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Compile Data Set for Download or QSAR

Found 13 hits Enz. Inhib. hit(s) with Target = 'Protein tyrosine phosphatase receptor type C-associated protein' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50131866
PNG
(7-Thiophosphonomethyl-naphthalene-1-carboxylic aci...)
Show SMILES OC(=O)c1cccc2ccc(CP(O)(O)=S)cc12
Show InChI InChI=1S/C12H11O4PS/c13-12(14)10-3-1-2-9-5-4-8(6-11(9)10)7-17(15,16)18/h1-6H,7H2,(H,13,14)(H2,15,16,18)
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2.00E+5n/an/an/an/an/an/an/an/a



Utah State University

Curated by ChEMBL


Assay Description
Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein)


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50131869
PNG
(CHEMBL122577 | Methyl-phosphonothioic acid)
Show SMILES CP(O)(O)=S
Show InChI InChI=1S/CH5O2PS/c1-4(2,3)5/h1H3,(H2,2,3,5)
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7.00E+6n/an/an/an/an/an/an/an/a



Utah State University

Curated by ChEMBL


Assay Description
Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein)


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50131863
PNG
(CHEMBL331460 | Phenylsulfanylmethyl-phosphonothioi...)
Show SMILES OP(O)(=S)CSc1ccccc1
Show InChI InChI=1S/C7H9O2PS2/c8-10(9,11)6-12-7-4-2-1-3-5-7/h1-5H,6H2,(H2,8,9,11)
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1.58E+7n/an/an/an/an/an/an/an/a



Utah State University

Curated by ChEMBL


Assay Description
Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein)


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50131867
PNG
(6-Thiophosphono-hexanoic acid | CHEMBL123990)
Show SMILES OC(=O)CCCCCP(O)(O)=S
Show InChI InChI=1S/C6H13O4PS/c7-6(8)4-2-1-3-5-11(9,10)12/h1-5H2,(H,7,8)(H2,9,10,12)
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2.90E+7n/an/an/an/an/an/an/an/a



Utah State University

Curated by ChEMBL


Assay Description
Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein)


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50131862
PNG
(CHEMBL122938 | methylphosphonic acid)
Show SMILES CP(O)(O)=O
Show InChI InChI=1S/CH5O3P/c1-5(2,3)4/h1H3,(H2,2,3,4)
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3.00E+7n/an/an/an/an/an/an/an/a



Utah State University

Curated by ChEMBL


Assay Description
Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein)


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50131860
PNG
(6-Phosphono-hexanoic acid | CHEMBL122539)
Show SMILES OC(=O)CCCCCP(O)(O)=O
Show InChI InChI=1S/C6H13O5P/c7-6(8)4-2-1-3-5-12(9,10)11/h1-5H2,(H,7,8)(H2,9,10,11)
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4.20E+7n/an/an/an/an/an/an/an/a



Utah State University

Curated by ChEMBL


Assay Description
Inhibitory activity against Tyrosine phosphatase from Yersinia (Yop protein)


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50212333
PNG
(5-[3'-(1-adamantyl)-2-chloro-4'-hydroxy-4-biphenyl...)
Show SMILES Oc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc(cc1Cl)-c1nnn[nH]1
Show InChI InChI=1S/C23H23ClN4O/c24-20-9-17(22-25-27-28-26-22)1-3-18(20)16-2-4-21(29)19(8-16)23-10-13-5-14(11-23)7-15(6-13)12-23/h1-4,8-9,13-15,29H,5-7,10-12H2,(H,25,26,27,28)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Burnham Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of CD45 PTP by fluorescence spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50212331
PNG
(5-[1-(3'-adamantan-1-yl-2-chloro-4'-hydroxy-biphen...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(c(Cl)c1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C26H24ClNO3S/c27-21-8-14(9-23-24(30)28-25(31)32-23)1-3-19(21)18-2-4-22(29)20(10-18)26-11-15-5-16(12-26)7-17(6-15)13-26/h1-4,8-10,15-17,29H,5-7,11-13H2,(H,28,30,31)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Burnham Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of CD45 PTP by fluorescence spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50083572
PNG
((S)-1,2-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[d...)
Show SMILES COc1cc2CCN[C@H]3Cc4ccccc4-c(c1OC)c23
Show InChI InChI=1S/C18H19NO2/c1-20-15-10-12-7-8-19-14-9-11-5-3-4-6-13(11)17(16(12)14)18(15)21-2/h3-6,10,14,19H,7-9H2,1-2H3/t14-/m0/s1
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n/an/a 5.30E+3n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against recombinant CD45 protein tyrosine phosphatase


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50202322
PNG
((-)-anonaine | (R)-6,7,7a,8-tetrahydro-5H-benzo[g]...)
Show SMILES C1Oc2cc3CCN[C@@H]4Cc5ccccc5-c(c2O1)c34
Show InChI InChI=1S/C17H15NO2/c1-2-4-12-10(3-1)7-13-15-11(5-6-18-13)8-14-17(16(12)15)20-9-19-14/h1-4,8,13,18H,5-7,9H2/t13-/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against recombinant CD45 protein tyrosine phosphatase


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50197829
PNG
((S)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrah...)
Show SMILES COc1cc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(-c2cc1OC)c34
Show InChI InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1
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n/an/a 8.80E+4n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against recombinant CD45 protein tyrosine phosphatase


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50284797
PNG
(7-Methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxo...)
Show SMILES CN1CCc2cc3OCOc3c3-c4ccccc4CC1c23
Show InChI InChI=1S/C18H17NO2/c1-19-7-6-12-9-15-18(21-10-20-15)17-13-5-3-2-4-11(13)8-14(19)16(12)17/h2-5,9,14H,6-8,10H2,1H3
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n/an/a 1.07E+5n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against recombinant CD45 protein tyrosine phosphatase


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase receptor type C-associated protein


(Homo sapiens)
BDBM50202301
PNG
(CHEMBL37736 | Liriodenine | hiriodenine)
Show SMILES O=C1c2ccccc2-c2c3OCOc3cc3ccnc1c23
Show InChI InChI=1S/C17H9NO3/c19-16-11-4-2-1-3-10(11)14-13-9(5-6-18-15(13)16)7-12-17(14)21-8-20-12/h1-7H,8H2
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n/an/a 1.82E+5n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against recombinant CD45 protein tyrosine phosphatase


Citation and Details
More data for this
Ligand-Target Pair