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Found 54 hits Enz. Inhib. hit(s) with Target = 'Protein-tyrosine phosphatase 4A3' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059084
PNG
(CHEMBL3393171)
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
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n/an/a 128n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of full length human fusion His6 tagged PRL3 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by imm...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059084
PNG
(CHEMBL3393171)
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
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n/an/a 240n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50436447
PNG
(CHEMBL2397162)
Show SMILES COc1ccccc1COc1ccccc1C=CC=C1SC(S)=NC1=O
Show InChI InChI=1S/C20H17NO3S2/c1-23-16-10-4-3-8-15(16)13-24-17-11-5-2-7-14(17)9-6-12-18-19(22)21-20(25)26-18/h2-12H,13H2,1H3,(H,21,22,25)
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n/an/a 800n/an/an/an/an/an/a



University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human His6-tagged full length PRL3 assessed as inhibition of DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184288
PNG
(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Br
Show InChI InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)
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n/an/a 900n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184288
PNG
(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Br
Show InChI InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)
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n/an/a 900n/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184297
PNG
(5-(5-(benzo[b]thiophen-3-yl)-2-(benzyloxy)benzylid...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(ccc1OCc1ccccc1)-c1csc2ccccc12
Show InChI InChI=1S/C25H17NO2S3/c27-24-23(31-25(29)26-24)13-18-12-17(20-15-30-22-9-5-4-8-19(20)22)10-11-21(18)28-14-16-6-2-1-3-7-16/h1-13,15H,14H2,(H,26,27,29)
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n/an/a 900n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184288
PNG
(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Br
Show InChI InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of human His6-tagged full length PRL3 assessed as inhibition of DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184287
PNG
(5-(5-(benzofuran-3-yl)-2-(benzyloxy)benzylidene)-2...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(ccc1OCc1ccccc1)-c1coc2ccccc12
Show InChI InChI=1S/C25H17NO3S2/c27-24-23(31-25(30)26-24)13-18-12-17(20-15-29-22-9-5-4-8-19(20)22)10-11-21(18)28-14-16-6-2-1-3-7-16/h1-13,15H,14H2,(H,26,27,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184285
PNG
(5-(2-(4-bromobenzyloxy)benzylidene)-2-thioxothiazo...)
Show SMILES SC1=NC(=O)C(S1)=Cc1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C17H12BrNO2S2/c18-13-7-5-11(6-8-13)10-21-14-4-2-1-3-12(14)9-15-16(20)19-17(22)23-15/h1-9H,10H2,(H,19,20,22)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184296
PNG
(5-((3-(2-chloro-6-fluorobenzyloxy)naphthalen-2-yl)...)
Show SMILES Fc1cccc(Cl)c1COc1cc2ccccc2cc1C=C1SC(S)=NC1=O
Show InChI InChI=1S/C21H13ClFNO2S2/c22-16-6-3-7-17(23)15(16)11-26-18-9-13-5-2-1-4-12(13)8-14(18)10-19-20(25)24-21(27)28-19/h1-10H,11H2,(H,24,25,27)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184298
PNG
(5-(4-Benzyloxy-biphenyl-3-ylmethylene)-2-thioxo-th...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(ccc1OCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H17NO2S2/c25-22-21(28-23(27)24-22)14-19-13-18(17-9-5-2-6-10-17)11-12-20(19)26-15-16-7-3-1-4-8-16/h1-14H,15H2,(H,24,25,27)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184293
PNG
(5-[1-[3-(biphenyl-4-ylmethoxy)-naphthalen-2-yl]-me...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc2ccccc2cc1OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H19NO2S2/c29-26-25(32-27(31)28-26)16-23-14-21-8-4-5-9-22(21)15-24(23)30-17-18-10-12-20(13-11-18)19-6-2-1-3-7-19/h1-16H,17H2,(H,28,29,31)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184291
PNG
(5-((3-(benzyloxy)naphthalen-2-yl)methylene)-2-thio...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc2ccccc2cc1OCc1ccccc1
Show InChI InChI=1S/C21H15NO2S2/c23-20-19(26-21(25)22-20)12-17-10-15-8-4-5-9-16(15)11-18(17)24-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,22,23,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184290
PNG
(5-(2-(2-chlorobenzyloxy)-5-bromobenzylidene)-2-thi...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1Cl
Show InChI InChI=1S/C17H11BrClNO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184294
PNG
(5-(2-(benzyloxy)-5-bromobenzylidene)-2-thioxothiaz...)
Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Br)ccc1OCc1ccccc1
Show InChI InChI=1S/C17H12BrNO2S2/c18-13-6-7-14(21-10-11-4-2-1-3-5-11)12(8-13)9-15-16(20)19-17(22)23-15/h1-9H,10H2,(H,19,20,22)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184292
PNG
(5-((3-(3,5-dimethoxybenzyloxy)naphthalen-2-yl)meth...)
Show SMILES COc1cc(COc2cc3ccccc3cc2C=C2SC(S)=NC2=O)cc(OC)c1
Show InChI InChI=1S/C23H19NO4S2/c1-26-18-7-14(8-19(12-18)27-2)13-28-20-10-16-6-4-3-5-15(16)9-17(20)11-21-22(25)24-23(29)30-21/h3-12H,13H2,1-2H3,(H,24,25,29)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM11318
PNG
(1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...)
Show SMILES Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
Show InChI InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL


Assay Description
Inhibition of PRL3 after 1 hr by DiFMUP assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184289
PNG
(5-[1-(4-benzyloxy-4'-dimethylamino-biphenyl-3-yl)-...)
Show SMILES CN(C)c1ccc(cc1)-c1ccc(OCc2ccccc2)c(C=C2SC(S)=NC2=O)c1
Show InChI InChI=1S/C25H22N2O2S2/c1-27(2)21-11-8-18(9-12-21)19-10-13-22(29-16-17-6-4-3-5-7-17)20(14-19)15-23-24(28)26-25(30)31-23/h3-15H,16H2,1-2H3,(H,26,28,30)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184286
PNG
(5-(2-(benzyloxy)-5-bromobenzyl)-2-thioxothiazolidi...)
Show SMILES Oc1nc(S)sc1Cc1cc(Br)ccc1OCc1ccccc1
Show InChI InChI=1S/C17H14BrNO2S2/c18-13-6-7-14(21-10-11-4-2-1-3-5-11)12(8-13)9-15-16(20)19-17(22)23-15/h1-8,20H,9-10H2,(H,19,22)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50312665
PNG
(CHEMBL1088572 | Sodium 2-(2-Fluorophenyl)-6,7-meth...)
Show SMILES OP([O-])(=O)OC1CC(=Nc2cc3OCOc3cc12)c1ccccc1F
Show InChI InChI=1S/C16H13FNO6P/c17-11-4-2-1-3-9(11)12-6-14(24-25(19,20)21)10-5-15-16(23-8-22-15)7-13(10)18-12/h1-5,7,14H,6,8H2,(H2,19,20,21)/p-1
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n/an/a 4.93E+3n/an/an/an/an/an/a



China Medical University

Curated by ChEMBL


Assay Description
Inhibition of human PTP4A3 by enzyme assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50184295
PNG
((Z)-5-(5-bromo-2-hydroxybenzylidene)-2-thioxothiaz...)
Show SMILES Oc1ccc(Br)cc1C=C1SC(S)=NC1=O
Show InChI InChI=1S/C10H6BrNO2S2/c11-6-1-2-7(13)5(3-6)4-8-9(14)12-10(15)16-8/h1-4,13H,(H,12,14,15)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391711
PNG
(CHEMBL2146958)
Show SMILES Oc1ccc(\C=c2/sc3nc4ccccc4n3c2=O)cc1O
Show InChI InChI=1S/C16H10N2O3S/c19-12-6-5-9(7-13(12)20)8-14-15(21)18-11-4-2-1-3-10(11)17-16(18)22-14/h1-8,19-20H/b14-8-
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n/an/a 1.10E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237949
PNG
(2-(5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)...)
Show SMILES OC(=O)c1ccccc1-c1ccc(C=C2SC(S)=NC2=O)o1
Show InChI InChI=1S/C15H9NO4S2/c17-13-12(22-15(21)16-13)7-8-5-6-11(20-8)9-3-1-2-4-10(9)14(18)19/h1-7H,(H,18,19)(H,16,17,21)
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n/an/a 1.33E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237952
PNG
(3-(2-((1-(3-chlorophenyl)-2,5-dioxoimidazolidin-4-...)
Show SMILES OC(=O)c1cccc(c1)-n1cccc1C=C1NC(=O)N(C1=O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H14ClN3O4/c22-14-5-2-7-17(11-14)25-19(26)18(23-21(25)29)12-16-8-3-9-24(16)15-6-1-4-13(10-15)20(27)28/h1-12H,(H,23,29)(H,27,28)
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n/an/a 1.54E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237948
PNG
((E)-2-(2-(5-(4-chlorophenyl)furan-2-yl)vinyl)-6-me...)
Show SMILES Clc1ccc(cc1)-c1ccc(\C=C\C2NC(=O)C(C#N)C(=S)N2c2ccccc2)o1
Show InChI InChI=1S/C23H16ClN3O2S/c24-16-8-6-15(7-9-16)20-12-10-18(29-20)11-13-21-26-22(28)19(14-25)23(30)27(21)17-4-2-1-3-5-17/h1-13,19,21H,(H,26,28)/b13-11+
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n/an/a 1.83E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391714
PNG
(CHEMBL2146957)
Show SMILES SC1=NC(=O)C(S1)=Cc1cn(nc1-c1cccc(OCc2ccccc2Cl)c1)-c1ccccc1
Show InChI InChI=1S/C26H18ClN3O2S2/c27-22-12-5-4-7-18(22)16-32-21-11-6-8-17(13-21)24-19(14-23-25(31)28-26(33)34-23)15-30(29-24)20-9-2-1-3-10-20/h1-15H,16H2,(H,28,31,33)
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n/an/a 2.76E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237950
PNG
(3-benzylsulfanyl-6-[1-(4-hydroxy-3-methoxy-phenyl)...)
Show SMILES COc1cc(\C=C2\C(=N)N3C(SCc4ccccc4)=NSC3=NC2=O)ccc1O
Show InChI InChI=1S/C20H16N4O3S2/c1-27-16-10-13(7-8-15(16)25)9-14-17(21)24-19(22-18(14)26)29-23-20(24)28-11-12-5-3-2-4-6-12/h2-10,21,25H,11H2,1H3/b14-9-,21-17?
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n/an/a 2.77E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM11318
PNG
(1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...)
Show SMILES Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
Show InChI InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
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n/an/a 2.80E+4n/an/an/an/an/an/a



Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL


Assay Description
Inhibition of PRL-3-mediated cell migration in human DLD1 cells after 15 hrs by crystal violet staining based microscopic assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237957
PNG
(4-(2-((2,5-dioxoimidazolidin-4-ylidene)methyl)-1H-...)
Show SMILES OC(=O)c1ccc(cc1)-n1cccc1\C=C1\NC(=O)NC1=O
Show InChI InChI=1S/C15H11N3O4/c19-13-12(16-15(22)17-13)8-11-2-1-7-18(11)10-5-3-9(4-6-10)14(20)21/h1-8H,(H,20,21)(H2,16,17,19,22)/b12-8+
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n/an/a 2.81E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059140
PNG
(CHEMBL3393148)
Show SMILES COc1cc(\C=C(/C#N)C(=O)OCC=C)cc(Br)c1O
Show InChI InChI=1S/C14H12BrNO4/c1-3-4-20-14(18)10(8-16)5-9-6-11(15)13(17)12(7-9)19-2/h3,5-7,17H,1,4H2,2H3/b10-5+
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n/an/a 3.14E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50387974
PNG
(CHEMBL2057830)
Show SMILES Oc1ccc(cc1)C1=NN2C(S1)=NC(=O)\C(=C\c1ccc(O)c(O)c1)C2=N
Show InChI InChI=1S/C18H12N4O4S/c19-15-12(7-9-1-6-13(24)14(25)8-9)16(26)20-18-22(15)21-17(27-18)10-2-4-11(23)5-3-10/h1-8,19,23-25H/b12-7+,19-15?
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n/an/a 3.32E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM11318
PNG
(1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...)
Show SMILES Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
Show InChI InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
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n/an/a 3.50E+4n/an/an/an/an/an/a



Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL


Assay Description
Inhibition of PRL-3-mediated cell invasion in human DLD1 cells after 20 hrs using crystal violet staining by Matrigel invasion assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237959
PNG
(2-(benzo[d]thiazol-2-ylamino)-6-phenylpyrimidine-4...)
Show SMILES OC(=O)c1cc(nc(Nc2nc3ccccc3s2)n1)-c1ccccc1
Show InChI InChI=1S/C18H12N4O2S/c23-16(24)14-10-13(11-6-2-1-3-7-11)19-17(20-14)22-18-21-12-8-4-5-9-15(12)25-18/h1-10H,(H,23,24)(H,19,20,21,22)
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n/an/a 3.78E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237954
PNG
(3-((5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-m...)
Show SMILES CCOc1cc(\C=C2/S\C(=N\c3cccc(c3)C(O)=O)N(C)C2=O)cc(Cl)c1O
Show InChI InChI=1S/C20H17ClN2O5S/c1-3-28-15-8-11(7-14(21)17(15)24)9-16-18(25)23(2)20(29-16)22-13-6-4-5-12(10-13)19(26)27/h4-10,24H,3H2,1-2H3,(H,26,27)/b16-9-,22-20+
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n/an/a 4.03E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237958
PNG
(5-(4-hydroxy-3-methoxybenzylidene)-2-(o-toluidino)...)
Show SMILES COc1cc(C=C2SC(Nc3ccccc3C)=NC2=O)ccc1O
Show InChI InChI=1S/C18H16N2O3S/c1-11-5-3-4-6-13(11)19-18-20-17(22)16(24-18)10-12-7-8-14(21)15(9-12)23-2/h3-10,21H,1-2H3,(H,19,20,22)
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n/an/a 4.15E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237951
PNG
(3-{5-[5-imino-7-oxo-2-pyridin-3-yl-7H-[1,3,4]thiad...)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)c2cccnc2)o1
Show InChI InChI=1S/C22H13N5O4S/c23-18-16(10-15-6-7-17(31-15)12-3-1-4-13(9-12)21(29)30)19(28)25-22-27(18)26-20(32-22)14-5-2-8-24-11-14/h1-11,23H,(H,29,30)/b16-10-,23-18?
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n/an/a 4.17E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237953
PNG
(2-(4-allyl-5-(3-chlorophenyl)-4H-1,2,4-triazol-3-y...)
Show SMILES Oc1ccc(cc1O)C(=O)CSc1nnc(-c2cccc(Cl)c2)n1CC=C
Show InChI InChI=1S/C19H16ClN3O3S/c1-2-8-23-18(13-4-3-5-14(20)9-13)21-22-19(23)27-11-17(26)12-6-7-15(24)16(25)10-12/h2-7,9-10,24-25H,1,8,11H2
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n/an/a 4.38E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237956
PNG
(1-(3,4-dihydroxyphenyl)-2-(1-(4-methoxyphenyl)-1H-...)
Show SMILES COc1ccc(cc1)-n1nnnc1SCC(=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H14N4O4S/c1-24-12-5-3-11(4-6-12)20-16(17-18-19-20)25-9-15(23)10-2-7-13(21)14(22)8-10/h2-8,21-22H,9H2,1H3
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n/an/a 4.47E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059086
PNG
(CHEMBL3393146)
Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCC=C)cc1Br
Show InChI InChI=1S/C13H10BrNO3/c1-2-5-18-13(17)10(8-15)6-9-3-4-12(16)11(14)7-9/h2-4,6-7,16H,1,5H2/b10-6+
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n/an/a 4.78E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50237955
PNG
((Z)-5-((2-methyl-2H-chromen-3-yl)methylene)-2-((E)...)
Show SMILES CC1Oc2ccccc2C=C1\C=c1/sc2nc(\C=C\c3ccccc3)nn2c1=O
Show InChI InChI=1S/C23H17N3O2S/c1-15-18(13-17-9-5-6-10-19(17)28-15)14-20-22(27)26-23(29-20)24-21(25-26)12-11-16-7-3-2-4-8-16/h2-15H,1H3/b12-11+,20-14-
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n/an/a 4.87E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50343142
PNG
(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-2-3-5-14-8-10-15(11-9-14)23-27(25,26)19-13-12-18-20-16(19)6-4-7-17(20)21(24)22-18/h4,6-13,23H,2-3,5H2,1H3,(H,22,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50343148
PNG
(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C25H28FN5O2S/c1-18(29-25(33)24(32)28-17-19-4-2-10-27-16-19)23(22-5-3-15-34-22)31-13-11-30(12-14-31)21-8-6-20(26)7-9-21/h2-10,15-16,18,23H,11-14,17H2,1H3,(H,28,32)(H,29,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50343147
PNG
(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Show InChI InChI=1S/C25H30N4O4S/c1-18(27-25(31)24(30)26-17-21-5-3-15-33-21)23(22-6-4-16-34-22)29-13-11-28(12-14-29)19-7-9-20(32-2)10-8-19/h3-10,15-16,18,23H,11-14,17H2,1-2H3,(H,26,30)(H,27,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059085
PNG
(CHEBI:8830 | RHODANINE | Rhodanine)
Show SMILES O=C1CSC(=S)N1
Show InChI InChI=1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
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n/an/a 5.30E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM45440
PNG
(4-[5-(4-amidinophenoxy)pentoxy]benzamidine;2-hydro...)
Show SMILES NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
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n/an/a 5.36E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)


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More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM45440
PNG
(4-[5-(4-amidinophenoxy)pentoxy]benzamidine;2-hydro...)
Show SMILES NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
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n/an/a 5.36E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PRL-3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391712
PNG
(CHEMBL2146959)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)CSc1nnc(-c2ccco2)c(n1)-c1ccco1
Show InChI InChI=1S/C19H13N5O5S/c25-16(20-12-5-1-2-6-13(12)24(26)27)11-30-19-21-17(14-7-3-9-28-14)18(22-23-19)15-8-4-10-29-15/h1-10H,11H2,(H,20,25)
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n/an/a 5.70E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50059141
PNG
(CHEMBL3393149)
Show SMILES COc1cc(\C=C(/C#N)C(=O)OC(C)C)cc(Br)c1O
Show InChI InChI=1S/C14H14BrNO4/c1-8(2)20-14(18)10(7-16)4-9-5-11(15)13(17)12(6-9)19-3/h4-6,8,17H,1-3H3/b10-4+
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n/an/a 6.94E+4n/an/an/an/an/an/a



European Molecular Biology Laboratory

Curated by ChEMBL


Assay Description
Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391715
PNG
(CHEMBL2146960)
Show SMILES Oc1ccc(C=c2c(=O)[nH]c3cc(=C)on3c2=N)cc1O
Show InChI InChI=1S/C14H11N3O4/c1-7-4-12-16-14(20)9(13(15)17(12)21-7)5-8-2-3-10(18)11(19)6-8/h2-6,15,18-19H,1H2,(H,16,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens)
BDBM50391713
PNG
(CHEMBL2146956)
Show SMILES c1ccc2nc(ccc2c1)-c1nnc2sc(nn12)-c1cnccn1
Show InChI InChI=1S/C16H9N7S/c1-2-4-11-10(3-1)5-6-12(19-11)14-20-21-16-23(14)22-15(24-16)13-9-17-7-8-18-13/h1-9H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of PRL3


Citation and Details
More data for this
Ligand-Target Pair
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