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Compile Data Set for Download or QSAR

Found 62 hits Enz. Inhib. hit(s) with Target = 'Proteasome subunit beta type-7' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007199
PNG
(CHEMBL3237863)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C40H58BN3O7/c1-27(2)19-36(41-50-35-21-32-20-34(39(32,4)5)40(35,6)51-41)44-38(47)33(43-28(3)45)22-37(46)42-18-17-31(25-48-23-29-13-9-7-10-14-29)26-49-24-30-15-11-8-12-16-30/h7-16,27,31-36H,17-26H2,1-6H3,(H,42,46)(H,43,45)(H,44,47)/t32-,33-,34-,35+,36-,40-/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007198
PNG
(CHEMBL3237862)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C39H56BN3O7/c1-26(2)17-35(40-49-34-19-31-18-33(38(31,4)5)39(34,6)50-40)43-37(46)32(42-27(3)44)20-36(45)41-21-30(24-47-22-28-13-9-7-10-14-28)25-48-23-29-15-11-8-12-16-29/h7-16,26,30-35H,17-25H2,1-6H3,(H,41,45)(H,42,44)(H,43,46)/t31-,32-,33-,34+,35-,39-/m0/s1
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n/an/a 3.90n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007206
PNG
(CHEMBL3237867)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)NCCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C42H62BN3O7/c1-29(2)22-38(43-52-37-24-34-23-36(41(34,4)5)42(37,6)53-43)46-40(49)35(45-30(3)47)19-20-39(48)44-21-13-18-33(27-50-25-31-14-9-7-10-15-31)28-51-26-32-16-11-8-12-17-32/h7-12,14-17,29,33-38H,13,18-28H2,1-6H3,(H,44,48)(H,45,47)(H,46,49)/t34-,35-,36-,37+,38-,42-/m0/s1
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n/an/a 4.10n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007196
PNG
(CHEMBL3237864)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C41H60BN3O7/c1-28(2)20-37(42-51-36-22-33-21-35(40(33,4)5)41(36,6)52-42)45-39(48)34(44-29(3)46)23-38(47)43-19-13-18-32(26-49-24-30-14-9-7-10-15-30)27-50-25-31-16-11-8-12-17-31/h7-12,14-17,28,32-37H,13,18-27H2,1-6H3,(H,43,47)(H,44,46)(H,45,48)/t33-,34-,35-,36+,37-,41-/m0/s1
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n/an/a 4.10n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007200
PNG
(CHEMBL3237873)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCCCOCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C32H50BN3O6/c1-21(2)16-28(33-41-27-18-24-17-26(31(24,4)5)32(27,6)42-33)36-30(39)25(35-22(3)37)19-29(38)34-14-10-11-15-40-20-23-12-8-7-9-13-23/h7-9,12-13,21,24-28H,10-11,14-20H2,1-6H3,(H,34,38)(H,35,37)(H,36,39)/t24-,25-,26-,27+,28-,32-/m0/s1
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n/an/a 4.80n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007193
PNG
(CHEMBL3237865)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)NCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C40H58BN3O7/c1-27(2)19-36(41-50-35-21-32-20-34(39(32,4)5)40(35,6)51-41)44-38(47)33(43-28(3)45)17-18-37(46)42-22-31(25-48-23-29-13-9-7-10-14-29)26-49-24-30-15-11-8-12-16-30/h7-16,27,31-36H,17-26H2,1-6H3,(H,42,46)(H,43,45)(H,44,47)/t32-,33-,34-,35+,36-,40-/m0/s1
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n/an/a 5.10n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007207
PNG
(CHEMBL3237860)
Show SMILES CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)N[C@H]1C[C@@H]1C[C@@H](CCc1ccccc1)NC(=O)[C@H](C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C32H41N3O6/c1-4-20(2)27-28(41-31(27)38)30(37)35-26-18-24(26)17-25(16-15-22-11-7-5-8-12-22)34-29(36)21(3)33-32(39)40-19-23-13-9-6-10-14-23/h5-14,20-21,24-28H,4,15-19H2,1-3H3,(H,33,39)(H,34,36)(H,35,37)/t20-,21-,24-,25+,26-,27-,28+/m0/s1
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n/an/a 5.70n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007195
PNG
(CHEMBL3237866)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C41H60BN3O7/c1-28(2)21-37(42-51-36-23-33-22-35(40(33,4)5)41(36,6)52-42)45-39(48)34(44-29(3)46)17-18-38(47)43-20-19-32(26-49-24-30-13-9-7-10-14-30)27-50-25-31-15-11-8-12-16-31/h7-16,28,32-37H,17-27H2,1-6H3,(H,43,47)(H,44,46)(H,45,48)/t33-,34-,35-,36+,37-,41-/m0/s1
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n/an/a 5.70n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007207
PNG
(CHEMBL3237860)
Show SMILES CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)N[C@H]1C[C@@H]1C[C@@H](CCc1ccccc1)NC(=O)[C@H](C)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C32H41N3O6/c1-4-20(2)27-28(41-31(27)38)30(37)35-26-18-24(26)17-25(16-15-22-11-7-5-8-12-22)34-29(36)21(3)33-32(39)40-19-23-13-9-6-10-14-23/h5-14,20-21,24-28H,4,15-19H2,1-3H3,(H,33,39)(H,34,36)(H,35,37)/t20-,21-,24-,25+,26-,27-,28+/m0/s1
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n/an/a 5.70n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like of human 20S proteasome using chromophoric Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007202
PNG
(CHEMBL3237868)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1cc(Cl)ccc1Cl)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C45H58BCl2N3O7/c1-29(2)20-40(46-57-39-22-33-21-38(44(33,3)4)45(39,5)58-46)51-43(54)37(50-42(53)35-23-34(47)16-17-36(35)48)24-41(52)49-19-18-32(27-55-25-30-12-8-6-9-13-30)28-56-26-31-14-10-7-11-15-31/h6-17,23,29,32-33,37-40H,18-22,24-28H2,1-5H3,(H,49,52)(H,50,53)(H,51,54)/t33-,37-,38-,39+,40-,45-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50069989
PNG
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007201
PNG
(CHEMBL3237870)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1cnccn1)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C43H58BN5O7/c1-29(2)20-38(44-55-37-22-33-21-36(42(33,3)4)43(37,5)56-44)49-40(51)34(48-41(52)35-24-45-18-19-46-35)23-39(50)47-17-16-32(27-53-25-30-12-8-6-9-13-30)28-54-26-31-14-10-7-11-15-31/h6-15,18-19,24,29,32-34,36-38H,16-17,20-23,25-28H2,1-5H3,(H,47,50)(H,48,52)(H,49,51)/t33-,34-,36-,37+,38-,43-/m0/s1
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n/an/a 7.10n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50069989
PNG
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
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n/an/a 7.10n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007205
PNG
(CHEMBL3237871)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1cccc(n1)-c1ccccc1)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C50H63BN4O7/c1-34(2)26-45(51-61-44-28-39-27-43(49(39,3)4)50(44,5)62-51)55-48(58)42(54-47(57)41-23-15-22-40(53-41)38-20-13-8-14-21-38)29-46(56)52-25-24-37(32-59-30-35-16-9-6-10-17-35)33-60-31-36-18-11-7-12-19-36/h6-23,34,37,39,42-45H,24-33H2,1-5H3,(H,52,56)(H,54,57)(H,55,58)/t39-,42-,43-,44+,45-,50-/m0/s1
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n/an/a 7.5n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007209
PNG
(CHEMBL3237874)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B(O)O
Show InChI InChI=1S/C29H42BN3O7/c1-21(2)14-27(30(37)38)33-29(36)26(32-22(3)34)15-28(35)31-16-25(19-39-17-23-10-6-4-7-11-23)20-40-18-24-12-8-5-9-13-24/h4-13,21,25-27,37-38H,14-20H2,1-3H3,(H,31,35)(H,32,34)(H,33,36)/t26-,27-/m0/s1
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PubMed
n/an/a 7.70n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007197
PNG
(CHEMBL3237869)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1ccccc1)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C45H60BN3O7/c1-31(2)23-40(46-55-39-25-36-24-38(44(36,3)4)45(39,5)56-46)49-43(52)37(48-42(51)35-19-13-8-14-20-35)26-41(50)47-22-21-34(29-53-27-32-15-9-6-10-16-32)30-54-28-33-17-11-7-12-18-33/h6-20,31,34,36-40H,21-30H2,1-5H3,(H,47,50)(H,48,51)(H,49,52)/t36-,37-,38-,39+,40-,45-/m0/s1
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n/an/a 7.80n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50277889
PNG
(CARFILZOMIB | CHEMBL451887)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1
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n/an/a 8.60n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007208
PNG
(CHEMBL3237861)
Show SMILES CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)NCCC(COCc1ccccc1)COCc1ccccc1
Show InChI InChI=1S/C27H35NO5/c1-3-20(2)24-25(33-27(24)30)26(29)28-15-14-23(18-31-16-21-10-6-4-7-11-21)19-32-17-22-12-8-5-9-13-22/h4-13,20,23-25H,3,14-19H2,1-2H3,(H,28,29)/t20-,24-,25+/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007208
PNG
(CHEMBL3237861)
Show SMILES CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)NCCC(COCc1ccccc1)COCc1ccccc1
Show InChI InChI=1S/C27H35NO5/c1-3-20(2)24-25(33-27(24)30)26(29)28-15-14-23(18-31-16-21-10-6-4-7-11-21)19-32-17-22-12-8-5-9-13-22/h4-13,20,23-25H,3,14-19H2,1-2H3,(H,28,29)/t20-,24-,25+/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like of human 20S proteasome using chromophoric Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007206
PNG
(CHEMBL3237867)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)NCCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C42H62BN3O7/c1-29(2)22-38(43-52-37-24-34-23-36(41(34,4)5)42(37,6)53-43)46-40(49)35(45-30(3)47)19-20-39(48)44-21-13-18-33(27-50-25-31-14-9-7-10-15-31)28-51-26-32-16-11-8-12-17-32/h7-12,14-17,29,33-38H,13,18-28H2,1-6H3,(H,44,48)(H,45,47)(H,46,49)/t34-,35-,36-,37+,38-,42-/m0/s1
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n/an/a 46n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007204
PNG
(CHEMBL3237872)
Show SMILES CNC(=O)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C22H38BN3O5/c1-12(2)8-18(26-20(29)15(25-13(3)27)11-19(28)24-7)23-30-17-10-14-9-16(21(14,4)5)22(17,6)31-23/h12,14-18H,8-11H2,1-7H3,(H,24,28)(H,25,27)(H,26,29)/t14-,15-,16-,17+,18-,22-/m0/s1
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n/an/a 54n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007195
PNG
(CHEMBL3237866)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C41H60BN3O7/c1-28(2)21-37(42-51-36-23-33-22-35(40(33,4)5)41(36,6)52-42)45-39(48)34(44-29(3)46)17-18-38(47)43-20-19-32(26-49-24-30-13-9-7-10-14-30)27-50-25-31-15-11-8-12-16-31/h7-16,28,32-37H,17-27H2,1-6H3,(H,43,47)(H,44,46)(H,45,48)/t33-,34-,35-,36+,37-,41-/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015247
PNG
(CHEMBL3262766)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C[C@@H](NC(=O)c1ccc2ccccc2c1)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C38H41N3O5/c1-25(2)20-32(35(43)38(3)24-46-38)41-37(45)33(21-26-12-6-4-7-13-26)39-34(42)23-31(28-15-8-5-9-16-28)40-36(44)30-19-18-27-14-10-11-17-29(27)22-30/h4-19,22,25,31-33H,20-21,23-24H2,1-3H3,(H,39,42)(H,40,44)(H,41,45)/t31-,32+,33+,38-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50069989
PNG
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007196
PNG
(CHEMBL3237864)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C41H60BN3O7/c1-28(2)20-37(42-51-36-22-33-21-35(40(33,4)5)41(36,6)52-42)45-39(48)34(44-29(3)46)23-38(47)43-19-13-18-32(26-49-24-30-14-9-7-10-15-30)27-50-25-31-16-11-8-12-17-31/h7-12,14-17,28,32-37H,13,18-27H2,1-6H3,(H,43,47)(H,44,46)(H,45,48)/t33-,34-,35-,36+,37-,41-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007197
PNG
(CHEMBL3237869)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1ccccc1)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C45H60BN3O7/c1-31(2)23-40(46-55-39-25-36-24-38(44(36,3)4)45(39,5)56-46)49-43(52)37(48-42(51)35-19-13-8-14-20-35)26-41(50)47-22-21-34(29-53-27-32-15-9-6-10-16-32)30-54-28-33-17-11-7-12-18-33/h6-20,31,34,36-40H,21-30H2,1-5H3,(H,47,50)(H,48,51)(H,49,52)/t36-,37-,38-,39+,40-,45-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007198
PNG
(CHEMBL3237862)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C39H56BN3O7/c1-26(2)17-35(40-49-34-19-31-18-33(38(31,4)5)39(34,6)50-40)43-37(46)32(42-27(3)44)20-36(45)41-21-30(24-47-22-28-13-9-7-10-14-28)25-48-23-29-15-11-8-12-16-29/h7-16,26,30-35H,17-25H2,1-6H3,(H,41,45)(H,42,44)(H,43,46)/t31-,32-,33-,34+,35-,39-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007199
PNG
(CHEMBL3237863)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C40H58BN3O7/c1-27(2)19-36(41-50-35-21-32-20-34(39(32,4)5)40(35,6)51-41)44-38(47)33(43-28(3)45)22-37(46)42-18-17-31(25-48-23-29-13-9-7-10-14-29)26-49-24-30-15-11-8-12-16-30/h7-16,27,31-36H,17-26H2,1-6H3,(H,42,46)(H,43,45)(H,44,47)/t32-,33-,34-,35+,36-,40-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007200
PNG
(CHEMBL3237873)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCCCOCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C32H50BN3O6/c1-21(2)16-28(33-41-27-18-24-17-26(31(24,4)5)32(27,6)42-33)36-30(39)25(35-22(3)37)19-29(38)34-14-10-11-15-40-20-23-12-8-7-9-13-23/h7-9,12-13,21,24-28H,10-11,14-20H2,1-6H3,(H,34,38)(H,35,37)(H,36,39)/t24-,25-,26-,27+,28-,32-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015246
PNG
(CHEMBL3262765)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C[C@@H](NC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C35H38F3N3O5/c1-22(2)18-28(31(43)34(3)21-46-34)41-33(45)29(19-23-10-6-4-7-11-23)39-30(42)20-27(24-12-8-5-9-13-24)40-32(44)25-14-16-26(17-15-25)35(36,37)38/h4-17,22,27-29H,18-21H2,1-3H3,(H,39,42)(H,40,44)(H,41,45)/t27-,28+,29+,34-/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015242
PNG
(CHEMBL3262758)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)c1ccc2ccccc2c1)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C38H41N3O5/c1-25(2)20-32(35(43)38(3)24-46-38)41-37(45)33(21-26-12-6-4-7-13-26)39-34(42)23-31(28-15-8-5-9-16-28)40-36(44)30-19-18-27-14-10-11-17-29(27)22-30/h4-19,22,25,31-33H,20-21,23-24H2,1-3H3,(H,39,42)(H,40,44)(H,41,45)/t31?,32-,33-,38+/m0/s1
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n/an/a 190n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007201
PNG
(CHEMBL3237870)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1cnccn1)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C43H58BN5O7/c1-29(2)20-38(44-55-37-22-33-21-36(42(33,3)4)43(37,5)56-44)49-40(51)34(48-41(52)35-24-45-18-19-46-35)23-39(50)47-17-16-32(27-53-25-30-12-8-6-9-13-30)28-54-26-31-14-10-7-11-15-31/h6-15,18-19,24,29,32-34,36-38H,16-17,20-23,25-28H2,1-5H3,(H,47,50)(H,48,52)(H,49,51)/t33-,34-,36-,37+,38-,43-/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015240
PNG
(CHEMBL3262756)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C35H38F3N3O5/c1-22(2)18-28(31(43)34(3)21-46-34)41-33(45)29(19-23-10-6-4-7-11-23)39-30(42)20-27(24-12-8-5-9-13-24)40-32(44)25-14-16-26(17-15-25)35(36,37)38/h4-17,22,27-29H,18-21H2,1-3H3,(H,39,42)(H,40,44)(H,41,45)/t27?,28-,29-,34+/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007202
PNG
(CHEMBL3237868)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1cc(Cl)ccc1Cl)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C45H58BCl2N3O7/c1-29(2)20-40(46-57-39-22-33-21-38(44(33,3)4)45(39,5)58-46)51-43(54)37(50-42(53)35-23-34(47)16-17-36(35)48)24-41(52)49-19-18-32(27-55-25-30-12-8-6-9-13-30)28-56-26-31-14-10-7-11-15-31/h6-17,23,29,32-33,37-40H,18-22,24-28H2,1-5H3,(H,49,52)(H,50,53)(H,51,54)/t33-,37-,38-,39+,40-,45-/m0/s1
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n/an/a 250n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015239
PNG
(CHEMBL3262755)
Show SMILES COc1ccc(cc1)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1)c1ccccc1
Show InChI InChI=1S/C35H41N3O6/c1-23(2)19-29(32(40)35(3)22-44-35)38-34(42)30(20-24-11-7-5-8-12-24)36-31(39)21-28(25-13-9-6-10-14-25)37-33(41)26-15-17-27(43-4)18-16-26/h5-18,23,28-30H,19-22H2,1-4H3,(H,36,39)(H,37,41)(H,38,42)/t28?,29-,30-,35+/m0/s1
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n/an/a 340n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015236
PNG
(CHEMBL3262752)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)c1cccnc1)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C33H38N4O5/c1-22(2)17-27(30(39)33(3)21-42-33)37-32(41)28(18-23-11-6-4-7-12-23)35-29(38)19-26(24-13-8-5-9-14-24)36-31(40)25-15-10-16-34-20-25/h4-16,20,22,26-28H,17-19,21H2,1-3H3,(H,35,38)(H,36,40)(H,37,41)/t26?,27-,28-,33+/m0/s1
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n/an/a 340n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015241
PNG
(CHEMBL3262757)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)c1ccc(cc1)C#N)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C35H38N4O5/c1-23(2)18-29(32(41)35(3)22-44-35)39-34(43)30(19-24-10-6-4-7-11-24)37-31(40)20-28(26-12-8-5-9-13-26)38-33(42)27-16-14-25(21-36)15-17-27/h4-17,23,28-30H,18-20,22H2,1-3H3,(H,37,40)(H,38,42)(H,39,43)/t28?,29-,30-,35+/m0/s1
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n/an/a 360n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015238
PNG
(CHEMBL3262754)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)c1ccc(F)cc1)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C34H38FN3O5/c1-22(2)18-28(31(40)34(3)21-43-34)38-33(42)29(19-23-10-6-4-7-11-23)36-30(39)20-27(24-12-8-5-9-13-24)37-32(41)25-14-16-26(35)17-15-25/h4-17,22,27-29H,18-21H2,1-3H3,(H,36,39)(H,37,41)(H,38,42)/t27?,28-,29-,34+/m0/s1
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n/an/a 380n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015237
PNG
(CHEMBL3262753)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)c1ccccc1)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C34H39N3O5/c1-23(2)19-28(31(39)34(3)22-42-34)37-33(41)29(20-24-13-7-4-8-14-24)35-30(38)21-27(25-15-9-5-10-16-25)36-32(40)26-17-11-6-12-18-26/h4-18,23,27-29H,19-22H2,1-3H3,(H,35,38)(H,36,40)(H,37,41)/t27?,28-,29-,34+/m0/s1
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n/an/a 440n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007204
PNG
(CHEMBL3237872)
Show SMILES CNC(=O)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C22H38BN3O5/c1-12(2)8-18(26-20(29)15(25-13(3)27)11-19(28)24-7)23-30-17-10-14-9-16(21(14,4)5)22(17,6)31-23/h12,14-18H,8-11H2,1-7H3,(H,24,28)(H,25,27)(H,26,29)/t14-,15-,16-,17+,18-,22-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015244
PNG
(CHEMBL3262762)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)C1CCOCC1)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C33H43N3O6/c1-22(2)18-27(30(38)33(3)21-42-33)36-32(40)28(19-23-10-6-4-7-11-23)34-29(37)20-26(24-12-8-5-9-13-24)35-31(39)25-14-16-41-17-15-25/h4-13,22,25-28H,14-21H2,1-3H3,(H,34,37)(H,35,39)(H,36,40)/t26?,27-,28-,33+/m0/s1
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n/an/a 630n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50015243
PNG
(CHEMBL3262761)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)c1cccs1)c1ccccc1)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C32H37N3O5S/c1-21(2)17-25(29(37)32(3)20-40-32)35-30(38)26(18-22-11-6-4-7-12-22)33-28(36)19-24(23-13-8-5-9-14-23)34-31(39)27-15-10-16-41-27/h4-16,21,24-26H,17-20H2,1-3H3,(H,33,36)(H,34,39)(H,35,38)/t24?,25-,26-,32+/m0/s1
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n/an/a 950n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007205
PNG
(CHEMBL3237871)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(=O)c1cccc(n1)-c1ccccc1)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C50H63BN4O7/c1-34(2)26-45(51-61-44-28-39-27-43(49(39,3)4)50(44,5)62-51)55-48(58)42(54-47(57)41-23-15-22-40(53-41)38-20-13-8-14-21-38)29-46(56)52-25-24-37(32-59-30-35-16-9-6-10-17-35)33-60-31-36-18-11-7-12-19-36/h6-23,34,37,39,42-45H,24-33H2,1-5H3,(H,52,56)(H,54,57)(H,55,58)/t39-,42-,43-,44+,45-,50-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007198
PNG
(CHEMBL3237862)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C39H56BN3O7/c1-26(2)17-35(40-49-34-19-31-18-33(38(31,4)5)39(34,6)50-40)43-37(46)32(42-27(3)44)20-36(45)41-21-30(24-47-22-28-13-9-7-10-14-28)25-48-23-29-15-11-8-12-16-29/h7-16,26,30-35H,17-25H2,1-6H3,(H,41,45)(H,42,44)(H,43,46)/t31-,32-,33-,34+,35-,39-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of human 20S proteasome using Ac-RLR-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50430990
PNG
(BELACTOSIN A)
Show SMILES CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)N[C@H]1C[C@H]1C[C@H](NC(=O)[C@H](C)N)C(O)=O
Show InChI InChI=1S/C17H27N3O6/c1-4-7(2)12-13(26-17(12)25)15(22)19-10-5-9(10)6-11(16(23)24)20-14(21)8(3)18/h7-13H,4-6,18H2,1-3H3,(H,19,22)(H,20,21)(H,23,24)/t7-,8-,9-,10-,11-,12-,13+/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50430990
PNG
(BELACTOSIN A)
Show SMILES CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)N[C@H]1C[C@H]1C[C@H](NC(=O)[C@H](C)N)C(O)=O
Show InChI InChI=1S/C17H27N3O6/c1-4-7(2)12-13(26-17(12)25)15(22)19-10-5-9(10)6-11(16(23)24)20-14(21)8(3)18/h7-13H,4-6,18H2,1-3H3,(H,19,22)(H,20,21)(H,23,24)/t7-,8-,9-,10-,11-,12-,13+/m0/s1
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n/an/a 1.44E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like of human 20S proteasome using chromophoric Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50069989
PNG
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of human 20S proteasome using Ac-RLR-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007200
PNG
(CHEMBL3237873)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCCCOCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C32H50BN3O6/c1-21(2)16-28(33-41-27-18-24-17-26(31(24,4)5)32(27,6)42-33)36-30(39)25(35-22(3)37)19-29(38)34-14-10-11-15-40-20-23-12-8-7-9-13-23/h7-9,12-13,21,24-28H,10-11,14-20H2,1-6H3,(H,34,38)(H,35,37)(H,36,39)/t24-,25-,26-,27+,28-,32-/m0/s1
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n/an/a 2.17E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of human 20S proteasome using Ac-RLR-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50018677
PNG
(CHEMBL3291290)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)NCCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)C(=O)[C@@]1(C)CO1
Show InChI InChI=1S/C34H47N3O7/c1-24(2)17-29(32(40)34(4)23-44-34)37-33(41)30(36-25(3)38)18-31(39)35-16-15-28(21-42-19-26-11-7-5-8-12-26)22-43-20-27-13-9-6-10-14-27/h5-14,24,28-30H,15-23H2,1-4H3,(H,35,39)(H,36,38)(H,37,41)/t29-,30-,34+/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like of human 20S proteasome using chromophoric Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Proteasome subunit beta type-7


(Homo sapiens)
BDBM50007193
PNG
(CHEMBL3237865)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)NCC(COCc1ccccc1)COCc1ccccc1)NC(C)=O)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1
Show InChI InChI=1S/C40H58BN3O7/c1-27(2)19-36(41-50-35-21-32-20-34(39(32,4)5)40(35,6)51-41)44-38(47)33(43-28(3)45)17-18-37(46)42-22-31(25-48-23-29-13-9-7-10-14-29)26-49-24-30-15-11-8-12-16-30/h7-16,27,31-36H,17-26H2,1-6H3,(H,42,46)(H,43,45)(H,44,47)/t32-,33-,34-,35+,36-,40-/m0/s1
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PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of human 20S proteasome using Ac-RLR-AMC as substrate


Citation and Details
More data for this
Ligand-Target Pair
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