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Compile Data Set for Download or QSAR

Found 53 hits Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 6' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM178103
PNG
(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Show SMILES CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN
Show InChI InChI=1S/C17H25N3O/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3
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0.800n/a 4n/an/an/an/an/an/a



University of Toronto



Assay Description
In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...


ACS Chem Biol 11: 772-81 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM178102
PNG
(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Show SMILES CN(CCN)Cc1c[nH]cc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H18F3N3/c1-21(6-5-19)10-12-8-20-9-14(12)11-3-2-4-13(7-11)15(16,17)18/h2-4,7-9,20H,5-6,10,19H2,1H3
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3n/a 9n/an/an/an/an/an/a



University of Toronto



Assay Description
In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...


ACS Chem Biol 11: 772-81 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM178101
PNG
(N1-Methyl-N1-((5-(3-(trifluoromethyl)phenyl)-2H-1,...)
Show SMILES CN(CCN)Cc1n[nH]nc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C13H16F3N5/c1-21(6-5-17)8-11-12(19-20-18-11)9-3-2-4-10(7-9)13(14,15)16/h2-4,7H,5-6,8,17H2,1H3,(H,18,19,20)
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110n/a 230n/an/an/an/an/an/a



University of Toronto



Assay Description
In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...


ACS Chem Biol 11: 772-81 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095436
PNG
(CHEMBL3589043)
Show SMILES CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(c2)C(=O)N(C)C)cc1
Show InChI InChI=1S/C23H29N5O2/c1-24-12-13-28(4)16-22-21(15-25-26-22)17-8-10-19(11-9-17)30-20-7-5-6-18(14-20)23(29)27(2)3/h5-11,14-15,24H,12-13,16H2,1-4H3,(H,25,26)
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n/an/a 2n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095355
PNG
(CHEMBL3589029)
Show SMILES CN(CCN)Cc1cn[nH]c1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H22N4O/c1-23(12-11-20)14-16-13-21-22-19(16)15-7-9-18(10-8-15)24-17-5-3-2-4-6-17/h2-10,13H,11-12,14,20H2,1H3,(H,21,22)
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n/an/a 2n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095438
PNG
(CHEMBL3589042)
Show SMILES CNCCN(C)Cc1c[nH]nc1-c1ccc(Oc2cccc(c2)C(=O)N(C)C)cc1
Show InChI InChI=1S/C23H29N5O2/c1-24-12-13-28(4)16-19-15-25-26-22(19)17-8-10-20(11-9-17)30-21-7-5-6-18(14-21)23(29)27(2)3/h5-11,14-15,24H,12-13,16H2,1-4H3,(H,25,26)
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n/an/a 3n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095435
PNG
(CHEMBL3590417)
Show SMILES CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2ccccc2C(=O)NC)cc1
Show InChI InChI=1S/C22H27N5O2/c1-23-12-13-27(3)15-20-19(14-25-26-20)16-8-10-17(11-9-16)29-21-7-5-4-6-18(21)22(28)24-2/h4-11,14,23H,12-13,15H2,1-3H3,(H,24,28)(H,25,26)
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n/an/a 5n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095432
PNG
(CHEMBL3589026)
Show SMILES CC(C)Oc1ccc(cc1)-c1[nH]ncc1CN(C)CCN
Show InChI InChI=1S/C16H24N4O/c1-12(2)21-15-6-4-13(5-7-15)16-14(10-18-19-16)11-20(3)9-8-17/h4-7,10,12H,8-9,11,17H2,1-3H3,(H,18,19)
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n/an/a 7n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095354
PNG
(CHEMBL3589030)
Show SMILES CC(C)Oc1ccc(cc1Cl)-c1[nH]ncc1CN(C)CCN
Show InChI InChI=1S/C16H23ClN4O/c1-11(2)22-15-5-4-12(8-14(15)17)16-13(9-19-20-16)10-21(3)7-6-18/h4-5,8-9,11H,6-7,10,18H2,1-3H3,(H,19,20)
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n/an/a 8n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095353
PNG
(CHEMBL3589031)
Show SMILES CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)c(Cl)c1
Show InChI InChI=1S/C17H25ClN4O/c1-12(2)23-16-6-5-13(9-15(16)18)17-14(10-20-21-17)11-22(4)8-7-19-3/h5-6,9-10,12,19H,7-8,11H2,1-4H3,(H,20,21)
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n/an/a 10n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095441
PNG
(CHEMBL3589039)
Show SMILES CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@@H](C2)OCCC2CCOCC2)cc1
Show InChI InChI=1/C25H38N4O3/c1-26-10-11-29(2)18-21-17-27-28-25(21)20-3-5-22(6-4-20)32-24-15-23(16-24)31-14-9-19-7-12-30-13-8-19/h3-6,17,19,23-24,26H,7-16,18H2,1-2H3,(H,27,28)/t23-,24-
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n/an/a 10n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095356
PNG
(CHEMBL3589028)
Show SMILES CC(C)Cc1ccc(cc1)-c1[nH]ncc1CN(C)CCN
Show InChI InChI=1S/C17H26N4/c1-13(2)10-14-4-6-15(7-5-14)17-16(11-19-20-17)12-21(3)9-8-18/h4-7,11,13H,8-10,12,18H2,1-3H3,(H,19,20)
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n/an/a 10n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095434
PNG
(CHEMBL3589912)
Show SMILES CN(CCN)Cc1cn[nH]c1-c1ccc(F)cc1
Show InChI InChI=1S/C13H17FN4/c1-18(7-6-15)9-11-8-16-17-13(11)10-2-4-12(14)5-3-10/h2-5,8H,6-7,9,15H2,1H3,(H,16,17)
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n/an/a 11n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095357
PNG
(CHEMBL3589027)
Show SMILES CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)cc1
Show InChI InChI=1S/C17H26N4O/c1-13(2)22-16-7-5-14(6-8-16)17-15(11-19-20-17)12-21(4)10-9-18-3/h5-8,11,13,18H,9-10,12H2,1-4H3,(H,19,20)
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n/an/a 11n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095440
PNG
(CHEMBL3589040)
Show SMILES CN(CCN)Cc1c[nH]nc1-c1ccc(OCCCN2CCOCC2)cc1
Show InChI InChI=1S/C20H31N5O2/c1-24(9-7-21)16-18-15-22-23-20(18)17-3-5-19(6-4-17)27-12-2-8-25-10-13-26-14-11-25/h3-6,15H,2,7-14,16,21H2,1H3,(H,22,23)
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n/an/a 13n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095439
PNG
(CHEMBL3589041)
Show SMILES CN(CCN)Cc1c[nH]nc1-c1ccc(cc1)N1CCN(CC1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C25H32N6O/c1-29(12-11-26)19-22-18-27-28-25(22)21-7-9-23(10-8-21)30-13-15-31(16-14-30)24(32)17-20-5-3-2-4-6-20/h2-10,18H,11-17,19,26H2,1H3,(H,27,28)
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n/an/a 20n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095352
PNG
(CHEMBL3589032)
Show SMILES CNCCN(C)Cc1cnn(C)c1-c1ccc(OC(C)C)c(Cl)c1
Show InChI InChI=1S/C18H27ClN4O/c1-13(2)24-17-7-6-14(10-16(17)19)18-15(11-21-23(18)5)12-22(4)9-8-20-3/h6-7,10-11,13,20H,8-9,12H2,1-5H3
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n/an/a 23n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095433
PNG
(CHEMBL3589913)
Show SMILES CCOc1ccc(cc1)-c1[nH]ncc1CN(C)CCNC
Show InChI InChI=1S/C16H24N4O/c1-4-21-15-7-5-13(6-8-15)16-14(11-18-19-16)12-20(3)10-9-17-2/h5-8,11,17H,4,9-10,12H2,1-3H3,(H,18,19)
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Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095351
PNG
(CHEMBL3589033)
Show SMILES CCC(CO)Oc1ccc(cc1)-c1[nH]ncc1CN(C)CCNC
Show InChI InChI=1/C18H28N4O2/c1-4-16(13-23)24-17-7-5-14(6-8-17)18-15(11-20-21-18)12-22(3)10-9-19-2/h5-8,11,16,19,23H,4,9-10,12-13H2,1-3H3,(H,20,21)
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Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095350
PNG
(CHEMBL3589034)
Show SMILES CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(CO)C(C)C)cc1
Show InChI InChI=1/C19H30N4O2/c1-14(2)18(13-24)25-17-7-5-15(6-8-17)19-16(11-21-22-19)12-23(4)10-9-20-3/h5-8,11,14,18,20,24H,9-10,12-13H2,1-4H3,(H,21,22)
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n/an/a 32n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158094
PNG
(CHEMBL3780926)
Show SMILES NCCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C14H22N2/c15-8-11-16-9-6-14(7-10-16)12-13-4-2-1-3-5-13/h1-5,14H,6-12,15H2
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n/an/a 230n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095349
PNG
(CHEMBL3589035)
Show SMILES CC(C)Oc1c(Cl)cc(cc1C(F)(F)F)-c1c[nH]nc1CN(C)CCN
Show InChI InChI=1S/C17H22ClF3N4O/c1-10(2)26-16-13(17(19,20)21)6-11(7-14(16)18)12-8-23-24-15(12)9-25(3)5-4-22/h6-8,10H,4-5,9,22H2,1-3H3,(H,23,24)
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n/an/a 320n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095348
PNG
(CHEMBL3589036)
Show SMILES CNCCN(C)Cc1cn[nH]c1-c1cc(OCCc2ccccc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H27F3N4O/c1-27-9-10-30(2)16-19-15-28-29-22(19)18-12-20(23(24,25)26)14-21(13-18)31-11-8-17-6-4-3-5-7-17/h3-7,12-15,27H,8-11,16H2,1-2H3,(H,28,29)
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n/an/a 327n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095347
PNG
(CHEMBL3589037)
Show SMILES CNCCN(C)Cc1cn[nH]c1-c1cc(OCCC2CCCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H33F3N4O/c1-27-9-10-30(2)16-19-15-28-29-22(19)18-12-20(23(24,25)26)14-21(13-18)31-11-8-17-6-4-3-5-7-17/h12-15,17,27H,3-11,16H2,1-2H3,(H,28,29)
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n/an/a 461n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095441
PNG
(CHEMBL3589039)
Show SMILES CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@@H](C2)OCCC2CCOCC2)cc1
Show InChI InChI=1/C25H38N4O3/c1-26-10-11-29(2)18-21-17-27-28-25(21)20-3-5-22(6-4-20)32-24-15-23(16-24)31-14-9-19-7-12-30-13-8-19/h3-6,17,19,23-24,26H,7-16,18H2,1-2H3,(H,27,28)/t23-,24-
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n/an/a 637n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of his-tagged PRMT6 (unknown origin) expressed in human A375 cells assessed as reduction in H3R2 methylation at 0.01 to 20 uM incubated fo...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095442
PNG
(CHEMBL3589038)
Show SMILES CNCCN(C)Cc1cn[nH]c1-c1cc(OC(CO)CC(C)C)cc(c1)C(F)(F)F
Show InChI InChI=1/C21H31F3N4O2/c1-14(2)7-19(13-29)30-18-9-15(8-17(10-18)21(22,23)24)20-16(11-26-27-20)12-28(4)6-5-25-3/h8-11,14,19,25,29H,5-7,12-13H2,1-4H3,(H,26,27)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158097
PNG
(CHEMBL3780701)
Show SMILES CNCCN1CCC(C)CC1
Show InChI InChI=1S/C9H20N2/c1-9-3-6-11(7-4-9)8-5-10-2/h9-10H,3-8H2,1-2H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158095
PNG
(CHEMBL3780444)
Show SMILES CNCCN(C)C
Show InChI InChI=1S/C5H14N2/c1-6-4-5-7(2)3/h6H,4-5H2,1-3H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50387477
PNG
(CHEMBL2047477)
Show SMILES CCn1c2cccc3cccc(c23)\c1=C\[CH+]\C=c1/n(CC)c2cccc3cccc1c23
Show InChI InChI=1S/C29H25N2/c1-3-30-24(22-14-5-10-20-12-7-18-26(30)28(20)22)16-9-17-25-23-15-6-11-21-13-8-19-27(29(21)23)31(25)4-2/h5-19H,3-4H2,1-2H3/q+1/b24-16-,25-17-
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n/an/a 1.26E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of His6X-tagged PRMT6 expressed in Escherichia coli BL21(DE3) cells using [14C]-S-adenosyl-L-methionine and histone H4 peptide after 8 min...


Eur J Med Chem 54: 647-59 (2012)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50095442
PNG
(CHEMBL3589038)
Show SMILES CNCCN(C)Cc1cn[nH]c1-c1cc(OC(CO)CC(C)C)cc(c1)C(F)(F)F
Show InChI InChI=1/C21H31F3N4O2/c1-14(2)7-19(13-29)30-18-9-15(8-17(10-18)21(22,23)24)20-16(11-26-27-20)12-28(4)6-5-25-3/h8-11,14,19,25,29H,5-7,12-13H2,1-4H3,(H,26,27)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Epizyme, Inc.

Curated by ChEMBL


Assay Description
Inhibition of his-tagged PRMT6 (unknown origin) expressed in human A375 cells assessed as reduction in H3R2 methylation at 0.01 to 20 uM incubated fo...


ACS Med Chem Lett 6: 655-9 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158094
PNG
(CHEMBL3780926)
Show SMILES NCCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C14H22N2/c15-8-11-16-9-6-14(7-10-16)12-13-4-2-1-3-5-13/h1-5,14H,6-12,15H2
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged human PRMT6 expressed in HEK293 cells assessed as reduction in H3R2 global methylation incubated for 20 hrs by Western blot...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50145918
PNG
(CHEMBL3763993)
Show SMILES CN1CCCN(Cc2ccc(CN)cc2)CC1
Show InChI InChI=1S/C14H23N3/c1-16-7-2-8-17(10-9-16)12-14-5-3-13(11-15)4-6-14/h3-6H,2,7-12,15H2,1H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50328743
PNG
(3-((4-acetamidophenyl)diazenyl)-4-hydroxy-7-(3-(5-...)
Show SMILES CC(=O)Nc1ccc(cc1)N=Nc1c(O)c2ccc(NC(=O)Nc3ccc4c(O)c(N=Nc5ccccc5)c(cc4c3)S(O)(=O)=O)cc2cc1S(O)(=O)=O
Show InChI InChI=1S/C35H27N7O10S2/c1-19(43)36-22-7-9-24(10-8-22)40-42-32-30(54(50,51)52)18-21-16-26(12-14-28(21)34(32)45)38-35(46)37-25-11-13-27-20(15-25)17-29(53(47,48)49)31(33(27)44)41-39-23-5-3-2-4-6-23/h2-18,44-45H,1H3,(H,36,43)(H2,37,38,46)(H,47,48,49)(H,50,51,52)
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n/an/a 3.92E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of His6x-tagged PRMT6-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using H3(1-31) peptide and [14C]-SAM by scint...


J Med Chem 53: 6028-39 (2010)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158369
PNG
(CHEMBL3781561)
Show SMILES Cc1nc(N)sc1-n1ccc(n1)C(F)(F)F
Show InChI InChI=1S/C8H7F3N4S/c1-4-6(16-7(12)13-4)15-3-2-5(14-15)8(9,10)11/h2-3H,1H3,(H2,12,13)
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n/an/a 4.60E+4n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158371
PNG
(CHEMBL3780738)
Show SMILES CNCc1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C12H13NS/c1-13-8-10-3-2-4-11(7-10)12-5-6-14-9-12/h2-7,9,13H,8H2,1H3
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n/an/a 6.90E+4n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158372
PNG
(CHEMBL3779956)
Show SMILES CN(C)Cc1ccc(CSCCN)o1
Show InChI InChI=1S/C10H18N2OS/c1-12(2)7-9-3-4-10(13-9)8-14-6-5-11/h3-4H,5-8,11H2,1-2H3
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n/an/a 7.20E+4n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158085
PNG
(CHEMBL3781201)
Show SMILES CNCc1ccc(C)s1
Show InChI InChI=1S/C7H11NS/c1-6-3-4-7(9-6)5-8-2/h3-4,8H,5H2,1-2H3
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n/an/a 9.90E+4n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM223137
PNG
(P5i-6)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H10ClN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50130929
PNG
(CHEMBL3633189)
Show SMILES NC(=N)c1ccc(Nc2ncnc(Nc3ccc(cc3)C#N)c2[N+]([O-])=O)cc1
Show InChI InChI=1S/C18H14N8O2/c19-9-11-1-5-13(6-2-11)24-17-15(26(27)28)18(23-10-22-17)25-14-7-3-12(4-8-14)16(20)21/h1-8,10H,(H3,20,21)(H2,22,23,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of PRMT6 (unknown origin) using biotinylated histone H4-derived peptide as substrate after 60 mins by AlphaLISA assay


Bioorg Med Chem Lett 25: 5449-53 (2015)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158084
PNG
(CHEMBL3780979)
Show SMILES CNCc1cccc(c1)-c1ccncc1
Show InChI InChI=1S/C13H14N2/c1-14-10-11-3-2-4-13(9-11)12-5-7-15-8-6-12/h2-9,14H,10H2,1H3
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50068109
PNG
(CHEMBL3402235)
Show SMILES CNCc1cccc(c1)-c1cccnc1
Show InChI InChI=1S/C13H14N2/c1-14-9-11-4-2-5-12(8-11)13-6-3-7-15-10-13/h2-8,10,14H,9H2,1H3
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n/an/a 1.04E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158370
PNG
(CHEMBL3780615)
Show SMILES CNCc1cccc(c1)-c1cccs1
Show InChI InChI=1S/C12H13NS/c1-13-9-10-4-2-5-11(8-10)12-6-3-7-14-12/h2-8,13H,9H2,1H3
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n/an/a 1.25E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158391
PNG
(CHEMBL3781682)
Show SMILES CNCc1cccc(c1)-c1csc(C)n1
Show InChI InChI=1S/C12H14N2S/c1-9-14-12(8-15-9)11-5-3-4-10(6-11)7-13-2/h3-6,8,13H,7H2,1-2H3
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n/an/a 1.36E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158389
PNG
(CHEMBL3781603)
Show SMILES CNCc1cccc(c1)-c1ccco1
Show InChI InChI=1S/C12H13NO/c1-13-9-10-4-2-5-11(8-10)12-6-3-7-14-12/h2-8,13H,9H2,1H3
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n/an/a 1.46E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158377
PNG
(CHEMBL3781043)
Show SMILES CNCc1cccc(c1)N1CCCCC1
Show InChI InChI=1S/C13H20N2/c1-14-11-12-6-5-7-13(10-12)15-8-3-2-4-9-15/h5-7,10,14H,2-4,8-9,11H2,1H3
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n/an/a 1.70E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50210461
PNG
((stilbamidine)4-[2-[4-amino(imino)methylphenyl]-(E...)
Show SMILES NC(=N)c1ccc(\C=C\c2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C16H16N4/c17-15(18)13-7-3-11(4-8-13)1-2-12-5-9-14(10-6-12)16(19)20/h1-10H,(H3,17,18)(H3,19,20)/b2-1+
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n/an/a 1.73E+5n/an/an/an/an/an/a



The University of Georgia

Curated by ChEMBL


Assay Description
Inhibition of His6x-tagged PRMT6 (unknown origin) using [3H]SAM and histone H3.1 as substrate at 20 uM after 1 hr by P81 filter binding assay


J Med Chem 57: 2611-22 (2014)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158087
PNG
(CHEMBL3781841)
Show SMILES CCNC(=O)[C@@H](C)N
Show InChI InChI=1/C5H12N2O/c1-3-7-5(8)4(2)6/h4H,3,6H2,1-2H3,(H,7,8)/t4-/s2
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n/an/a>2.00E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50007728
PNG
(CHEMBL424121 | DB867)
Show SMILES NC(=N)c1ccc(cc1)-c1ccc(o1)-c1ccc(nc1)C(N)=N
Show InChI InChI=1S/C17H15N5O/c18-16(19)11-3-1-10(2-4-11)14-7-8-15(23-14)12-5-6-13(17(20)21)22-9-12/h1-9H,(H3,18,19)(H3,20,21)
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n/an/a 2.11E+5n/an/an/an/an/an/a



The University of Georgia

Curated by ChEMBL


Assay Description
Inhibition of His6x-tagged PRMT6 (unknown origin) using [3H]SAM and histone H3.1 as substrate at 20 uM after 1 hr by P81 filter binding assay


J Med Chem 57: 2611-22 (2014)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50388602
PNG
(FURAMIDINE)
Show SMILES NC(=N)c1ccc(cc1)-c1ccc(o1)-c1ccc(cc1)C(N)=N
Show InChI InChI=1S/C18H16N4O/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22/h1-10H,(H3,19,20)(H3,21,22)
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n/an/a 2.83E+5n/an/an/an/an/an/a



The University of Georgia

Curated by ChEMBL


Assay Description
Inhibition of His6x-tagged PRMT6 (unknown origin) using [3H]SAM and histone H3.1 as substrate at 20 uM after 1 hr by P81 filter binding assay


J Med Chem 57: 2611-22 (2014)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50158373
PNG
(CHEMBL3781266)
Show SMILES NCc1cccc(CN2CCCC2)c1
Show InChI InChI=1S/C12H18N2/c13-9-11-4-3-5-12(8-11)10-14-6-1-2-7-14/h3-5,8H,1-2,6-7,9-10,13H2
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n/an/a 3.60E+5n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-...


J Med Chem 59: 1176-83 (2016)

More data for this
Ligand-Target Pair
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