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Compile Data Set for Download or QSAR

Found 132 hits Enz. Inhib. hit(s) with Target = 'Proteasome component C5' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteasome component C5


(Homo sapiens)
BDBM50021350
PNG
(CHEMBL3287940)
Show SMILES CC(C)C[C@H](NC(=O)CCn1ccc2ccccc2c1=O)B(O)O
Show InChI InChI=1S/C17H23BN2O4/c1-12(2)11-15(18(23)24)19-16(21)8-10-20-9-7-13-5-3-4-6-14(13)17(20)22/h3-7,9,12,15,23-24H,8,10-11H2,1-2H3,(H,19,21)/t15-/m0/s1
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240n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50021352
PNG
(CHEMBL3287943)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccc2ccc(Br)cc2c1=O)B(O)O
Show InChI InChI=1S/C16H20BBrN2O4/c1-10(2)7-14(17(23)24)19-15(21)9-20-6-5-11-3-4-12(18)8-13(11)16(20)22/h3-6,8,10,14,23-24H,7,9H2,1-2H3,(H,19,21)/t14-/m0/s1
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310n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50444909
PNG
(CHEMBL3099618)
Show SMILES CCC(=C(c1ccc(OCCN2CCCCCC2)cc1)c1ccc(OCCN2CCCCCC2)cc1)c1ccccc1
Show InChI InChI=1S/C38H50N2O2/c1-2-37(32-14-8-7-9-15-32)38(33-16-20-35(21-17-33)41-30-28-39-24-10-3-4-11-25-39)34-18-22-36(23-19-34)42-31-29-40-26-12-5-6-13-27-40/h7-9,14-23H,2-6,10-13,24-31H2,1H3
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340n/an/an/an/an/an/an/an/a



Institute of Bio-Science and Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate Linewea...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50069985
PNG
((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
Show InChI InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
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470n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434766
PNG
(CHEMBL2385812)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccc(cc1=O)N1CCOCC1)B(O)O
Show InChI InChI=1S/C16H26BN3O5/c1-12(2)9-14(17(23)24)18-15(21)11-20-4-3-13(10-16(20)22)19-5-7-25-8-6-19/h3-4,10,12,14,23-24H,5-9,11H2,1-2H3,(H,18,21)/t14-/m0/s1
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520n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50444908
PNG
(CHEMBL3099624)
Show SMILES C(CN1CCCCCC1)Oc1ccc(cc1)C(=Cc1ccccc1)c1ccc(OCCN2CCCCCC2)cc1
Show InChI InChI=1S/C36H46N2O2/c1-2-9-23-37(22-8-1)26-28-39-34-18-14-32(15-19-34)36(30-31-12-6-5-7-13-31)33-16-20-35(21-17-33)40-29-27-38-24-10-3-4-11-25-38/h5-7,12-21,30H,1-4,8-11,22-29H2
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670n/an/an/an/an/an/an/an/a



Institute of Bio-Science and Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate Linewea...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50021348
PNG
(CHEMBL3287937)
Show SMILES CC(C)C[C@H](NC(=O)CCn1ccc2ncccc2c1=O)B(O)O
Show InChI InChI=1S/C16H22BN3O4/c1-11(2)10-14(17(23)24)19-15(21)6-9-20-8-5-13-12(16(20)22)4-3-7-18-13/h3-5,7-8,11,14,23-24H,6,9-10H2,1-2H3,(H,19,21)/t14-/m0/s1
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690n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50021349
PNG
(CHEMBL3287939)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccc2ccccc2c1=O)B(O)O
Show InChI InChI=1S/C16H21BN2O4/c1-11(2)9-14(17(22)23)18-15(20)10-19-8-7-12-5-3-4-6-13(12)16(19)21/h3-8,11,14,22-23H,9-10H2,1-2H3,(H,18,20)/t14-/m0/s1
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990n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50444888
PNG
(CHEMBL3099621)
Show SMILES C(CN1CCCCCC1)Oc1ccc(cc1)C(=C(c1ccccc1)c1ccccc1)c1ccc(OCCN2CCCCCC2)cc1
Show InChI InChI=1S/C42H50N2O2/c1-2-12-28-43(27-11-1)31-33-45-39-23-19-37(20-24-39)42(41(35-15-7-5-8-16-35)36-17-9-6-10-18-36)38-21-25-40(26-22-38)46-34-32-44-29-13-3-4-14-30-44/h5-10,15-26H,1-4,11-14,27-34H2
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1.02E+3n/an/an/an/an/an/an/an/a



Institute of Bio-Science and Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate Linewea...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50021351
PNG
(CHEMBL3287942)
Show SMILES COc1cc2ccn(CCC(=O)N[C@@H](CC(C)C)B(O)O)c(=O)c2cc1OC
Show InChI InChI=1S/C19H27BN2O6/c1-12(2)9-17(20(25)26)21-18(23)6-8-22-7-5-13-10-15(27-3)16(28-4)11-14(13)19(22)24/h5,7,10-12,17,25-26H,6,8-9H2,1-4H3,(H,21,23)/t17-/m0/s1
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1.25E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434768
PNG
(CHEMBL2385810)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccccc1=O)B(O)O
Show InChI InChI=1S/C12H19BN2O4/c1-9(2)7-10(13(18)19)14-11(16)8-15-6-4-3-5-12(15)17/h3-6,9-10,18-19H,7-8H2,1-2H3,(H,14,16)/t10-/m0/s1
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1.38E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434765
PNG
(CHEMBL2385813)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccc(cc1=O)N1CCCCC1)B(O)O
Show InChI InChI=1S/C17H28BN3O4/c1-13(2)10-15(18(24)25)19-16(22)12-21-9-6-14(11-17(21)23)20-7-4-3-5-8-20/h6,9,11,13,15,24-25H,3-5,7-8,10,12H2,1-2H3,(H,19,22)/t15-/m0/s1
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1.42E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434763
PNG
(CHEMBL2385817)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccc2ncccc2c1=O)B(O)O
Show InChI InChI=1S/C15H20BN3O4/c1-10(2)8-13(16(22)23)18-14(20)9-19-7-5-12-11(15(19)21)4-3-6-17-12/h3-7,10,13,22-23H,8-9H2,1-2H3,(H,18,20)/t13-/m0/s1
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1.55E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434763
PNG
(CHEMBL2385817)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccc2ncccc2c1=O)B(O)O
Show InChI InChI=1S/C15H20BN3O4/c1-10(2)8-13(16(22)23)18-14(20)9-19-7-5-12-11(15(19)21)4-3-6-17-12/h3-7,10,13,22-23H,8-9H2,1-2H3,(H,18,20)/t13-/m0/s1
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1.55E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50021353
PNG
(CHEMBL3287944)
Show SMILES CC(C)C[C@H](NC(=O)CCn1ccc2ccc(Br)cc2c1=O)B(O)O
Show InChI InChI=1S/C17H22BBrN2O4/c1-11(2)9-15(18(24)25)20-16(22)6-8-21-7-5-12-3-4-13(19)10-14(12)17(21)23/h3-5,7,10-11,15,24-25H,6,8-9H2,1-2H3,(H,20,22)/t15-/m0/s1
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2.04E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434760
PNG
(CHEMBL2385820)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccc2N(C)CCCc2c1=O)B(O)O
Show InChI InChI=1S/C16H26BN3O4/c1-11(2)9-14(17(23)24)18-15(21)10-20-8-6-13-12(16(20)22)5-4-7-19(13)3/h6,8,11,14,23-24H,4-5,7,9-10H2,1-3H3,(H,18,21)/t14-/m0/s1
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3.90E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434767
PNG
(CHEMBL2385811)
Show SMILES CCN(CC)c1ccn(CC(=O)N[C@@H](CC(C)C)B(O)O)c(=O)c1
Show InChI InChI=1S/C16H28BN3O4/c1-5-19(6-2)13-7-8-20(16(22)10-13)11-15(21)18-14(17(23)24)9-12(3)4/h7-8,10,12,14,23-24H,5-6,9,11H2,1-4H3,(H,18,21)/t14-/m0/s1
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4.42E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434764
PNG
(CHEMBL2385814)
Show SMILES CC(C)C[C@H](NC(=O)Cn1ccc(Nc2ccccc2)cc1=O)B(O)O
Show InChI InChI=1S/C18H24BN3O4/c1-13(2)10-16(19(25)26)21-17(23)12-22-9-8-15(11-18(22)24)20-14-6-4-3-5-7-14/h3-9,11,13,16,20,25-26H,10,12H2,1-2H3,(H,21,23)/t16-/m0/s1
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5.14E+3n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434762
PNG
(CHEMBL2385818)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)n1ccc2ncccc2c1=O)B(O)O
Show InChI InChI=1S/C16H22BN3O4/c1-10(2)9-14(17(23)24)19-15(21)11(3)20-8-6-13-12(16(20)22)5-4-7-18-13/h4-8,10-11,14,23-24H,9H2,1-3H3,(H,19,21)/t11-,14-/m0/s1
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1.36E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410909
PNG
(CHEMBL207591)
Show SMILES CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C=O
Show InChI InChI=1S/C32H50N4O8/c1-9-21(4)27(36-31(42)43-19-23-13-11-10-12-14-23)30(41)35-25(15-16-26(38)44-32(6,7)8)29(40)33-22(5)28(39)34-24(18-37)17-20(2)3/h10-14,18,20-22,24-25,27H,9,15-17,19H2,1-8H3,(H,33,40)(H,34,39)(H,35,41)(H,36,42)/t21-,22-,24-,25-,27-/m0/s1
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1.40E+4n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434761
PNG
(CHEMBL2385819)
Show SMILES CC(C)C[C@H](NC(=O)Cn1cc(Br)c2ncccc2c1=O)B(O)O
Show InChI InChI=1S/C15H19BBrN3O4/c1-9(2)6-12(16(23)24)19-13(21)8-20-7-11(17)14-10(15(20)22)4-3-5-18-14/h3-5,7,9,12,23-24H,6,8H2,1-2H3,(H,19,21)/t12-/m0/s1
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1.76E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of human 20S proteasome post-glutamyl peptide hydrolyzing activity using Z-Leu-Leu-Glu-AMC as substrate measured over 10 mins by fluoresce...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50434761
PNG
(CHEMBL2385819)
Show SMILES CC(C)C[C@H](NC(=O)Cn1cc(Br)c2ncccc2c1=O)B(O)O
Show InChI InChI=1S/C15H19BBrN3O4/c1-9(2)6-12(16(23)24)19-13(21)8-20-7-11(17)14-10(15(20)22)4-3-5-18-14/h3-5,7,9,12,23-24H,6,8H2,1-2H3,(H,19,21)/t12-/m0/s1
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1.76E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50007719
PNG
(CHEMBL3233441)
Show SMILES CC(C)CCNC(=O)Cn1cc(Br)c2ncccc2c1=O
Show InChI InChI=1S/C15H18BrN3O2/c1-10(2)5-7-17-13(20)9-19-8-12(16)14-11(15(19)21)4-3-6-18-14/h3-4,6,8,10H,5,7,9H2,1-2H3,(H,17,20)
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2.23E+4n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Messina

