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Compile Data Set for Download or QSAR

Found 68 hits Enz. Inhib. hit(s) with Target = 'Protein arginine methyltransferase 3 (PRMT3)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM178103
PNG
(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Show SMILES CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN
Show InChI InChI=1S/C17H25N3O/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3
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55n/a 119n/an/an/an/an/an/a



University of Toronto



Assay Description
In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM178102
PNG
(N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-py...)
Show SMILES CN(CCN)Cc1c[nH]cc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H18F3N3/c1-21(6-5-19)10-12-8-20-9-14(12)11-3-2-4-13(7-11)15(16,17)18/h2-4,7-9,20H,5-6,10,19H2,1H3
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550n/a 1.10E+3n/an/an/an/an/an/a



University of Toronto



Assay Description
In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50431676
PNG
(CHEMBL2349526)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Br)c2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H20BrN5O5S/c16-6-3-21(13-9(6)12(18)19-5-20-13)14-11(23)10(22)8(26-14)4-27-2-1-7(17)15(24)25/h3,5,7-8,10-11,14,22-23H,1-2,4,17H2,(H,24,25)(H2,18,19,20)/t7-,8+,10+,11+,14+/m0/s1
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1.15E+3n/an/an/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM178101
PNG
(N1-Methyl-N1-((5-(3-(trifluoromethyl)phenyl)-2H-1,...)
Show SMILES CN(CCN)Cc1n[nH]nc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C13H16F3N5/c1-21(6-5-17)8-11-12(19-20-18-11)9-3-2-4-10(7-9)13(14,15)16/h2-4,7H,5-6,8,17H2,1H3,(H,18,19,20)
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>5.00E+4n/a>1.00E+5n/an/an/an/an/an/a



University of Toronto



Assay Description
In brief, the tritiated S-adenosyl-L-methionine (3HSAM, PerkinElmer Life Sciences) was used as the donor of methyl group. The (3H) methylated biotin ...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427787
PNG
(CHEMBL2325198)
Show SMILES O=C(NCC(=O)N1CCCCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C14H17N5O2S/c20-13(19-6-2-1-3-7-19)9-15-14(21)16-10-4-5-11-12(8-10)22-18-17-11/h4-5,8H,1-3,6-7,9H2,(H2,15,16,21)
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n/an/a 230n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427778
PNG
(CHEMBL2325177)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)Nc2ccc3nnsc3c2)cc1
Show InChI InChI=1S/C14H11N5O3S/c20-14(15-8-9-1-4-11(5-2-9)19(21)22)16-10-3-6-12-13(7-10)23-18-17-12/h1-7H,8H2,(H2,15,16,20)
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n/an/a 300n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427788
PNG
(CHEMBL2325197)
Show SMILES Fc1ccc(cc1)C(=O)CNC(=O)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H11FN4O2S/c16-10-3-1-9(2-4-10)13(21)8-17-15(22)18-11-5-6-12-14(7-11)23-20-19-12/h1-7H,8H2,(H2,17,18,22)
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n/an/a 360n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427772
PNG
(CHEMBL2325183)
Show SMILES O=C(NCC(=O)c1ccccc1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H12N4O2S/c20-13(10-4-2-1-3-5-10)9-16-15(21)17-11-6-7-12-14(8-11)22-19-18-12/h1-8H,9H2,(H2,16,17,21)
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n/an/a 480n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427790
PNG
(CHEMBL2325195)
Show SMILES OC(CNC(=O)Nc1ccc2nnsc2c1)C1CCCCC1
Show InChI InChI=1S/C15H20N4O2S/c20-13(10-4-2-1-3-5-10)9-16-15(21)17-11-6-7-12-14(8-11)22-19-18-12/h6-8,10,13,20H,1-5,9H2,(H2,16,17,21)
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n/an/a 490n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427789
PNG
(CHEMBL2325196)
Show SMILES O=C(NCC(=O)C1CCCCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H18N4O2S/c20-13(10-4-2-1-3-5-10)9-16-15(21)17-11-6-7-12-14(8-11)22-19-18-12/h6-8,10H,1-5,9H2,(H2,16,17,21)
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n/an/a 840n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427777
PNG
(CHEMBL2325178)
Show SMILES CS(=O)(=O)c1ccc(CNC(=O)Nc2ccc3nnsc3c2)cc1
Show InChI InChI=1S/C15H14N4O3S2/c1-24(21,22)12-5-2-10(3-6-12)9-16-15(20)17-11-4-7-13-14(8-11)23-19-18-13/h2-8H,9H2,1H3,(H2,16,17,20)
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n/an/a 850n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427767
PNG
(CHEMBL2325442)
Show SMILES O=C(NCCC1CCCCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H20N4OS/c20-15(16-9-8-11-4-2-1-3-5-11)17-12-6-7-13-14(10-12)21-19-18-13/h6-7,10-11H,1-5,8-9H2,(H2,16,17,20)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427768
PNG
(CHEMBL2325441)
Show SMILES O=C(NCCC1=CCCCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H18N4OS/c20-15(16-9-8-11-4-2-1-3-5-11)17-12-6-7-13-14(10-12)21-19-18-13/h4,6-7,10H,1-3,5,8-9H2,(H2,16,17,20)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PRMT3 (211 to 531) using histone-4 (1 to 24) as substrate by S-adenosylhomocysteine hydrolase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427776
PNG
(CHEMBL2325179)
Show SMILES O=C(NCc1ccc(cc1)C#N)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H11N5OS/c16-8-10-1-3-11(4-2-10)9-17-15(21)18-12-5-6-13-14(7-12)22-20-19-13/h1-7H,9H2,(H2,17,18,21)
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427794
PNG
(CHEMBL2325191)
Show SMILES OC(CNC(=O)Nc1ccc2nnsc2c1)c1ccccc1
Show InChI InChI=1S/C15H14N4O2S/c20-13(10-4-2-1-3-5-10)9-16-15(21)17-11-6-7-12-14(8-11)22-19-18-12/h1-8,13,20H,9H2,(H2,16,17,21)
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427771
PNG
(CHEMBL2325184)
Show SMILES Fc1ccc(CCCNC(=O)Nc2ccc3nnsc3c2)cc1
Show InChI InChI=1S/C16H15FN4OS/c17-12-5-3-11(4-6-12)2-1-9-18-16(22)19-13-7-8-14-15(10-13)23-21-20-14/h3-8,10H,1-2,9H2,(H2,18,19,22)
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50431676
PNG
(CHEMBL2349526)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Br)c2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H20BrN5O5S/c16-6-3-21(13-9(6)12(18)19-5-20-13)14-11(23)10(22)8(26-14)4-27-2-1-7(17)15(24)25/h3,5,7-8,10-11,14,22-23H,1-2,4,17H2,(H,24,25)(H2,18,19,20)/t7-,8+,10+,11+,14+/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427768
