/a>5.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331892
PNG
(CHEMBL1290779 | E-5-Methyl-3-[[4-(sulfamoyl)phenyl...)
Show SMILES Cc1ccc2NC(=O)\C(=C\c3ccc(cc3)S(N)(=O)=O)c2c1
Show InChI InChI=1S/C16H14N2O3S/c1-10-2-7-15-13(8-10)14(16(19)18-15)9-11-3-5-12(6-4-11)22(17,20)21/h2-9H,1H3,(H,18,19)(H2,17,20,21)/b14-9+
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n/an/a>5.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331893
PNG
(CHEMBL1290780 | E-6-Chloro-3-[[4-(sulfamoyl)phenyl...)
Show SMILES NS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C15H11ClN2O3S/c16-10-3-6-12-13(15(19)18-14(12)8-10)7-9-1-4-11(5-2-9)22(17,20)21/h1-8H,(H,18,19)(H2,17,20,21)/b13-7+
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n/an/a>5.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331897
PNG
(CHEMBL1289107 | E-5-Fluoro-3-[[4-(methylsulfonyl)p...)
Show SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(F)cc23)cc1
Show InChI InChI=1S/C16H12FNO3S/c1-22(20,21)12-5-2-10(3-6-12)8-14-13-9-11(17)4-7-15(13)18-16(14)19/h2-9H,1H3,(H,18,19)/b14-8+
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n/an/a>5.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Oryctolagus cuniculus)
BDBM50331899
PNG
(CHEMBL1289226 | E-5-Methyl-3-[[4-(methylsulfonyl)p...)
Show SMILES Cc1ccc2NC(=O)\C(=C\c3ccc(cc3)S(C)(=O)=O)c2c1
Show InChI InChI=1S/C17H15NO3S/c1-11-3-8-16-14(9-11)15(17(19)18-16)10-12-4-6-13(7-5-12)22(2,20)21/h3-10H,1-2H3,(H,18,19)/b15-10+
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n/an/a>5.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...


Citation and Details
More data for this
Ligand-Target Pair