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome beta 1 subunit assessed as Cbz-Leu-Leu-Glu-AMC substrate hydrolysis after 10 mins by fluo...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50069984
PNG
((R)-1-((S)-2-((S)-2-(benzyloxycarbonyl)-4-methylpe...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)B(O)O
Show InChI InChI=1S/C25H42BN3O6/c1-16(2)12-20(24(31)29-22(26(33)34)14-18(5)6)27-23(30)21(13-17(3)4)28-25(32)35-15-19-10-8-7-9-11-19/h7-11,16-18,20-22,33-34H,12-15H2,1-6H3,(H,27,30)(H,28,32)(H,29,31)/t20-,21-,22-/m0/s1
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4.80E+4n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410898
PNG
(CHEMBL205757)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)c1nnc(o1)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C35H49N7O7S/c1-21(2)18-27(30(44)34-40-39-33(49-34)24-12-14-25(15-13-24)42(8)9)38-31(45)23(4)37-32(46)28(19-29(43)36-20-35(5,6)7)41-50(47,48)26-16-10-22(3)11-17-26/h10-17,21,23,27-28,41H,18-20H2,1-9H3,(H,36,43)(H,37,46)(H,38,45)/t23-,27-,28-/m0/s1
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>3.00E+5n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410903
PNG
(CHEMBL207598)
Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)c1nnc(o1)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C36H51N7O8S/c1-22(2)18-27(31(45)35-41-40-34(51-35)24-12-14-25(15-13-24)43(7)8)38-33(47)29(20-50-9)39-32(46)28(19-30(44)37-21-36(4,5)6)42-52(48,49)26-16-10-23(3)11-17-26/h10-17,22,27-29,42H,18-21H2,1-9H3,(H,37,44)(H,38,47)(H,39,46)/t27-,28-,29-/m0/s1
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>3.00E+5n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410901
PNG
(CHEMBL206413)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)c1cccc(C)c1)C(=O)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C33H44N6O7S/c1-20(2)16-25(28(41)32-38-37-31(46-32)23-13-9-8-10-14-23)36-29(42)22(4)35-30(43)26(18-27(40)34-19-33(5,6)7)39-47(44,45)24-15-11-12-21(3)17-24/h8-15,17,20,22,25-26,39H,16,18-19H2,1-7H3,(H,34,40)(H,35,43)(H,36,42)/t22-,25-,26-/m0/s1
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>4.50E+5n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410902
PNG
(CHEMBL205687)
Show SMILES C[C@H](NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)NC(C)(C)C(=O)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C31H40N6O7S/c1-19-13-15-22(16-14-19)45(42,43)37-23(17-24(38)32-18-30(3,4)5)27(41)33-20(2)26(40)34-31(6,7)25(39)29-36-35-28(44-29)21-11-9-8-10-12-21/h8-16,20,23,37H,17-18H2,1-7H3,(H,32,38)(H,33,41)(H,34,40)/t20-,23-/m0/s1
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>4.50E+5n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410899
PNG
(CHEMBL383674)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C33H44N6O7S/c1-20(2)17-25(28(41)32-38-37-31(46-32)23-11-9-8-10-12-23)36-29(42)22(4)35-30(43)26(18-27(40)34-19-33(5,6)7)39-47(44,45)24-15-13-21(3)14-16-24/h8-16,20,22,25-26,39H,17-19H2,1-7H3,(H,34,40)(H,35,43)(H,36,42)/t22-,25-,26-/m0/s1
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>9.00E+5n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410904
PNG
(CHEMBL377532)
Show SMILES COC[C@H](NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)c1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C34H46N6O8S/c1-21(2)17-25(29(42)33-39-38-32(48-33)23-11-9-8-10-12-23)36-31(44)27(19-47-7)37-30(43)26(18-28(41)35-20-34(4,5)6)40-49(45,46)24-15-13-22(3)14-16-24/h8-16,21,25-27,40H,17-20H2,1-7H3,(H,35,41)(H,36,44)(H,37,43)/t25-,26-,27-/m0/s1
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>9.00E+5n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410896
PNG
(CHEMBL383122)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)NCC(C)(C)C)NS(=O)(=O)N(C)C)C(=O)c1nnc(o1)C(C)C
Show InChI InChI=1S/C25H45N7O7S/c1-14(2)11-17(20(34)24-30-29-23(39-24)15(3)4)28-21(35)16(5)27-22(36)18(31-40(37,38)32(9)10)12-19(33)26-13-25(6,7)8/h14-18,31H,11-13H2,1-10H3,(H,26,33)(H,27,36)(H,28,35)/t16-,17-,18-/m0/s1
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>9.00E+5n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50410900
PNG
(CHEMBL207425)
Show SMILES COC[C@H](NC(=O)[C@H](COCc1ccccc1)NS(=O)(=O)c1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C35H41N5O8S/c1-23(2)19-28(31(41)35-39-38-34(48-35)26-13-9-6-10-14-26)36-32(42)29(21-46-4)37-33(43)30(22-47-20-25-11-7-5-8-12-25)40-49(44,45)27-17-15-24(3)16-18-27/h5-18,23,28-30,40H,19-22H2,1-4H3,(H,36,42)(H,37,43)/t28-,29-,30-/m0/s1
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>9.00E+5n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of post glutamyl peptide hydrolase-like proteasome activity of human 20S proteasome


