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Compile Data Set for Download or QSAR

Found 866 hits Enz. Inhib. hit(s) with Target = 'Protein kinase C (PKC)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C gamma


(Rattus norvegicus)
BDBM50064089
PNG
(4-hydroxymethyl-7,10-diisopropyl-8,10,13-trimethyl...)
Show SMILES CC(C)[C@@H]1N(C)c2cc3c(c4[nH]cc(C[C@@H](CO)NC1=O)c24)[C@](C)(CC[C@]3(C)C(C)C)C=C
Show InChI InChI=1S/C28H41N3O2/c1-9-27(6)10-11-28(7,17(4)5)20-13-21-22-18(14-29-24(22)23(20)27)12-19(15-32)30-26(33)25(16(2)3)31(21)8/h9,13-14,16-17,19,25,29,32H,1,10-12,15H2,2-8H3,(H,30,33)/t19-,25-,27-,28+/m0/s1
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2n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma


Bioorg Med Chem Lett 6: 353-356 (1996)


Article DOI: 10.1016/0960-894X(96)00026-1
BindingDB Entry DOI: 10.7270/Q2NG4QMM
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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5.30 -48.0n/an/an/an/an/an/a30



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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19 -44.8n/an/an/an/an/an/a30



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein kinase C gamma


(Rattus norvegicus)
BDBM50057512
PNG
((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22?,24-,26-,27-,28-/m1/s1
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53n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma


Bioorg Med Chem Lett 6: 353-356 (1996)


Article DOI: 10.1016/0960-894X(96)00026-1
BindingDB Entry DOI: 10.7270/Q2NG4QMM
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36604
PNG
(5'-Deoxybalanol, 7)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccccc1
Show InChI InChI=1S/C28H26N2O9/c31-19-9-4-8-17(27(36)37)23(19)25(34)24-20(32)12-16(13-21(24)33)28(38)39-22-10-5-11-29-14-18(22)30-26(35)15-6-2-1-3-7-15/h1-4,6-9,12-13,18,22,29,31-33H,5,10-11,14H2,(H,30,35)(H,36,37)/t18-,22-/m1/s1
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69 -41.6 95n/an/an/an/a7.530



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36603
PNG
(4'',6''-Dideoxybalanol, 6)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O8/c31-19-12-10-17(11-13-19)26(34)30-21-15-29-14-2-5-23(21)38-28(37)18-8-6-16(7-9-18)25(33)24-20(27(35)36)3-1-4-22(24)32/h1,3-4,6-13,21,23,29,31-32H,2,5,14-15H2,(H,30,34)(H,35,36)/t21-,23-/m1/s1
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80 -41.2 111n/an/an/an/a7.530



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50228843
PNG
(CHEMBL436718)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CCNCCNS(=O)(=O)c1cccc2cnccc12)C(O)=O
Show InChI InChI=1S/C53H94N28O12S/c54-48(55)68-18-2-9-32(41(84)77-34(11-4-20-70-50(58)59)43(86)79-36(13-6-22-72-52(62)63)45(88)81-37(47(90)91)14-7-23-73-53(64)65)76-42(85)33(10-3-19-69-49(56)57)78-44(87)35(12-5-21-71-51(60)61)80-46(89)38(29-82)75-40(83)17-25-66-26-27-74-94(92,93)39-15-1-8-30-28-67-24-16-31(30)39/h1,8,15-16,24,28,32-38,66,74,82H,2-7,9-14,17-23,25-27,29H2,(H,75,83)(H,76,85)(H,77,84)(H,78,87)(H,79,86)(H,80,89)(H,81,88)(H,90,91)(H4,54,55,68)(H4,56,57,69)(H4,58,59,70)(H4,60,61,71)(H4,62,63,72)(H4,64,65,73)/t32-,33-,34-,35-,36-,37-,38-/m0/s1
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100n/an/an/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Displacement of ATP from protein kinase C (PKC)


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50478562
PNG
(CHEMBL502491)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@]3(CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O)OC
Show InChI InChI=1S/C37H58O8/c1-8-9-10-11-12-13-14-15-16-17-18-19-30(40)44-33-25(3)36(42)28(31-34(5,6)37(31,33)45-26(4)39)21-27(23-38)22-35(43-7)29(36)20-24(2)32(35)41/h20-21,25,28-29,31,33,38,42H,8-19,22-23H2,1-7H3/t25-,28+,29-,31-,33-,35-,36-,37-/m1/s1
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500n/an/an/an/an/an/an/an/a



Sterling Research Group

Curated by ChEMBL


Assay Description
Displacement of radiolabeled PDBU from PKC in rat forebrain


J Nat Prod 54: 1440-3


Article DOI: 10.1021/np50077a040
BindingDB Entry DOI: 10.7270/Q2377CGF
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3207
PNG
(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Show SMILES OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h1-2,4-5,7-10,12-13,20,23,29,31-33H,3,6,11,14H2,(H,30,35)(H,36,37)/t20-,23-/m1/s1
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640 -35.9 834n/an/an/an/a7.530



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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660n/an/an/an/an/an/an/an/a



Temple University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 316: 869-74 (2006)


Article DOI: 10.1124/jpet.105.097303
BindingDB Entry DOI: 10.7270/Q2PN9464
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50280897
PNG
(CHEMBL281660 | Tetradecanoic acid (2S,3R)-2-(2-hyd...)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1CC(=O)O[C@H]1CCO
Show InChI InChI=1S/C20H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-19(22)25-18-16-20(23)24-17(18)14-15-21/h17-18,21H,2-16H2,1H3/t17-,18+/m0/s1
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880n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein kinase C gamma


(Rattus norvegicus)
BDBM50280454
PNG
((10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-3...)
Show SMILES CC(C)[C@@H]1N(C)c2cccc3NCC(C[C@@H](CO)NC1=O)c23
Show InChI InChI=1S/C17H25N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,10-12,16,18,21H,7-9H2,1-3H3,(H,19,22)/t11?,12-,16-/m0/s1
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1.03E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma


Bioorg Med Chem Lett 6: 353-356 (1996)


Article DOI: 10.1016/0960-894X(96)00026-1
BindingDB Entry DOI: 10.7270/Q2NG4QMM
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282658
PNG
(((2R,3R)-2-Hydroxymethyl-5-oxo-tetrahydro-furan-3-...)
Show SMILES CCCCCCCCCCCCCCOC(=O)C[C@@H]1CC(=O)O[C@H]1CO
Show InChI InChI=1S/C21H38O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-25-20(23)15-18-16-21(24)26-19(18)17-22/h18-19,22H,2-17H2,1H3/t18-,19+/m1/s1
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1.47E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50280896
PNG
(CHEMBL276429 | Tetradecanoic acid (2S,3R)-2-hydrox...)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1CC(=O)O[C@H]1CO
Show InChI InChI=1S/C19H34O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-18(21)23-16-14-19(22)24-17(16)15-20/h16-17,20H,2-15H2,1H3/t16-,17+/m1/s1
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1.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36605
PNG
(KT5720, 9)
Show SMILES CCCCCCOC(=O)[C@@]1(O)CC2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23?,31-,32-/m0/s1
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>2.00E+3>-33.1n/an/an/an/an/an/a30



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein kinase C gamma


(Rattus norvegicus)
BDBM50015677
PNG
((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester | 1,...)
Show SMILES CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC
Show InChI InChI=1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1
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2.93E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma


Bioorg Med Chem Lett 6: 353-356 (1996)


Article DOI: 10.1016/0960-894X(96)00026-1
BindingDB Entry DOI: 10.7270/Q2NG4QMM
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282661
PNG
(CHEMBL29762 | Tetradecanoic acid (2R,3S)-2-hydroxy...)
Show SMILES CCCCCCCCCCCCCC(=O)OC[C@@H]1CC(=O)O[C@H]1CO
Show InChI InChI=1S/C20H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-19(22)24-16-17-14-20(23)25-18(17)15-21/h17-18,21H,2-16H2,1H3/t17-,18-/m0/s1
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3.10E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36602
PNG
(14''-Decarboxybalanol hydrochloride, 5)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1C[NH2+]CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1
Show InChI InChI=1S/C27H26N2O8/c30-17-9-7-15(8-10-17)26(35)29-19-14-28-11-3-6-23(19)37-27(36)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-20(18)31/h1-2,4-5,7-10,12-13,19,23,28,30-33H,3,6,11,14H2,(H,29,35)/p+1/t19-,23-/m1/s1
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5.00E+3 -30.8 6.90E+3n/an/an/an/an/a30



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM86727
PNG
(1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2HCl...)
Show SMILES CC1CN(CCN1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3
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6.00E+3n/an/an/an/an/an/an/an/a



Temple University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 316: 869-74 (2006)


Article DOI: 10.1124/jpet.105.097303
BindingDB Entry DOI: 10.7270/Q2PN9464
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50216682
PNG
(1-(5-Isoquinolinesulfonyl)-2-methylpiperazine | 1-...)
Show SMILES CC1CNCCN1S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3
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6.00E+3n/an/an/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Displacement of ATP from protein kinase C (PKC)


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50228839
PNG
(CHEMBL415414)
Show SMILES C[C@H](NC(=O)[C@H](C)NS(=O)(=O)c1cccc2cnccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C54H94N28O13S/c1-28(74-41(85)29(2)82-96(94,95)39-17-3-10-30-26-67-25-18-31(30)39)40(84)81-38(27-83)47(91)79-35(14-7-22-71-52(61)62)45(89)77-33(12-5-20-69-50(57)58)43(87)75-32(11-4-19-68-49(55)56)42(86)76-34(13-6-21-70-51(59)60)44(88)78-36(15-8-23-72-53(63)64)46(90)80-37(48(92)93)16-9-24-73-54(65)66/h3,10,17-18,25-26,28-29,32-38,82-83H,4-9,11-16,19-24,27H2,1-2H3,(H,74,85)(H,75,87)(H,76,86)(H,77,89)(H,78,88)(H,79,91)(H,80,90)(H,81,84)(H,92,93)(H4,55,56,68)(H4,57,58,69)(H4,59,60,70)(H4,61,62,71)(H4,63,64,72)(H4,65,66,73)/t28-,29-,32-,33-,34-,35-,36-,37-,38-/m0/s1
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8.00E+3n/an/an/an/an/an/an/an/a



URA CNRS 1309

Curated by ChEMBL


Assay Description
Displacement of ATP from protein kinase C (PKC)


J Med Chem 34: 73-8 (1991)


Article DOI: 10.1021/jm00105a012
BindingDB Entry DOI: 10.7270/Q2J38VS9
More data for this
Ligand-Target Pair
Protein kinase C iota type/zeta type


(Homo sapiens (Human))
BDBM50463484
PNG
(CHEMBL4248525)
Show SMILES CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(cs3)-c3c[nH]c4ncccc34)c2)CC1
Show InChI InChI=1S/C26H30N6O2S/c1-31-10-12-32(13-11-31)9-4-14-34-20-6-2-5-19(15-20)16-24(33)30-26-29-23(18-35-26)22-17-28-25-21(22)7-3-8-27-25/h2-3,5-8,15,17-18H,4,9-14,16H2,1H3,(H,27,28)(H,29,30,33)
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>1.00E+4n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PKCiota (unknown origin)


Bioorg Med Chem Lett 28: 2622-2626 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM86729
PNG
((R)-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cycloh...)
Show SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Temple University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 316: 869-74 (2006)


Article DOI: 10.1124/jpet.105.097303
BindingDB Entry DOI: 10.7270/Q2PN9464
More data for this
Ligand-Target Pair
Protein kinase C iota type/zeta type


(Homo sapiens (Human))
BDBM50463479
PNG
(CHEMBL4249925)
Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of PKCiota (unknown origin)


Bioorg Med Chem Lett 28: 2622-2626 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus (Rat))
BDBM50009723
PNG
(2,6-Diamino-hexanoic acid (1-tridecanoyl-piperidin...)
Show SMILES CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H50N4O2/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26/h22-23H,2-21,26-27H2,1H3,(H,28,31)/t22?,23-/m0/s1
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1.20E+4n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Effect of Phosphatidylserine on inhibition of Protein kinase C alpha


J Med Chem 34: 2928-31 (1991)


Article DOI: 10.1021/jm00113a038
BindingDB Entry DOI: 10.7270/Q2KH0NZG
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282657
PNG
(CHEMBL29668 | [(2S,3R)-2-(2-Hydroxy-ethyl)-5-oxo-t...)
Show SMILES CCCCCCCCCCCCCCOC(=O)C[C@@H]1CC(=O)O[C@H]1CCO
Show InChI InChI=1S/C22H40O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-26-21(24)17-19-18-22(25)27-20(19)14-15-23/h19-20,23H,2-18H2,1H3/t19-,20+/m1/s1
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1.86E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50241867
PNG
(((2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hy...)
Show SMILES C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO)[C@H]2OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1
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2.20E+4n/an/an/an/an/an/an/an/a



Sanofi Recherche

Curated by ChEMBL


Assay Description
Displacement of [gamma32P]ATP from rat brain PKC by competitive Lineweaver-Burke plot analysis


J Nat Prod 54: 1595-600


Article DOI: 10.1021/np50078a016
BindingDB Entry DOI: 10.7270/Q23T9KWX
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50241867
PNG
(((2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hy...)
Show SMILES C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO)[C@H]2OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1
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2.80E+4n/an/an/an/an/an/an/an/a



Sanofi Recherche

Curated by ChEMBL


Assay Description
Inhibition of rat brain PKC using histone type 3-S as substrate by noncompetitive Lineweaver-Burke plot analysis


J Nat Prod 54: 1595-600


Article DOI: 10.1021/np50078a016
BindingDB Entry DOI: 10.7270/Q23T9KWX
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36606
PNG
(H-89, 10)
Show SMILES Brc1ccc(\C=C\CNCCNOS(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-26-27(25)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
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3.17E+4 -26.1n/an/an/an/an/an/a30



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50283971
PNG
(CHEMBL153171 | Tetradecanoic acid (2S,3R)-2-hydrox...)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1CCCC(=O)O[C@H]1CO
Show InChI InChI=1S/C21H38O5/c1-2-3-4-5-6-7-8-9-10-11-12-15-20(23)25-18-14-13-16-21(24)26-19(18)17-22/h18-19,22H,2-17H2,1H3/t18-,19+/m1/s1
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4.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-phorbol-12,13-dibutyrate from rat brain protein kinase C alpha


Bioorg Med Chem Lett 4: 543-548 (1994)


Article DOI: 10.1016/S0960-894X(01)80151-7
BindingDB Entry DOI: 10.7270/Q23B6025
More data for this
Ligand-Target Pair
Protein kinase C iota (PKCι)


(Homo sapiens (Human))
BDBM50331612
PNG
(CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b...)
Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Show InChI InChI=1S/C19H16N2O2/c1-22-14-8-6-13(7-9-14)12-21-16-10-11-20-19-18(16)15-4-2-3-5-17(15)23-19/h2-11H,12H2,1H3,(H,20,21)
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human PKC-iota


Bioorg Med Chem Lett 20: 6915-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.004
BindingDB Entry DOI: 10.7270/Q2GF0TQS
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36600
PNG
(Benzophenone fragment, 2)
Show SMILES COC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1
Show InChI InChI=1S/C16H12O8/c1-24-16(23)7-5-10(18)13(11(19)6-7)14(20)12-8(15(21)22)3-2-4-9(12)17/h2-6,17-19H,1H3,(H,21,22)
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>1.00E+6>-17.4n/an/an/an/an/a7.530



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36601
PNG
(Hexahydroazepine, 3)
Show SMILES O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C13H18N2O3/c16-10-5-3-9(4-6-10)13(18)15-11-8-14-7-1-2-12(11)17/h3-6,11-12,14,16-17H,1-2,7-8H2,(H,15,18)/t11-,12-/m1/s1
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>1.00E+6>-17.4n/an/an/an/an/an/a30



University of California San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1016/1074-5521(95)90124-8
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein kinase C iota (PKCι)


(Homo sapiens (Human))
BDBM50395892
PNG
(CHEMBL2163772)
Show SMILES Oc1ccc2oc3ncc(O)c(-c4ccccc4)c3c2c1
Show InChI InChI=1S/C17H11NO3/c19-11-6-7-14-12(8-11)16-15(10-4-2-1-3-5-10)13(20)9-18-17(16)21-14/h1-9,19-20H
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of PKCiota


Bioorg Med Chem Lett 22: 6914-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.006
BindingDB Entry DOI: 10.7270/Q2M61MC1
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.0800n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition Protein kinase C (PKC)


J Med Chem 45: 3772-93 (2002)


