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Found 64 hits Enz. Inhib. hit(s) with Target = 'Protein-cysteine N-palmitoyltransferase porcupine' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50133866
PNG
(CHEMBL3633802)
Show SMILES Cn1c2ncn(CC(=O)Nc3ccc(nn3)-c3ccccc3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
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n/an/a 18n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of mouse porcupine expressed in human HT1080 cells assessed as reduction in beta catenin reporter activity using firefly luciferase substr...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428000
PNG
(CHEMBL2322628)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(cn1)-c1ccoc1
Show InChI InChI=1S/C22H17N5O3S2/c28-18(26-21-23-10-15(11-24-21)14-6-8-30-12-14)13-32-22-25-17-7-9-31-19(17)20(29)27(22)16-4-2-1-3-5-16/h1-6,8,10-12H,7,9,13H2,(H,23,24,26,28)
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n/an/an/an/a 1.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428001
PNG
(CHEMBL2322627)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cccs1
Show InChI InChI=1S/C23H18N4O2S3/c28-20(26-19-9-8-15(13-24-19)18-7-4-11-30-18)14-32-23-25-17-10-12-31-21(17)22(29)27(23)16-5-2-1-3-6-16/h1-9,11,13H,10,12,14H2,(H,24,26,28)
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n/an/an/an/a 0.300n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428002
PNG
(CHEMBL2322626)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccsc1
Show InChI InChI=1S/C23H18N4O2S3/c28-20(26-19-7-6-15(12-24-19)16-8-10-30-13-16)14-32-23-25-18-9-11-31-21(18)22(29)27(23)17-4-2-1-3-5-17/h1-8,10,12-13H,9,11,14H2,(H,24,26,28)
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n/an/an/an/a 2n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428003
PNG
(CHEMBL2322625)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccco1
Show InChI InChI=1S/C23H18N4O3S2/c28-20(26-19-9-8-15(13-24-19)18-7-4-11-30-18)14-32-23-25-17-10-12-31-21(17)22(29)27(23)16-5-2-1-3-6-16/h1-9,11,13H,10,12,14H2,(H,24,26,28)
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n/an/an/an/a 3.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428004
PNG
(CHEMBL2322624)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccoc1
Show InChI InChI=1S/C23H18N4O3S2/c28-20(26-19-7-6-15(12-24-19)16-8-10-30-13-16)14-32-23-25-18-9-11-31-21(18)22(29)27(23)17-4-2-1-3-5-17/h1-8,10,12-13H,9,11,14H2,(H,24,26,28)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428005
PNG
(CHEMBL2322623)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cncnc1
Show InChI InChI=1S/C23H18N6O2S2/c30-20(28-19-7-6-15(12-26-19)16-10-24-14-25-11-16)13-33-23-27-18-8-9-32-21(18)22(31)29(23)17-4-2-1-3-5-17/h1-7,10-12,14H,8-9,13H2,(H,26,28,30)
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n/an/an/an/a 5.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428006
PNG
(CHEMBL2323233)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cccnc1
Show InChI InChI=1S/C24H19N5O2S2/c30-21(28-20-9-8-17(14-26-20)16-5-4-11-25-13-16)15-33-24-27-19-10-12-32-22(19)23(31)29(24)18-6-2-1-3-7-18/h1-9,11,13-14H,10,12,15H2,(H,26,28,30)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428007
PNG
(CHEMBL2323232)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(cn1)-c1ccccc1
Show InChI InChI=1S/C24H19N5O2S2/c30-20(28-23-25-13-17(14-26-23)16-7-3-1-4-8-16)15-33-24-27-19-11-12-32-21(19)22(31)29(24)18-9-5-2-6-10-18/h1-10,13-14H,11-12,15H2,(H,25,26,28,30)
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n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428008
PNG
(CHEMBL2323231)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428009
PNG
(CHEMBL2323230)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-18-11-12-20(26-15-18)17-7-3-1-4-8-17)16-33-25-28-21-13-14-32-23(21)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,27,30)
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n/an/an/an/a 0.300n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428010
PNG
(CHEMBL2323229)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-19-8-6-17(7-9-19)18-10-13-26-14-11-18)16-33-25-28-21-12-15-32-23(21)24(31)29(25)20-4-2-1-3-5-20/h1-11,13-14H,12,15-16H2,(H,27,30)
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n/an/an/an/a 3n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428011
PNG
(CHEMBL2323228)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-19-10-8-17(9-11-19)18-5-4-13-26-15-18)16-33-25-28-21-12-14-32-23(21)24(31)29(25)20-6-2-1-3-7-20/h1-11,13,15H,12,14,16H2,(H,27,30)
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n/an/an/an/a 0.450n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428012
PNG
(CHEMBL2322635)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-18-11-9-17(10-12-18)20-8-4-5-14-26-20)16-33-25-28-21-13-15-32-23(21)24(31)29(25)19-6-2-1-3-7-19/h1-12,14H,13,15-16H2,(H,27,30)
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n/an/an/an/a 4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428013
PNG
(CHEMBL2322634)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C26H21N3O2S2/c30-23(27-21-14-8-7-13-20(21)18-9-3-1-4-10-18)17-33-26-28-22-15-16-32-24(22)25(31)29(26)19-11-5-2-6-12-19/h1-14H,15-17H2,(H,27,30)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428014
PNG
(CHEMBL2322633)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H21N3O2S2/c30-23(27-20-11-7-10-19(16-20)18-8-3-1-4-9-18)17-33-26-28-22-14-15-32-24(22)25(31)29(26)21-12-5-2-6-13-21/h1-13,16H,14-15,17H2,(H,27,30)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428015
PNG
(CHEMBL2322632)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H21N3O2S2/c30-23(27-20-13-11-19(12-14-20)18-7-3-1-4-8-18)17-33-26-28-22-15-16-32-24(22)25(31)29(26)21-9-5-2-6-10-21/h1-14H,15-17H2,(H,27,30)
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n/an/an/an/a 0.75n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428016
PNG
(CHEMBL2323243)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C25H26N4O2S2/c30-22(26-18-9-11-19(12-10-18)28-14-5-2-6-15-28)17-33-25-27-21-13-16-32-23(21)24(31)29(25)20-7-3-1-4-8-20/h1,3-4,7-12H,2,5-6,13-17H2,(H,26,30)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428017
PNG
(CHEMBL2323242)
Show SMILES CN(C)c1ccc(NC(=O)CSc2nc3CCSc3c(=O)n2-c2ccccc2)cc1
Show InChI InChI=1S/C22H22N4O2S2/c1-25(2)16-10-8-15(9-11-16)23-19(27)14-30-22-24-18-12-13-29-20(18)21(28)26(22)17-6-4-3-5-7-17/h3-11H,12-14H2,1-2H3,(H,23,27)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428018
PNG
(CHEMBL2323241)
Show SMILES CC(=O)c1ccc(NC(=O)CSc2nc3CCSc3c(=O)n2-c2ccccc2)cc1
Show InChI InChI=1S/C22H19N3O3S2/c1-14(26)15-7-9-16(10-8-15)23-19(27)13-30-22-24-18-11-12-29-20(18)21(28)25(22)17-5-3-2-4-6-17/h2-10H,11-13H2,1H3,(H,23,27)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428019
PNG
(CHEMBL2323240)
Show SMILES CCOc1ccc(NC(=O)CSc2nc3CCSc3c(=O)n2-c2ccccc2)cc1
Show InChI InChI=1S/C22H21N3O3S2/c1-2-28-17-10-8-15(9-11-17)23-19(26)14-30-22-24-18-12-13-29-20(18)21(27)25(22)16-6-4-3-5-7-16/h3-11H,2,12-14H2,1H3,(H,23,26)
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The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428020
PNG
(CHEMBL2323239)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C23H18N4O2S3/c28-19(26-22-24-13-18(32-22)15-7-3-1-4-8-15)14-31-23-25-17-11-12-30-20(17)21(29)27(23)16-9-5-2-6-10-16/h1-10,13H,11-12,14H2,(H,24,26,28)
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n/an/an/an/a 55n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428021
PNG
(CHEMBL2323238)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C23H18N4O2S3/c28-19(26-22-24-18(13-31-22)15-7-3-1-4-8-15)14-32-23-25-17-11-12-30-20(17)21(29)27(23)16-9-5-2-6-10-16/h1-10,13H,11-12,14H2,(H,24,26,28)
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n/an/an/an/a 350n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428022
PNG
(CHEMBL2323237)
Show SMILES COc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)ccc2c1
Show InChI InChI=1S/C24H20N4O3S2/c1-31-17-8-9-18-15(13-17)7-10-20(25-18)27-21(29)14-33-24-26-19-11-12-32-22(19)23(30)28(24)16-5-3-2-4-6-16/h2-10,13H,11-12,14H2,1H3,(H,25,27,29)
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n/an/an/an/a 580n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428023
PNG
(CHEMBL2323236)
Show SMILES COc1ccc2nc(NC(=O)CNC(=O)c3ccc(=O)n(c3)-c3ccccc3)sc2c1
Show InChI InChI=1S/C22H18N4O4S/c1-30-16-8-9-17-18(11-16)31-22(24-17)25-19(27)12-23-21(29)14-7-10-20(28)26(13-14)15-5-3-2-4-6-15/h2-11,13H,12H2,1H3,(H,23,29)(H,24,25,27)
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428024
PNG
(CHEMBL2323235)
Show SMILES O=C(CNC(=O)c1nn(-c2ccccc2)c(=O)c2ccccc12)Nc1nccs1
Show InChI InChI=1S/C20H15N5O3S/c26-16(23-20-21-10-11-29-20)12-22-18(27)17-14-8-4-5-9-15(14)19(28)25(24-17)13-6-2-1-3-7-13/h1-11H,12H2,(H,22,27)(H,21,23,26)
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428025
PNG
(CHEMBL2323234)
Show SMILES CCOC(=O)c1ccc(NC(=O)CSc2nc3CCSc3c(=O)n2-c2ccccc2)cc1