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50398609
PNG
(CHEMBL2141296)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



University of California-San Diego

Curated by ChEMBL


Assay Description
Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proteasome component C5


(Homo sapiens)
BDBM50069989
PNG
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



University of California-San Diego

Curated by ChEMBL


Assay Description
Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proteasome component C5


(Homo sapiens)
BDBM50430967
PNG
(CHEMBL2337848)
Show SMILES CC[C@H](C)C(=O)C(=O)N[C@H]1Cc2ccc(O)c(c2)-c2cccc3c2NC(=O)[C@@]3(O)[C@H](O)[C@H](NC(=O)[C@H](CC(N)=O)CC1=O)C(=O)N\C=C/C
Show InChI InChI=1S/C34H39N5O10/c1-4-11-36-31(46)27-29(44)34(49)21-8-6-7-19(26(21)39-33(34)48)20-12-17(9-10-23(20)40)13-22(37-32(47)28(43)16(3)5-2)24(41)14-18(15-25(35)42)30(45)38-27/h4,6-12,16,18,22,27,29,40,44,49H,5,13-15H2,1-3H3,(H2,35,42)(H,36,46)(H,37,47)(H,38,45)(H,39,48)/b11-4-/t16-,18-,22-,27-,29+,34-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



University Paris 6

Curated by ChEMBL


Assay Description
Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity in...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50069985
PNG
((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
Show InChI InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Institute of Bio-Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate measured for 1 hr b...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50069989
PNG
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome beta 1 subunit using Ac-nLPnLD-AMC as substrate after 60 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proteasome component C5


(Homo sapiens)
BDBM50307480
PNG
(CHEMBL579296 | Pyrazine-2-carboxylic acid(1-[3-met...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)NC(=O)c1cnccn1)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C31H37BF6N4O4/c1-16(2)8-25(32-45-24-14-18-13-23(28(18,3)4)29(24,5)46-32)42-26(43)21(41-27(44)22-15-39-6-7-40-22)11-17-9-19(30(33,34)35)12-20(10-17)31(36,37)38/h6-7,9-10,12,15-16,18,21,23-25H,8,11,13-14H2,1-5H3,(H,41,44)(H,42,43)/t18-,21-,23-,24?,25-,29-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome beta 1 using nLPnLD as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50370717
PNG
(EPOXOMYCIN | Epoxomicin)
Show SMILES CCC(C)C(NC(=O)C(C(C)CC)N(C)C(C)=O)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)C1(C)CO1
Show InChI InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(H,29,37)(H,30,38)(H,31,36)
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n/an/a 300n/an/an/an/an/an/a



