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Found 29 hits Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13320
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid [6-Cyano-1-(...)
Show SMILES CC(=C)CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C23H27N7O2S/c1-17(2)11-30(33(31,32)23-14-27(3)16-26-23)20-8-19-7-18(9-24)5-6-22(19)29(12-20)13-21-10-25-15-28(21)4/h5-7,10,14-16,20H,1,8,11-13H2,2-4H3
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n/an/a 0.700n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13321
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid (2-Bromoally...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(Br)=C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C22H24BrN7O2S/c1-16(23)10-30(33(31,32)22-13-27(2)15-26-22)19-7-18-6-17(8-24)4-5-21(18)29(11-19)12-20-9-25-14-28(20)3/h4-6,9,13-15,19H,1,7,10-12H2,2-3H3
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n/an/a 0.800n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13319
PNG
(BMS-386914 | CHEMBL183536 | [[6-Cyano-1-(3-methyl-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(=O)OC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C25H31N7O4S/c1-25(2,3)36-24(33)15-32(37(34,35)23-14-29(4)17-28-23)20-9-19-8-18(10-26)6-7-22(19)31(12-20)13-21-11-27-16-30(21)5/h6-8,11,14,16-17,20H,9,12-13,15H2,1-5H3
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n/an/a 1.20n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13323
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-[6-cy...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(Cc1ccccc1)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C26H27N7O2S/c1-30-17-26(29-19-30)36(34,35)33(14-20-6-4-3-5-7-20)23-11-22-10-21(12-27)8-9-25(22)32(15-23)16-24-13-28-18-31(24)2/h3-10,13,17-19,23H,11,14-16H2,1-2H3
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n/an/a 1.20n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13322
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC(=O)NC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C25H32N8O3S/c1-25(2,3)29-23(34)14-33(37(35,36)24-15-30(4)17-28-24)20-9-19-8-18(10-26)6-7-22(19)32(12-20)13-21-11-27-16-31(21)5/h6-8,11,15-17,20H,9,12-14H2,1-5H3,(H,29,34)
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n/an/a 1.5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13331
PNG
(N-tert-butyl-2-({6-isocyano-1-[(1-methyl-1H-imidaz...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-24(34)17-33(37(35,36)25-8-6-7-11-29-25)21-13-19-12-20(27-4)9-10-23(19)32(15-21)16-22-14-28-18-31(22)5/h6-12,14,18,21H,13,15-17H2,1-3,5H3,(H,30,34)
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n/an/a 1.80n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13328
PNG
(N-{6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1...)
Show SMILES Cc1onc(c1CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1ccccn1)-c1ccccc1
Show InChI InChI=1S/C31H29N7O3S/c1-22-28(31(35-41-22)24-8-4-3-5-9-24)20-38(42(39,40)30-10-6-7-13-34-30)26-15-25-14-23(16-32)11-12-29(25)37(18-26)19-27-17-33-21-36(27)2/h3-14,17,21,26H,15,18-20H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13325
PNG
(4-{[[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CC1CCN(CC1)C(=O)OC(C)(C)C)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C30H40N8O4S/c1-30(2,3)42-29(39)36-10-8-22(9-11-36)16-38(43(40,41)28-19-34(4)21-33-28)25-13-24-12-23(14-31)6-7-27(24)37(17-25)18-26-15-32-20-35(26)5/h6-7,12,15,19-22,25H,8-11,13,16-18H2,1-5H3
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n/an/a 3.20n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13324
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid [6-Cyano-1-(...)
Show SMILES Cc1ccccc1CN(C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C27H29N7O2S/c1-20-6-4-5-7-22(20)14-34(37(35,36)27-17-31(2)19-30-27)24-11-23-10-21(12-28)8-9-26(23)33(15-24)16-25-13-29-18-32(25)3/h4-10,13,17-19,24H,11,14-16H2,1-3H3
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n/an/a 3.40n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13327
PNG
(N-{6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccccn1)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C26H25N7O2S/c1-31-19-28-15-24(31)18-32-17-23(13-21-12-20(14-27)8-9-25(21)32)33(16-22-6-2-4-10-29-22)36(34,35)26-7-3-5-11-30-26/h2-12,15,19,23H,13,16-18H2,1H3
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n/an/a 3.80n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13335
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(CC(=O)NC(C)(C)C)S(=O)(=O)c1nccn1C
Show InChI InChI=1S/C25H32N8O3S/c1-25(2,3)29-23(34)16-33(37(35,36)24-28-8-9-30(24)4)20-11-19-10-18(12-26)6-7-22(19)32(14-20)15-21-13-27-17-31(21)5/h6-10,13,17,20H,11,14-16H2,1-5H3,(H,29,34)
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n/an/a 5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13332
PNG
(N-tert-Butyl-2-[[6-isocyano-1-(3-methyl-3H-imidazo...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1cccnc1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-25(34)17-33(37(35,36)23-7-6-10-28-14-23)21-12-19-11-20(27-4)8-9-24(19)32(15-21)16-22-13-29-18-31(22)5/h6-11,13-14,18,21H,12,15-17H2,1-3,5H3,(H,30,34)
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n/an/a 6n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13315
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC1CCCCC1
Show InChI InChI=1S/C25H33N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h8-11,15,18-20,22H,3-7,12-13,16-17H2,1-2H3
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n/an/a 7.5n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13334
PNG
(N-tert-Butyl-2-[[6-cyano-1-(3-methyl-3H-imidazol-4...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(CC(=O)NC(C)(C)C)S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C28H33FN6O3S/c1-28(2,3)32-27(36)17-35(39(37,38)18-20-5-8-23(29)9-6-20)24-12-22-11-21(13-30)7-10-26(22)34(15-24)16-25-14-31-19-33(25)4/h5-11,14,19,24H,12,15-18H2,1-4H3,(H,32,36)
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n/an/a 7.60n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13330
PNG
(N-[(6-chloro-2,1,3-benzothiadiazol-5-yl)methyl]-N-...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1cc2nsnc2cc1Cl)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C27H23ClN8O2S2/c1-34-17-30-13-22(34)16-35-15-21(9-19-8-18(12-29)5-6-26(19)35)36(40(37,38)27-4-2-3-7-31-27)14-20-10-24-25(11-23(20)28)33-39-32-24/h2-8,10-11,13,17,21H,9,14-16H2,1H3
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n/an/a 10n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13313
PNG
(N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H27N5O2S/c1-30-22-29-19-26(30)21-31(25-14-12-23(18-28)13-15-25)16-17-32(20-24-8-4-2-5-9-24)35(33,34)27-10-6-3-7-11-27/h2-15,19,22H,16-17,20-21H2,1H3
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n/an/a 13n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13311
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cc1ccccc1CN(CCN(Cc1cncn1C)c1ccc(cc1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C26H29N7O2S/c1-21-6-4-5-7-23(21)16-33(36(34,35)26-18-30(2)20-29-26)13-12-32(17-25-15-28-19-31(25)3)24-10-8-22(14-27)9-11-24/h4-11,15,18-20H,12-13,16-17H2,1-3H3
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n/an/a 15.5n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13307
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C25H27N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h3-11,15,18-20H,12-13,16-17H2,1-2H3
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n/an/a 25n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13310
PNG
(N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccn1
Show InChI InChI=1S/C24H26N8O2S/c1-29-17-24(28-19-29)35(33,34)32(15-21-5-3-4-10-27-21)12-11-31(16-23-14-26-18-30(23)2)22-8-6-20(13-25)7-9-22/h3-10,14,17-19H,11-12,15-16H2,1-2H3
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n/an/a 43n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13309
PNG
(N-(2-{(4-bromophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(Br)cc1)Cc1ccccn1
Show InChI InChI=1S/C23H26BrN7O2S/c1-28-16-23(27-18-28)34(32,33)31(14-20-5-3-4-10-26-20)12-11-30(15-22-13-25-17-29(22)2)21-8-6-19(24)7-9-21/h3-10,13,16-18H,11-12,14-15H2,1-2H3
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n/an/a 83n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13333
PNG
(N-tert-Butyl-2-[[6-isocyano-1-(3-methyl-3H-imidazo...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)[N+]#[C-])N(CC(=O)NC(C)(C)C)S(=O)(=O)c1ccncc1
Show InChI InChI=1S/C26H31N7O3S/c1-26(2,3)30-25(34)17-33(37(35,36)23-8-10-28-11-9-23)21-13-19-12-20(27-4)6-7-24(19)32(15-21)16-22-14-29-18-31(22)5/h6-12,14,18,21H,13,15-17H2,1-3,5H3,(H,30,34)
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n/an/a 160n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13314
PNG
(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C33H34N6O2S/c1-36(2)32-13-7-12-31-30(32)11-8-14-33(31)42(40,41)39(23-27-9-5-4-6-10-27)20-19-38(24-29-22-35-25-37(29)3)28-17-15-26(21-34)16-18-28/h4-18,22,25H,19-20,23-24H2,1-3H3
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n/an/a 180n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13308
PNG
(N-benzyl-N-(2-{(4-bromophenyl)[(1-methyl-1H-imidaz...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(Br)cc1)Cc1ccccc1
Show InChI InChI=1S/C24H27BrN6O2S/c1-28-17-24(27-19-28)34(32,33)31(15-20-6-4-3-5-7-20)13-12-30(16-23-14-26-18-29(23)2)22-10-8-21(25)9-11-22/h3-11,14,17-19H,12-13,15-16H2,1-2H3
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n/an/a 290n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13318
PNG
(N-(4-cyanobenzyl)-N-(2-{(4-cyanophenyl)[(1-methyl-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N8O2S/c1-31-18-26(30-20-31)37(35,36)34(16-23-5-3-21(13-27)4-6-23)12-11-33(17-25-15-29-19-32(25)2)24-9-7-22(14-28)8-10-24/h3-10,15,18-20H,11-12,16-17H2,1-2H3
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n/an/a 350n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13329
PNG
(N-[(1-bromonaphthalen-2-yl)methyl]-N-{6-cyano-1-[(...)
Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccc2ccccc2c1Br)S(=O)(=O)c1ccccn1
Show InChI InChI=1S/C31H27BrN6O2S/c1-36-21-34-17-27(36)20-37-19-26(15-25-14-22(16-33)9-12-29(25)37)38(41(39,40)30-8-4-5-13-35-30)18-24-11-10-23-6-2-3-7-28(23)31(24)32/h2-14,17,21,26H,15,18-20H2,1H3
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n/an/a 440n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13316
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Biphenyl-4-y...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H31N7O2S/c1-35-22-31(34-24-35)41(39,40)38(20-26-8-12-28(13-9-26)27-6-4-3-5-7-27)17-16-37(21-30-19-33-23-36(30)2)29-14-10-25(18-32)11-15-29/h3-15,19,22-24H,16-17,20-21H2,1-2H3
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n/an/a 880n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13312
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[Biphenyl...)
Show SMILES Cc1ccccc1CN(CCN(Cc1cncn1C)c1ccc(cc1)-c1ccccc1)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C31H34N6O2S/c1-25-9-7-8-12-28(25)20-37(40(38,39)31-22-34(2)24-33-31)18-17-36(21-30-19-32-23-35(30)3)29-15-13-27(14-16-29)26-10-5-4-6-11-26/h4-16,19,22-24H,17-18,20-21H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13317
PNG
(N-tert-butyl-2-({2-[(4-cyanophenyl)[(1-methyl-1H-i...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H32N8O3S/c1-24(2,3)28-22(33)15-32(36(34,35)23-16-29(4)18-27-23)11-10-31(14-21-13-26-17-30(21)5)20-8-6-19(12-25)7-9-20/h6-9,13,16-18H,10-11,14-15H2,1-5H3,(H,28,33)
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n/an/a>1.00E+3n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)

More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13326
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid (1-Bromonaph...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(Cc1ccc2ccccc2c1Br)C1CN(Cc2cncn2C)c2ccc(cc2C1)C#N
Show InChI InChI=1S/C30H28BrN7O2S/c1-35-18-29(34-20-35)41(39,40)38(15-23-9-8-22-5-3-4-6-27(22)30(23)31)25-12-24-11-21(13-32)7-10-28(24)37(16-25)17-26-14-33-19-36(26)2/h3-11,14,18-20,25H,12,15-17H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 48: 3704-13 (2005)

More data for this
Ligand-Target Pair