PNG
(CHEMBL2325441)
Show SMILES O=C(NCCC1=CCCCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H18N4OS/c20-15(16-9-8-11-4-2-1-3-5-11)17-12-6-7-13-14(10-12)21-19-18-13/h4,6-7,10H,1-3,5,8-9H2,(H2,16,17,20)
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427770
PNG
(CHEMBL2325185)
Show SMILES O=C(NCCC1CCNCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C14H19N5OS/c20-14(16-8-5-10-3-6-15-7-4-10)17-11-1-2-12-13(9-11)21-19-18-12/h1-2,9-10,15H,3-8H2,(H2,16,17,20)
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427775
PNG
(CHEMBL2325180)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2ccc3nnsc3c2)cc1
Show InChI InChI=1S/C15H11F3N4OS/c16-15(17,18)10-3-1-9(2-4-10)8-19-14(23)20-11-5-6-12-13(7-11)24-22-21-12/h1-7H,8H2,(H2,19,20,23)
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n/an/a 3.10E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427796
PNG
(CHEMBL2325189)
Show SMILES O=C(NCCCC1CCNCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H21N5OS/c21-15(17-7-1-2-11-5-8-16-9-6-11)18-12-3-4-13-14(10-12)22-20-19-13/h3-4,10-11,16H,1-2,5-9H2,(H2,17,18,21)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427791
PNG
(CHEMBL2325194)
Show SMILES OC(CNC(=O)Nc1ccc2nnsc2c1)c1ccccc1F
Show InChI InChI=1S/C15H13FN4O2S/c16-11-4-2-1-3-10(11)13(21)8-17-15(22)18-9-5-6-12-14(7-9)23-20-19-12/h1-7,13,21H,8H2,(H2,17,18,22)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427757
PNG
(CHEMBL2325163)
Show SMILES O=C(NCCC1CCOCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C14H18N4O2S/c19-14(15-6-3-10-4-7-20-8-5-10)16-11-1-2-12-13(9-11)21-18-17-12/h1-2,9-10H,3-8H2,(H2,15,16,19)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427769
PNG
(CHEMBL2325186)
Show SMILES N[C@H]1CC[C@@H](CCNC(=O)Nc2ccc3nnsc3c2)CC1
Show InChI InChI=1S/C15H21N5OS/c16-11-3-1-10(2-4-11)7-8-17-15(21)18-12-5-6-13-14(9-12)22-20-19-13/h5-6,9-11H,1-4,7-8,16H2,(H2,17,18,21)/t10-,11+
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427774
PNG
(CHEMBL2325181)
Show SMILES Fc1ccc(CNC(=O)Nc2ccc3nnsc3c2)cc1
Show InChI InChI=1S/C14H11FN4OS/c15-10-3-1-9(2-4-10)8-16-14(20)17-11-5-6-12-13(7-11)21-19-18-12/h1-7H,8H2,(H2,16,17,20)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427792
PNG
(CHEMBL2325193)
Show SMILES OC(CNC(=O)Nc1ccc2nnsc2c1)c1ccc(F)cc1
Show InChI InChI=1S/C15H13FN4O2S/c16-10-3-1-9(2-4-10)13(21)8-17-15(22)18-11-5-6-12-14(7-11)23-20-19-12/h1-7,13,21H,8H2,(H2,17,18,22)
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n/an/a 4.40E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427793
PNG
(CHEMBL2325192)
Show SMILES FC(F)(CNC(=O)Nc1ccc2nnsc2c1)c1ccccc1
Show InChI InChI=1S/C15H12F2N4OS/c16-15(17,10-4-2-1-3-5-10)9-18-14(22)19-11-6-7-12-13(8-11)23-21-20-12/h1-8H,9H2,(H2,18,19,22)
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427756
PNG
(CHEMBL2325164)
Show SMILES O=C(NCCN1CCCCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C14H19N5OS/c20-14(15-6-9-19-7-2-1-3-8-19)16-11-4-5-12-13(10-11)21-18-17-12/h4-5,10H,1-3,6-9H2,(H2,15,16,20)
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n/an/a 5.20E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427797
PNG
(CHEMBL2325188)
Show SMILES N[C@H]1CC[C@H](CCCNC(=O)Nc2ccc3nnsc3c2)CC1
Show InChI InChI=1S/C16H23N5OS/c17-12-5-3-11(4-6-12)2-1-9-18-16(22)19-13-7-8-14-15(10-13)23-21-20-14/h7-8,10-12H,1-6,9,17H2,(H2,18,19,22)/t11-,12-
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n/an/a 5.30E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427795
PNG
(CHEMBL2325190)
Show SMILES NC(CNC(=O)Nc1ccc2nnsc2c1)c1ccccc1
Show InChI InChI=1S/C15H15N5OS/c16-12(10-4-2-1-3-5-10)9-17-15(21)18-11-6-7-13-14(8-11)22-20-19-13/h1-8,12H,9,16H2,(H2,17,18,21)
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50328743
PNG
(3-((4-acetamidophenyl)diazenyl)-4-hydroxy-7-(3-(5-...)
Show SMILES CC(=O)Nc1ccc(cc1)N=Nc1c(O)c2ccc(NC(=O)Nc3ccc4c(O)c(N=Nc5ccccc5)c(cc4c3)S(O)(=O)=O)cc2cc1S(O)(=O)=O
Show InChI InChI=1S/C35H27N7O10S2/c1-19(43)36-22-7-9-24(10-8-22)40-42-32-30(54(50,51)52)18-21-16-26(12-14-28(21)34(32)45)38-35(46)37-25-11-13-27-20(15-25)17-29(53(47,48)49)31(33(27)44)41-39-23-5-3-2-4-6-23/h2-18,44-45H,1H3,(H,36,43)(H2,37,38,46)(H,47,48,49)(H,50,51,52)
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n/an/a 7.10E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of His6x-tagged PRMT3-mediated arginine methylation expressed in Escherichia coli BL21 (DE3) using GAR R4 peptide and [14C]-SAM by scintil...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427754
PNG
(CHEMBL2325166)
Show SMILES O=C(NCCCN1CCOCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C14H19N5O2S/c20-14(15-4-1-5-19-6-8-21-9-7-19)16-11-2-3-12-13(10-11)22-18-17-12/h2-3,10H,1,4-9H2,(H2,15,16,20)
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n/an/a 7.20E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50387477
PNG
(CHEMBL2047477)
Show SMILES CCn1c2cccc3cccc(c23)\c1=C\[CH+]\C=c1/n(CC)c2cccc3cccc1c23
Show InChI InChI=1S/C29H25N2/c1-3-30-24(22-14-5-10-20-12-7-18-26(30)28(20)22)16-9-17-25-23-15-6-11-21-13-8-19-27(29(21)23)31(25)4-2/h5-19H,3-4H2,1-2H3/q+1/b24-16-,25-17-
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n/an/a 8.30E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of His6X-tagged PRMT3 expressed in Escherichia coli BL21(DE3) cells using [14C]-S-adenosyl-L-methionine and histone H4 peptide after 8 min...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427785
PNG
(CHEMBL2325170)
Show SMILES CC(C)(C)CCNC(=O)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C13H18N4OS/c1-13(2,3)6-7-14-12(18)15-9-4-5-10-11(8-9)19-17-16-10/h4-5,8H,6-7H2,1-3H3,(H2,14,15,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427798
PNG
(CHEMBL2325187)
Show SMILES N[C@H]1CC[C@H](CCNC(=O)Nc2ccc3nnsc3c2)CC1
Show InChI InChI=1S/C15H21N5OS/c16-11-3-1-10(2-4-11)7-8-17-15(21)18-12-5-6-13-14(9-12)22-20-19-13/h5-6,9-11H,1-4,7-8,16H2,(H2,17,18,21)/t10-,11-
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50353131
PNG
(CHEMBL1829304)
Show SMILES COc1cc2c(NC3CCN(CC3)C3CCCCC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C
Show InChI InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427753
PNG
(CHEMBL2325167)
Show SMILES O=C(NCCN1CCCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C13H17N5OS/c19-13(14-5-8-18-6-1-2-7-18)15-10-3-4-11-12(9-10)20-17-16-11/h3-4,9H,1-2,5-8H2,(H2,14,15,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427755
PNG
(CHEMBL2325165)
Show SMILES O=C(NCCN1CCOCC1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C13H17N5O2S/c19-13(14-3-4-18-5-7-20-8-6-18)15-10-1-2-11-12(9-10)21-17-16-11/h1-2,9H,3-8H2,(H2,14,15,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427781
PNG
(CHEMBL2325174)
Show SMILES O=C(NCc1ccncc1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C13H11N5OS/c19-13(15-8-9-3-5-14-6-4-9)16-10-1-2-11-12(7-10)20-18-17-11/h1-7H,8H2,(H2,15,16,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427779
PNG
(CHEMBL2325176)
Show SMILES COc1ccc(CNC(=O)Nc2ccc3nnsc3c2)cc1
Show InChI InChI=1S/C15H14N4O2S/c1-21-12-5-2-10(3-6-12)9-16-15(20)17-11-4-7-13-14(8-11)22-19-18-13/h2-8H,9H2,1H3,(H2,16,17,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427780
PNG
(CHEMBL2325175)
Show SMILES CN(C)c1ccc(CNC(=O)Nc2ccc3nnsc3c2)cc1
Show InChI InChI=1S/C16H17N5OS/c1-21(2)13-6-3-11(4-7-13)10-17-16(22)18-12-5-8-14-15(9-12)23-20-19-14/h3-9H,10H2,1-2H3,(H2,17,18,22)
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n/an/a>1.50E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427786
PNG
(CHEMBL2325169)
Show SMILES CCNC(=O)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C9H10N4OS/c1-2-10-9(14)11-6-3-4-7-8(5-6)15-13-12-7/h3-5H,2H2,1H3,(H2,10,11,14)
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n/an/a>1.50E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427782
PNG
(CHEMBL2325173)
Show SMILES O=C(NCc1cccnc1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C13H11N5OS/c19-13(15-8-9-2-1-5-14-7-9)16-10-3-4-11-12(6-10)20-18-17-11/h1-7H,8H2,(H2,15,16,19)
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n/an/a>1.50E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427783
PNG
(CHEMBL2325172)
Show SMILES O=C(NCc1ccccn1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C13H11N5OS/c19-13(15-8-10-3-1-2-6-14-10)16-9-4-5-11-12(7-9)20-18-17-11/h1-7H,8H2,(H2,15,16,19)
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University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50301077
PNG
(2-(4-(2-(2,6-dimethoxyphenyl)-7-methyl-1H-benzo[d]...)
Show SMILES CNCCN1CCC(CC1)c1cc(C)c2nc([nH]c2c1)-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H32N4O2/c1-16-14-18(17-8-11-28(12-9-17)13-10-25-2)15-19-23(16)27-24(26-19)22-20(29-3)6-5-7-21(22)30-4/h5-7,14-15,17,25H,8-13H2,1-4H3,(H,26,27)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PRMT3


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM27659
PNG
(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...)
Show SMILES C[C@H](N)C(=O)NCc1cccc(c1)-n1nc(cc1C(=O)NCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O2/c1-14(26)20(31)27-13-16-8-5-9-17(10-16)30-18(11-19(29-30)22(23,24)25)21(32)28-12-15-6-3-2-4-7-15/h2-11,14H,12-13,26H2,1H3,(H,27,31)(H,28,32)/t14-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged PRMT3 by methylation assay


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427773
PNG
(CHEMBL2325182)
Show SMILES FC(F)(F)c1ccccc1CNC(=O)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C15H11F3N4OS/c16-15(17,18)11-4-2-1-3-9(11)8-19-14(23)20-10-5-6-12-13(7-10)24-22-21-12/h1-7H,8H2,(H2,19,20,23)
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n/an/a>2.50E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50427784
PNG
(CHEMBL2325171)
Show SMILES O=C(NCc1ccccc1)Nc1ccc2nnsc2c1
Show InChI InChI=1S/C14H12N4OS/c19-14(15-9-10-4-2-1-3-5-10)16-11-6-7-12-13(8-11)20-18-17-12/h1-8H,9H2,(H2,15,16,19)
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n/an/a>2.50E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50258790
PNG
((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)
Show SMILES C[C@H](N)C(=O)NCc1cccc(c1)-n1nc(cc1-c1nnc(o1)-c1cccc2ncsc12)C(F)(F)F
Show InChI InChI=1S/C23H18F3N7O2S/c1-12(27)20(34)28-10-13-4-2-5-14(8-13)33-17(9-18(32-33)23(24,25)26)22-31-30-21(35-22)15-6-3-7-16-19(15)36-11-29-16/h2-9,11-12H,10,27H2,1H3,(H,28,34)/t12-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 by methylation assay


Citation and Details
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM50323813
PNG
(7-(2-(2-(Dimethylamino)ethoxy)ethoxy)-6-methoxy-2-...)
Show SMILES COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCOCCN(C)C)N1CCCN(C)CC1
Show InChI InChI=1S/C27H45N7O3/c1-31(2)15-16-36-17-18-37-25-20-23-22(19-24(25)35-5)26(28-21-7-11-33(4)12-8-21)30-27(29-23)34-10-6-9-32(3)13-14-34/h19-21H,6-18H2,1-5H3,(H,28,29,30)
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n/an/a>4.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Activity at methyl transferase activity PRMT3 by enzyme coupled S-adenocylehomocystein detection assay


Citation and Details
More data for this
Ligand-Target Pair
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