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Found 22 hits Enz. Inhib. hit(s) with Target = 'Protein-tyrosine kinase 2-beta' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402999
PNG
(CHEMBL2207441)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(n[nH]1)-c1ccc2nccnc2c1)C(C)(C)C
Show InChI InChI=1S/C26H26N8O/c1-16-5-8-18(9-6-16)34-24(15-22(33-34)26(2,3)4)30-25(35)29-23-14-20(31-32-23)17-7-10-19-21(13-17)28-12-11-27-19/h5-15H,1-4H3,(H3,29,30,31,32,35)
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n/an/a 62n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402996
PNG
(CHEMBL2207440)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(n[nH]1)-c1ccc2ncccc2c1)C(C)(C)C
Show InChI InChI=1S/C27H27N7O/c1-17-7-10-20(11-8-17)34-25(16-23(33-34)27(2,3)4)30-26(35)29-24-15-22(31-32-24)19-9-12-21-18(14-19)6-5-13-28-21/h5-16H,1-4H3,(H3,29,30,31,32,35)
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n/an/a 98n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50318872
PNG
(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-((...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(COc2cccnc2)n[nH]1)C(C)(C)C
Show InChI InChI=1S/C24H27N7O2/c1-16-7-9-18(10-8-16)31-22(13-20(30-31)24(2,3)4)27-23(32)26-21-12-17(28-29-21)15-33-19-6-5-11-25-14-19/h5-14H,15H2,1-4H3,(H3,26,27,28,29,32)
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n/an/a 190n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50403004
PNG
(CHEMBL2207439)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(n[nH]1)-c1ccc2nccn2c1)C(C)(C)C
Show InChI InChI=1S/C25H26N8O/c1-16-5-8-18(9-6-16)33-23(14-20(31-33)25(2,3)4)28-24(34)27-21-13-19(29-30-21)17-7-10-22-26-11-12-32(22)15-17/h5-15H,1-4H3,(H3,27,28,29,30,34)
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n/an/a 236n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50403003
PNG
(CHEMBL2207823)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cccc2cc([nH]c12)C(=O)N1CCCC1)C(C)(C)C
Show InChI InChI=1S/C28H32N6O2/c1-18-10-12-20(13-11-18)34-24(17-23(32-34)28(2,3)4)31-27(36)30-21-9-7-8-19-16-22(29-25(19)21)26(35)33-14-5-6-15-33/h7-13,16-17,29H,5-6,14-15H2,1-4H3,(H2,30,31,36)
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n/an/a 265n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50403002
PNG
(CHEMBL2207430)
Show SMILES CCOCCCNC(=O)c1cc2cccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c2[nH]1
Show InChI InChI=1S/C29H36N6O3/c1-6-38-16-8-15-30-27(36)23-17-20-9-7-10-22(26(20)31-23)32-28(37)33-25-18-24(29(3,4)5)34-35(25)21-13-11-19(2)12-14-21/h7,9-14,17-18,31H,6,8,15-16H2,1-5H3,(H,30,36)(H2,32,33,37)
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n/an/a 283n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50403001
PNG
(CHEMBL2207438)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(n[nH]1)-c1ccc2OCCOc2c1)C(C)(C)C
Show InChI InChI=1S/C26H28N6O3/c1-16-5-8-18(9-6-16)32-24(15-22(31-32)26(2,3)4)28-25(33)27-23-14-19(29-30-23)17-7-10-20-21(13-17)35-12-11-34-20/h5-10,13-15H,11-12H2,1-4H3,(H3,27,28,29,30,33)
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n/an/a 328n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402998
PNG
(CHEMBL2207433)
Show SMILES COc1ccc(cn1)-c1cc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)[nH]n1
Show InChI InChI=1S/C24H27N7O2/c1-15-6-9-17(10-7-15)31-21(13-19(30-31)24(2,3)4)27-23(32)26-20-12-18(28-29-20)16-8-11-22(33-5)25-14-16/h6-14H,1-5H3,(H3,26,27,28,29,32)
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n/an/a 524n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402990
PNG
(CHEMBL2207427)
Show SMILES CC(C)NC(=O)c1cc2cccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c2[nH]1
Show InChI InChI=1S/C27H32N6O2/c1-16(2)28-25(34)21-14-18-8-7-9-20(24(18)29-21)30-26(35)31-23-15-22(27(4,5)6)32-33(23)19-12-10-17(3)11-13-19/h7-16,29H,1-6H3,(H,28,34)(H2,30,31,35)
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n/an/a 530n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402997
PNG
(CHEMBL2207429)
Show SMILES CN(CCc1ccccn1)C(=O)c1cc2cccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c2[nH]1
Show InChI InChI=1S/C32H35N7O2/c1-21-12-14-24(15-13-21)39-28(20-27(37-39)32(2,3)4)36-31(41)35-25-11-8-9-22-19-26(34-29(22)25)30(40)38(5)18-16-23-10-6-7-17-33-23/h6-15,17,19-20,34H,16,18H2,1-5H3,(H2,35,36,41)
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n/an/a 553n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402993
PNG
(CHEMBL2207432)
Show SMILES COc1ccc(nc1)-c1cc(NC(=O)Nc2cc(nn2-c2ccc(C)cc2)C(C)(C)C)[nH]n1
Show InChI InChI=1S/C24H27N7O2/c1-15-6-8-16(9-7-15)31-22(13-20(30-31)24(2,3)4)27-23(32)26-21-12-19(28-29-21)18-11-10-17(33-5)14-25-18/h6-14H,1-5H3,(H3,26,27,28,29,32)
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n/an/a 607n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50403000
PNG
(CHEMBL2207437)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(n[nH]1)-c1ccc(=O)n(C)c1)C(C)(C)C
Show InChI InChI=1S/C24H27N7O2/c1-15-6-9-17(10-7-15)31-21(13-19(29-31)24(2,3)4)26-23(33)25-20-12-18(27-28-20)16-8-11-22(32)30(5)14-16/h6-14H,1-5H3,(H3,25,26,27,28,33)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402994
PNG
(CHEMBL2207426)
Show SMILES CNC(=O)c1cc2cccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c2[nH]1
Show InChI InChI=1S/C25H28N6O2/c1-15-9-11-17(12-10-15)31-21(14-20(30-31)25(2,3)4)29-24(33)28-18-8-6-7-16-13-19(23(32)26-5)27-22(16)18/h6-14,27H,1-5H3,(H,26,32)(H2,28,29,33)
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n/an/a 2.78E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402995
PNG
(CHEMBL2207436)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(n[nH]1)-c1ccc(=O)[nH]n1)C(C)(C)C
Show InChI InChI=1S/C22H24N8O2/c1-13-5-7-14(8-6-13)30-19(12-17(29-30)22(2,3)4)24-21(32)23-18-11-16(26-27-18)15-9-10-20(31)28-25-15/h5-12H,1-4H3,(H,28,31)(H3,23,24,26,27,32)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50403007
PNG
(CHEMBL2207435)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(n[nH]1)-c1ccc(=O)[nH]c1)C(C)(C)C
Show InChI InChI=1S/C23H25N7O2/c1-14-5-8-16(9-6-14)30-20(12-18(29-30)23(2,3)4)26-22(32)25-19-11-17(27-28-19)15-7-10-21(31)24-13-15/h5-13H,1-4H3,(H,24,31)(H3,25,26,27,28,32)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50402991
PNG
(CHEMBL2207428)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cccc2cc([nH]c12)C(=O)N1CCC2(CCNC2)C1)C(C)(C)C
Show InChI InChI=1S/C31H37N7O2/c1-20-8-10-22(11-9-20)38-26(17-25(36-38)30(2,3)4)35-29(40)34-23-7-5-6-21-16-24(33-27(21)23)28(39)37-15-13-31(19-37)12-14-32-18-31/h5-11,16-17,32-33H,12-15,18-19H2,1-4H3,(H2,34,35,40)
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n/an/a 7.66E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay


Bioorg Med Chem Lett 22: 7523-9 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301356
PNG
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1
Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35)
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n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301356
PNG
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1
Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35)
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n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301356
PNG
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1
Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35)
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n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301364
PNG
(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccs4)nc3)c2cc1OC
Show InChI InChI=1S/C32H24N4O5S/c1-39-27-16-23-25(17-28(27)40-2)33-13-12-26(23)41-22-10-11-30(34-18-22)35-31(37)24-15-20(29-9-6-14-42-29)19-36(32(24)38)21-7-4-3-5-8-21/h3-19H,1-2H3,(H,34,35,37)
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n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301364
PNG
(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccs4)nc3)c2cc1OC
Show InChI InChI=1S/C32H24N4O5S/c1-39-27-16-23-25(17-28(27)40-2)33-13-12-26(23)41-22-10-11-30(34-18-22)35-31(37)24-15-20(29-9-6-14-42-29)19-36(32(24)38)21-7-4-3-5-8-21/h3-19H,1-2H3,(H,34,35,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC sid
UniChem

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PubMed
n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301364
PNG
(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccs4)nc3)c2cc1OC
Show InChI InChI=1S/C32H24N4O5S/c1-39-27-16-23-25(17-28(27)40-2)33-13-12-26(23)41-22-10-11-30(34-18-22)35-31(37)24-15-20(29-9-6-14-42-29)19-36(32(24)38)21-7-4-3-5-8-21/h3-19H,1-2H3,(H,34,35,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair