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Compile Data Set for Download or QSAR

Found 353 hits Enz. Inhib. hit(s) with Target = 'Protein Wnt-3a' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Wnt-3a


(Mus musculus)
BDBM89484
PNG
(MLS002702998 | Ossamycin | SMR001566807 | cid_5351...)
Show SMILES CC[C@@H](O)C[C@H]1CCC[C@@]2(C[C@@H]3OC(=O)\C=C\[C@@](C)(O)[C@@H](O)[C@H](C)[C@@H](O)[C@H](OC4CCC(C(C)O4)N(C)C)[C@@H](O)[C@](C)(O)CCCCC\C=C/[C@@H]4CC(C)(C)O[C@@]4(O)C[C@H](O2)[C@H]3C)O1
Show InChI InChI=1S/C49H85NO14/c1-11-34(51)26-35-19-17-24-48(62-35)28-37-30(2)38(63-48)29-49(58)33(27-45(5,6)64-49)18-15-13-12-14-16-23-46(7,56)44(55)42(61-40-21-20-36(50(9)10)32(4)59-40)41(53)31(3)43(54)47(8,57)25-22-39(52)60-37/h15,18,22,25,30-38,40-44,51,53-58H,11-14,16-17,19-21,23-24,26-29H2,1-10H3/b18-15-,25-22+/t30-,31+,32?,33+,34+,35+,36?,37-,38-,40?,41+,42-,43-,44+,46+,47+,48+,49-/m0/s1
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Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50380591
PNG
(CHEMBL2016633)
Show SMILES Oc1c2[C@@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,30-31H,13H2,(H,27,29)/t16-,17-/m0/s1
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50318567
PNG
(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1nc2CCSCc2c(=O)[nH]1
Show InChI InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89448
PNG
(3-amino-N-(4-methoxyphenyl)-4-(1-piperidinyl)benze...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(N3CCCCC3)c(N)c2)cc1
Show InChI InChI=1S/C18H23N3O3S/c1-24-15-7-5-14(6-8-15)20-25(22,23)16-9-10-18(17(19)13-16)21-11-3-2-4-12-21/h5-10,13,20H,2-4,11-12,19H2,1H3
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50380595
PNG
(CHEMBL1867804)
Show SMILES COc1ccc(cc1)-n1c(C)nnc1SCc1nc(no1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C21H21N5O4S/c1-13-23-24-21(26(13)15-6-8-16(27-2)9-7-15)31-12-19-22-20(25-30-19)14-5-10-17(28-3)18(11-14)29-4/h5-11H,12H2,1-4H3
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50380590
PNG
(CHEMBL1898239)
Show SMILES COc1ccc(cc1)-c1noc(CSc2nnc(C)n2-c2ccc(OC)cc2)n1
Show InChI InChI=1S/C20H19N5O3S/c1-13-22-23-20(25(13)15-6-10-17(27-3)11-7-15)29-12-18-21-19(24-28-18)14-4-8-16(26-2)9-5-14/h4-11H,12H2,1-3H3
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89312
PNG
(1-[4-(diethylsulfamoyl)phenyl]sulfonyl-3-piperidin...)
Show SMILES CCOC(=O)C1CCCN(C1)S(=O)(=O)c1ccc(cc1)S(=O)(=O)N(CC)CC
Show InChI InChI=1S/C18H28N2O6S2/c1-4-19(5-2)27(22,23)16-9-11-17(12-10-16)28(24,25)20-13-7-8-15(14-20)18(21)26-6-3/h9-12,15H,4-8,13-14H2,1-3H3
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89388
PNG
(MLS001214642 | SMR000543664 | cid_16404356)
Show SMILES CCC(C)NC(=O)CCC(=O)OC1O[C@H]2OC3(C)CC[C@H]4[C@H](C)CCC(C1C)C24OO3
Show InChI InChI=1S/C23H37NO7/c1-6-14(3)24-18(25)9-10-19(26)27-20-15(4)17-8-7-13(2)16-11-12-22(5)29-21(28-20)23(16,17)31-30-22/h13-17,20-21H,6-12H2,1-5H3,(H,24,25)/t13-,14?,15?,16+,17?,20?,21+,22?,23?/m1/s1
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89283
PNG
(4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid...)
Show SMILES CC(=O)c1c(C)[nH]c(C(=O)OCC(=O)Nc2ccc(C)cc2[N+]([O-])=O)c1C
Show InChI InChI=1S/C18H19N3O6/c1-9-5-6-13(14(7-9)21(25)26)20-15(23)8-27-18(24)17-10(2)16(12(4)22)11(3)19-17/h5-7,19H,8H2,1-4H3,(H,20,23)
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM65186
PNG
(Dodecyl-dimethyl-prop-2-ynyl-ammonium | MLS0005904...)
Show SMILES CCCCCCCCCCCC[N+](C)(C)CC#C
Show InChI InChI=1S/C17H34N/c1-5-7-8-9-10-11-12-13-14-15-17-18(3,4)16-6-2/h2H,5,7-17H2,1,3-4H3/q+1
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM77198
PNG
(5,6-dimethyl-4-[4-[2-(4-methylphenoxy)ethyl]-1-pip...)
Show SMILES Cc1sc2ncnc(N3CCN(CCOc4ccc(C)cc4)CC3)c2c1C
Show InChI InChI=1S/C21H26N4OS/c1-15-4-6-18(7-5-15)26-13-12-24-8-10-25(11-9-24)20-19-16(2)17(3)27-21(19)23-14-22-20/h4-7,14H,8-13H2,1-3H3
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89389
PNG
(MLS001214678 | SMR000543667 | cid_16405253)
Show SMILES CC(C)CC(NC(=O)CCCNC(=O)CCC(=O)OC1O[C@H]2OC3(C)CC[C@H]4[C@H](C)CCC(C1C)C24OO3)C(O)=O
Show InChI InChI=1S/C29H46N2O10/c1-16(2)15-21(25(35)36)31-23(33)7-6-14-30-22(32)10-11-24(34)37-26-18(4)20-9-8-17(3)19-12-13-28(5)39-27(38-26)29(19,20)41-40-28/h16-21,26-27H,6-15H2,1-5H3,(H,30,32)(H,31,33)(H,35,36)/t17-,18?,19+,20?,21?,26?,27+,28?,29?/m1/s1
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89401
PNG
(MLS001126732 | SMR000657962 | [3-(3-hydroxypropyl)...)
Show SMILES OCCCC1CCCN(C1)C(=O)c1cc(COc2cccc3cnccc23)on1
Show InChI InChI=1S/C22H25N3O4/c26-11-3-5-16-4-2-10-25(14-16)22(27)20-12-18(29-24-20)15-28-21-7-1-6-17-13-23-9-8-19(17)21/h1,6-9,12-13,16,26H,2-5,10-11,14-15H2
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50380612
PNG
(CHEMBL1611739)
Show SMILES COc1ccc(cc1)-c1noc(CSc2nnc(-c3ccncc3)n2-c2ccc(OC)cc2)n1
Show InChI InChI=1S/C24H20N6O3S/c1-31-19-7-3-16(4-8-19)22-26-21(33-29-22)15-34-24-28-27-23(17-11-13-25-14-12-17)30(24)18-5-9-20(32-2)10-6-18/h3-14H,15H2,1-2H3
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89372
PNG
(1-(4-bromobenzyl)-2-methyl-1H-benzimidazole | 1-(4...)
Show SMILES Cc1nc2ccccc2n1Cc1ccc(Br)cc1
Show InChI InChI=1S/C15H13BrN2/c1-11-17-14-4-2-3-5-15(14)18(11)10-12-6-8-13(16)9-7-12/h2-9H,10H2,1H3
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89292
PNG
(2,3-dihydro-1,4-benzodioxin-3-ylmethyl-(5,6-dimeth...)
Show SMILES Cc1sc2ncnc(NCC3COc4ccccc4O3)c2c1C
Show InChI InChI=1S/C17H17N3O2S/c1-10-11(2)23-17-15(10)16(19-9-20-17)18-7-12-8-21-13-5-3-4-6-14(13)22-12/h3-6,9,12H,7-8H2,1-2H3,(H,18,19,20)
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89406
PNG
(1-(4-Diethylsulfamoyl-benzenesulfonyl)-piperidine-...)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(cc1)S(=O)(=O)N1CCCC(C1)C(=O)NC1CC1
Show InChI InChI=1S/C19H29N3O5S2/c1-3-21(4-2)28(24,25)17-9-11-18(12-10-17)29(26,27)22-13-5-6-15(14-22)19(23)20-16-7-8-16/h9-12,15-16H,3-8,13-14H2,1-2H3,(H,20,23)
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89317
PNG
(3-(2-amino-5-bromo-phenyl)-1H-quinoxalin-2-one | 3...)
Show SMILES Nc1ccc(Br)cc1-c1nc2ccccc2[nH]c1=O
Show InChI InChI=1S/C14H10BrN3O/c15-8-5-6-10(16)9(7-8)13-14(19)18-12-4-2-1-3-11(12)17-13/h1-7H,16H2,(H,18,19)
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM54412
PNG
(1-[1-(2-Fluoro-benzyl)-1H-indol-3-yl]-ethanone | 1...)
Show SMILES CC(=O)c1cn(Cc2ccccc2F)c2ccccc12
Show InChI InChI=1S/C17H14FNO/c1-12(20)15-11-19(17-9-5-3-7-14(15)17)10-13-6-2-4-8-16(13)18/h2-9,11H,10H2,1H3
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89392
PNG
(2-[(5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)amino]...)
Show SMILES Cc1sc2ncnc(NCC(O)c3ccc(cc3)[N+]([O-])=O)c2c1C
Show InChI InChI=1S/C16H16N4O3S/c1-9-10(2)24-16-14(9)15(18-8-19-16)17-7-13(21)11-3-5-12(6-4-11)20(22)23/h3-6,8,13,21H,7H2,1-2H3,(H,17,18,19)
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50380592
PNG
(CHEMBL1552719)
Show SMILES COc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccc(C)cc2)nnc1-c1ccncc1
Show InChI InChI=1S/C24H20N6O2S/c1-16-3-5-17(6-4-16)22-26-21(32-29-22)15-33-24-28-27-23(18-11-13-25-14-12-18)30(24)19-7-9-20(31-2)10-8-19/h3-14H,15H2,1-2H3
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89307
PNG
(4-[5-(6-quinolyloxymethyl)isoxazole-3-carbonyl]pip...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)c1cc(COc2ccc3ncccc3c2)on1
Show InChI InChI=1S/C21H22N4O5/c1-2-28-21(27)25-10-8-24(9-11-25)20(26)19-13-17(30-23-19)14-29-16-5-6-18-15(12-16)4-3-7-22-18/h3-7,12-13H,2,8-11,14H2,1H3
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM64675
PNG
(10-methyl-3-(4-phenylphenyl)-2H-[1,3,4]thiadiazino...)
Show SMILES C[n+]1c2SCC(=Nn2c2ccccc12)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H18N3S/c1-24-20-9-5-6-10-21(20)25-22(24)26-15-19(23-25)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,15H2,1H3/q+1
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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89400
PNG
(2-[1-[5-(5-isoquinolyloxymethyl)isoxazole-3-carbon...)
Show SMILES CCOC(=O)CC1CCCCN1C(=O)c1cc(COc2cccc3cnccc23)on1
Show InChI InChI=1S/C23H25N3O5/c1-2-29-22(27)12-17-7-3-4-11-26(17)23(28)20-13-18(31-25-20)15-30-21-8-5-6-16-14-24-10-9-19(16)21/h5-6,8-10,13-14,17H,2-4,7,11-12,15H2,1H3
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n/an/a 777n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89387
PNG
(MLS001214654 | SMR000543665 | cid_16404087)
Show SMILES C[C@@H]1CCC2C(C)C(OC(=O)CCC(=O)NC(C)(C)CO)O[C@H]3OC4(C)CC[C@@H]1C23OO4
Show InChI InChI=1S/C23H37NO8/c1-13-6-7-16-14(2)19(28-18(27)9-8-17(26)24-21(3,4)12-25)29-20-23(16)15(13)10-11-22(5,30-20)31-32-23/h13-16,19-20,25H,6-12H2,1-5H3,(H,24,26)/t13-,14?,15+,16?,19?,20+,22?,23?/m1/s1
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n/an/a 794n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89425
PNG
(3-(benzenesulfonyl)-N-(3-ethyl-4-methoxy-1,3-benzo...)
Show SMILES CCn1c2c(OC)cccc2sc1=NC(=O)CCS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H20N2O4S2/c1-3-21-18-15(25-2)10-7-11-16(18)26-19(21)20-17(22)12-13-27(23,24)14-8-5-4-6-9-14/h4-11H,3,12-13H2,1-2H3
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n/an/a 803n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89421
PNG
(4-[4-(2-hydroxyethyl)-1-piperazinyl]-N-(4-methoxyp...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(N3CCN(CCO)CC3)c(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C19H24N4O6S/c1-29-16-4-2-15(3-5-16)20-30(27,28)17-6-7-18(19(14-17)23(25)26)22-10-8-21(9-11-22)12-13-24/h2-7,14,20,24H,8-13H2,1H3
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Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89256
PNG
((3-Butoxy-propyl)-(5H-pyrimido[5,4-b]indol-4-yl)-a...)
Show SMILES CCCCOCCCNc1ncnc2c3ccccc3[nH]c12
Show InChI InChI=1S/C17H22N4O/c1-2-3-10-22-11-6-9-18-17-16-15(19-12-20-17)13-7-4-5-8-14(13)21-16/h4-5,7-8,12,21H,2-3,6,9-11H2,1H3,(H,18,19,20)
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n/an/a 843n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM65438
PNG
((5-methylthieno[2,3-d]pyrimidin-4-yl)-[2-(2-pyridy...)
Show SMILES Cc1csc2ncnc(NCCc3ccccn3)c12
Show InChI InChI=1S/C14H14N4S/c1-10-8-19-14-12(10)13(17-9-18-14)16-7-5-11-4-2-3-6-15-11/h2-4,6,8-9H,5,7H2,1H3,(H,16,17,18)
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n/an/a 887n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

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PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM53616
PNG
(1-ethyl-2,3,3,5-tetramethyl-3H-indolium | 1-ethyl-...)
Show SMILES CC[N+]1=C(C)C(C)(C)c2cc(C)ccc12
Show InChI InChI=1S/C14H20N/c1-6-15-11(3)14(4,5)12-9-10(2)7-8-13(12)15/h7-9H,6H2,1-5H3/q+1
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n/an/a 892n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89265
PNG
(MLS000580834 | N-(3-Chloro-4-methyl-phenyl)-2-oxo-...)
Show SMILES CC(=NNC(=O)C(=O)Nc1ccc(C)c(Cl)c1)c1ccncc1
Show InChI InChI=1S/C16H15ClN4O2/c1-10-3-4-13(9-14(10)17)19-15(22)16(23)21-20-11(2)12-5-7-18-8-6-12/h3-9H,1-2H3,(H,19,22)(H,21,23)
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n/an/a 909n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50380611
PNG
(CHEMBL1483505)
Show SMILES CCOc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccc(OC)cc2)nnc1-c1ccncc1
Show InChI InChI=1S/C25H22N6O3S/c1-3-33-21-10-6-19(7-11-21)31-24(18-12-14-26-15-13-18)28-29-25(31)35-16-22-27-23(30-34-22)17-4-8-20(32-2)9-5-17/h4-15H,3,16H2,1-2H3
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PubMed
n/an/a 919n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM77540
PNG
(4-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-acetylamino...)
Show SMILES CCOC(=O)c1ccc(NC(=O)Cn2cnc3cc(C)c(C)cc23)cc1
Show InChI InChI=1S/C20H21N3O3/c1-4-26-20(25)15-5-7-16(8-6-15)22-19(24)11-23-12-21-17-9-13(2)14(3)10-18(17)23/h5-10,12H,4,11H2,1-3H3,(H,22,24)
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n/an/a 931n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89257
PNG
((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-(2-methy...)
Show SMILES Cc1sc2ncnc(NCC(C)(C)N3CCOCC3)c2c1C
Show InChI InChI=1S/C16H24N4OS/c1-11-12(2)22-15-13(11)14(18-10-19-15)17-9-16(3,4)20-5-7-21-8-6-20/h10H,5-9H2,1-4H3,(H,17,18,19)
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n/an/a 942n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89414
PNG
(MLS001111074 | N-[1-(4-tert-butylphenyl)-4,5,6,7-t...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1ncc2C(CCCc12)NC(=O)CCN1CCCC1=O
Show InChI InChI=1S/C24H32N4O2/c1-24(2,3)17-9-11-18(12-10-17)28-21-7-4-6-20(19(21)16-25-28)26-22(29)13-15-27-14-5-8-23(27)30/h9-12,16,20H,4-8,13-15H2,1-3H3,(H,26,29)
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n/an/a 973n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89324
PNG
(MLS000733162 | N-(3-methoxybenzyl)-N-methyl-5-[(qu...)
Show SMILES COc1cccc(CN(C)C(=O)c2cc(COc3ccc4ncccc4c3)on2)c1
Show InChI InChI=1S/C23H21N3O4/c1-26(14-16-5-3-7-18(11-16)28-2)23(27)22-13-20(30-25-22)15-29-19-8-9-21-17(12-19)6-4-10-24-21/h3-13H,14-15H2,1-2H3
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n/an/a 1.02E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89423
PNG
(2-(benzenesulfonyl)-N-(3-ethyl-4-methoxy-1,3-benzo...)
Show SMILES CCn1c2c(OC)cccc2sc1=NC(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H18N2O4S2/c1-3-20-17-14(24-2)10-7-11-15(17)25-18(20)19-16(21)12-26(22,23)13-8-5-4-6-9-13/h4-11H,3,12H2,1-2H3
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n/an/a 1.03E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50380614
PNG
(CHEMBL2016634)
Show SMILES COc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccccc2)nnc1-c1ccncc1
Show InChI InChI=1S/C23H18N6O2S/c1-30-19-9-7-18(8-10-19)29-22(17-11-13-24-14-12-17)26-27-23(29)32-15-20-25-21(28-31-20)16-5-3-2-4-6-16/h2-14H,15H2,1H3
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n/an/a 1.06E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM36933
PNG
(MLS000041708 | N-[2-(3,4-dimethoxyphenyl)ethyl]-4-...)
Show SMILES COc1ccc(CCNc2ncnc3c4ccccc4oc23)cc1OC
Show InChI InChI=1S/C20H19N3O3/c1-24-16-8-7-13(11-17(16)25-2)9-10-21-20-19-18(22-12-23-20)14-5-3-4-6-15(14)26-19/h3-8,11-12H,9-10H2,1-2H3,(H,21,22,23)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89248
PNG
(2-(3-Methyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-N-(...)
Show SMILES Cn1nc(CC(=O)NCc2ccc(cc2)C(F)(F)F)c2ccccc2c1=O
Show InChI InChI=1S/C19H16F3N3O2/c1-25-18(27)15-5-3-2-4-14(15)16(24-25)10-17(26)23-11-12-6-8-13(9-7-12)19(20,21)22/h2-9H,10-11H2,1H3,(H,23,26)
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n/an/a 1.09E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89255
PNG
(4-[4-(4-methoxyphenyl)-1-piperazinyl]-5H-pyrimido[...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)c1ncnc2c3ccccc3[nH]c12
Show InChI InChI=1S/C21H21N5O/c1-27-16-8-6-15(7-9-16)25-10-12-26(13-11-25)21-20-19(22-14-23-21)17-4-2-3-5-18(17)24-20/h2-9,14,24H,10-13H2,1H3
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n/an/a 1.14E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89451
PNG
(3-amino-N-(4-methoxyphenyl)-4-(4-morpholinyl)benze...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(N3CCOCC3)c(N)c2)cc1
Show InChI InChI=1S/C17H21N3O4S/c1-23-14-4-2-13(3-5-14)19-25(21,22)15-6-7-17(16(18)12-15)20-8-10-24-11-9-20/h2-7,12,19H,8-11,18H2,1H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM50380615
PNG
(CHEMBL1459534)
Show SMILES O=C1Nc2ccccc2C11OCC2(CO1)COC1(OC2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)
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n/an/a 1.17E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89253
PNG
(8-[2-(4-tert-Butyl-phenoxy)-ethylamino]-1,3,7-trim...)