Article DOI: 10.1021/jm020143r
BindingDB Entry DOI: 10.7270/Q2WW7JD9
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519062
PNG
(CHEMBL4442196)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](OC(C)=O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C46H56O13/c1-25(2)42-22-31(23-53-39(49)29-17-11-8-12-18-29)45-34-37(42)57-46(58-42,59-45)32(54-28(5)48)21-15-7-6-10-16-26(3)33-27(4)36(55-40(50)30-19-13-9-14-20-30)44(52,35(33)45)41(51)43(24-47)38(34)56-43/h8-9,11-14,17-20,26-27,31-38,41,47,51-52H,1,6-7,10,15-16,21-24H2,2-5H3/t26-,27+,31+,32-,33+,34-,35-,36+,37-,38+,41-,42-,43+,44-,45-,46?/m1/s1
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n/an/a 0.0900n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519087
PNG
(CHEMBL3741746)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C44H54O12/c1-24(2)40-21-29(22-51-37(47)27-16-10-7-11-17-27)43-32-35(40)54-44(55-40,56-43)30(46)20-14-6-5-9-15-25(3)31-26(4)34(52-38(48)28-18-12-8-13-19-28)42(50,33(31)43)39(49)41(23-45)36(32)53-41/h7-8,10-13,16-19,25-26,29-36,39,45-46,49-50H,1,5-6,9,14-15,20-23H2,2-4H3/t25-,26+,29+,30-,31+,32-,33-,34+,35-,36+,39-,40-,41+,42-,43-,44?/m1/s1
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n/an/a 0.130n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519068
PNG
(CHEMBL4575056)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCCC(=O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C44H52O12/c1-24(2)40-21-29(22-51-37(47)27-16-10-7-11-17-27)43-32-35(40)54-44(55-40,56-43)30(46)20-14-6-5-9-15-25(3)31-26(4)34(52-38(48)28-18-12-8-13-19-28)42(50,33(31)43)39(49)41(23-45)36(32)53-41/h7-8,10-13,16-19,25-26,29,31-36,39,45,49-50H,1,5-6,9,14-15,20-23H2,2-4H3/t25-,26+,29+,31+,32-,33-,34+,35-,36+,39-,40-,41+,42-,43-,44?/m1/s1
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n/an/a 0.140n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519060
PNG
(CHEMBL4528495)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccc3ccccc3c2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C48H56O12/c1-26(2)44-23-33(24-55-41(51)30-16-9-7-10-17-30)47-36-39(44)58-48(59-44,60-47)34(50)19-11-6-5-8-14-27(3)35-28(4)38(46(54,37(35)47)43(53)45(25-49)40(36)57-45)56-42(52)32-21-20-29-15-12-13-18-31(29)22-32/h7,9-10,12-13,15-18,20-22,27-28,33-40,43,49-50,53-54H,1,5-6,8,11,14,19,23-25H2,2-4H3/t27-,28+,33+,34-,35+,36-,37-,38+,39-,40+,43-,44-,45+,46-,47-,48?/m1/s1
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n/an/a 0.150n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519083
PNG
(CHEMBL4538431)
Show SMILES COc1ccc(cc1)C(=O)O[C@H]1[C@@H](C)[C@H]2[C@@H]3[C@]1(O)[C@H](O)[C@@]1(CO)O[C@H]1[C@H]1[C@H]4OC5(O[C@]4(C[C@@H](COC(=O)c4ccccc4)[C@]31O5)C(C)=C)[C@H](O)CCCCCC[C@H]2C
Show InChI InChI=1S/C45H56O13/c1-24(2)41-21-29(22-53-38(48)27-14-10-8-11-15-27)44-33-36(41)56-45(57-41,58-44)31(47)16-12-7-6-9-13-25(3)32-26(4)35(54-39(49)28-17-19-30(52-5)20-18-28)43(51,34(32)44)40(50)42(23-46)37(33)55-42/h8,10-11,14-15,17-20,25-26,29,31-37,40,46-47,50-51H,1,6-7,9,12-13,16,21-23H2,2-5H3/t25-,26+,29+,31-,32+,33-,34-,35+,36-,37+,40-,41-,42+,43-,44-,45?/m1/s1
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n/an/a 0.170n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519084
PNG
(CHEMBL4443190)
Show SMILES CC(C)[C@]12C[C@@H](COC(=O)c3ccccc3)[C@@]34OC5(O[C@@H]1[C@@H]3[C@@H]1O[C@]1(CO)[C@@H](O)[C@]1(O)[C@@H](OC(=O)c3ccccc3)[C@@H](C)[C@@H]([C@@H]41)[C@H](C)CCCCCC[C@H]5O)O2
