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Found 33 hits Enz. Inhib. hit(s) with Target = 'Protein-serine O-palmitoleoyltransferase porcupine' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125819
PNG
(CHEMBL3623895)
Show SMILES CC(Oc1ccc(cc1)-c1ccnc(C)c1)C(=O)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1/C24H21N5O2/c1-16-13-19(9-10-26-16)18-3-6-21(7-4-18)31-17(2)24(30)29-23-8-5-20(14-28-23)22-15-25-11-12-27-22/h3-15,17H,1-2H3,(H,28,29,30)
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n/an/a 0.110n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125820
PNG
(CHEMBL3623894)
Show SMILES Cc1cc(ccn1)-c1ccc(CCC(=O)Nc2ccc(cn2)-c2cnccn2)cc1
Show InChI InChI=1S/C24H21N5O/c1-17-14-20(10-11-26-17)19-5-2-18(3-6-19)4-9-24(30)29-23-8-7-21(15-28-23)22-16-25-12-13-27-22/h2-3,5-8,10-16H,4,9H2,1H3,(H,28,29,30)
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n/an/a 0.190n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125941
PNG
(CHEMBL3623875)
Show SMILES Cc1cc(ccn1)-c1ccc(OC(=O)Nc2ccc(cn2)-c2cnccn2)cc1
Show InChI InChI=1S/C22H17N5O2/c1-15-12-17(8-9-24-15)16-2-5-19(6-3-16)29-22(28)27-21-7-4-18(13-26-21)20-14-23-10-11-25-20/h2-14H,1H3,(H,26,27,28)
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n/an/a 0.230n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125818
PNG
(CHEMBL3623896)
Show SMILES Cc1ccc(cn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C
Show InChI InChI=1S/C23H20N6O/c1-15-9-17(11-28-23(15)19-4-3-16(2)26-13-19)10-22(30)29-21-6-5-18(12-27-21)20-14-24-7-8-25-20/h3-9,11-14H,10H2,1-2H3,(H,27,29,30)
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n/an/a 0.380n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin)


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50133870
PNG
(CHEBI:78030 | CHEMBL3188386)
Show SMILES Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C
Show InChI InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
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n/an/a 0.400n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50133865
PNG
(CHEMBL3633801)
Show SMILES C[C@@H](C(=O)Nc1ccc(cc1)-c1ccsc1)n1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1/C20H19N5O3S/c1-12(25-11-21-17-16(25)19(27)24(3)20(28)23(17)2)18(26)22-15-6-4-13(5-7-15)14-8-9-29-10-14/h4-12H,1-3H3,(H,22,26)/t12-/s2
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n/an/a 0.5n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125824
PNG
(CHEMBL3623893)
Show SMILES Cc1cc(ccn1)-c1ccc(SCC(=O)Nc2ccc(cn2)-c2cnccn2)cc1
Show InChI InChI=1S/C23H19N5OS/c1-16-12-18(8-9-25-16)17-2-5-20(6-3-17)30-15-23(29)28-22-7-4-19(13-27-22)21-14-24-10-11-26-21/h2-14H,15H2,1H3,(H,27,28,29)
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n/an/a 0.530n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125818
PNG
(CHEMBL3623896)
Show SMILES Cc1ccc(cn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C
Show InChI InChI=1S/C23H20N6O/c1-15-9-17(11-28-23(15)19-4-3-16(2)26-13-19)10-22(30)29-21-6-5-18(12-27-21)20-14-24-7-8-25-20/h3-9,11-14H,10H2,1-2H3,(H,27,29,30)
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n/an/a 0.570n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125825
PNG
(CHEMBL3623892)
Show SMILES CN(CC(=O)Nc1ccc(cn1)-c1cnccn1)c1ccc(cc1)-c1ccnc(C)c1
Show InChI InChI=1S/C24H22N6O/c1-17-13-19(9-10-26-17)18-3-6-21(7-4-18)30(2)16-24(31)29-23-8-5-20(14-28-23)22-15-25-11-12-27-22/h3-15H,16H2,1-2H3,(H,28,29,31)
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n/an/a 0.670n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125826
PNG
(CHEMBL3623891)
Show SMILES Cc1cc(ccn1)-c1ccc(NCC(=O)Nc2ccc(cn2)-c2cnccn2)cc1
Show InChI InChI=1S/C23H20N6O/c1-16-12-18(8-9-25-16)17-2-5-20(6-3-17)27-15-23(30)29-22-7-4-19(13-28-22)21-14-24-10-11-26-21/h2-14,27H,15H2,1H3,(H,28,29,30)
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n/an/a 0.960n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125942
PNG
(CHEMBL3623874)
Show SMILES Cc1cc(ccn1)-c1ccc(OC(=O)Nc2ccc(cc2)-c2cccnc2)cc1
Show InChI InChI=1S/C24H19N3O2/c1-17-15-20(12-14-26-17)18-6-10-23(11-7-18)29-24(28)27-22-8-4-19(5-9-22)21-3-2-13-25-16-21/h2-16H,1H3,(H,27,28)
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n/an/a 2.20n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125831
PNG
(CHEMBL3623887)
Show SMILES O=C(COc1ccc2cc(ccc2c1)C#N)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C22H15N5O2/c23-11-15-1-2-17-10-19(5-3-16(17)9-15)29-14-22(28)27-21-6-4-18(12-26-21)20-13-24-7-8-25-20/h1-10,12-13H,14H2,(H,26,27,28)
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n/an/a 2.70n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50133866
PNG
(CHEMBL3633802)
Show SMILES Cn1c2ncn(CC(=O)Nc3ccc(nn3)-c3ccccc3)c2c(=O)n(C)c1=O
Show InChI InChI=1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
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n/an/a 2.90n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50133868
PNG
(CHEMBL3633804)
Show SMILES Cn1c2nc3CC[C@@H](CC(=O)Nc4ccc(nn4)-c4ccccc4)n3c2c(=O)n(C)c1=O
Show InChI InChI=1/C22H21N7O3/c1-27-20-19(21(31)28(2)22(27)32)29-14(8-11-17(29)24-20)12-18(30)23-16-10-9-15(25-26-16)13-6-4-3-5-7-13/h3-7,9-10,14H,8,11-12H2,1-2H3,(H,23,26,30)/t14-/s2
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n/an/a 5n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine in human HEK293 cells by STF reporter assay


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125943
PNG
(CHEMBL3623873)
Show SMILES Cc1cc(ccn1)-c1ccc(OC(=O)Nc2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H20N2O2/c1-18-17-22(15-16-26-18)21-9-13-24(14-10-21)29-25(28)27-23-11-7-20(8-12-23)19-5-3-2-4-6-19/h2-17H,1H3,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125829
PNG
(CHEMBL3623889)
Show SMILES CC(=O)N1CCc2ccc(OCC(=O)Nc3ccc(cn3)-c3cnccn3)cc2C1
Show InChI InChI=1S/C22H21N5O3/c1-15(28)27-9-6-16-2-4-19(10-18(16)13-27)30-14-22(29)26-21-5-3-17(11-25-21)20-12-23-7-8-24-20/h2-5,7-8,10-12H,6,9,13-14H2,1H3,(H,25,26,29)
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n/an/a 24n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50133869
PNG
(CHEMBL3633800)
Show SMILES COc1cc(F)ccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C23H19FN4O3S3/c1-12-3-5-14-18(9-12)34-22(25-14)27-19(29)11-33-23-26-15-7-8-32-20(15)21(30)28(23)16-6-4-13(24)10-17(16)31-2/h3-6,9-10H,7-8,11H2,1-2H3,(H,25,27,29)
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n/an/a 27n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125899
PNG
(CHEMBL3623879)
Show SMILES O=C(COc1ccc2ccncc2c1)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C20H15N5O2/c26-20(13-27-17-3-1-14-5-6-21-10-16(14)9-17)25-19-4-2-15(11-24-19)18-12-22-7-8-23-18/h1-12H,13H2,(H,24,25,26)
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n/an/a 30n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125904
PNG
(CHEMBL3623878)
Show SMILES Cc1cc(ccn1)-c1cccc(SCC(=O)Nc2ccc(cn2)-c2cnccn2)c1
Show InChI InChI=1S/C23H19N5OS/c1-16-11-18(7-8-25-16)17-3-2-4-20(12-17)30-15-23(29)28-22-6-5-19(13-27-22)21-14-24-9-10-26-21/h2-14H,15H2,1H3,(H,27,28,29)
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n/an/a 40n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50428029
PNG
(CHEMBL1257063)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(OC)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C26H21N5O5S/c1-35-16-9-7-15(8-10-16)31-25(34)19-6-4-3-5-18(19)23(30-31)24(33)27-14-22(32)29-26-28-20-12-11-17(36-2)13-21(20)37-26/h3-13H,14H2,1-2H3,(H,27,33)(H,28,29,32)
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n/an/a 60n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50133864
PNG
(CHEMBL2139947)
Show SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cc2)-c2cccnc2)cc1
Show InChI InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
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n/an/a 74n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125938
PNG
(CHEMBL3623877)
Show SMILES Cc1cc(ccn1)-c1cccc(NCC(=O)Nc2ccc(cn2)-c2cnccn2)c1
Show InChI InChI=1S/C23H20N6O/c1-16-11-18(7-8-25-16)17-3-2-4-20(12-17)27-15-23(30)29-22-6-5-19(13-28-22)21-14-24-9-10-26-21/h2-14,27H,15H2,1H3,(H,28,29,30)
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n/an/a 164n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125940
PNG
(CHEMBL3623876)
Show SMILES Cc1cc(ccn1)-c1cccc(OCC(=O)Nc2ccc(cn2)-c2cnccn2)c1
Show InChI InChI=1S/C23H19N5O2/c1-16-11-18(7-8-25-16)17-3-2-4-20(12-17)30-15-23(29)28-22-6-5-19(13-27-22)21-14-24-9-10-26-21/h2-14H,15H2,1H3,(H,27,28,29)
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n/an/a 188n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125827
PNG
(CHEMBL3623890)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(OCC(=O)Nc2ccc(cn2)-c2cnccn2)cc1
Show InChI InChI=1S/C23H24N6O3/c1-17(30)28-10-12-29(13-11-28)19-3-5-20(6-4-19)32-16-23(31)27-22-7-2-18(14-26-22)21-15-24-8-9-25-21/h2-9,14-15H,10-13,16H2,1H3,(H,26,27,31)
