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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Protection of telomeres protein 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protection of telomeres protein 1


(Homo sapiens)
BDBM50276829
PNG
(CHEMBL443702 | N,N',N'',N'''-(9,9'-(ethane-1,2-diy...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NCNCCNCNc3c4ccc(NC(=O)CCN5CCCC5)cc4nc4cc(NC(=O)CCN5CCCC5)ccc34)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C58H76N14O4/c73-53(17-31-69-23-1-2-24-69)63-41-9-13-45-49(35-41)67-50-36-42(64-54(74)18-32-70-25-3-4-26-70)10-14-46(50)57(45)61-39-59-21-22-60-40-62-58-47-15-11-43(65-55(75)19-33-71-27-5-6-28-71)37-51(47)68-52-38-44(12-16-48(52)58)66-56(76)20-34-72-29-7-8-30-72/h9-16,35-38,59-60H,1-8,17-34,39-40H2,(H,61,67)(H,62,68)(H,63,73)(H,64,74)(H,65,75)(H,66,76)
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n/an/a 1.10E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of human 35S-labeled Pot1 binding to human telomeric DNA


Citation and Details
More data for this
Ligand-Target Pair
Protection of telomeres protein 1


(Homo sapiens)
BDBM50276827
PNG
(CHEMBL448813 | N,N',N'',N'''-(9,9'-(hexane-1,6-diy...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NCCCCCCNc3c4ccc(NC(=O)CCN5CCCC5)cc4nc4cc(NC(=O)CCN5CCCC5)ccc34)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C60H78N12O4/c73-55(21-35-69-27-5-6-28-69)63-43-13-17-47-51(39-43)67-52-40-44(64-56(74)22-36-70-29-7-8-30-70)14-18-48(52)59(47)61-25-3-1-2-4-26-62-60-49-19-15-45(65-57(75)23-37-71-31-9-10-32-71)41-53(49)68-54-42-46(16-20-50(54)60)66-58(76)24-38-72-33-11-12-34-72/h13-20,39-42H,1-12,21-38H2,(H,61,67)(H,62,68)(H,63,73)(H,64,74)(H,65,75)(H,66,76)
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n/an/a 1.70E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of human 35S-labeled Pot1 binding to human telomeric DNA


Citation and Details
More data for this
Ligand-Target Pair
Protection of telomeres protein 1


(Homo sapiens)
BDBM50276828
PNG
(CHEMBL506865 | N,N',N'',N'''-(9,9'-(ethane-1,2-diy...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NCOCCOCNc3c4ccc(NC(=O)CCN5CCCC5)cc4nc4cc(NC(=O)CCN5CCCC5)ccc34)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C58H74N12O6/c71-53(17-29-67-21-1-2-22-67)61-41-9-13-45-49(35-41)65-50-36-42(62-54(72)18-30-68-23-3-4-24-68)10-14-46(50)57(45)59-39-75-33-34-76-40-60-58-47-15-11-43(63-55(73)19-31-69-25-5-6-26-69)37-51(47)66-52-38-44(12-16-48(52)58)64-56(74)20-32-70-27-7-8-28-70/h9-16,35-38H,1-8,17-34,39-40H2,(H,59,65)(H,60,66)(H,61,71)(H,62,72)(H,63,73)(H,64,74)
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n/an/a 4.50E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of human 35S-labeled Pot1 binding to human telomeric DNA


Citation and Details
More data for this
Ligand-Target Pair
Protection of telomeres protein 1


(Homo sapiens)
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/a 6.30E+4n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of human 35S-labeled Pot1 binding to human telomeric DNA


Citation and Details
More data for this
Ligand-Target Pair