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Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'Protein tyrosine phosphatase type IVA 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059084
PNG
(CHEMBL3393171)
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
PC cid
PC sid
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Article
PubMed
n/an/a 277n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of human PRL2 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by immobilized metal ion affinity-bas...


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50312665
PNG
(CHEMBL1088572 | Sodium 2-(2-Fluorophenyl)-6,7-meth...)
Show SMILES OP([O-])(=O)OC1CC(=Nc2cc3OCOc3cc12)c1ccccc1F
Show InChI InChI=1S/C16H13FNO6P/c17-11-4-2-1-3-9(11)12-6-14(24-25(19,20)21)10-5-15-16(23-8-22-15)7-13(10)18-12/h1-5,7,14H,6,8H2,(H2,19,20,21)/p-1
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 314n/an/an/an/an/an/a



China Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PTP4A2 by enzyme assay


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059140
PNG
(CHEMBL3393148)
Show SMILES COc1cc(\C=C(/C#N)C(=O)OCC=C)cc(Br)c1O
Show InChI InChI=1S/C14H12BrNO4/c1-3-4-20-14(18)10(8-16)5-9-6-11(15)13(17)12(7-9)19-2/h3,5-7,17H,1,4H2,2H3/b10-5+
PDB
MMDB

NCI pathway
KEGG

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Article
PubMed
n/an/a 3.14E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059141
PNG
(CHEMBL3393149)
Show SMILES COc1cc(\C=C(/C#N)C(=O)OC(C)C)cc(Br)c1O
Show InChI InChI=1S/C14H14BrNO4/c1-8(2)20-14(18)10(7-16)4-9-5-11(15)13(17)12(6-9)19-3/h4-6,8,17H,1-3H3/b10-4+
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

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PC sid
UniChem

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Article
PubMed
n/an/a 6.94E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059084
PNG
(CHEMBL3393171)
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
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Article
PubMed
n/an/a 1.04E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059086
PNG
(CHEMBL3393146)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCC=C)cc1Br
Show InChI InChI=1S/C13H10BrNO3/c1-2-5-18-13(17)10(8-15)6-9-3-4-12(16)11(14)7-9/h2-4,6-7,16H,1,5H2/b10-6+
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

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PC sid
UniChem

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Article
PubMed
n/an/a 1.04E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059142
PNG
(CHEMBL3393150)
Show SMILES CCOC(=O)C(=C\c1cc(Br)c(O)c(Br)c1)\C#N
Show InChI InChI=1S/C12H9Br2NO3/c1-2-18-12(17)8(6-15)3-7-4-9(13)11(16)10(14)5-7/h3-5,16H,2H2,1H3/b8-3+
PDB
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KEGG

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PC cid
PC sid
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Article
PubMed
n/an/a 1.09E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059143
PNG
(CHEMBL3393151)
Show SMILES CC(C)OC(=O)C(=C/c1ccc(O)c(Br)c1)\C#N
Show InChI InChI=1S/C13H12BrNO3/c1-8(2)18-13(17)10(7-15)5-9-3-4-12(16)11(14)6-9/h3-6,8,16H,1-2H3/b10-5-
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

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antibodypedia
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AffyNet 
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/a 1.50E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059139
PNG
(CHEMBL3393147)
Show SMILES OC(=O)c1ccc[n+]2c([O-])c(sc12)-c1ccccc1
Show InChI InChI=1S/C14H9NO3S/c16-12-11(9-5-2-1-3-6-9)19-13-10(14(17)18)7-4-8-15(12)13/h1-8H,(H-,16,17,18)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.88E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein tyrosine phosphatase type IVA 2


(Homo sapiens)
BDBM50059085
PNG
(CHEBI:8830 | RHODANINE | Rhodanine)
Show SMILES O=C1CSC(=S)N1
Show InChI InChI=1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

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CHEMBL
KEGG
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/a 1.88E+5n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair