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Found 20 hits Enz. Inhib. hit(s) with Target = 'Protein tyrosine phosphatase type IVA 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059084
PNG
(CHEMBL3393171)
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
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n/an/a 173n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of full length human fusion His6 tagged PRL1 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by imm...


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50312665
PNG
(CHEMBL1088572 | Sodium 2-(2-Fluorophenyl)-6,7-meth...)
Show SMILES OP([O-])(=O)OC1CC(=Nc2cc3OCOc3cc12)c1ccccc1F
Show InChI InChI=1S/C16H13FNO6P/c17-11-4-2-1-3-9(11)12-6-14(24-25(19,20)21)10-5-15-16(23-8-22-15)7-13(10)18-12/h1-5,7,14H,6,8H2,(H2,19,20,21)/p-1
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n/an/a 676n/an/an/an/an/an/a



China Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PTP4A1 by enzyme assay


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50391711
PNG
(CHEMBL2146958)
Show SMILES Oc1ccc(\C=c2/sc3nc4ccccc4n3c2=O)cc1O
Show InChI InChI=1S/C16H10N2O3S/c19-12-6-5-9(7-13(12)20)8-14-15(21)18-11-4-2-1-3-10(11)17-16(18)22-14/h1-8,19-20H/b14-8-
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n/an/a 1.40E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL1


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50391713
PNG
(CHEMBL2146956)
Show SMILES c1ccc2nc(ccc2c1)-c1nnc2sc(nn12)-c1cnccn1
Show InChI InChI=1S/C16H9N7S/c1-2-4-11-10(3-1)5-6-12(19-11)14-20-21-16-23(14)22-15(24-16)13-9-17-7-8-18-13/h1-9H
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n/an/a 2.10E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL1


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059140
PNG
(CHEMBL3393148)
Show SMILES COc1cc(\C=C(/C#N)C(=O)OCC=C)cc(Br)c1O
Show InChI InChI=1S/C14H12BrNO4/c1-3-4-20-14(18)10(8-16)5-9-6-11(15)13(17)12(7-9)19-2/h3,5-7,17H,1,4H2,2H3/b10-5+
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n/an/a 3.13E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50391714
PNG
(CHEMBL2146957)
Show SMILES SC1=NC(=O)C(S1)=Cc1cn(nc1-c1cccc(OCc2ccccc2Cl)c1)-c1ccccc1
Show InChI InChI=1S/C26H18ClN3O2S2/c27-22-12-5-4-7-18(22)16-32-21-11-6-8-17(13-21)24-19(14-23-25(31)28-26(33)34-23)15-30(29-24)20-9-2-1-3-10-20/h1-15H,16H2,(H,28,31,33)
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n/an/a 3.72E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL1


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50387974
PNG
(CHEMBL2057830)
Show SMILES Oc1ccc(cc1)C1=NN2C(S1)=NC(=O)\C(=C\c1ccc(O)c(O)c1)C2=N
Show InChI InChI=1S/C18H12N4O4S/c19-15-12(7-9-1-6-13(24)14(25)8-9)16(26)20-18-22(15)21-17(27-18)10-2-4-11(23)5-3-10/h1-8,19,23-25H/b12-7+,19-15?
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n/an/a 3.98E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL1


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50343147
PNG
(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Show InChI InChI=1S/C25H30N4O4S/c1-18(27-25(31)24(30)26-17-21-5-3-15-33-21)23(22-6-4-16-34-22)29-13-11-28(12-14-29)19-7-9-20(32-2)10-8-19/h3-10,15-16,18,23H,11-14,17H2,1-2H3,(H,26,30)(H,27,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL1 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50343148
PNG
(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C25H28FN5O2S/c1-18(29-25(33)24(32)28-17-19-4-2-10-27-16-19)23(22-5-3-15-34-22)31-13-11-30(12-14-31)21-8-6-20(26)7-9-21/h2-10,15-16,18,23H,11-14,17H2,1H3,(H,28,32)(H,29,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL1 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50343142
PNG
(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-2-3-5-14-8-10-15(11-9-14)23-27(25,26)19-13-12-18-20-16(19)6-4-7-17(20)21(24)22-18/h4,6-13,23H,2-3,5H2,1H3,(H,22,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL1 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059141
PNG
(CHEMBL3393149)
Show SMILES COc1cc(\C=C(/C#N)C(=O)OC(C)C)cc(Br)c1O
Show InChI InChI=1S/C14H14BrNO4/c1-8(2)20-14(18)10(7-16)4-9-5-11(15)13(17)12(6-9)19-3/h4-6,8,17H,1-3H3/b10-4+
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n/an/a 5.67E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059084
PNG
(CHEMBL3393171)
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
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n/an/a 7.00E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059086
PNG
(CHEMBL3393146)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCC=C)cc1Br
Show InChI InChI=1S/C13H10BrNO3/c1-2-5-18-13(17)10(8-15)6-9-3-4-12(16)11(14)7-9/h2-4,6-7,16H,1,5H2/b10-6+
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n/an/a 7.01E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059142
PNG
(CHEMBL3393150)
Show SMILES CCOC(=O)C(=C\c1cc(Br)c(O)c(Br)c1)\C#N
Show InChI InChI=1S/C12H9Br2NO3/c1-2-18-12(17)8(6-15)3-7-4-9(13)11(16)10(14)5-7/h3-5,16H,2H2,1H3/b8-3+
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n/an/a 8.91E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50391712
PNG
(CHEMBL2146959)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)CSc1nnc(-c2ccco2)c(n1)-c1ccco1
Show InChI InChI=1S/C19H13N5O5S/c25-16(20-12-5-1-2-6-13(12)24(26)27)11-30-19-21-17(14-7-3-9-28-14)18(22-23-19)15-8-4-10-29-15/h1-10H,11H2,(H,20,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL1


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50391715
PNG
(CHEMBL2146960)
Show SMILES Oc1ccc(C=c2c(=O)[nH]c3cc(=C)on3c2=N)cc1O
Show InChI InChI=1S/C14H11N3O4/c1-7-4-12-16-14(20)9(13(15)17(12)21-7)5-8-2-3-10(18)11(19)6-8/h2-6,15,18-19H,1H2,(H,16,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL1


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50237957
PNG
(4-(2-((2,5-dioxoimidazolidin-4-ylidene)methyl)-1H-...)
Show SMILES OC(=O)c1ccc(cc1)-n1cccc1\C=C1\NC(=O)NC1=O
Show InChI InChI=1S/C15H11N3O4/c19-13-12(16-15(22)17-13)8-11-2-1-7-18(11)10-5-3-9(4-6-10)14(20)21/h1-8H,(H,20,21)(H2,16,17,19,22)/b12-8+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL1


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059143
PNG
(CHEMBL3393151)
Show SMILES CC(C)OC(=O)C(=C/c1ccc(O)c(Br)c1)\C#N
Show InChI InChI=1S/C13H12BrNO3/c1-8(2)18-13(17)10(7-15)5-9-3-4-12(16)11(14)6-9/h3-6,8,16H,1-2H3/b10-5-
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n/an/a 1.33E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059085
PNG
(CHEBI:8830 | RHODANINE | Rhodanine)
Show SMILES O=C1CSC(=S)N1
Show InChI InChI=1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
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n/an/a 2.09E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 1


(Homo sapiens)
BDBM50059139
PNG
(CHEMBL3393147)
Show SMILES OC(=O)c1ccc[n+]2c([O-])c(sc12)-c1ccccc1
Show InChI InChI=1S/C14H9NO3S/c16-12-11(9-5-2-1-3-6-9)19-13-10(14(17)18)7-4-8-15(12)13/h1-8H,(H-,16,17,18)
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n/an/a 2.09E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair