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Found 11 hits Enz. Inhib. hit(s) with Target = 'Protein phosphatase methylesterase 1' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400986
PNG
(CHEMBL1550905)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)n1cccc1\C=C(/C#N)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C19H12FN3O6S2/c20-14-6-8-17(9-7-14)30(26,27)19(13-21)11-15-4-2-10-22(15)31(28,29)18-5-1-3-16(12-18)23(24)25/h1-12H/b19-11+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
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PC sid
UniChem

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Article
PubMed
n/an/a 600n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400987
PNG
(CHEMBL1316687)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1cccc(c1)C#N)\C#N
Show InChI InChI=1S/C20H12FN3O4S2/c21-16-6-8-18(9-7-16)29(25,26)20(14-23)12-17-4-2-10-24(17)30(27,28)19-5-1-3-15(11-19)13-22/h1-12H/b20-12+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PubMed
n/an/a 640n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400996
PNG
(CHEMBL1699083)
Show SMILES CS(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1cccc(c1)C#N)\C#N
Show InChI InChI=1S/C15H11N3O4S2/c1-23(19,20)15(11-17)9-13-5-3-7-18(13)24(21,22)14-6-2-4-12(8-14)10-16/h2-9H,1H3/b15-9+
PDB
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KEGG

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PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400995
PNG
(CHEMBL1706554)
Show SMILES CS(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1ccc(cc1)[N+]([O-])=O)\C#N
Show InChI InChI=1S/C14H11N3O6S2/c1-24(20,21)14(10-15)9-12-3-2-8-16(12)25(22,23)13-6-4-11(5-7-13)17(18)19/h2-9H,1H3/b14-9+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PC sid
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Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400994
PNG
(CHEMBL1719837)
Show SMILES CS(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1ccc(Cl)cc1)\C#N
Show InChI InChI=1S/C14H11ClN2O4S2/c1-22(18,19)14(10-16)9-12-3-2-8-17(12)23(20,21)13-6-4-11(15)5-7-13/h2-9H,1H3/b14-9+
PDB
MMDB

KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400988
PNG
(CHEMBL1701914)
Show SMILES CC(C)(C)S(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1cccc(c1)C#N)\C#N
Show InChI InChI=1S/C18H17N3O4S2/c1-18(2,3)26(22,23)17(13-20)11-15-7-5-9-21(15)27(24,25)16-8-4-6-14(10-16)12-19/h4-11H,1-3H3/b17-11+
PDB
MMDB

KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 3.40E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400993
PNG
(CHEMBL1729870)
Show SMILES CS(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1ccc(cc1)C#N)\C#N
Show InChI InChI=1S/C15H11N3O4S2/c1-23(19,20)15(11-17)9-13-3-2-8-18(13)24(21,22)14-6-4-12(10-16)5-7-14/h2-9H,1H3/b15-9+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400989
PNG
(CHEMBL1718102)
Show SMILES Fc1ccc(cc1)S(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1ccccc1)\C#N
Show InChI InChI=1S/C19H13FN2O4S2/c20-15-8-10-17(11-9-15)27(23,24)19(14-21)13-16-5-4-12-22(16)28(25,26)18-6-2-1-3-7-18/h1-13H/b19-13+
PDB
MMDB

KEGG

UniProtKB/SwissProt

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CHEMBL
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PC sid
UniChem

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Article
PubMed
n/an/a 4.80E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400991
PNG
(CHEMBL1711185)
Show SMILES CC(C)(C)S(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1ccccc1)\C#N
Show InChI InChI=1S/C17H18N2O4S2/c1-17(2,3)24(20,21)16(13-18)12-14-8-7-11-19(14)25(22,23)15-9-5-4-6-10-15/h4-12H,1-3H3/b16-12+
PDB
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KEGG

UniProtKB/SwissProt

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AffyNet 
CHEMBL
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PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/a 6.80E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400990
PNG
(CHEMBL1723004)
Show SMILES O=S(=O)(C(=C\c1cccn1S(=O)(=O)c1ccccc1)\C#N)c1ccccc1
Show InChI InChI=1S/C19H14N2O4S2/c20-15-19(26(22,23)17-9-3-1-4-10-17)14-16-8-7-13-21(16)27(24,25)18-11-5-2-6-12-18/h1-14H/b19-14+
PDB
MMDB

KEGG

UniProtKB/SwissProt

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GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair
Protein phosphatase methylesterase 1


(Mus musculus)
BDBM50400992
PNG
(CHEMBL1701983)
Show SMILES CS(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)\C#N
Show InChI InChI=1S/C14H7F5N2O4S2/c1-26(22,23)8(6-20)5-7-3-2-4-21(7)27(24,25)14-12(18)10(16)9(15)11(17)13(14)19/h2-5H,1H3/b8-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profilin...


Citation and Details
More data for this
Ligand-Target Pair