Show SMILES Cn1c(NCCOc2ccc(cc2)C(C)(C)C)nc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C20H27N5O3/c1-20(2,3)13-7-9-14(10-8-13)28-12-11-21-18-22-16-15(23(18)4)17(26)25(6)19(27)24(16)5/h7-10H,11-12H2,1-6H3,(H,21,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM68071
PNG
(MLS000374456 | N-[4-(1-benzofuran-2-yl)-1,3-thiazo...)
Show SMILES CC1CN(CC(C)O1)S(=O)(=O)c1ccc(cc1)C(=O)Nc1nc(cs1)-c1cc2ccccc2o1
Show InChI InChI=1S/C24H23N3O5S2/c1-15-12-27(13-16(2)31-15)34(29,30)19-9-7-17(8-10-19)23(28)26-24-25-20(14-33-24)22-11-18-5-3-4-6-21(18)32-22/h3-11,14-16H,12-13H2,1-2H3,(H,25,26,28)
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n/an/a 1.28E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89413
PNG
(5-(5-isoquinolinyloxymethyl)-N-methyl-N-(2-thiazol...)
Show SMILES CN(Cc1nccs1)C(=O)c1cc(COc2cccc3cnccc23)on1
Show InChI InChI=1S/C19H16N4O3S/c1-23(11-18-21-7-8-27-18)19(24)16-9-14(26-22-16)12-25-17-4-2-3-13-10-20-6-5-15(13)17/h2-10H,11-12H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM83552
PNG
(2-(1,3-Dimethyl-2,6-dioxo-7-propyl-2,3,6,7-tetrahy...)
Show SMILES CCCn1c(SCC(=O)Nc2nc(cs2)-c2ccc(OC)cc2)nc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C22H24N6O4S2/c1-5-10-28-17-18(26(2)22(31)27(3)19(17)30)25-21(28)34-12-16(29)24-20-23-15(11-33-20)13-6-8-14(32-4)9-7-13/h6-9,11H,5,10,12H2,1-4H3,(H,23,24,29)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM89338
PNG
(6-(4-chlorophenyl)-7-(4-ethoxyphenyl)-2,3-dihydroi...)
Show SMILES CCOc1ccc(cc1)-n1c2SCC[n+]2cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18ClN2OS/c1-2-23-17-9-7-16(8-10-17)22-18(13-21-11-12-24-19(21)22)14-3-5-15(20)6-4-14/h3-10,13H,2,11-12H2,1H3/q+1
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n/an/a 1.33E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM38951
PNG
(2,4-dimethyl-N-(3,4,5-trimethoxyphenyl)benzenesulf...)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2C)cc(OC)c1OC
Show InChI InChI=1S/C17H21NO5S/c1-11-6-7-16(12(2)8-11)24(19,20)18-13-9-14(21-3)17(23-5)15(10-13)22-4/h6-10,18H,1-5H3
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n/an/a 1.38E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Protein Wnt-3a


(Mus musculus)
BDBM35354
PNG
(4-N-(2-methylcyclohexyl)-1-N-(pyridin-4-ylmethyl)b...)
Show SMILES CC1CCCCC1NS(=O)(=O)c1ccc(cc1)S(=O)(=O)NCc1ccncc1
Show InChI InChI=1S/C19H25N3O4S2/c1-15-4-2-3-5-19(15)22-28(25,26)18-8-6-17(7-9-18)27(23,24)21-14-16-10-12-20-13-11-16/h6-13,15,19,21-22H,2-5,14H2,1H3
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n/an/a 1.43E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
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