University Paris 6

Curated by ChEMBL


Assay Description
Inhibition of postacid activity of 20s proteasome beta-1 subunit in HEK293 cells using Z-nLPnLD-Glo as substrate incubated for 2 hrs prior to substra...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50430968
PNG
(CHEMBL2337847)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCC(=O)NCCCCCC(=O)NCCCCCC(=O)NCCCCCC(=O)NCCCCCC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C128H172N18O22/c1-91(119(157)143-107(121(159)137-87-95-45-15-3-16-46-95)85-127(165)101-53-31-33-55-103(101)145-125(127)163)139-123(161)105(83-93-67-71-99(72-68-93)167-89-97-49-19-5-20-50-97)141-117(155)65-29-13-43-81-133-113(151)61-25-9-39-77-129-109(147)57-23-7-37-75-131-111(149)59-27-11-41-79-135-115(153)63-35-36-64-116(154)136-80-42-12-28-60-112(150)132-76-38-8-24-58-110(148)130-78-40-10-26-62-114(152)134-82-44-14-30-66-118(156)142-106(84-94-69-73-100(74-70-94)168-90-98-51-21-6-22-52-98)124(162)140-92(2)120(158)144-108(122(160)138-88-96-47-17-4-18-48-96)86-128(166)102-54-32-34-56-104(102)146-126(128)164/h3-6,15-22,31-34,45-56,67-74,91-92,105-108,165-166H,7-14,23-30,35-44,57-66,75-90H2,1-2H3,(H,129,147)(H,130,148)(H,131,149)(H,132,150)(H,133,151)(H,134,152)(H,135,153)(H,136,154)(H,137,159)(H,138,160)(H,139,161)(H,140,162)(H,141,155)(H,142,156)(H,143,157)(H,144,158)(H,145,163)(H,146,164)/t91-,92-,105-,106-,107-,108-,127+,128+/m0/s1
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n/an/a 336n/an/an/an/an/an/a



University Paris 6

Curated by ChEMBL


Assay Description
Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity in...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50430969
PNG
(CHEMBL2337846)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCC(=O)NCCCCCC(=O)NCCCCCC(=O)NCCCCCC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C116H150N16O20/c1-81(107(141)129-97(109(143)123-77-85-39-13-3-14-40-85)75-115(149)91-47-27-29-49-93(91)131-113(115)147)125-111(145)95(73-83-59-63-89(64-60-83)151-79-87-43-17-5-18-44-87)127-105(139)57-25-11-37-71-119-101(135)53-21-7-33-67-117-99(133)51-23-9-35-69-121-103(137)55-31-32-56-104(138)122-70-36-10-24-52-100(134)118-68-34-8-22-54-102(136)120-72-38-12-26-58-106(140)128-96(74-84-61-65-90(66-62-84)152-80-88-45-19-6-20-46-88)112(146)126-82(2)108(142)130-98(110(144)124-78-86-41-15-4-16-42-86)76-116(150)92-48-28-30-50-94(92)132-114(116)148/h3-6,13-20,27-30,39-50,59-66,81-82,95-98,149-150H,7-12,21-26,31-38,51-58,67-80H2,1-2H3,(H,117,133)(H,118,134)(H,119,135)(H,120,136)(H,121,137)(H,122,138)(H,123,143)(H,124,144)(H,125,145)(H,126,146)(H,127,139)(H,128,140)(H,129,141)(H,130,142)(H,131,147)(H,132,148)/t81-,82-,95-,96-,97-,98-,115+,116+/m0/s1
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n/an/a 346n/an/an/an/an/an/a



University Paris 6

Curated by ChEMBL


Assay Description
Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity in...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50444889
PNG
(CHEMBL3099620)
Show SMILES C(CN1CCCCCC1)Oc1ccc(cc1)C(=C(C1CCCCC1)c1ccccc1)c1ccc(OCCN2CCCCCC2)cc1
Show InChI InChI=1S/C42H56N2O2/c1-2-12-28-43(27-11-1)31-33-45-39-23-19-37(20-24-39)42(41(35-15-7-5-8-16-35)36-17-9-6-10-18-36)38-21-25-40(26-22-38)46-34-32-44-29-13-3-4-14-30-44/h5,7-8,15-16,19-26,36H,1-4,6,9-14,17-18,27-34H2
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n/an/a 350n/an/an/an/an/an/a



