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Compile Data Set for Download or QSAR

Found 33 hits Enz. Inhib. hit(s) with Target = 'Protein phosphatase 1D' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein phosphatase 1D


(Homo sapiens)
BDBM50446563
PNG
(CHEMBL3109288)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)N[C@@H](CSCC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](COP(O)(O)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C40H55N7O19P2S/c1-3-21(2)34-40(58)46-29(18-65-67(59,60)61)39(57)43-26(15-22-7-5-4-6-8-22)31(48)20-69-19-30(35(41)53)42-25(13-14-32(49)50)36(54)45-28(17-33(51)52)37(55)44-27(38(56)47-34)16-23-9-11-24(12-10-23)66-68(62,63)64/h4-12,21,25-30,34,42H,3,13-20H2,1-2H3,(H2,41,53)(H,43,57)(H,44,55)(H,45,54)(H,46,58)(H,47,56)(H,49,50)(H,51,52)(H2,59,60,61)(H2,62,63,64)/t21-,25-,26-,27-,28-,29-,30-,34-/m0/s1
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150n/an/an/an/an/an/an/an/a



The City University of New York

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PPM1D (1 to 420) assessed as phosphoric acid release after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50118477
PNG
(CHEMBL3613748)
Show SMILES CC[Si](CC)(CC)O[C@@H]1CCC[C@@H]2[C@@H]1C[C@@H](C[C@@]2(C)C(O)=O)O[Si](C)(C)C(C)(C)C
Show InChI InChI=1/C24H48O4Si2/c1-10-30(11-2,12-3)28-21-15-13-14-20-19(21)16-18(17-24(20,7)22(25)26)27-29(8,9)23(4,5)6/h18-21H,10-17H2,1-9H3,(H,25,26)/t18-,19-,20+,21+,24+/s2
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228n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEP...


Bioorg Med Chem 23: 6246-9 (2015)

More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50118478
PNG
(CHEMBL3613749)
Show SMILES Cc1ncc(Cl)cc1NCc1ccc(s1)C(=O)N[C@@H](CC1CCCC1)C(=O)NC1CC1
Show InChI InChI=1/C23H29ClN4O2S/c1-14-19(11-16(24)12-25-14)26-13-18-8-9-21(31-18)23(30)28-20(10-15-4-2-3-5-15)22(29)27-17-6-7-17/h8-9,11-12,15,17,20,26H,2-7,10,13H2,1H3,(H,27,29)(H,28,30)/t20-/s2
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n/an/a 86n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-N...


Bioorg Med Chem 23: 6246-9 (2015)

More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50361941
PNG
(CHEMBL1939361)
Show SMILES CC[Si](CC)(CC)O[C@@H]1C[C@H](C)C[C@@H]2[C@@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1[C@](C)(CO)C[C@H](O)C[C@@]21C
Show InChI InChI=1S/C30H60O4Si2/c1-12-36(13-2,14-3)34-25-16-21(4)15-24-23(25)17-26(33-35(10,11)28(5,6)7)27-29(8,20-31)18-22(32)19-30(24,27)9/h21-27,31-32H,12-20H2,1-11H3/t21-,22+,23+,24-,25-,26+,27-,29+,30+/m1/s1
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n/an/a 87n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-N...


Bioorg Med Chem 23: 6246-9 (2015)

More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50118477
PNG
(CHEMBL3613748)
Show SMILES CC[Si](CC)(CC)O[C@@H]1CCC[C@@H]2[C@@H]1C[C@@H](C[C@@]2(C)C(O)=O)O[Si](C)(C)C(C)(C)C
Show InChI InChI=1/C24H48O4Si2/c1-10-30(11-2,12-3)28-21-15-13-14-20-19(21)16-18(17-24(20,7)22(25)26)27-29(8,9)23(4,5)6/h18-21H,10-17H2,1-9H3,(H,25,26)/t18-,19-,20+,21+,24+/s2
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n/an/a 110n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-N...


Bioorg Med Chem 23: 6246-9 (2015)

More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50118476
PNG
(CHEMBL3613747)
Show SMILES CC[Si](CC)(CC)O[C@@H]1CCC[C@@H]2[C@@H]1C[C@@H](C[C@@]2(C)CO)O[Si](C)(C)C(C)(C)C
Show InChI InChI=1/C24H50O3Si2/c1-10-29(11-2,12-3)27-22-15-13-14-21-20(22)16-19(17-24(21,7)18-25)26-28(8,9)23(4,5)6/h19-22,25H,10-18H2,1-9H3/t19-,20-,21+,22+,24-/s2
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n/an/a 215n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-N...


Bioorg Med Chem 23: 6246-9 (2015)

More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50361941
PNG
(CHEMBL1939361)
Show SMILES CC[Si](CC)(CC)O[C@@H]1C[C@H](C)C[C@@H]2[C@@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1[C@](C)(CO)C[C@H](O)C[C@@]21C
Show InChI InChI=1S/C30H60O4Si2/c1-12-36(13-2,14-3)34-25-16-21(4)15-24-23(25)17-26(33-35(10,11)28(5,6)7)27-29(8,20-31)18-22(32)19-30(24,27)9/h21-27,31-32H,12-20H2,1-11H3/t21-,22+,23+,24-,25-,26+,27-,29+,30+/m1/s1
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n/an/a 480n/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal histidine-tagged PPM1Dc after 10 mins using BIOMOL GREEN assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046580
PNG
(CHEMBL3314462)
Show SMILES Fc1cccc(c1)-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C16H9FN2O2S/c17-11-3-1-2-10(6-11)15-18-13(8-22-15)9-4-5-12-14(7-9)21-16(20)19-12/h1-8H,(H,19,20)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046581
PNG
(CHEMBL3314461)
Show SMILES O=c1[nH]c2ccc(cc2o1)-c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C15H9N3O2S/c19-15-18-11-2-1-10(7-13(11)20-15)12-8-21-14(17-12)9-3-5-16-6-4-9/h1-8H,(H,18,19)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046582
PNG
(CHEMBL3314460)
Show SMILES O=c1[nH]c2ccc(cc2o1)-c1csc(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C17H9N3O2S/c18-8-10-1-3-11(4-2-10)16-19-14(9-23-16)12-5-6-13-15(7-12)22-17(21)20-13/h1-7,9H,(H,20,21)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046583
PNG
(CHEMBL3314459)
Show SMILES Cc1ccc(cc1)-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C17H12N2O2S/c1-10-2-4-11(5-3-10)16-18-14(9-22-16)12-6-7-13-15(8-12)21-17(20)19-13/h2-9H,1H3,(H,19,20)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046667
PNG
(CHEMBL3314458)
Show SMILES Clc1ccc(cc1)-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C16H9ClN2O2S/c17-11-4-1-9(2-5-11)15-18-13(8-22-15)10-3-6-12-14(7-10)21-16(20)19-12/h1-8H,(H,19,20)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046668
PNG
(CHEMBL3314457)
Show SMILES O=c1[nH]c2ccc(cc2o1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C16H10N2O2S/c19-16-18-12-7-6-11(8-14(12)20-16)13-9-21-15(17-13)10-4-2-1-3-5-10/h1-9H,(H,18,19)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046670
PNG
(CHEMBL3314469)
Show SMILES COc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C17H11FN2O3S/c1-22-14-7-10(18)3-4-11(14)16-19-13(8-24-16)9-2-5-12-15(6-9)23-17(21)20-12/h2-8H,1H3,(H,20,21)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046671
PNG
(CHEMBL3314470)
Show SMILES OCc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C17H11FN2O3S/c18-11-2-3-12(10(5-11)7-21)16-19-14(8-24-16)9-1-4-13-15(6-9)23-17(22)20-13/h1-6,8,21H,7H2,(H,20,22)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046672
PNG
(CHEMBL3314471)
Show SMILES Cc1cc(F)ccc1-c1nc(cs1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C18H13FN2OS/c1-10-6-13(19)3-4-14(10)18-21-16(9-23-18)11-2-5-15-12(7-11)8-17(22)20-15/h2-7,9H,8H2,1H3,(H,20,22)
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n/an/a<2.00E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046673
PNG
(CHEMBL3314472)
Show SMILES Cc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C17H12FN3OS/c1-9-6-11(18)3-4-12(9)16-19-15(8-23-16)10-2-5-13-14(7-10)21-17(22)20-13/h2-8H,1H3,(H2,20,21,22)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046674
PNG
(CHEMBL3314473)
Show SMILES CN(C)CCn1c2cc(ccc2[nH]c1=O)-c1csc(n1)-c1ccc(F)cc1C
Show InChI InChI=1S/C21H21FN4OS/c1-13-10-15(22)5-6-16(13)20-23-18(12-28-20)14-4-7-17-19(11-14)26(21(27)24-17)9-8-25(2)3/h4-7,10-12H,8-9H2,1-3H3,(H,24,27)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046675
PNG
(CHEMBL3314474)
Show SMILES CN(C)CCn1c2ccc(cc2[nH]c1=O)-c1csc(n1)-c1ccc(F)cc1C
Show InChI InChI=1S/C21H21FN4OS/c1-13-10-15(22)5-6-16(13)20-23-18(12-28-20)14-4-7-19-17(11-14)24-21(27)26(19)9-8-25(2)3/h4-7,10-12H,8-9H2,1-3H3,(H,24,27)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046676
PNG
(CHEMBL3314475)
Show SMILES CN(C)Cc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C19H16FN3O2S/c1-23(2)9-12-7-13(20)4-5-14(12)18-21-16(10-26-18)11-3-6-15-17(8-11)25-19(24)22-15/h3-8,10H,9H2,1-2H3,(H,22,24)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046677
PNG
(CHEMBL3314476)
Show SMILES Fc1ccc(-c2nc(cs2)-c2ccc3[nH]c(=O)oc3c2)c(CN2CCOCC2)c1
Show InChI InChI=1S/C21H18FN3O3S/c22-15-2-3-16(14(9-15)11-25-5-7-27-8-6-25)20-23-18(12-29-20)13-1-4-17-19(10-13)28-21(26)24-17/h1-4,9-10,12H,5-8,11H2,(H,24,26)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046678
PNG
(CHEMBL3314477)
Show SMILES CN(C)CCc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C20H18FN3O2S/c1-24(2)8-7-12-9-14(21)4-5-15(12)19-22-17(11-27-19)13-3-6-16-18(10-13)26-20(25)23-16/h3-6,9-11H,7-8H2,1-2H3,(H,23,25)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046679
PNG
(CHEMBL3314478)
Show SMILES NCCOCc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C19H16FN3O3S/c20-13-2-3-14(12(7-13)9-25-6-5-21)18-22-16(10-27-18)11-1-4-15-17(8-11)26-19(24)23-15/h1-4,7-8,10H,5-6,9,21H2,(H,23,24)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046680
PNG
(CHEMBL3314479)
Show SMILES Fc1ccc(-c2nc(cs2)-c2ccc3[nH]c(=O)oc3c2)c(COCCN2CCCC2)c1
Show InChI InChI=1S/C23H22FN3O3S/c24-17-4-5-18(16(11-17)13-29-10-9-27-7-1-2-8-27)22-25-20(14-31-22)15-3-6-19-21(12-15)30-23(28)26-19/h3-6,11-12,14H,1-2,7-10,13H2,(H,26,28)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046681
PNG
(CHEMBL3313937)
Show SMILES COCCOCc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C20H17FN2O4S/c1-25-6-7-26-10-13-8-14(21)3-4-15(13)19-22-17(11-28-19)12-2-5-16-18(9-12)27-20(24)23-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,24)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046682
PNG
(CHEMBL3314480)
Show SMILES COCCOCc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C20H18FN3O3S/c1-26-6-7-27-10-13-8-14(21)3-4-15(13)19-22-18(11-28-19)12-2-5-16-17(9-12)24-20(25)23-16/h2-5,8-9,11H,6-7,10H2,1H3,(H2,23,24,25)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046579
PNG
(CHEMBL3314463)
Show SMILES Fc1ccc(cc1F)-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C16H8F2N2O2S/c17-10-3-1-9(5-11(10)18)15-19-13(7-23-15)8-2-4-12-14(6-8)22-16(21)20-12/h1-7H,(H,20,21)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046578
PNG
(CHEMBL3314464)
Show SMILES Cc1cc(ccc1F)-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C17H11FN2O2S/c1-9-6-11(2-4-12(9)18)16-19-14(8-23-16)10-3-5-13-15(7-10)22-17(21)20-13/h2-8H,1H3,(H,20,21)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046577
PNG
(CHEMBL3314465)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C17H8F4N2O2S/c18-11-3-1-9(5-10(11)17(19,20)21)15-22-13(7-26-15)8-2-4-12-14(6-8)25-16(24)23-12/h1-7H,(H,23,24)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046574
PNG
(CHEMBL3314468)
Show SMILES CCc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C18H13FN2O2S/c1-2-10-7-12(19)4-5-13(10)17-20-15(9-24-17)11-3-6-14-16(8-11)23-18(22)21-14/h3-9H,2H2,1H3,(H,21,22)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046576
PNG
(CHEMBL3314466)
Show SMILES Oc1cc(ccc1F)-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C16H9FN2O3S/c17-10-3-1-9(5-13(10)20)15-18-12(7-23-15)8-2-4-11-14(6-8)22-16(21)19-11/h1-7,20H,(H,19,21)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046669
PNG
(CHEMBL3314456)
Show SMILES Fc1ccc(cc1)-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C16H9FN2O2S/c17-11-4-1-9(2-5-11)15-18-13(8-22-15)10-3-6-12-14(7-10)21-16(20)19-12/h1-8H,(H,19,20)
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n/an/a 2.30E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase 1D


(Homo sapiens)
BDBM50046575
PNG
(CHEMBL3314467)
Show SMILES Cc1cc(F)ccc1-c1nc(cs1)-c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C17H11FN2O2S/c1-9-6-11(18)3-4-12(9)16-19-14(8-23-16)10-2-5-13-15(7-10)22-17(21)20-13/h2-8H,1H3,(H,20,21)
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of PPM1D (unknown origin) phosphatase activity using peptide substrate TDDEMT*GY*VAT by malachite green/molybdate based assay


Citation and Details
More data for this
Ligand-Target Pair