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n/an/a 483n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125830
PNG
(CHEMBL3623888)
Show SMILES O=C(COc1ccc(cc1)C#N)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C18H13N5O2/c19-9-13-1-4-15(5-2-13)25-12-18(24)23-17-6-3-14(10-22-17)16-11-20-7-8-21-16/h1-8,10-11H,12H2,(H,22,23,24)
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n/an/a 485n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125897
PNG
(CHEMBL3623881)
Show SMILES O=C(COc1ccc2[nH]ncc2c1)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C18H14N6O2/c25-18(11-26-14-2-3-15-13(7-14)9-22-24-15)23-17-4-1-12(8-21-17)16-10-19-5-6-20-16/h1-10H,11H2,(H,22,24)(H,21,23,25)
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Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125896
PNG
(CHEMBL3623882)
Show SMILES O=C(CNc1ccc2[nH]ncc2c1)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C18H15N7O/c26-18(11-21-14-2-3-15-13(7-14)9-23-25-15)24-17-4-1-12(8-22-17)16-10-19-5-6-20-16/h1-10,21H,11H2,(H,23,25)(H,22,24,26)
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Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125895
PNG
(CHEMBL3623883)
Show SMILES Cn1ncc2cc(OCC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C19H16N6O2/c1-25-17-4-3-15(8-14(17)10-23-25)27-12-19(26)24-18-5-2-13(9-22-18)16-11-20-6-7-21-16/h2-11H,12H2,1H3,(H,22,24,26)
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Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125876
PNG
(CHEMBL3623884)
Show SMILES Cn1ncc2cc(NCC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12
Show InChI InChI=1S/C19H17N7O/c1-26-17-4-3-15(8-14(17)10-24-26)22-12-19(27)25-18-5-2-13(9-23-18)16-11-20-6-7-21-16/h2-11,22H,12H2,1H3,(H,23,25,27)
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Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125858
PNG
(CHEMBL3623885)
Show SMILES Nc1noc2ccc(OCC(=O)Nc3ccc(cn3)-c3cnccn3)cc12
Show InChI InChI=1S/C18H14N6O3/c19-18-13-7-12(2-3-15(13)27-24-18)26-10-17(25)23-16-4-1-11(8-22-16)14-9-20-5-6-21-14/h1-9H,10H2,(H2,19,24)(H,22,23,25)
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Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125839
PNG
(CHEMBL3623886)
Show SMILES COc1ccc2cc(OCC(=O)Nc3ccc(cn3)-c3cnccn3)ccc2c1
Show InChI InChI=1S/C22H18N4O3/c1-28-18-5-2-16-11-19(6-3-15(16)10-18)29-14-22(27)26-21-7-4-17(12-25-21)20-13-23-8-9-24-20/h2-13H,14H2,1H3,(H,25,26,27)
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Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125898
PNG
(CHEMBL3623880)
Show SMILES O=C(COc1ccc2ccccc2c1)Nc1ccc(cn1)-c1cnccn1
Show InChI InChI=1S/C21H16N4O2/c26-21(14-27-18-7-5-15-3-1-2-4-16(15)11-18)25-20-8-6-17(12-24-20)19-13-22-9-10-23-19/h1-13H,14H2,(H,24,25,26)
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Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50133867
PNG
(CHEMBL3633803)
Show SMILES C[C@H](C(=O)Nc1ccc(cc1)-c1ccsc1)n1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1/C20H19N5O3S/c1-12(25-11-21-17-16(25)19(27)24(3)20(28)23(17)2)18(26)22-15-6-4-13(5-7-15)14-8-9-29-10-14/h4-12H,1-3H3,(H,22,26)/t12-/s2
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n/an/a 5.40E+3n/an/an/an/an/an/a



Experimental Therapeutics Centre

Curated by ChEMBL


Assay Description
Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after...


Bioorg Med Chem Lett 25: 5472-6 (2015)

More data for this
Ligand-Target Pair