Show InChI InChI=1S/C23H21N3O4S2/c1-2-30-22(29)15-8-10-16(11-9-15)24-19(27)14-32-23-25-18-12-13-31-20(18)21(28)26(23)17-6-4-3-5-7-17/h3-11H,2,12-14H2,1H3,(H,24,27)
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n/an/an/an/a 300n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428026
PNG
(CHEMBL1444402)
Show SMILES CCn1c(SCC(=O)Nc2nc3ccccc3s2)nc2CC(C)Sc2c1=O
Show InChI InChI=1S/C18H18N4O2S3/c1-3-22-16(24)15-12(8-10(2)26-15)20-18(22)25-9-14(23)21-17-19-11-6-4-5-7-13(11)27-17/h4-7,10H,3,8-9H2,1-2H3,(H,19,21,23)
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n/an/an/an/a 4.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM37088
PNG
(2-[(3,6-dimethyl-4-oxidanylidene-6,7-dihydrothieno...)
Show SMILES CC1Cc2nc(SCC(=O)Nc3nc4ccc(C)cc4s3)n(C)c(=O)c2S1
Show InChI InChI=1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23)
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n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428027
PNG
(CHEMBL1257090)
Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
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n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50365355
PNG
(CHEMBL1257089)
Show SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccc(F)cc3)sc2c1
Show InChI InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
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n/an/an/an/a 40n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428028
PNG
(CHEMBL1257064)
Show SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
Show InChI InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
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n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428029
PNG
(CHEMBL1257063)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(OC)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C26H21N5O5S/c1-35-16-9-7-15(8-10-16)31-25(34)19-6-4-3-5-18(19)23(30-31)24(33)27-14-22(32)29-26-28-20-12-11-17(36-2)13-21(20)37-26/h3-13H,14H2,1-2H3,(H,27,33)(H,28,29,32)
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n/an/an/an/a 60n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428030
PNG
(CHEMBL2325508)
Show SMILES CCOC(=O)c1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C27H21N5O5S/c1-2-37-26(36)16-12-13-20-21(14-16)38-27(29-20)30-22(33)15-28-24(34)23-18-10-6-7-11-19(18)25(35)32(31-23)17-8-4-3-5-9-17/h3-14H,2,15H2,1H3,(H,28,34)(H,29,30,33)
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428031
PNG
(CHEMBL2325507)
Show SMILES [O-][N+](=O)c1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16N6O5S/c31-20(27-24-26-18-11-10-15(30(34)35)12-19(18)36-24)13-25-22(32)21-16-8-4-5-9-17(16)23(33)29(28-21)14-6-2-1-3-7-14/h1-12H,13H2,(H,25,32)(H,26,27,31)
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n/an/an/an/a 240n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428032
PNG
(CHEMBL2325506)
Show SMILES COc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)nc2CCSc2c1=O
Show InChI InChI=1S/C23H17F3N4O3S3/c1-33-14-5-3-13(4-6-14)30-20(32)19-16(8-9-34-19)28-22(30)35-11-18(31)29-21-27-15-7-2-12(23(24,25)26)10-17(15)36-21/h2-7,10H,8-9,11H2,1H3,(H,27,29,31)
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n/an/an/an/a 100n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428033
PNG
(CHEMBL2325505)
Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)nc2CCSc2c1=O
Show InChI InChI=1S/C23H17F3N4O3S3/c1-33-16-5-3-2-4-15(16)30-20(32)19-14(8-9-34-19)28-22(30)35-11-18(31)29-21-27-13-7-6-12(23(24,25)26)10-17(13)36-21/h2-7,10H,8-9,11H2,1H3,(H,27,29,31)
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n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428034
PNG
(CHEMBL2324267)
Show SMILES Fc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)nc2CCSc2c1=O
Show InChI InChI=1S/C22H14F4N4O2S3/c23-12-2-4-13(5-3-12)30-19(32)18-15(7-8-33-18)28-21(30)34-10-17(31)29-20-27-14-6-1-11(22(24,25)26)9-16(14)35-20/h1-6,9H,7-8,10H2,(H,27,29,31)
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n/an/an/an/a 100n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428035
PNG
(CHEMBL2324266)
Show SMILES FC(F)(F)c1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
Show InChI InChI=1S/C22H15F3N4O2S3/c23-22(24,25)12-6-7-14-16(10-12)34-20(26-14)28-17(30)11-33-21-27-15-8-9-32-18(15)19(31)29(21)13-4-2-1-3-5-13/h1-7,10H,8-9,11H2,(H,26,28,30)
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n/an/an/an/a 40n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428036
PNG
(CHEMBL2324265)
Show SMILES Fc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)c2ccccc2c1=O
Show InChI InChI=1S/C25H15F4N5O3S/c26-14-6-8-15(9-7-14)34-23(37)17-4-2-1-3-16(17)21(33-34)22(36)30-12-20(35)32-24-31-18-10-5-13(25(27,28)29)11-19(18)38-24/h1-11H,12H2,(H,30,36)(H,31,32,35)
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n/an/an/an/a 90n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428037
PNG
(CHEMBL2325513)
Show SMILES FC(F)(F)c1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C25H16F3N5O3S/c26-25(27,28)14-10-11-18-19(12-14)37-24(30-18)31-20(34)13-29-22(35)21-16-8-4-5-9-17(16)23(36)33(32-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,29,35)(H,30,31,34)
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n/an/an/an/a 110n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428038
PNG
(CHEMBL2325512)
Show SMILES COc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(Cl)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C22H17ClN4O3S3/c1-30-14-5-3-13(4-6-14)27-20(29)19-16(8-9-31-19)25-22(27)32-11-18(28)26-21-24-15-7-2-12(23)10-17(15)33-21/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
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n/an/an/an/a 35n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428039
PNG
(CHEMBL2325511)
Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(Cl)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C22H17ClN4O3S3/c1-30-16-5-3-2-4-15(16)27-20(29)19-14(8-9-31-19)25-22(27)32-11-18(28)26-21-24-13-7-6-12(23)10-17(13)33-21/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
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n/an/an/an/a 50n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428040
PNG
(CHEMBL2325510)
Show SMILES Fc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(Cl)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C21H14ClFN4O2S3/c22-11-1-6-14-16(9-11)32-20(24-14)26-17(28)10-31-21-25-15-7-8-30-18(15)19(29)27(21)13-4-2-12(23)3-5-13/h1-6,9H,7-8,10H2,(H,24,26,28)
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n/an/an/an/a 175n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428041
PNG
(CHEMBL2325509)
Show SMILES Clc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
Show InChI InChI=1S/C21H15ClN4O2S3/c22-12-6-7-14-16(10-12)31-20(23-14)25-17(27)11-30-21-24-15-8-9-29-18(15)19(28)26(21)13-4-2-1-3-5-13/h1-7,10H,8-9,11H2,(H,23,25,27)
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n/an/an/an/a 40n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428042
PNG
(CHEMBL2324275)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(Cl)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C25H18ClN5O4S/c1-35-16-9-7-15(8-10-16)31-24(34)18-5-3-2-4-17(18)22(30-31)23(33)27-13-21(32)29-25-28-19-11-6-14(26)12-20(19)36-25/h2-12H,13H2,1H3,(H,27,33)(H,28,29,32)
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n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428043
PNG
(CHEMBL2324274)
Show SMILES Fc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(Cl)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C24H15ClFN5O3S/c25-13-5-10-18-19(11-13)35-24(28-18)29-20(32)12-27-22(33)21-16-3-1-2-4-17(16)23(34)31(30-21)15-8-6-14(26)7-9-15/h1-11H,12H2,(H,27,33)(H,28,29,32)
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n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428044
PNG
(CHEMBL2324273)
Show SMILES Clc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16ClN5O3S/c25-14-10-11-18-19(12-14)34-24(27-18)28-20(31)13-26-22(32)21-16-8-4-5-9-17(16)23(33)30(29-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,26,32)(H,27,28,31)
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n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428045
PNG
(CHEMBL2324272)
Show SMILES Fc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16FN5O3S/c25-14-10-11-18-19(12-14)34-24(27-18)28-20(31)13-26-22(32)21-16-8-4-5-9-17(16)23(33)30(29-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,26,32)(H,27,28,31)
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n/an/an/an/a 470n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428046
PNG
(CHEMBL2324271)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccccc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C25H19N5O4S/c1-34-16-12-10-15(11-13-16)30-24(33)18-7-3-2-6-17(18)22(29-30)23(32)26-14-21(31)28-25-27-19-8-4-5-9-20(19)35-25/h2-13H,14H2,1H3,(H,26,32)(H,27,28,31)
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n/an/an/an/a 2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
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