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Found 234 hits Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50289981
PNG
(Prenyl pyrophosphate analogue | {[(2E,6E)-8-[(3-be...)
Show SMILES C\C(CC\C=C(/C)COC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C24H28O10P2/c1-18(14-15-33-36(30,31)34-35(27,28)29)8-6-9-19(2)17-32-24(26)22-13-7-12-21(16-22)23(25)20-10-4-3-5-11-20/h3-5,7,9-14,16H,6,8,15,17H2,1-2H3,(H,30,31)(H2,27,28,29)/p-3/b18-14+,19-9+
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380n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of yeast Farnesyl transferase


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50289982
PNG
(Prenyl pyrophosphate analogue)
Show SMILES C\C(CC\C=C(/C)CNC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C24H29NO9P2/c1-18(14-15-33-36(31,32)34-35(28,29)30)8-6-9-19(2)17-25-24(27)22-13-7-12-21(16-22)23(26)20-10-4-3-5-11-20/h3-5,7,9-14,16H,6,8,15,17H2,1-2H3,(H,25,27)(H,31,32)(H2,28,29,30)/p-3/b18-14+,19-9+
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700n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of yeast Farnesyl transferase


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50289979
PNG
(Prenyl pyrophosphate analogue | {[(2E)-4-[(3-benzo...)
Show SMILES C\C(COC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C19H20O10P2/c1-14(10-11-28-31(25,26)29-30(22,23)24)13-27-19(21)17-9-5-8-16(12-17)18(20)15-6-3-2-4-7-15/h2-10,12H,11,13H2,1H3,(H,25,26)(H2,22,23,24)/p-3/b14-10+
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960n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of yeast Farnesyl transferase


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50289978
PNG
(Prenyl pyrophosphate analogue | {[(2E)-4-[(3-benzo...)
Show SMILES C\C(CNC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1S/C19H21NO9P2/c1-14(10-11-28-31(26,27)29-30(23,24)25)13-20-19(22)17-9-5-8-16(12-17)18(21)15-6-3-2-4-7-15/h2-10,12H,11,13H2,1H3,(H,20,22)(H,26,27)(H2,23,24,25)/p-3/b14-10+
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6.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of yeast Farnesyl transferase


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50144314
PNG
((2E,4E,6E,8E)-3,7,11-trimethyldodeca-2,4,6,8,10-pe...)
Show SMILES CC(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\COP(O)(=O)OP(O)(O)=O
Show InChI InChI=1S/C15H24O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h5-11H,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b8-5+,10-6+,14-9+,15-11+
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8.80E+3n/an/an/an/an/an/an/an/a



The University of Utah

Curated by ChEMBL


Assay Description
Dissociation constant against yeast farnesyltransferase


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50080764
PNG
((S)-2-({5-[(Benzyl-pyridin-3-yl-amino)-methyl]-2'-...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cccnc2)cc1-c1ccccc1C)C(O)=O
Show InChI InChI=1S/C32H33N3O3S/c1-23-9-6-7-13-27(23)29-19-25(14-15-28(29)31(36)34-30(32(37)38)16-18-39-2)22-35(26-12-8-17-33-20-26)21-24-10-4-3-5-11-24/h3-15,17,19-20,30H,16,18,21-22H2,1-2H3,(H,34,36)(H,37,38)/t30-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase


J Med Chem 44: 3117-24 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50067563
PNG
((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C)C(O)=O
Show InChI InChI=1S/C25H26N2O4S/c1-17-6-3-4-8-20(17)22-14-18(16-31-19-7-5-12-26-15-19)9-10-21(22)24(28)27-23(25(29)30)11-13-32-2/h3-10,12,14-15,23H,11,13,16H2,1-2H3,(H,27,28)(H,29,30)/t23-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase


J Med Chem 44: 3117-24 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50177232
PNG
(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)
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n/an/a 5n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Anchorage-independent growth of transformed NIH3T3 cells in soft agar


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50177232
PNG
(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCCn3ccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C32H39BrClN7O2/c33-24-17-23-8-7-22-18-25(34)9-10-27(22)30(29(23)37-19-24)40-15-16-41(32(43)38-26-5-2-1-3-6-26)28(20-40)31(42)36-11-4-13-39-14-12-35-21-39/h9-10,12,14,17-19,21,26,28,30H,1-8,11,13,15-16,20H2,(H,36,42)(H,38,43)
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n/an/a 5.20n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Anchorage-independent growth of transformed NIH3T3 cells in soft agar


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50072626
PNG
((S)-2-[2-({(S)-2-[2-(4-Cyano-benzylsulfanyl)-acety...)
Show SMILES CCC(C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1cccc2ccccc12)NC(=O)CSCc1ccc(cc1)C#N
Show InChI InChI=1S/C34H42N4O4S2/c1-4-24(2)31(37-33(40)23-44-22-26-14-12-25(18-35)13-15-26)20-38(21-32(39)36-30(34(41)42)16-17-43-3)19-28-10-7-9-27-8-5-6-11-29(27)28/h5-15,24,30-31H,4,16-17,19-23H2,1-3H3,(H,36,39)(H,37,40)(H,41,42)/t24?,30-,31+/m0/s1
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n/an/a 5.40n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase


J Med Chem 44: 3117-24 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50104054
PNG
(4-Methylsulfanyl-2-{[5-(5-phenyl-furan-2-ylmethoxy...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccc2)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C30H29NO5S/c1-37-17-16-27(30(33)34)31-29(32)25-14-12-21(18-26(25)22-8-4-2-5-9-22)19-35-20-24-13-15-28(36-24)23-10-6-3-7-11-23/h2-15,18,27H,16-17,19-20H2,1H3,(H,31,32)(H,33,34)/t27-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase


J Med Chem 44: 3117-24 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50104052
PNG
(2-{2-[(2-{2-[1-(4-Cyano-benzyl)-4,5-dihydro-1H-imi...)
Show SMILES CCC(C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1cccc2ccccc12)NC(=O)CC1CN(Cc2ccc(cc2)C#N)C=N1
Show InChI InChI=1S/C37H46N6O4S/c1-4-26(2)34(41-35(44)18-31-22-43(25-39-31)20-28-14-12-27(19-38)13-15-28)23-42(24-36(45)40-33(37(46)47)16-17-48-3)21-30-10-7-9-29-8-5-6-11-32(29)30/h5-15,25-26,31,33-34H,4,16-18,20-24H2,1-3H3,(H,40,45)(H,41,44)(H,46,47)/t26?,31?,33-,34+/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase


J Med Chem 44: 3117-24 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50097814
PNG
((S)-2-[(5-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C
Show InChI InChI=1S/C25H30N4O3S/c1-17-6-4-5-7-20(17)22-12-18(13-26-14-19-15-27-16-28-19)8-9-21(22)24(30)29-23(10-11-33-3)25(31)32-2/h4-9,12,15-16,23,26H,10-11,13-14H2,1-3H3,(H,27,28)(H,29,30)/t23-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50104047
PNG
((E)-N-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)\C=C\c3ccc(o3)-c3ccc(cc3)[N+]([O-])=O)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C35H27N3O6/c1-23-7-9-24(10-8-23)21-34(40)37-31-18-13-27(22-30(31)35(41)26-5-3-2-4-6-26)36-33(39)20-17-29-16-19-32(44-29)25-11-14-28(15-12-25)38(42)43/h2-20,22H,21H2,1H3,(H,36,39)(H,37,40)/b20-17+
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n/an/a 35n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase


J Med Chem 44: 3117-24 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103281
PNG
(1-(3-Benzoyl-4-diphenylacetylamino-phenylcarbamoyl...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)C(c2ccccc2)c2ccccc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C30H27N3O3S/c31-25(19-37)29(35)32-23-16-17-26(24(18-23)28(34)22-14-8-3-9-15-22)33-30(36)27(20-10-4-1-5-11-20)21-12-6-2-7-13-21/h1-18,25,27,37H,19,31H2,(H,32,35)(H,33,36)/p+1/t25-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50079787
PNG
(CHEMBL303859 | methyl 2-[1-[5-amino-2-isopropyl-6-...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1C[C@@H](CN1C[C@H](\C=C\[C@@H](N)CS)C(C)C)Oc1ccccc1
Show InChI InChI=1S/C26H41N3O4S2/c1-18(2)19(10-11-20(27)17-34)15-29-16-22(33-21-8-6-5-7-9-21)14-24(29)25(30)28-23(12-13-35-4)26(31)32-3/h5-11,18-20,22-24,34H,12-17,27H2,1-4H3,(H,28,30)/b11-10+/t19-,20+,22-,23-,24-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Eisai Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-ras


Bioorg Med Chem Lett 9: 2095-100 (1999)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327974
PNG
(CHEMBL1258797 | N-Benzyl,N-{2-[(4-Cyanophenyl)-(3-...)
Show SMILES CCCS(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C24H29N5O2S/c1-3-15-32(30,31)29(18-22-7-5-4-6-8-22)14-13-28(19-24-17-26-20-27(24)2)23-11-9-21(16-25)10-12-23/h4-12,17,20H,3,13-15,18-19H2,1-2H3
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n/an/a 70n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103269
PNG
(1-{3-Benzoyl-4-[2-(4-bromo-phenyl)-acetylamino]-ph...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(Br)cc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H22BrN3O3S/c25-17-8-6-15(7-9-17)12-22(29)28-21-11-10-18(27-24(31)20(26)14-32)13-19(21)23(30)16-4-2-1-3-5-16/h1-11,13,20,32H,12,14,26H2,(H,27,31)(H,28,29)/p+1/t20-/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103285
PNG
(1-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenylcarba...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)[C@@H]([NH3+])CS)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C25H25N3O3S/c1-16-7-9-17(10-8-16)13-23(29)28-22-12-11-19(27-25(31)21(26)15-32)14-20(22)24(30)18-5-3-2-4-6-18/h2-12,14,21,32H,13,15,26H2,1H3,(H,27,31)(H,28,29)/p+1/t21-/m0/s1
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n/an/a 77n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103271
PNG
(1-(3-Benzoyl-4-phenylmethanesulfonylamino-phenylca...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NS(=O)(=O)Cc2ccccc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H23N3O4S2/c24-20(14-31)23(28)25-18-11-12-21(19(13-18)22(27)17-9-5-2-6-10-17)26-32(29,30)15-16-7-3-1-4-8-16/h1-13,20,26,31H,14-15,24H2,(H,25,28)/p+1/t20-/m0/s1
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n/an/a 85n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327998
PNG
(CHEMBL1258350 | N-(2-((4-cyano-2-fluorophenyl)((1-...)
Show SMILES Cn1cncc1CN(CCN(CC1CCCCC1)S(=O)(=O)c1ccccn1)c1ccc(cc1F)C#N
Show InChI InChI=1S/C26H31FN6O2S/c1-31-20-29-17-23(31)19-32(25-11-10-22(16-28)15-24(25)27)13-14-33(18-21-7-3-2-4-8-21)36(34,35)26-9-5-6-12-30-26/h5-6,9-12,15,17,20-21H,2-4,7-8,13-14,18-19H2,1H3
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n/an/a 89n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327976
PNG
(CHEMBL215476 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)
Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccn1)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N6O2S/c1-30-21-28-18-25(30)20-31(24-12-10-22(17-27)11-13-24)15-16-32(19-23-7-3-2-4-8-23)35(33,34)26-9-5-6-14-29-26/h2-14,18,21H,15-16,19-20H2,1H3
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n/an/a 90n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM13315
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC1CCCCC1
Show InChI InChI=1S/C25H33N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h8-11,15,18-20,22H,3-7,12-13,16-17H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103280
PNG
(1-(3-Benzoyl-4-p-tolylmethanesulfonylamino-phenylc...)
Show SMILES Cc1ccc(CS(=O)(=O)Nc2ccc(NC(=O)[C@@H]([NH3+])CS)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C24H25N3O4S2/c1-16-7-9-17(10-8-16)15-33(30,31)27-22-12-11-19(26-24(29)21(25)14-32)13-20(22)23(28)18-5-3-2-4-6-18/h2-13,21,27,32H,14-15,25H2,1H3,(H,26,29)/p+1/t21-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50065394
PNG
((S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylami...)
Show SMILES CCC(C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(=O)OC)Cc1ccccc1)NC[C@@H](N)CS
Show InChI InChI=1S/C24H42N4O3S2/c1-5-18(2)22(26-13-20(25)17-32)15-28(14-19-9-7-6-8-10-19)16-23(29)27-21(11-12-33-4)24(30)31-3/h6-10,18,20-22,26,32H,5,11-17,25H2,1-4H3,(H,27,29)/t18?,20-,21+,22-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of post-translational processing of v-Ras protein in NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103262
PNG
(1-{3-Benzoyl-4-[2-(4-chloro-phenyl)-acetylamino]-p...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(Cl)cc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H22ClN3O3S/c25-17-8-6-15(7-9-17)12-22(29)28-21-11-10-18(27-24(31)20(26)14-32)13-19(21)23(30)16-4-2-1-3-5-16/h1-11,13,20,32H,12,14,26H2,(H,27,31)(H,28,29)/p+1/t20-/m0/s1
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n/an/a 105n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103274
PNG
(1-{3-Benzoyl-4-[2-(4-nitro-phenyl)-acetylamino]-ph...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(cc2)[N+]([O-])=O)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H22N4O5S/c25-20(14-34)24(31)26-17-8-11-21(19(13-17)23(30)16-4-2-1-3-5-16)27-22(29)12-15-6-9-18(10-7-15)28(32)33/h1-11,13,20,34H,12,14,25H2,(H,26,31)(H,27,29)/p+1/t20-/m0/s1
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n/an/a 115n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103261
PNG
(1-{3-Benzoyl-4-[2-(2,4-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(Cl)cc2Cl)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-16-7-6-15(19(26)11-16)10-22(30)29-21-9-8-17(28-24(32)20(27)13-33)12-18(21)23(31)14-4-2-1-3-5-14/h1-9,11-12,20,33H,10,13,27H2,(H,28,32)(H,29,30)/p+1/t20-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM16182
PNG
((2S)-2-[(4-{[(1H-imidazol-4-ylmethyl)amino]methyl}...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C)C(O)=O
Show InChI InChI=1S/C24H28N4O3S/c1-16-5-3-4-6-19(16)21-11-17(12-25-13-18-14-26-15-27-18)7-8-20(21)23(29)28-22(24(30)31)9-10-32-2/h3-8,11,14-15,22,25H,9-10,12-13H2,1-2H3,(H,26,27)(H,28,29)(H,30,31)/t22-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of mammalian H-Ras processing in NIH 3T3 cells


Bioorg Med Chem Lett 11: 761-4 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327997
PNG
(CHEMBL1258232 | N-(2-((4-cyanophenyl)((1-methyl-1H...)
Show SMILES Cn1cncc1CN(CCN(CC1CCCCC1)S(=O)(=O)c1ccccn1)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H32N6O2S/c1-30-21-28-18-25(30)20-31(24-12-10-22(17-27)11-13-24)15-16-32(19-23-7-3-2-4-8-23)35(33,34)26-9-5-6-14-29-26/h5-6,9-14,18,21,23H,2-4,7-8,15-16,19-20H2,1H3
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n/an/a 268n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327999
PNG
(CHEMBL1258351 | N-(2-((5-cyanopyridin-2-yl)((1-met...)
Show SMILES Cn1cncc1CN(CCN(CC1CCCCC1)S(=O)(=O)c1ccccn1)c1ccc(cn1)C#N
Show InChI InChI=1S/C25H31N7O2S/c1-30-20-27-17-23(30)19-31(24-11-10-22(15-26)16-29-24)13-14-32(18-21-7-3-2-4-8-21)35(33,34)25-9-5-6-12-28-25/h5-6,9-12,16-17,20-21H,2-4,7-8,13-14,18-19H2,1H3
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n/an/a 288n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327990
PNG
(1-methyl-1H-imidazole-4-sulfonic acid {2-[(4-cyano...)
Show SMILES Cc1cccc(CN(CCN(Cc2cncn2C)c2ccc(cc2)C#N)S(=O)(=O)c2cn(C)cn2)c1
Show InChI InChI=1S/C26H29N7O2S/c1-21-5-4-6-23(13-21)16-33(36(34,35)26-18-30(2)20-29-26)12-11-32(17-25-15-28-19-31(25)3)24-9-7-22(14-27)8-10-24/h4-10,13,15,18-20H,11-12,16-17H2,1-3H3
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n/an/a 300n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM13313
PNG
(N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H27N5O2S/c1-30-22-29-19-26(30)21-31(25-14-12-23(18-28)13-15-25)16-17-32(20-24-8-4-2-5-9-24)35(33,34)27-10-6-3-7-11-27/h2-15,19,22H,16-17,20-21H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103270
PNG
(1-{3-Benzoyl-4-[2-(2,6-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2c(Cl)cccc2Cl)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-18-7-4-8-19(26)16(18)12-22(30)29-21-10-9-15(28-24(32)20(27)13-33)11-17(21)23(31)14-5-2-1-3-6-14/h1-11,20,33H,12-13,27H2,(H,28,32)(H,29,30)/p+1/t20-/m0/s1
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n/an/a 340n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50079805
PNG
(CHEMBL302834 | methyl 2-[1-[5-amino-6-sulfanyl-(5R...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1C[C@@H](CN1CCCC[C@@H](N)CS)Oc1ccccc1
Show InChI InChI=1S/C23H37N3O4S2/c1-29-23(28)20(11-13-32-2)25-22(27)21-14-19(30-18-9-4-3-5-10-18)15-26(21)12-7-6-8-17(24)16-31/h3-5,9-10,17,19-21,31H,6-8,11-16,24H2,1-2H3,(H,25,27)/t17-,19+,20+,21+/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Eisai Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-ras


Bioorg Med Chem Lett 9: 2095-100 (1999)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50059858
PNG
((S)-2-((3Z,6E)-(2S,5S,8R)-8-Amino-2-benzyl-5-isopr...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1ccccc1)\C=C/[C@@H](\C=C\[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H36N2O3S2/c1-17(2)19(11-12-21(25)16-30)9-10-20(15-18-7-5-4-6-8-18)23(27)26-22(24(28)29)13-14-31-3/h4-12,17,19-22,30H,13-16,25H2,1-3H3,(H,26,27)(H,28,29)/b10-9-,12-11+/t19-,20+,21+,22-/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Eisai Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-ras


Bioorg Med Chem Lett 9: 2095-100 (1999)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103272
PNG
(1-[3-Benzoyl-4-(2-naphthalen-1-yl-acetylamino)-phe...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2cccc3ccccc23)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C28H25N3O3S/c29-24(17-35)28(34)30-21-13-14-25(23(16-21)27(33)19-8-2-1-3-9-19)31-26(32)15-20-11-6-10-18-7-4-5-12-22(18)20/h1-14,16,24,35H,15,17,29H2,(H,30,34)(H,31,32)/p+1/t24-/m0/s1
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n/an/a 380n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50104050
PNG
(5-Phenyl-pentanoic acid [3-benzoyl-4-(2-p-tolyl-ac...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)CCCCc3ccccc3)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C33H32N2O3/c1-24-16-18-26(19-17-24)22-32(37)35-30-21-20-28(23-29(30)33(38)27-13-6-3-7-14-27)34-31(36)15-9-8-12-25-10-4-2-5-11-25/h2-7,10-11,13-14,16-21,23H,8-9,12,15,22H2,1H3,(H,34,36)(H,35,37)
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n/an/a 390n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase


J Med Chem 44: 3117-24 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103260
PNG
(1-[3-Benzoyl-4-(2-o-tolyl-acetylamino)-phenylcarba...)
Show SMILES Cc1ccccc1CC(=O)Nc1ccc(NC(=O)[C@@H]([NH3+])CS)cc1C(=O)c1ccccc1
Show InChI InChI=1S/C25H25N3O3S/c1-16-7-5-6-10-18(16)13-23(29)28-22-12-11-19(27-25(31)21(26)15-32)14-20(22)24(30)17-8-3-2-4-9-17/h2-12,14,21,32H,13,15,26H2,1H3,(H,27,31)(H,28,29)/p+1/t21-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327987
PNG
(CHEMBL1257889 | N-(2-((4-cyanophenyl)((1-methyl-1H...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1cccs1
Show InChI InChI=1S/C23H25N7O2S2/c1-27-16-23(26-18-27)34(31,32)30(15-22-4-3-11-33-22)10-9-29(14-21-13-25-17-28(21)2)20-7-5-19(12-24)6-8-20/h3-8,11,13,16-18H,9-10,14-15H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327985
PNG
(CHEMBL452319 | N-(2-((4-cyanophenyl)((1-methyl-1H-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccsc1
Show InChI InChI=1S/C23H25N7O2S2/c1-27-15-23(26-18-27)34(31,32)30(13-20-7-10-33-16-20)9-8-29(14-22-12-25-17-28(22)2)21-5-3-19(11-24)4-6-21/h3-7,10,12,15-18H,8-9,13-14H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103258
PNG
(1-{3-Benzoyl-4-[2-(2,3-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2cccc(Cl)c2Cl)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-18-8-4-7-15(22(18)26)11-21(30)29-20-10-9-16(28-24(32)19(27)13-33)12-17(20)23(31)14-5-2-1-3-6-14/h1-10,12,19,33H,11,13,27H2,(H,28,32)(H,29,30)/p+1/t19-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50059876
PNG
(CHEMBL217423 | [(S)-1-[(S)-1-{(S)-2-Benzyloxy-1-[(...)
Show SMILES C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H57N9O9/c1-35(49(55)64)59-50(65)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(68)48(33-70-30-37-13-5-2-6-14-37)62-51(66)45(25-36-21-23-42(24-22-36)71-31-38-15-7-3-8-16-38)60-52(67)47(27-41-29-56-34-58-41)63-54(69)72-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33H2,1H3,(H2,55,64)(H,56,58)(H,59,65)(H,60,67)(H,61,68)(H,62,66)(H,63,69)/t35-,45+,46+,47+,48+/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of Ras-processing in H-Ras transformed NIH3T3 fibroblasts


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50104055
PNG
(CHEMBL276748 | N-[3-Benzoyl-4-(2-p-tolyl-acetylami...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)\C=C\c3csc(n3)-c3ccc(cc3)[N+]([O-])=O)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C34H26N4O5S/c1-22-7-9-23(10-8-22)19-32(40)37-30-17-13-26(20-29(30)33(41)24-5-3-2-4-6-24)35-31(39)18-14-27-21-44-34(36-27)25-11-15-28(16-12-25)38(42)43/h2-18,20-21H,19H2,1H3,(H,35,39)(H,37,40)/b18-14+
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n/an/a 455n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase


J Med Chem 44: 3117-24 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103277
PNG
(1-[3-Benzoyl-4-(2-naphthalen-2-yl-acetylamino)-phe...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc3ccccc3c2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C28H25N3O3S/c29-24(17-35)28(34)30-22-12-13-25(23(16-22)27(33)20-7-2-1-3-8-20)31-26(32)15-18-10-11-19-6-4-5-9-21(19)14-18/h1-14,16,24,35H,15,17,29H2,(H,30,34)(H,31,32)/p+1/t24-/m0/s1
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n/an/a 460n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae)
BDBM50103284
PNG
(1-{3-Benzoyl-4-[2-(3,4-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(Cl)c(Cl)c2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-18-8-6-14(10-19(18)26)11-22(30)29-21-9-7-16(28-24(32)20(27)13-33)12-17(21)23(31)15-4-2-1-3-5-15/h1-10,12,20,33H,11,13,27H2,(H,28,32)(H,29,30)/p+1/t20-/m0/s1
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n/an/a 480n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.


J Med Chem 44: 2886-99 (2001)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50079785
PNG
(CHEMBL433102 | methyl 2-[1-[5-amino-6-sulfanyl-(E,...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1C[C@@H](CN1CC\C=C\[C@@H](N)CS)Oc1ccccc1
Show InChI InChI=1S/C23H35N3O4S2/c1-29-23(28)20(11-13-32-2)25-22(27)21-14-19(30-18-9-4-3-5-10-18)15-26(21)12-7-6-8-17(24)16-31/h3-6,8-10,17,19-21,31H,7,11-16,24H2,1-2H3,(H,25,27)/b8-6+/t17-,19+,20+,21+/m1/s1
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n/an/a 490n/an/an/an/an/an/a



Eisai Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-ras


Bioorg Med Chem Lett 9: 2095-100 (1999)

More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50327975
PNG
(CHEMBL215475 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)
Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1cccs1)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H25N5O2S2/c1-28-20-27-17-24(28)19-29(23-11-9-21(16-26)10-12-23)13-14-30(18-22-6-3-2-4-7-22)34(31,32)25-8-5-15-33-25/h2-12,15,17,20H,13-14,18-19H2,1H3
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n/an/a 500n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50059846
PNG
(CHEMBL103575 | L-745631 | [(R)-4-((S)-2-Amino-3-me...)
Show SMILES COCC[C@@H]1CN(CCN1C[C@H](N)CS)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C21H29N3O2S/c1-26-12-9-18-14-24(11-10-23(18)13-17(22)15-27)21(25)20-8-4-6-16-5-2-3-7-19(16)20/h2-8,17-18,27H,9-15,22H2,1H3/t17-,18+/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of Ras processing


Citation and Details
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50369376
PNG
(CHEMBL1790751)
Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(=O)OC)Cc1cccc2ccccc12)NC[C@@H](N)CS
Show InChI InChI=1S/C28H44N4O3S2/c1-5-20(2)26(30-15-23(29)19-36)17-32(16-22-11-8-10-21-9-6-7-12-24(21)22)18-27(33)31-25(13-14-37-4)28(34)35-3/h6-12,20,23,25-26,30,36H,5,13-19,29H2,1-4H3,(H,31,33)/t20-,23-,25+,26-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of post-translational processing of v-Ras protein in NIH3T3 cells


Citation and Details
More data for this
Ligand-Target Pair
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