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Found 54 hits Enz. Inhib. hit(s) with Target = 'Protein-tyrosine phosphatase 4A3' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059084
PNG
(CHEMBL3393171)
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
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n/an/a 128n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of full length human fusion His6 tagged PRL3 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by imm...


Eur J Med Chem 88: 89-100 (2014)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059084
PNG
(CHEMBL3393171)
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
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n/an/a 240n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Eur J Med Chem 88: 89-100 (2014)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50436447
PNG
(CHEMBL2397162)
Show SMILES COc1ccccc1COc1ccccc1C=CC=C1SC(S)=NC1=O
Show InChI InChI=1S/C20H17NO3S2/c1-23-16-10-4-3-8-15(16)13-24-17-11-5-2-7-14(17)9-6-12-18-19(22)21-20(25)26-18/h2-12H,13H2,1H3,(H,21,22,25)
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n/an/a 800n/an/an/an/an/an/a



University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human His6-tagged full length PRL3 assessed as inhibition of DiFMUP dephosphorylation


Bioorg Med Chem Lett 23: 3769-74 (2013)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184288
PNG
(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Br
Show InChI InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)
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n/an/a 900n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184288
PNG
(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Br
Show InChI InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)
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n/an/a 900n/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of PRL-3


Bioorg Med Chem 19: 2145-55 (2011)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184297
PNG
(5-(5-(benzo[b]thiophen-3-yl)-2-(benzyloxy)benzylid...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(ccc1OCc1ccccc1)-c1csc2ccccc12
Show InChI InChI=1S/C25H17NO2S3/c27-24-23(31-25(29)26-24)13-18-12-17(20-15-30-22-9-5-4-8-19(20)22)10-11-21(18)28-14-16-6-2-1-3-7-16/h1-13,15H,14H2,(H,26,27,29)
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n/an/a 900n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184288
PNG
(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Br
Show InChI InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human His6-tagged full length PRL3 assessed as inhibition of DiFMUP dephosphorylation


Bioorg Med Chem Lett 23: 3769-74 (2013)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184287
PNG
(5-(5-(benzofuran-3-yl)-2-(benzyloxy)benzylidene)-2...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(ccc1OCc1ccccc1)-c1coc2ccccc12
Show InChI InChI=1S/C25H17NO3S2/c27-24-23(31-25(30)26-24)13-18-12-17(20-15-29-22-9-5-4-8-19(20)22)10-11-21(18)28-14-16-6-2-1-3-7-16/h1-13,15H,14H2,(H,26,27,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184285
PNG
(5-(2-(4-bromobenzyloxy)benzylidene)-2-thioxothiazo...)
Show SMILES SC1=NC(=O)C(S1)=Cc1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C17H12BrNO2S2/c18-13-7-5-11(6-8-13)10-21-14-4-2-1-3-12(14)9-15-16(20)19-17(22)23-15/h1-9H,10H2,(H,19,20,22)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184296
PNG
(5-((3-(2-chloro-6-fluorobenzyloxy)naphthalen-2-yl)...)
Show SMILES Fc1cccc(Cl)c1COc1cc2ccccc2cc1C=C1SC(S)=NC1=O
Show InChI InChI=1S/C21H13ClFNO2S2/c22-16-6-3-7-17(23)15(16)11-26-18-9-13-5-2-1-4-12(13)8-14(18)10-19-20(25)24-21(27)28-19/h1-10H,11H2,(H,24,25,27)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184298
PNG
(5-(4-Benzyloxy-biphenyl-3-ylmethylene)-2-thioxo-th...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(ccc1OCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H17NO2S2/c25-22-21(28-23(27)24-22)14-19-13-18(17-9-5-2-6-10-17)11-12-20(19)26-15-16-7-3-1-4-8-16/h1-14H,15H2,(H,24,25,27)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184293
PNG
(5-[1-[3-(biphenyl-4-ylmethoxy)-naphthalen-2-yl]-me...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc2ccccc2cc1OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H19NO2S2/c29-26-25(32-27(31)28-26)16-23-14-21-8-4-5-9-22(21)15-24(23)30-17-18-10-12-20(13-11-18)19-6-2-1-3-7-19/h1-16H,17H2,(H,28,29,31)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184291
PNG
(5-((3-(benzyloxy)naphthalen-2-yl)methylene)-2-thio...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc2ccccc2cc1OCc1ccccc1
Show InChI InChI=1S/C21H15NO2S2/c23-20-19(26-21(25)22-20)12-17-10-15-8-4-5-9-16(15)11-18(17)24-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,22,23,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184290
PNG
(5-(2-(2-chlorobenzyloxy)-5-bromobenzylidene)-2-thi...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Cl
Show InChI InChI=1S/C17H11BrClNO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184294
PNG
(5-(2-(benzyloxy)-5-bromobenzylidene)-2-thioxothiaz...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1
Show InChI InChI=1S/C17H12BrNO2S2/c18-13-6-7-14(21-10-11-4-2-1-3-5-11)12(8-13)9-15-16(20)19-17(22)23-15/h1-9H,10H2,(H,19,20,22)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184292
PNG
(5-((3-(3,5-dimethoxybenzyloxy)naphthalen-2-yl)meth...)
Show SMILES COc1cc(COc2cc3ccccc3cc2C=C2SC(S)=NC2=O)cc(OC)c1
Show InChI InChI=1S/C23H19NO4S2/c1-26-18-7-14(8-19(12-18)27-2)13-28-20-10-16-6-4-3-5-15(16)9-17(20)11-21-22(25)24-23(29)30-21/h3-12H,13H2,1-2H3,(H,24,25,29)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM11318
PNG
(1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...)
Show SMILES Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
Show InChI InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL


Assay Description
Inhibition of PRL3 after 1 hr by DiFMUP assay


Bioorg Med Chem Lett 22: 323-6 (2011)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184289
PNG
(5-[1-(4-benzyloxy-4'-dimethylamino-biphenyl-3-yl)-...)
Show SMILES CN(C)c1ccc(cc1)-c1ccc(OCc2ccccc2)c(C=C2SC(S)=NC2=O)c1
Show InChI InChI=1S/C25H22N2O2S2/c1-27(2)21-11-8-18(9-12-21)19-10-13-22(29-16-17-6-4-3-5-7-17)20(14-19)15-23-24(28)26-25(30)31-23/h3-15H,16H2,1-2H3,(H,26,28,30)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184286
PNG
(5-(2-(benzyloxy)-5-bromobenzyl)-2-thioxothiazolidi...)
Show SMILES Oc1nc(S)sc1Cc1cc(Br)ccc1OCc1ccccc1
Show InChI InChI=1S/C17H14BrNO2S2/c18-13-6-7-14(21-10-11-4-2-1-3-5-11)12(8-13)9-15-16(20)19-17(22)23-15/h1-8,20H,9-10H2,(H,19,22)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50312665
PNG
(CHEMBL1088572 | Sodium 2-(2-Fluorophenyl)-6,7-meth...)
Show SMILES OP([O-])(=O)OC1CC(=Nc2cc3OCOc3cc12)c1ccccc1F
Show InChI InChI=1S/C16H13FNO6P/c17-11-4-2-1-3-9(11)12-6-14(24-25(19,20)21)10-5-15-16(23-8-22-15)7-13(10)18-12/h1-5,7,14H,6,8H2,(H2,19,20,21)/p-1
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n/an/a 4.93E+3n/an/an/an/an/an/a



China Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PTP4A3 by enzyme assay


J Med Chem 53: 1616-26 (2010)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184295
PNG
((Z)-5-(5-bromo-2-hydroxybenzylidene)-2-thioxothiaz...)
Show SMILES Oc1ccc(Br)cc1C=C1SC(S)=NC1=O
Show InChI InChI=1S/C10H6BrNO2S2/c11-6-1-2-7(13)5(3-6)4-8-9(14)12-10(15)16-8/h1-4,13H,(H,12,14,15)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391711
PNG
(CHEMBL2146958)
Show SMILES Oc1ccc(\C=c2/sc3nc4ccccc4n3c2=O)cc1O
Show InChI InChI=1S/C16H10N2O3S/c19-12-6-5-9(7-13(12)20)8-14-15(21)18-11-4-2-1-3-10(11)17-16(18)22-14/h1-8,19-20H/b14-8-
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n/an/a 1.10E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Bioorg Med Chem Lett 22: 6333-7 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237949
PNG
(2-(5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)...)
Show SMILES OC(=O)c1ccccc1-c1ccc(C=C2SC(S)=NC2=O)o1
Show InChI InChI=1S/C15H9NO4S2/c17-13-12(22-15(21)16-13)7-8-5-6-11(20-8)9-3-1-2-4-10(9)14(18)19/h1-7H,(H,18,19)(H,16,17,21)
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n/an/a 1.33E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237952
PNG
(3-(2-((1-(3-chlorophenyl)-2,5-dioxoimidazolidin-4-...)
Show SMILES OC(=O)c1cccc(c1)-n1cccc1C=C1NC(=O)N(C1=O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H14ClN3O4/c22-14-5-2-7-17(11-14)25-19(26)18(23-21(25)29)12-16-8-3-9-24(16)15-6-1-4-13(10-15)20(27)28/h1-12H,(H,23,29)(H,27,28)
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n/an/a 1.54E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237948
PNG
((E)-2-(2-(5-(4-chlorophenyl)furan-2-yl)vinyl)-6-me...)
Show SMILES Clc1ccc(cc1)-c1ccc(\C=C\C2NC(=O)C(C#N)C(=S)N2c2ccccc2)o1
Show InChI InChI=1S/C23H16ClN3O2S/c24-16-8-6-15(7-9-16)20-12-10-18(29-20)11-13-21-26-22(28)19(14-25)23(30)27(21)17-4-2-1-3-5-17/h1-13,19,21H,(H,26,28)/b13-11+
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n/an/a 1.83E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391714
PNG
(CHEMBL2146957)
Show SMILES SC1=NC(=O)C(S1)=Cc1cn(nc1-c1cccc(OCc2ccccc2Cl)c1)-c1ccccc1
Show InChI InChI=1S/C26H18ClN3O2S2/c27-22-12-5-4-7-18(22)16-32-21-11-6-8-17(13-21)24-19(14-23-25(31)28-26(33)34-23)15-30(29-24)20-9-2-1-3-10-20/h1-15H,16H2,(H,28,31,33)
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n/an/a 2.76E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Bioorg Med Chem Lett 22: 6333-7 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237950
PNG
(3-benzylsulfanyl-6-[1-(4-hydroxy-3-methoxy-phenyl)...)
Show SMILES COc1cc(\C=C2\C(=N)N3C(SCc4ccccc4)=NSC3=NC2=O)ccc1O
Show InChI InChI=1S/C20H16N4O3S2/c1-27-16-10-13(7-8-15(16)25)9-14-17(21)24-19(22-18(14)26)29-23-20(24)28-11-12-5-3-2-4-6-12/h2-10,21,25H,11H2,1H3/b14-9-,21-17?
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n/an/a 2.77E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM11318
PNG
(1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...)
Show SMILES Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
Show InChI InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
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n/an/a 2.80E+4n/an/an/an/an/an/a



Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL


Assay Description
Inhibition of PRL-3-mediated cell migration in human DLD1 cells after 15 hrs by crystal violet staining based microscopic assay


Bioorg Med Chem Lett 22: 323-6 (2011)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237957
PNG
(4-(2-((2,5-dioxoimidazolidin-4-ylidene)methyl)-1H-...)
Show SMILES OC(=O)c1ccc(cc1)-n1cccc1\C=C1\NC(=O)NC1=O
Show InChI InChI=1S/C15H11N3O4/c19-13-12(16-15(22)17-13)8-11-2-1-7-18(11)10-5-3-9(4-6-10)14(20)21/h1-8H,(H,20,21)(H2,16,17,19,22)/b12-8+
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n/an/a 2.81E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059140
PNG
(CHEMBL3393148)
Show SMILES COc1cc(\C=C(/C#N)C(=O)OCC=C)cc(Br)c1O
Show InChI InChI=1S/C14H12BrNO4/c1-3-4-20-14(18)10(8-16)5-9-6-11(15)13(17)12(7-9)19-2/h3,5-7,17H,1,4H2,2H3/b10-5+
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n/an/a 3.14E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Eur J Med Chem 88: 89-100 (2014)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50387974
PNG
(CHEMBL2057830)
Show SMILES Oc1ccc(cc1)C1=NN2C(S1)=NC(=O)\C(=C\c1ccc(O)c(O)c1)C2=N
Show InChI InChI=1S/C18H12N4O4S/c19-15-12(7-9-1-6-13(24)14(25)8-9)16(26)20-18-22(15)21-17(27-18)10-2-4-11(23)5-3-10/h1-8,19,23-25H/b12-7+,19-15?
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n/an/a 3.32E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Bioorg Med Chem Lett 22: 6333-7 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM11318
PNG
(1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...)
Show SMILES Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
Show InChI InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
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n/an/a 3.50E+4n/an/an/an/an/an/a



Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL


Assay Description
Inhibition of PRL-3-mediated cell invasion in human DLD1 cells after 20 hrs using crystal violet staining by Matrigel invasion assay


Bioorg Med Chem Lett 22: 323-6 (2011)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237959
PNG
(2-(benzo[d]thiazol-2-ylamino)-6-phenylpyrimidine-4...)
Show SMILES OC(=O)c1cc(nc(Nc2nc3ccccc3s2)n1)-c1ccccc1
Show InChI InChI=1S/C18H12N4O2S/c23-16(24)14-10-13(11-6-2-1-3-7-11)19-17(20-14)22-18-21-12-8-4-5-9-15(12)25-18/h1-10H,(H,23,24)(H,19,20,21,22)
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n/an/a 3.78E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237954
PNG
(3-((5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-m...)
Show SMILES CCOc1cc(\C=C2/S\C(=N\c3cccc(c3)C(O)=O)N(C)C2=O)cc(Cl)c1O
Show InChI InChI=1S/C20H17ClN2O5S/c1-3-28-15-8-11(7-14(21)17(15)24)9-16-18(25)23(2)20(29-16)22-13-6-4-5-12(10-13)19(26)27/h4-10,24H,3H2,1-2H3,(H,26,27)/b16-9-,22-20+
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n/an/a 4.03E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237958
PNG
(5-(4-hydroxy-3-methoxybenzylidene)-2-(o-toluidino)...)
Show SMILES COc1cc(C=C2SC(Nc3ccccc3C)=NC2=O)ccc1O
Show InChI InChI=1S/C18H16N2O3S/c1-11-5-3-4-6-13(11)19-18-20-17(22)16(24-18)10-12-7-8-14(21)15(9-12)23-2/h3-10,21H,1-2H3,(H,19,20,22)
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n/an/a 4.15E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237951
PNG
(3-{5-[5-imino-7-oxo-2-pyridin-3-yl-7H-[1,3,4]thiad...)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)c2cccnc2)o1
Show InChI InChI=1S/C22H13N5O4S/c23-18-16(10-15-6-7-17(31-15)12-3-1-4-13(9-12)21(29)30)19(28)25-22-27(18)26-20(32-22)14-5-2-8-24-11-14/h1-11,23H,(H,29,30)/b16-10-,23-18?
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n/an/a 4.17E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237953
PNG
(2-(4-allyl-5-(3-chlorophenyl)-4H-1,2,4-triazol-3-y...)
Show SMILES Oc1ccc(cc1O)C(=O)CSc1nnc(-c2cccc(Cl)c2)n1CC=C
Show InChI InChI=1S/C19H16ClN3O3S/c1-2-8-23-18(13-4-3-5-14(20)9-13)21-22-19(23)27-11-17(26)12-6-7-15(24)16(25)10-12/h2-7,9-10,24-25H,1,8,11H2
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n/an/a 4.38E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237956
PNG
(1-(3,4-dihydroxyphenyl)-2-(1-(4-methoxyphenyl)-1H-...)
Show SMILES COc1ccc(cc1)-n1nnnc1SCC(=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H14N4O4S/c1-24-12-5-3-11(4-6-12)20-16(17-18-19-20)25-9-15(23)10-2-7-13(21)14(22)8-10/h2-8,21-22H,9H2,1H3
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n/an/a 4.47E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059086
PNG
(CHEMBL3393146)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCC=C)cc1Br
Show InChI InChI=1S/C13H10BrNO3/c1-2-5-18-13(17)10(8-15)6-9-3-4-12(16)11(14)7-9/h2-4,6-7,16H,1,5H2/b10-6+
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n/an/a 4.78E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Eur J Med Chem 88: 89-100 (2014)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237955
PNG
((Z)-5-((2-methyl-2H-chromen-3-yl)methylene)-2-((E)...)
Show SMILES CC1Oc2ccccc2C=C1\C=c1/sc2nc(\C=C\c3ccccc3)nn2c1=O
Show InChI InChI=1S/C23H17N3O2S/c1-15-18(13-17-9-5-6-10-19(17)28-15)14-20-22(27)26-23(29-20)24-21(25-26)12-11-16-7-3-2-4-8-16/h2-15H,1H3/b12-11+,20-14-
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n/an/a 4.87E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50343142
PNG
(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-2-3-5-14-8-10-15(11-9-14)23-27(25,26)19-13-12-18-20-16(19)6-4-7-17(20)21(24)22-18/h4,6-13,23H,2-3,5H2,1H3,(H,22,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


ACS Med Chem Lett 1: 355-359 (2010)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50343148
PNG
(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C25H28FN5O2S/c1-18(29-25(33)24(32)28-17-19-4-2-10-27-16-19)23(22-5-3-15-34-22)31-13-11-30(12-14-31)21-8-6-20(26)7-9-21/h2-10,15-16,18,23H,11-14,17H2,1H3,(H,28,32)(H,29,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


ACS Med Chem Lett 1: 355-359 (2010)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50343147
PNG
(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Show InChI InChI=1S/C25H30N4O4S/c1-18(27-25(31)24(30)26-17-21-5-3-15-33-21)23(22-6-4-16-34-22)29-13-11-28(12-14-29)19-7-9-20(32-2)10-8-19/h3-10,15-16,18,23H,11-14,17H2,1-2H3,(H,26,30)(H,27,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


ACS Med Chem Lett 1: 355-359 (2010)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059085
PNG
(CHEBI:8830 | RHODANINE | Rhodanine)
Show SMILES O=C1CSC(=S)N1
Show InChI InChI=1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
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n/an/a 5.30E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Eur J Med Chem 88: 89-100 (2014)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM45440
PNG
(4-[5-(4-amidinophenoxy)pentoxy]benzamidine;2-hydro...)
Show SMILES NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
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n/an/a 5.36E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Bioorg Med Chem Lett 18: 2250-5 (2008)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM45440
PNG
(4-[5-(4-amidinophenoxy)pentoxy]benzamidine;2-hydro...)
Show SMILES NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
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n/an/a 5.36E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Bioorg Med Chem Lett 16: 2996-9 (2006)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391712
PNG
(CHEMBL2146959)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)CSc1nnc(-c2ccco2)c(n1)-c1ccco1
Show InChI InChI=1S/C19H13N5O5S/c25-16(20-12-5-1-2-6-13(12)24(26)27)11-30-19-21-17(14-7-3-9-28-14)18(22-23-19)15-8-4-10-29-15/h1-10H,11H2,(H,20,25)
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n/an/a 5.70E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Bioorg Med Chem Lett 22: 6333-7 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059141
PNG
(CHEMBL3393149)
Show SMILES COc1cc(\C=C(/C#N)C(=O)OC(C)C)cc(Br)c1O
Show InChI InChI=1S/C14H14BrNO4/c1-8(2)20-14(18)10(7-16)4-9-5-11(15)13(17)12(6-9)19-3/h4-6,8,17H,1-3H3/b10-4+
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n/an/a 6.94E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Eur J Med Chem 88: 89-100 (2014)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391715
PNG
(CHEMBL2146960)
Show SMILES Oc1ccc(C=c2c(=O)[nH]c3cc(=C)on3c2=N)cc1O
Show InChI InChI=1S/C14H11N3O4/c1-7-4-12-16-14(20)9(13(15)17(12)21-7)5-8-2-3-10(18)11(19)6-8/h2-6,15,18-19H,1H2,(H,16,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Bioorg Med Chem Lett 22: 6333-7 (2012)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391713
PNG
(CHEMBL2146956)
Show SMILES c1ccc2nc(ccc2c1)-c1nnc2sc(nn12)-c1cnccn1
Show InChI InChI=1S/C16H9N7S/c1-2-4-11-10(3-1)5-6-12(19-11)14-20-21-16-23(14)22-15(24-16)13-9-17-7-8-18-13/h1-9H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Bioorg Med Chem Lett 22: 6333-7 (2012)

More data for this
Ligand-Target Pair
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