Institute of Bio-Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate measured for 1 hr b...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50444908
PNG
(CHEMBL3099624)
Show SMILES C(CN1CCCCCC1)Oc1ccc(cc1)C(=Cc1ccccc1)c1ccc(OCCN2CCCCCC2)cc1
Show InChI InChI=1S/C36H46N2O2/c1-2-9-23-37(22-8-1)26-28-39-34-18-14-32(15-19-34)36(30-31-12-6-5-7-13-31)33-16-20-35(21-17-33)40-29-27-38-24-10-3-4-11-25-38/h5-7,12-21,30H,1-4,8-11,22-29H2
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n/an/a 370n/an/an/an/an/an/a



Institute of Bio-Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate measured for 1 hr b...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50444888
PNG
(CHEMBL3099621)
Show SMILES C(CN1CCCCCC1)Oc1ccc(cc1)C(=C(c1ccccc1)c1ccccc1)c1ccc(OCCN2CCCCCC2)cc1
Show InChI InChI=1S/C42H50N2O2/c1-2-12-28-43(27-11-1)31-33-45-39-23-19-37(20-24-39)42(41(35-15-7-5-8-16-35)36-17-9-6-10-18-36)38-21-25-40(26-22-38)46-34-32-44-29-13-3-4-14-30-44/h5-10,15-26H,1-4,11-14,27-34H2
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n/an/a 370n/an/an/an/an/an/a



Institute of Bio-Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate measured for 1 hr b...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50430961
PNG
(CHEMBL2337844)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C104H128N14O18/c1-71(95(125)115-87(97(127)109-67-75-33-11-3-12-34-75)65-103(133)81-41-23-25-43-83(81)117-101(103)131)111-99(129)85(63-73-51-55-79(56-52-73)135-69-77-37-15-5-16-38-77)113-93(123)49-22-10-32-62-107-91(121)47-20-8-30-60-105-89(119)45-19-7-29-59-106-90(120)46-21-9-31-61-108-92(122)48-27-28-50-94(124)114-86(64-74-53-57-80(58-54-74)136-70-78-39-17-6-18-40-78)100(130)112-72(2)96(126)116-88(98(128)110-68-76-35-13-4-14-36-76)66-104(134)82-42-24-26-44-84(82)118-102(104)132/h3-6,11-18,23-26,33-44,51-58,71-72,85-88,133-134H,7-10,19-22,27-32,45-50,59-70H2,1-2H3,(H,105,119)(H,106,120)(H,107,121)(H,108,122)(H,109,127)(H,110,128)(H,111,129)(H,112,130)(H,113,123)(H,114,124)(H,115,125)(H,116,126)(H,117,131)(H,118,132)/t71-,72-,85-,86-,87-,88-,103+,104+/m0/s1
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n/an/a 370n/an/an/an/an/an/a



University Paris 6

Curated by ChEMBL


Assay Description
Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity in...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50398608
PNG
(MARIZOMIB)
Show SMILES C[C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2CCCl)[C@@H](O)[C@H]1CCCC=C1
Show InChI InChI=1S/C15H20ClNO4/c1-14-10(7-8-16)12(19)17-15(14,13(20)21-14)11(18)9-5-3-2-4-6-9/h3,5,9-11,18H,2,4,6-8H2,1H3,(H,17,19)/t9-,10+,11+,14+,15+/m1/s1
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n/an/a 430n/an/an/an/an/an/a



University of California-San Diego

Curated by ChEMBL


Assay Description
Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50444909
PNG
(CHEMBL3099618)
Show SMILES CCC(=C(c1ccc(OCCN2CCCCCC2)cc1)c1ccc(OCCN2CCCCCC2)cc1)c1ccccc1
Show InChI InChI=1S/C38H50N2O2/c1-2-37(32-14-8-7-9-15-32)38(33-16-20-35(21-17-33)41-30-28-39-24-10-3-4-11-25-39)34-18-22-36(23-19-34)42-31-29-40-26-12-5-6-13-27-40/h7-9,14-23H,2-6,10-13,24-31H2,1H3
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n/an/a 430n/an/an/an/an/an/a



Institute of Bio-Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate measured for 1 hr b...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50307479
PNG
(CHEMBL592161 | Pyrazine-2-carboxylic acid(1-[3-met...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c(F)c(F)c(F)c(F)c1F)NC(=O)c1cnccn1)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C29H34BF5N4O4/c1-13(2)8-20(30-42-19-10-14-9-18(28(14,3)4)29(19,5)43-30)39-26(40)16(38-27(41)17-12-36-6-7-37-17)11-15-21(31)23(33)25(35)24(34)22(15)32/h6-7,12-14,16,18-20H,8-11H2,1-5H3,(H,38,41)(H,39,40)/t14-,16-,18-,19?,20-,29-/m0/s1
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n/an/a 440n/an/an/an/an/an/a



Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of 26S proteasome beta 1 using nLPnLD as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50430970
PNG
(CHEMBL2337845)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C110H139N15O19/c1-76(101(133)122-92(103(135)116-72-80-36-12-3-13-37-80)70-109(141)86-44-25-27-46-88(86)124-107(109)139)118-105(137)90(68-78-55-59-84(60-56-78)143-74-82-40-16-5-17-41-82)120-99(131)53-24-11-35-67-114-97(129)51-22-9-33-65-112-95(127)49-20-7-31-63-111-94(126)48-21-8-32-64-113-96(128)50-23-10-34-66-115-98(130)52-29-30-54-100(132)121-91(69-79-57-61-85(62-58-79)144-75-83-42-18-6-19-43-83)106(138)119-77(2)102(134)123-93(104(136)117-73-81-38-14-4-15-39-81)71-110(142)87-45-26-28-47-89(87)125-108(110)140/h3-6,12-19,25-28,36-47,55-62,76-77,90-93,141-142H,7-11,20-24,29-35,48-54,63-75H2,1-2H3,(H,111,126)(H,112,127)(H,113,128)(H,114,129)(H,115,130)(H,116,135)(H,117,136)(H,118,137)(H,119,138)(H,120,131)(H,121,132)(H,122,133)(H,123,134)(H,124,139)(H,125,140)/t76-,77-,90-,91-,92-,93-,109+,110+/m0/s1
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n/an/a 448n/an/an/an/an/an/a



University Paris 6

Curated by ChEMBL


Assay Description
Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity in...


Citation and Details
More data for this
Ligand-Target Pair
Proteasome component C5


(Homo sapiens)
BDBM50430962
PNG
(CHEMBL2337843)
Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C98H117N13O17/c1-66(89(117)108-82(91(119)102-62-70-30-10-3-11-31-70)60-97(125)76-38-21-23-40-78(76)110-95(97)123)104-93(121)80(58-68-47-51-74(52-48-68)127-64-72-34-14-5-15-35-72)106-87(115)45-20-9-29-57-100-85(113)43-18-7-27-55-99-84(112)42-19-8-28-56-101-86(114)44-25-26-46-88(116)107-81(59-69-49-53-75(54-50-69)128-65-73-36-16-6-17-37-73)94(122)105-67(2)90(118)109-83(92(120)103-63-71-32-12-4-13-33-71)61-98(126)77-39-22-24-41-79(77)111-96(98)124/h3-6,10-17,21-24,30-41,47-54,66-67,80-83,125-126H,7-9,18-20,25-29,42-46,55-65H2,1-2H3,(H,99,112)(H,100,113)(H,101,114)(H,102,119)(H,103,120)(H,104,121)(H,105,122)(H,106,115)(H,107,116)(H,108,117)(H,109,118)(H,110,123)(H,111,124)/t66-,67-,80-,81-,82-,83-,97+,98+/m0/s1
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n/an/a 590n/an/an/an/an/an/a



University Paris 6

Curated by ChEMBL


Assay Description
Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity in...


Citation and Details
More data for this
Ligand-Target Pair
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