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Found 30 hits Enz. Inhib. hit(s) with Target = 'Protein kinase B (Akt1 E49C, C296S, C310S and C344S )' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM25013
PNG
(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Show SMILES CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N
Show InChI InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM50313650
PNG
(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1
Show InChI InChI=1S/C25H21N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31)
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n/an/a 6n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153703
PNG
(2-(4-((4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]im...)
Show SMILES Clc1ccc2n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C33H28ClN5O2/c34-24-10-11-30-29(18-24)37-33(41)39(30)25-13-16-38(17-14-25)20-21-6-8-23(9-7-21)31-26(22-4-2-1-3-5-22)19-27-28(36-31)12-15-35-32(27)40/h1-12,15,18-19,25H,13-14,16-17,20H2,(H,35,40)(H,37,41)
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n/an/a 10n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM50237622
PNG
(4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4...)
Show SMILES NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H20ClN5/c19-14-3-1-13(2-4-14)11-18(20)6-9-24(10-7-18)17-15-5-8-21-16(15)22-12-23-17/h1-5,8,12H,6-7,9-11,20H2,(H,21,22,23)
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n/an/a 29n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153702
PNG
(2-(4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O2/c39-32-27-20-26(23-6-2-1-3-7-23)31(35-28(27)14-17-34-32)24-12-10-22(11-13-24)21-37-18-15-25(16-19-37)38-30-9-5-4-8-29(30)36-33(38)40/h1-14,17,20,25H,15-16,18-19,21H2,(H,34,39)(H,36,40)
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n/an/a 33n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153707
PNG
(3-Phenyl-2-(4-((4-(pyrimidin-2-yl)piperazin-1-yl)m...)
Show SMILES O=c1[nH]ccc2nc(-c3ccc(CN4CCN(CC4)c4ncccn4)cc3)c(cc12)-c1ccccc1
Show InChI InChI=1S/C29H26N6O/c36-28-25-19-24(22-5-2-1-3-6-22)27(33-26(25)11-14-30-28)23-9-7-21(8-10-23)20-34-15-17-35(18-16-34)29-31-12-4-13-32-29/h1-14,19H,15-18,20H2,(H,30,36)
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n/an/a 400n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153705
PNG
(Methyl 1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphth...)
Show SMILES COC(=O)C1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C28H27N3O3/c1-34-28(33)22-12-15-31(16-13-22)18-19-7-9-21(10-8-19)26-23(20-5-3-2-4-6-20)17-24-25(30-26)11-14-29-27(24)32/h2-11,14,17,22H,12-13,15-16,18H2,1H3,(H,29,32)
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n/an/a 600n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153704
PNG
(2-(4-((3,4-Dihydroisoquinolin-2(1H)-yl)methyl)phen...)
Show SMILES O=c1[nH]ccc2nc(-c3ccc(CN4CCc5ccccc5C4)cc3)c(cc12)-c1ccccc1
Show InChI InChI=1S/C30H25N3O/c34-30-27-18-26(23-7-2-1-3-8-23)29(32-28(27)14-16-31-30)24-12-10-21(11-13-24)19-33-17-15-22-6-4-5-9-25(22)20-33/h1-14,16,18H,15,17,19-20H2,(H,31,34)
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n/an/a 900n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153706
PNG
(2-(4-((4-(4-Methoxyphenyl)piperazin-1-yl)methyl)ph...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C32H30N4O2/c1-38-27-13-11-26(12-14-27)36-19-17-35(18-20-36)22-23-7-9-25(10-8-23)31-28(24-5-3-2-4-6-24)21-29-30(34-31)15-16-33-32(29)37/h2-16,21H,17-20,22H2,1H3,(H,33,37)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153708
PNG
(3-Phenyl-2-(4-((4-(tetrahydrofuran-2-carbonyl)pipe...)
Show SMILES O=C(C1CCCO1)N1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Show InChI InChI=1/C30H30N4O3/c35-29-25-19-24(22-5-2-1-3-6-22)28(32-26(25)12-13-31-29)23-10-8-21(9-11-23)20-33-14-16-34(17-15-33)30(36)27-7-4-18-37-27/h1-3,5-6,8-13,19,27H,4,7,14-18,20H2,(H,31,35)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153712
PNG
(5,7-diphenyl-N-(thiophen-2-ylmethyl)-7H-pyrrolo[2,...)
Show SMILES C(Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccccc1)c1cccs1
Show InChI InChI=1S/C23H18N4S/c1-3-8-17(9-4-1)20-15-27(18-10-5-2-6-11-18)23-21(20)22(25-16-26-23)24-14-19-12-7-13-28-19/h1-13,15-16H,14H2,(H,24,25,26)
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n/an/a 7.10E+4n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153710
PNG
(7-(4-methylphenyl)-5-phenyl-N-(pyridin-3-ylmethyl)...)
Show SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3cccnc3)ncnc12
Show InChI InChI=1S/C25H21N5/c1-18-9-11-21(12-10-18)30-16-22(20-7-3-2-4-8-20)23-24(28-17-29-25(23)30)27-15-19-6-5-13-26-14-19/h2-14,16-17H,15H2,1H3,(H,27,28,29)
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n/an/a 1.60E+5n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153709
PNG
(7-(4-methylphenyl)-5-phenyl-N-(thiophen-2-ylmethyl...)
Show SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3cccs3)ncnc12
Show InChI InChI=1S/C24H20N4S/c1-17-9-11-19(12-10-17)28-15-21(18-6-3-2-4-7-18)22-23(26-16-27-24(22)28)25-14-20-8-5-13-29-20/h2-13,15-16H,14H2,1H3,(H,25,26,27)
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n/an/a 1.96E+5n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153715
PNG
(7-(3-chloro-4-methylphenyl)-5-phenyl-N-(thiophen-2...)
Show SMILES Cc1ccc(cc1Cl)-n1cc(-c2ccccc2)c2c(NCc3cccs3)ncnc12
Show InChI InChI=1S/C24H19ClN4S/c1-16-9-10-18(12-21(16)25)29-14-20(17-6-3-2-4-7-17)22-23(27-15-28-24(22)29)26-13-19-8-5-11-30-19/h2-12,14-15H,13H2,1H3,(H,26,27,28)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153714
PNG
(N-benzyl-7-(4-methylphenyl)-5-phenyl-7H-pyrrolo[2,...)
Show SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C26H22N4/c1-19-12-14-22(15-13-19)30-17-23(21-10-6-3-7-11-21)24-25(28-18-29-26(24)30)27-16-20-8-4-2-5-9-20/h2-15,17-18H,16H2,1H3,(H,27,28,29)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153714
PNG
(N-benzyl-7-(4-methylphenyl)-5-phenyl-7H-pyrrolo[2,...)
Show SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3ccccc3)ncnc12
Show InChI InChI=1S/C26H22N4/c1-19-12-14-22(15-13-19)30-17-23(21-10-6-3-7-11-21)24-25(28-18-29-26(24)30)27-16-20-8-4-2-5-9-20/h2-15,17-18H,16H2,1H3,(H,27,28,29)
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n/an/an/a 6.00E+3n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153713
PNG
(7-(3-methylphenyl)-5-phenyl-N-(thiophen-2-ylmethyl...)
Show SMILES Cc1cccc(c1)-n1cc(-c2ccccc2)c2c(NCc3cccs3)ncnc12
Show InChI InChI=1S/C24H20N4S/c1-17-7-5-10-19(13-17)28-15-21(18-8-3-2-4-9-18)22-23(26-16-27-24(22)28)25-14-20-11-6-12-29-20/h2-13,15-16H,14H2,1H3,(H,25,26,27)
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n/an/an/a 9.90E+4n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153712
PNG
(5,7-diphenyl-N-(thiophen-2-ylmethyl)-7H-pyrrolo[2,...)
Show SMILES C(Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccccc1)c1cccs1
Show InChI InChI=1S/C23H18N4S/c1-3-8-17(9-4-1)20-15-27(18-10-5-2-6-11-18)23-21(20)22(25-16-26-23)24-14-19-12-7-13-28-19/h1-13,15-16H,14H2,(H,24,25,26)
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n/an/an/a 2.20E+3n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153711
PNG
(7-(4-fluorophenyl)-5-phenyl-N-(pyridin-2-ylmethyl)...)
Show SMILES Fc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3ccccn3)ncnc12
Show InChI InChI=1S/C24H18FN5/c25-18-9-11-20(12-10-18)30-15-21(17-6-2-1-3-7-17)22-23(28-16-29-24(22)30)27-14-19-8-4-5-13-26-19/h1-13,15-16H,14H2,(H,27,28,29)
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n/an/an/a 2.00E+4n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153710
PNG
(7-(4-methylphenyl)-5-phenyl-N-(pyridin-3-ylmethyl)...)
Show SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3cccnc3)ncnc12
Show InChI InChI=1S/C25H21N5/c1-18-9-11-21(12-10-18)30-16-22(20-7-3-2-4-8-20)23-24(28-17-29-25(23)30)27-15-19-6-5-13-26-14-19/h2-14,16-17H,15H2,1H3,(H,27,28,29)
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n/an/an/a 7.80E+3n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153709
PNG
(7-(4-methylphenyl)-5-phenyl-N-(thiophen-2-ylmethyl...)
Show SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3cccs3)ncnc12
Show InChI InChI=1S/C24H20N4S/c1-17-9-11-19(12-10-17)28-15-21(18-6-3-2-4-7-18)22-23(26-16-27-24(22)28)25-14-20-8-5-13-29-20/h2-13,15-16H,14H2,1H3,(H,25,26,27)
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n/an/an/a 2.20E+3n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


