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Found 51 hits Enz. Inhib. hit(s) with Target = 'Protein-tyrosine phosphatase MEG2 (PTP-Meg2)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM199180
PNG
(US9217012, 10)
Show SMILES CCc1ccc(cc1)C(=O)NCCCCC(NC(=O)C(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)C(Cc1ccccc1)NC(=O)COC1CC(C)CCC1C(C)C)C(N)=O
Show InChI InChI=1/C46H62F2N5O9P/c1-5-31-15-19-34(20-16-31)43(56)50-24-10-9-13-37(42(49)55)52-45(58)39(27-33-17-21-35(22-18-33)46(47,48)63(59,60)61)53-44(57)38(26-32-11-7-6-8-12-32)51-41(54)28-62-40-25-30(4)14-23-36(40)29(2)3/h6-8,11-12,15-22,29-30,36-40H,5,9-10,13-14,23-28H2,1-4H3,(H2,49,55)(H,50,56)(H,51,54)(H,52,58)(H,53,57)(H2,59,60,61)
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US Patent
>1.00E+3n/an/an/an/an/an/an/an/a



Indiana University Research and Technology Corporation

US Patent


Assay Description
PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ...


US Patent US9217012 (2015)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50436358
PNG
(CHEMBL2396718)
Show SMILES CCCNC(=O)COc1ccc(cc1)-c1oc2cc(O)c(cc2c1C#Cc1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34)
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n/an/a 590n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant PTP-MEG2 (unknown origin) using pNPP as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425815
PNG
(CHEMBL2316908)
Show SMILES OC(=O)c1cc2c(C#Cc3ccc(Oc4ccccc4)cc3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C29H18O5/c30-26-18-27-24(17-25(26)29(31)32)23(28(34-27)20-7-3-1-4-8-20)16-13-19-11-14-22(15-12-19)33-21-9-5-2-6-10-21/h1-12,14-15,17-18,30H,(H,31,32)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425808
PNG
(CHEMBL2316906)
Show SMILES OC(=O)c1cc2c(C#Cc3cc(F)cc(F)c3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C23H12F2O4/c24-15-8-13(9-16(25)10-15)6-7-17-18-11-19(23(27)28)20(26)12-21(18)29-22(17)14-4-2-1-3-5-14/h1-5,8-12,26H,(H,27,28)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50436357
PNG
(CHEMBL2396719)
Show SMILES OC(=O)c1cc2c(C#Cc3cccc(Cl)c3)c(oc2cc1O)-c1ccc(OCC(=O)NC2CC2)cc1
Show InChI InChI=1S/C28H20ClNO6/c29-18-3-1-2-16(12-18)4-11-21-22-13-23(28(33)34)24(31)14-25(22)36-27(21)17-5-9-20(10-6-17)35-15-26(32)30-19-7-8-19/h1-3,5-6,9-10,12-14,19,31H,7-8,15H2,(H,30,32)(H,33,34)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant PTP-MEG2 (unknown origin) using pNPP as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425806
PNG
(CHEMBL2316907)
Show SMILES OC(=O)c1cc2c(C#Cc3ccc(OC(F)(F)F)cc3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C24H13F3O5/c25-24(26,27)32-16-9-6-14(7-10-16)8-11-17-18-12-19(23(29)30)20(28)13-21(18)31-22(17)15-4-2-1-3-5-15/h1-7,9-10,12-13,28H,(H,29,30)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425818
PNG
(CHEMBL2316905)
Show SMILES OC(=O)c1cc2c(C#Cc3cccc(Cl)c3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C23H13ClO4/c24-16-8-4-5-14(11-16)9-10-17-18-12-19(23(26)27)20(25)13-21(18)28-22(17)15-6-2-1-3-7-15/h1-8,11-13,25H,(H,26,27)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425807
PNG
(CHEMBL2316902)
Show SMILES OC(=O)c1cc2c(C#Cc3cccc(c3)C(F)(F)F)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C24H13F3O4/c25-24(26,27)16-8-4-5-14(11-16)9-10-17-18-12-19(23(29)30)20(28)13-21(18)31-22(17)15-6-2-1-3-7-15/h1-8,11-13,28H,(H,29,30)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425816
PNG
(CHEMBL2316910)
Show SMILES OC(=O)c1cc2c(C#Cc3ccc(F)cc3F)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C23H12F2O4/c24-15-8-6-13(19(25)10-15)7-9-16-17-11-18(23(27)28)20(26)12-21(17)29-22(16)14-4-2-1-3-5-14/h1-6,8,10-12,26H,(H,27,28)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425809
PNG
(CHEMBL2316896)
Show SMILES OC(=O)c1cc2c(CCc3ccc(Oc4ccccc4)cc3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C29H22O5/c30-26-18-27-24(17-25(26)29(31)32)23(28(34-27)20-7-3-1-4-8-20)16-13-19-11-14-22(15-12-19)33-21-9-5-2-6-10-21/h1-12,14-15,17-18,30H,13,16H2,(H,31,32)
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n/an/a 7.70E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425810
PNG
(CHEMBL2316895)
Show SMILES OC(=O)c1cc2c(CCc3ccc(OC(F)(F)F)cc3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C24H17F3O5/c25-24(26,27)32-16-9-6-14(7-10-16)8-11-17-18-12-19(23(29)30)20(28)13-21(18)31-22(17)15-4-2-1-3-5-15/h1-7,9-10,12-13,28H,8,11H2,(H,29,30)
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n/an/a 8.40E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425811
PNG
(CHEMBL2316894)
Show SMILES OC(=O)c1cc2c(CCc3cccc(c3)C(F)(F)F)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C24H17F3O4/c25-24(26,27)16-8-4-5-14(11-16)9-10-17-18-12-19(23(29)30)20(28)13-21(18)31-22(17)15-6-2-1-3-7-15/h1-8,11-13,28H,9-10H2,(H,29,30)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425819
PNG
(CHEMBL2316904)
Show SMILES OC(=O)c1cc2c(C#Cc3cccc(F)c3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C23H13FO4/c24-16-8-4-5-14(11-16)9-10-17-18-12-19(23(26)27)20(25)13-21(18)28-22(17)15-6-2-1-3-7-15/h1-8,11-13,25H,(H,26,27)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425814
PNG
(CHEMBL2311593)
Show SMILES OC(=O)c1cc2c(\C=C/c3cc(F)cc(F)c3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C23H14F2O4/c24-15-8-13(9-16(25)10-15)6-7-17-18-11-19(23(27)28)20(26)12-21(18)29-22(17)14-4-2-1-3-5-14/h1-12,26H,(H,27,28)/b7-6-
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n/an/a 9.20E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50031906
PNG
(CHEMBL3360905)
Show SMILES CCOC(=O)C1=C(C)N=c2s\c(=C\c3ccc(OCc4ccc(cc4)C(O)=O)cc3)c(=O)n2C1c1ccc(cc1)N(C)C
Show InChI InChI=1/C33H31N3O6S/c1-5-41-32(40)28-20(2)34-33-36(29(28)23-12-14-25(15-13-23)35(3)4)30(37)27(43-33)18-21-8-16-26(17-9-21)42-19-22-6-10-24(11-7-22)31(38)39/h6-18,29H,5,19H2,1-4H3,(H,38,39)/b27-18+
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n/an/a 1.07E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of MEG2 (unknown origin) assessed as reduction in pNPP hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425813
PNG
(CHEMBL2316897)
Show SMILES OC(=O)c1cc2c(\C=C/c3ccc(OC(F)(F)F)cc3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C24H15F3O5/c25-24(26,27)32-16-9-6-14(7-10-16)8-11-17-18-12-19(23(29)30)20(28)13-21(18)31-22(17)15-4-2-1-3-5-15/h1-13,28H,(H,29,30)/b11-8-
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n/an/a 1.14E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425820
PNG
(CHEMBL2316903)
Show SMILES OC(=O)c1cc2c(C#Cc3ccccc3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C23H14O4/c24-20-14-21-18(13-19(20)23(25)26)17(12-11-15-7-3-1-4-8-15)22(27-21)16-9-5-2-6-10-16/h1-10,13-14,24H,(H,25,26)
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n/an/a 1.51E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425817
PNG
(CHEMBL2316909)
Show SMILES COc1cccc(c1)C#Cc1c(oc2cc(O)c(cc12)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C24H16O5/c1-28-17-9-5-6-15(12-17)10-11-18-19-13-20(24(26)27)21(25)14-22(19)29-23(18)16-7-3-2-4-8-16/h2-9,12-14,25H,1H3,(H,26,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50335895
PNG
(6-hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobuty...)
Show SMILES OC(=O)c1cc2c(-c3cn(CCCC(=O)Nc4cccc5ccccc45)nn3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C31H24N4O5/c36-26-17-27-23(16-22(26)31(38)39)29(30(40-27)20-9-2-1-3-10-20)25-18-35(34-33-25)15-7-14-28(37)32-24-13-6-11-19-8-4-5-12-21(19)24/h1-6,8-13,16-18,36H,7,14-15H2,(H,32,37)(H,38,39)
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n/an/a 3.18E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTP-Meg2


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50031908
PNG
(CHEMBL3360906)
Show SMILES Cc1cccc(CSc2nnc(NC(=O)CSc3nc4ccc(cc4s3)N3C(=O)c4ccccc4C3=O)s2)c1
Show InChI InChI=1S/C27H19N5O3S4/c1-15-5-4-6-16(11-15)13-36-27-31-30-25(39-27)29-22(33)14-37-26-28-20-10-9-17(12-21(20)38-26)32-23(34)18-7-2-3-8-19(18)24(32)35/h2-12H,13-14H2,1H3,(H,29,30,33)
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n/an/a 3.75E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of MEG2 (unknown origin) assessed as reduction in pNPP hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50343148
PNG
(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C25H28FN5O2S/c1-18(29-25(33)24(32)28-17-19-4-2-10-27-16-19)23(22-5-3-15-34-22)31-13-11-30(12-14-31)21-8-6-20(26)7-9-21/h2-10,15-16,18,23H,11-14,17H2,1H3,(H,28,32)(H,29,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human MEG2 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50343147
PNG
(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Show InChI InChI=1S/C25H30N4O4S/c1-18(27-25(31)24(30)26-17-21-5-3-15-33-21)23(22-6-4-16-34-22)29-13-11-28(12-14-29)19-7-9-20(32-2)10-8-19/h3-10,15-16,18,23H,11-14,17H2,1-2H3,(H,26,30)(H,27,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human MEG2 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50343142
PNG
(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-2-3-5-14-8-10-15(11-9-14)23-27(25,26)19-13-12-18-20-16(19)6-4-7-17(20)21(24)22-18/h4,6-13,23H,2-3,5H2,1H3,(H,22,24)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human MEG2 expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50112356
PNG
(CHEMBL3609373)
Show SMILES OS(=O)(=O)C(C(=O)Nc1ccc(NC(=O)C(=O)Nc2ccc(I)cc2)cc1)c1ccccc1
Show InChI InChI=1/C22H18IN3O6S/c23-15-6-8-16(9-7-15)25-21(28)22(29)26-18-12-10-17(11-13-18)24-20(27)19(33(30,31)32)14-4-2-1-3-5-14/h1-13,19H,(H,24,27)(H,25,28)(H,26,29)(H,30,31,32)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of phosphatase activity of human Meg2 using pNPP as a substrate after 10 mins by spectrophotometer analysis


ACS Med Chem Lett 6: 782-6 (2015)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50112358
PNG
(CHEMBL3609374)
Show SMILES OS(=O)(=O)C(C(=O)Nc1ccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccccc2)cc1)c1ccccc1
Show InChI InChI=1/C28H23N3O6S/c32-26(25(38(35,36)37)21-9-5-2-6-10-21)29-23-15-17-24(18-16-23)31-28(34)27(33)30-22-13-11-20(12-14-22)19-7-3-1-4-8-19/h1-18,25H,(H,29,32)(H,30,33)(H,31,34)(H,35,36,37)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of phosphatase activity of human Meg2 using pNPP as a substrate after 10 mins by spectrophotometer analysis


ACS Med Chem Lett 6: 782-6 (2015)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50112357
PNG
(CHEMBL3609375)
Show SMILES CC(C)c1ccc(NC(=O)C(=O)Nc2ccc(NC(=O)C(c3ccccc3)S(O)(=O)=O)cc2)cc1
Show InChI InChI=1/C25H25N3O6S/c1-16(2)17-8-10-19(11-9-17)27-24(30)25(31)28-21-14-12-20(13-15-21)26-23(29)22(35(32,33)34)18-6-4-3-5-7-18/h3-16,22H,1-2H3,(H,26,29)(H,27,30)(H,28,31)(H,32,33,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of phosphatase activity of human Meg2 using pNPP as a substrate after 10 mins by spectrophotometer analysis


ACS Med Chem Lett 6: 782-6 (2015)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM53072
PNG
((5Z)-3-allyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene...)
Show SMILES CCN1\C(Sc2ccccc12)=C1\SC(=S)N(CC=C)C1=O
Show InChI InChI=1S/C15H14N2OS3/c1-3-9-17-13(18)12(21-15(17)19)14-16(4-2)10-7-5-6-8-11(10)20-14/h3,5-8H,1,4,9H2,2H3/b14-12-
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n/an/a 5.94E+4n/an/an/an/an/an/a



Case Western Reserve University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged MEG2 (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincubated for 30...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50343530
PNG
(5,7-dichloro-4-((3-(4-methoxyphenylthio)benzyl)(me...)
Show SMILES COc1ccc(Sc2cccc(CN(C)c3cc(nc4cc(Cl)cc(Cl)c34)C(O)=O)c2)cc1
Show InChI InChI=1S/C25H20Cl2N2O3S/c1-29(23-13-22(25(30)31)28-21-12-16(26)11-20(27)24(21)23)14-15-4-3-5-19(10-15)33-18-8-6-17(32-2)7-9-18/h3-13H,14H2,1-2H3,(H,30,31)
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n/an/a 6.61E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of MEG2 (unknown origin) assessed as reduction in pNPP hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363857
PNG
(CHEMBL1946248)
Show SMILES CCOP(O)(=O)C(N[C@@H](CO)C([O-])=O)c1ccccc1O
Show InChI InChI=1S/C12H18NO7P/c1-2-20-21(18,19)11(13-9(7-14)12(16)17)8-5-3-4-6-10(8)15/h3-6,9,11,13-15H,2,7H2,1H3,(H,16,17)(H,18,19)/p-1/t9-,11?/m0/s1
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n/an/a 6.86E+4n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50031910
PNG
(CHEMBL3360908)
Show SMILES CCN1C(=O)N\C(=C\c2ccc(OCc3ccc(cc3)C(O)=O)c(I)c2)C1=O
Show InChI InChI=1S/C20H17IN2O5/c1-2-23-18(24)16(22-20(23)27)10-13-5-8-17(15(21)9-13)28-11-12-3-6-14(7-4-12)19(25)26/h3-10H,2,11H2,1H3,(H,22,27)(H,25,26)/b16-10+
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n/an/a 7.85E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of MEG2 (unknown origin) assessed as reduction in pNPP hydrolysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425823
PNG
(CHEMBL2316901)
Show SMILES OC(=O)c1cc2c(C#C)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C17H10O4/c1-2-11-12-8-13(17(19)20)14(18)9-15(12)21-16(11)10-6-4-3-5-7-10/h1,3-9,18H,(H,19,20)
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n/an/a 8.50E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425822
PNG
(CHEMBL2316899)
Show SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@]2(O)C#Cc1c(oc2cc(O)c(cc12)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C36H36O6/c1-34-14-10-23(37)18-22(34)8-9-25-28(34)12-15-35(2)29(25)13-17-36(35,41)16-11-24-26-19-27(33(39)40)30(38)20-31(26)42-32(24)21-6-4-3-5-7-21/h3-7,18-20,25,28-29,38,41H,8-10,12-15,17H2,1-2H3,(H,39,40)/t25-,28+,29+,34+,35+,36-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425821
PNG
(CHEMBL2316900)
Show SMILES OCC#Cc1c(oc2cc(O)c(cc12)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C18H12O5/c19-8-4-7-12-13-9-14(18(21)22)15(20)10-16(13)23-17(12)11-5-2-1-3-6-11/h1-3,5-6,9-10,19-20H,8H2,(H,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50425812
PNG
(CHEMBL2316898)
Show SMILES OC(=O)c1cc2c(CCc3cccc(F)c3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C23H17FO4/c24-16-8-4-5-14(11-16)9-10-17-18-12-19(23(26)27)20(25)13-21(18)28-22(17)15-6-2-1-3-7-15/h1-8,11-13,25H,9-10H2,(H,26,27)
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n/an/a 1.10E+5n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363855
PNG
(CHEMBL1946246)
Show SMILES CCOP(=O)(OCC)[C@H](Nc1ccccc1Cl)c1ccccc1O
Show InChI InChI=1S/C17H21ClNO4P/c1-3-22-24(21,23-4-2)17(13-9-5-8-12-16(13)20)19-15-11-7-6-10-14(15)18/h5-12,17,19-20H,3-4H2,1-2H3/t17-/m0/s1
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n/an/a 1.46E+5n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363856
PNG
(CHEMBL1946247)
Show SMILES Oc1ccc(N[C@H](c2ccccc2O)P(O)(O)=O)cc1
Show InChI InChI=1S/C13H14NO5P/c15-10-7-5-9(6-8-10)14-13(20(17,18)19)11-3-1-2-4-12(11)16/h1-8,13-16H,(H2,17,18,19)/t13-/m0/s1
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n/an/a 1.60E+5n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363853
PNG
(CHEMBL1946244)
Show SMILES CCOP(=O)(OCC)[C@H](Nc1ccc(Br)cc1)c1ccccc1O
Show InChI InChI=1S/C17H21BrNO4P/c1-3-22-24(21,23-4-2)17(15-7-5-6-8-16(15)20)19-14-11-9-13(18)10-12-14/h5-12,17,19-20H,3-4H2,1-2H3/t17-/m0/s1
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n/an/a 1.73E+5n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363854
PNG
(CHEMBL1946245)
Show SMILES CCOP(=O)(OCC)[C@H](Nc1ccc(cc1)[N+]([O-])=O)c1ccccc1O
Show InChI InChI=1S/C17H21N2O6P/c1-3-24-26(23,25-4-2)17(15-7-5-6-8-16(15)20)18-13-9-11-14(12-10-13)19(21)22/h5-12,17-18,20H,3-4H2,1-2H3/t17-/m0/s1
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n/an/a 2.91E+5n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363852
PNG
(CHEMBL1946243)
Show SMILES CCOP(=O)(OCC)[C@H](Nc1ccc(Cl)cc1)c1ccccc1O
Show InChI InChI=1S/C17H21ClNO4P/c1-3-22-24(21,23-4-2)17(15-7-5-6-8-16(15)20)19-14-11-9-13(18)10-12-14/h5-12,17,19-20H,3-4H2,1-2H3/t17-/m0/s1
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n/an/a 3.47E+5n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50420258
PNG
(CEFSULODIN)
Show SMILES NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)C(c2ccccc2)S(O)(=O)=O)C3=O)C(O)=O)cc1
Show InChI InChI=1S/C22H20N4O8S2/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34)/p+1/t15-,17?,21-/m1/s1
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n/an/a 3.50E+5n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of phosphatase activity of human Meg2 using pNPP as a substrate after 10 mins by spectrophotometer analysis


ACS Med Chem Lett 6: 782-6 (2015)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363865
PNG
(CHEMBL1946386)
Show SMILES CCOP(O)(=O)C(NCCNC(c1ccccc1O)P(O)(=O)OCC)c1ccccc1O
Show InChI InChI=1S/C20H30N2O8P2/c1-3-29-31(25,26)19(15-9-5-7-11-17(15)23)21-13-14-22-20(32(27,28)30-4-2)16-10-6-8-12-18(16)24/h5-12,19-24H,3-4,13-14H2,1-2H3,(H,25,26)(H,27,28)
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363866
PNG
(CHEMBL1946387)
Show SMILES CCOP(O)(=O)C(NCC([O-])=O)c1ccccc1O
Show InChI InChI=1S/C11H16NO6P/c1-2-18-19(16,17)11(12-7-10(14)15)8-5-3-4-6-9(8)13/h3-6,11-13H,2,7H2,1H3,(H,14,15)(H,16,17)/p-1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363867
PNG
(CHEMBL1946388)
Show SMILES CCOP(O)(=O)C(N[C@@H](C)C([O-])=O)c1ccccc1O
Show InChI InChI=1S/C12H18NO6P/c1-3-19-20(17,18)11(13-8(2)12(15)16)9-6-4-5-7-10(9)14/h4-8,11,13-14H,3H2,1-2H3,(H,15,16)(H,17,18)/p-1/t8-,11?/m0/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363868
PNG
(CHEMBL1946389)
Show SMILES CCOP(O)(=O)C(N[C@@H]([C@@H](C)O)C([O-])=O)c1ccccc1O
Show InChI InChI=1S/C13H20NO7P/c1-3-21-22(19,20)12(9-6-4-5-7-10(9)16)14-11(8(2)15)13(17)18/h4-8,11-12,14-16H,3H2,1-2H3,(H,17,18)(H,19,20)/p-1/t8-,11+,12?/m1/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363864
PNG
(CHEMBL1946385)
Show SMILES CCOP(O)(=O)C(NCCCNC(c1ccccc1O)P(O)(=O)OCC)c1ccccc1O
Show InChI InChI=1S/C21H32N2O8P2/c1-3-30-32(26,27)20(16-10-5-7-12-18(16)24)22-14-9-15-23-21(33(28,29)31-4-2)17-11-6-8-13-19(17)25/h5-8,10-13,20-25H,3-4,9,14-15H2,1-2H3,(H,26,27)(H,28,29)
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363863
PNG
(CHEMBL1946384)
Show SMILES CCOP(O)(=O)C(NCCCCCCNC(c1ccccc1O)P(O)(=O)OCC)c1ccccc1O
Show InChI InChI=1S/C24H38N2O8P2/c1-3-33-35(29,30)23(19-13-7-9-15-21(19)27)25-17-11-5-6-12-18-26-24(36(31,32)34-4-2)20-14-8-10-16-22(20)28/h7-10,13-16,23-28H,3-6,11-12,17-18H2,1-2H3,(H,29,30)(H,31,32)
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363862
PNG
(CHEMBL1946383)
Show SMILES CCOP(O)(=O)C(N[C@@H](Cc1ccc(O)cc1)C([O-])=O)c1ccccc1O
Show InChI InChI=1S/C18H22NO7P/c1-2-26-27(24,25)17(14-5-3-4-6-16(14)21)19-15(18(22)23)11-12-7-9-13(20)10-8-12/h3-10,15,17,19-21H,2,11H2,1H3,(H,22,23)(H,24,25)/p-1/t15-,17?/m0/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363861
PNG
(CHEMBL1946252)
Show SMILES CCOP(O)(=O)C(N[C@@H](Cc1ccccc1)C([O-])=O)c1ccccc1O
Show InChI InChI=1S/C18H22NO6P/c1-2-25-26(23,24)17(14-10-6-7-11-16(14)20)19-15(18(21)22)12-13-8-4-3-5-9-13/h3-11,15,17,19-20H,2,12H2,1H3,(H,21,22)(H,23,24)/p-1/t15-,17?/m0/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363859
PNG
(CHEMBL1946250)
Show SMILES CCOP(O)(=O)C(N[C@@H](Cc1c[nH]c2ccccc12)C([O-])=O)c1ccccc1O
Show InChI InChI=1S/C20H23N2O6P/c1-2-28-29(26,27)19(15-8-4-6-10-18(15)23)22-17(20(24)25)11-13-12-21-16-9-5-3-7-14(13)16/h3-10,12,17,19,21-23H,2,11H2,1H3,(H,24,25)(H,26,27)/p-1/t17-,19?/m0/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase MEG2 (PTP-Meg2)


(Homo sapiens (Human))
BDBM50363858
PNG
(CHEMBL1946249)
Show SMILES CCOP(O)(=O)C(N[C@@H](Cc1cnc[nH]1)C([O-])=O)c1ccccc1O
Show InChI InChI=1S/C15H20N3O6P/c1-2-24-25(22,23)14(11-5-3-4-6-13(11)19)18-12(15(20)21)7-10-8-16-9-17-10/h3-6,8-9,12,14,18-19H,2,7H2,1H3,(H,16,17)(H,20,21)(H,22,23)/p-1/t12-,14?/m0/s1
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n/an/a>1.00E+7n/an/an/an/an/an/a



Shanxi University

Curated by ChEMBL


Assay Description
Inhibition of human PTP-MEG2 using p-nitrophenol phosphate as substrate incubated for 35 mins prior to substrate addition measured after 30 mins by s...


Citation and Details
More data for this
Ligand-Target Pair
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