Show InChI InChI=1S/C44H56O12/c1-24(2)40-21-29(22-51-37(47)27-16-10-7-11-17-27)43-32-35(40)54-44(55-40,56-43)30(46)20-14-6-5-9-15-25(3)31-26(4)34(52-38(48)28-18-12-8-13-19-28)42(50,33(31)43)39(49)41(23-45)36(32)53-41/h7-8,10-13,16-19,24-26,29-36,39,45-46,49-50H,5-6,9,14-15,20-23H2,1-4H3/t25-,26+,29+,30-,31+,32-,33-,34+,35-,36+,39-,40-,41+,42-,43-,44?/m1/s1
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n/an/a 0.180n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519069
PNG
(CHEMBL4435580)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccc(cc2)[N+]([O-])=O)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C44H53NO14/c1-23(2)40-20-28(21-54-37(48)26-13-9-7-10-14-26)43-32-35(40)57-44(58-40,59-43)30(47)15-11-6-5-8-12-24(3)31-25(4)34(55-38(49)27-16-18-29(19-17-27)45(52)53)42(51,33(31)43)39(50)41(22-46)36(32)56-41/h7,9-10,13-14,16-19,24-25,28,30-36,39,46-47,50-51H,1,5-6,8,11-12,15,20-22H2,2-4H3/t24-,25+,28+,30-,31+,32-,33-,34+,35-,36+,39-,40-,41+,42-,43-,44?/m1/s1
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n/an/a 0.220n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466813
PNG
(CHEMBL222469)
Show SMILES COc1c2SSSc2c(CCN(C)C)c(SC)c1OC
Show InChI InChI=1S/C13H19NO2S4/c1-14(2)7-6-8-11(17-5)9(15-3)10(16-4)13-12(8)18-20-19-13/h6-7H2,1-5H3
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466812
PNG
(CHEMBL4291190)
Show SMILES NCCc1cc(O)c(O)c2SSSSSc12
Show InChI InChI=1S/C8H9NO2S5/c9-2-1-4-3-5(10)6(11)8-7(4)12-14-16-15-13-8/h3,10-11H,1-2,9H2
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466811
PNG
(CHEMBL222470)
Show SMILES COc1c(OC)c2SSSSSc2c(CCN(C)C)c1SC
Show InChI InChI=1S/C13H19NO2S6/c1-14(2)7-6-8-11(17-5)9(15-3)10(16-4)13-12(8)18-20-22-21-19-13/h6-7H2,1-5H3
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466809
PNG
(CHEMBL4281395)
Show SMILES COc1c(OC)c2SSSSSc2c(CCN)c1SC
Show InChI InChI=1S/C11H15NO2S6/c1-13-7-8(14-2)11-10(16-18-20-19-17-11)6(4-5-12)9(7)15-3/h4-5,12H2,1-3H3
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466810
PNG
(CHEMBL4284802)
Show SMILES COc1c2SSSc2c(CCN)c(SC)c1OC
Show InChI InChI=1S/C11H15NO2S4/c1-13-7-8(14-2)11-10(16-18-17-11)6(4-5-12)9(7)15-3/h4-5,12H2,1-3H3
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519063
PNG
(CHEMBL4587471)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccncc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C43H53NO12/c1-23(2)39-20-28(21-51-36(47)26-13-9-7-10-14-26)42-31-34(39)54-43(55-39,56-42)29(46)15-11-6-5-8-12-24(3)30-25(4)33(52-37(48)27-16-18-44-19-17-27)41(50,32(30)42)38(49)40(22-45)35(31)53-40/h7,9-10,13-14,16-19,24-25,28-35,38,45-46,49-50H,1,5-6,8,11-12,15,20-22H2,2-4H3/t24-,25+,28+,29-,30+,31-,32-,33+,34-,35+,38-,39-,40+,41-,42-,43?/m1/s1
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n/an/a 0.360n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase C


Citation and Details

BindingDB Entry DOI: 10.7270/Q27946V3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50468260
PNG
(CHEMBL4282837)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccc(O)cc3c3c4CNC(=O)c4c4c5cc(O)ccc5n2c4c13
Show InChI InChI=1S/C28H26N4O5/c1-28-26(36-3)17(29-2)10-20(37-28)31-18-6-4-12(33)8-14(18)22-23-16(11-30-27(23)35)21-15-9-13(34)5-7-19(15)32(28)25(21)24(22)31/h4-9,17,20,26,29,33-34H,10-11H2,1-3H3,(H,30,35)/t17-,20-,26-,28+/m1/s1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



PAK Research Center

Curated by ChEMBL


Assay Description
Inhibition of rat brain PKC using RGFR derived peptide substrate


Eur J Med Chem 142: 229-243 (2017)


Article DOI: 10.1016/j.ejmech.2017.07.043
BindingDB Entry DOI: 10.7270/Q21J9DG3
More data for this
Ligand-Target Pair
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