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Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM50313650
PNG
(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1
Show InChI InChI=1S/C25H21N5O/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31)
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n/an/an/a 90n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


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More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153708
PNG
(3-Phenyl-2-(4-((4-(tetrahydrofuran-2-carbonyl)pipe...)
Show SMILES O=C(C1CCCO1)N1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Show InChI InChI=1/C30H30N4O3/c35-29-25-19-24(22-5-2-1-3-6-22)28(32-26(25)12-13-31-29)23-10-8-21(9-11-23)20-33-14-16-34(17-15-33)30(36)27-7-4-18-37-27/h1-3,5-6,8-13,19,27H,4,7,14-18,20H2,(H,31,35)
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n/an/an/a 8.00E+3n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153707
PNG
(3-Phenyl-2-(4-((4-(pyrimidin-2-yl)piperazin-1-yl)m...)
Show SMILES O=c1[nH]ccc2nc(-c3ccc(CN4CCN(CC4)c4ncccn4)cc3)c(cc12)-c1ccccc1
Show InChI InChI=1S/C29H26N6O/c36-28-25-19-24(22-5-2-1-3-6-22)27(33-26(25)11-14-30-28)23-9-7-21(8-10-23)20-34-15-17-35(18-16-34)29-31-12-4-13-32-29/h1-14,19H,15-18,20H2,(H,30,36)
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n/an/an/a 1.10E+3n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


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More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153715
PNG
(7-(3-chloro-4-methylphenyl)-5-phenyl-N-(thiophen-2...)
Show SMILES Cc1ccc(cc1Cl)-n1cc(-c2ccccc2)c2c(NCc3cccs3)ncnc12
Show InChI InChI=1S/C24H19ClN4S/c1-16-9-10-18(12-21(16)25)29-14-20(17-6-3-2-4-7-17)22-23(27-15-28-24(22)29)26-13-19-8-5-11-30-19/h2-12,14-15H,13H2,1H3,(H,26,27,28)
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n/an/an/a 2.64E+5n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


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More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153705
PNG
(Methyl 1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphth...)
Show SMILES COC(=O)C1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C28H27N3O3/c1-34-28(33)22-12-15-31(16-13-22)18-19-7-9-21(10-8-19)26-23(20-5-3-2-4-6-20)17-24-25(30-26)11-14-29-27(24)32/h2-11,14,17,22H,12-13,15-16,18H2,1H3,(H,29,32)
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n/an/an/a 900n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


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More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153704
PNG
(2-(4-((3,4-Dihydroisoquinolin-2(1H)-yl)methyl)phen...)
Show SMILES O=c1[nH]ccc2nc(-c3ccc(CN4CCc5ccccc5C4)cc3)c(cc12)-c1ccccc1
Show InChI InChI=1S/C30H25N3O/c34-30-27-18-26(23-7-2-1-3-8-23)29(32-28(27)14-16-31-30)24-12-10-21(11-13-24)19-33-17-15-22-6-4-5-9-25(22)20-33/h1-14,16,18H,15,17,19-20H2,(H,31,34)
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n/an/an/a 6.00E+3n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153703
PNG
(2-(4-((4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]im...)
Show SMILES Clc1ccc2n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C33H28ClN5O2/c34-24-10-11-30-29(18-24)37-33(41)39(30)25-13-16-38(17-14-25)20-21-6-8-23(9-7-21)31-26(22-4-2-1-3-5-22)19-27-28(36-31)12-15-35-32(27)40/h1-12,15,18-19,25H,13-14,16-17,20H2,(H,35,40)(H,37,41)
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n/an/an/a 150n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153702
PNG
(2-(4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-...)
Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C33H29N5O2/c39-32-27-20-26(23-6-2-1-3-7-23)31(35-28(27)14-17-34-32)24-12-10-22(11-13-24)21-37-18-15-25(16-19-37)38-30-9-5-4-8-29(30)36-33(38)40/h1-14,17,20,25H,15-16,18-19,21H2,(H,34,39)(H,36,40)
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n/an/an/a 410n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S )


(Homo sapiens (Human))
BDBM153706
PNG
(2-(4-((4-(4-Methoxyphenyl)piperazin-1-yl)methyl)ph...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C32H30N4O2/c1-38-27-13-11-26(12-14-27)36-19-17-35(18-20-36)22-23-7-9-25(10-8-23)31-28(24-5-3-2-4-6-24)21-29-30(34-31)15-16-33-32(29)37/h2-16,21H,17-20,22H2,1H3,(H,33,37)
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n/an/an/a 7.20E+3n/an/an/an/an/a



Technische Universitšt Dortmund



Assay Description
Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...


Citation and Details
More data for this
Ligand-Target Pair