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Compile Data Set for Download or QSAR

Found 81 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene protein Wnt-3' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265468
PNG
(CHEMBL497177 | N-[1-(N-Methylglycyl)piperidin-4-yl...)
Show SMILES CNCC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H24F3N3O5S2/c1-25-14-20(28)27-11-9-15(10-12-27)26-34(31,32)19-13-17(7-8-18(19)21(22,23)24)33(29,30)16-5-3-2-4-6-16/h2-8,13,15,25-26H,9-12,14H2,1H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265469
PNG
(CHEMBL497383 | N-[1-(N,N-Dimethylglycyl)piperidin-...)
Show SMILES CN(C)CC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H26F3N3O5S2/c1-27(2)15-21(29)28-12-10-16(11-13-28)26-35(32,33)20-14-18(8-9-19(20)22(23,24)25)34(30,31)17-6-4-3-5-7-17/h3-9,14,16,26H,10-13,15H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265479
PNG
(5-(Phenylsulfonyl)-N-[1-(pyrrolidin-1-ylacetyl)pip...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H28F3N3O5S2/c25-24(26,27)21-9-8-20(36(32,33)19-6-2-1-3-7-19)16-22(21)37(34,35)28-18-10-14-30(15-11-18)23(31)17-29-12-4-5-13-29/h1-3,6-9,16,18,28H,4-5,10-15,17H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265544
PNG
(CHEMBL525970 | N-[1-(1-Acetyl-L-prolyl)piperidin-4...)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H28F3N3O6S2/c1-17(32)31-13-5-8-22(31)24(33)30-14-11-18(12-15-30)29-39(36,37)23-16-20(9-10-21(23)25(26,27)28)38(34,35)19-6-3-2-4-7-19/h2-4,6-7,9-10,16,18,22,29H,5,8,11-15H2,1H3/t22-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265545
PNG
(CHEMBL500903 | N-[1-(1-Isobutyryl-L-prolyl)piperid...)
Show SMILES CC(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C27H32F3N3O6S2/c1-18(2)25(34)33-14-6-9-23(33)26(35)32-15-12-19(13-16-32)31-41(38,39)24-17-21(10-11-22(24)27(28,29)30)40(36,37)20-7-4-3-5-8-20/h3-5,7-8,10-11,17-19,23,31H,6,9,12-16H2,1-2H3/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265546
PNG
(CHEMBL447079 | N-{1-[1-(2,2-Dimethylpropanoyl)-L-p...)
Show SMILES CC(C)(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H34F3N3O6S2/c1-27(2,3)26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-42(39,40)24-18-21(11-12-22(24)28(29,30)31)41(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265547
PNG
(CHEMBL455476 | N-{1-[1-(3,3-Dimethylbutanoyl)-L-pr...)
Show SMILES CC(C)(C)CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C29H36F3N3O6S2/c1-28(2,3)19-26(36)35-15-7-10-24(35)27(37)34-16-13-20(14-17-34)33-43(40,41)25-18-22(11-12-23(25)29(30,31)32)42(38,39)21-8-5-4-6-9-21/h4-6,8-9,11-12,18,20,24,33H,7,10,13-17,19H2,1-3H3/t24-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265548
PNG
(CHEMBL501332 | N-[1-(N,N-Dimethylglycyl-L-prolyl)p...)
Show SMILES CN(C)CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C27H33F3N4O6S2/c1-32(2)18-25(35)34-14-6-9-23(34)26(36)33-15-12-19(13-16-33)31-42(39,40)24-17-21(10-11-22(24)27(28,29)30)41(37,38)20-7-4-3-5-8-20/h3-5,7-8,10-11,17,19,23,31H,6,9,12-16,18H2,1-2H3/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265549
PNG
(CHEMBL507695 | N-{1-[1-(Cyclohexylcarbonyl)-L-prol...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)C1CCCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C30H36F3N3O6S2/c31-30(32,33)25-14-13-24(43(39,40)23-10-5-2-6-11-23)20-27(25)44(41,42)34-22-15-18-35(19-16-22)29(38)26-12-7-17-36(26)28(37)21-8-3-1-4-9-21/h2,5-6,10-11,13-14,20-22,26,34H,1,3-4,7-9,12,15-19H2/t26-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265550
PNG
(CHEMBL510748 | N-[1-(1-Benzoyl-L-prolyl)piperidin-...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C30H30F3N3O6S2/c31-30(32,33)25-14-13-24(43(39,40)23-10-5-2-6-11-23)20-27(25)44(41,42)34-22-15-18-35(19-16-22)29(38)26-12-7-17-36(26)28(37)21-8-3-1-4-9-21/h1-6,8-11,13-14,20,22,26,34H,7,12,15-19H2/t26-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265551
PNG
(CHEMBL462363 | N-(1-{1-[4-(Dimethylamino)benzoyl]-...)
Show SMILES CN(C)c1ccc(cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C32H35F3N4O6S2/c1-37(2)24-12-10-22(11-13-24)30(40)39-18-6-9-28(39)31(41)38-19-16-23(17-20-38)36-47(44,45)29-21-26(14-15-27(29)32(33,34)35)46(42,43)25-7-4-3-5-8-25/h3-5,7-8,10-15,21,23,28,36H,6,9,16-20H2,1-2H3/t28-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265552
PNG
(CHEMBL454478 | N-[1-(1-Isonicotinoyl-L-prolyl)pipe...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)c1ccncc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C29H29F3N4O6S2/c30-29(31,32)24-9-8-23(43(39,40)22-5-2-1-3-6-22)19-26(24)44(41,42)34-21-12-17-35(18-13-21)28(38)25-7-4-16-36(25)27(37)20-10-14-33-15-11-20/h1-3,5-6,8-11,14-15,19,21,25,34H,4,7,12-13,16-18H2/t25-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265553
PNG
((2S)-N-Ethyl-2-{[4-({[5-(phenylsulfonyl)-2-(triflu...)
Show SMILES CCNC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H31F3N4O6S2/c1-2-30-25(35)33-14-6-9-22(33)24(34)32-15-12-18(13-16-32)31-41(38,39)23-17-20(10-11-21(23)26(27,28)29)40(36,37)19-7-4-3-5-8-19/h3-5,7-8,10-11,17-18,22,31H,2,6,9,12-16H2,1H3,(H,30,35)/t22-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265554
PNG
((2S)-N-(tert-Butyl)-2-{[4-({[5-(phenylsulfonyl)-2-...)
Show SMILES CC(C)(C)NC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H35F3N4O6S2/c1-27(2,3)32-26(37)35-15-7-10-23(35)25(36)34-16-13-19(14-17-34)33-43(40,41)24-18-21(11-12-22(24)28(29,30)31)42(38,39)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,33H,7,10,13-17H2,1-3H3,(H,32,37)/t23-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265555
PNG
((2S)-N-Phenyl-2-{[4-({[5-(phenylsulfonyl)-2-(trifl...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C30H31F3N4O6S2/c31-30(32,33)25-14-13-24(44(40,41)23-10-5-2-6-11-23)20-27(25)45(42,43)35-22-15-18-36(19-16-22)28(38)26-12-7-17-37(26)29(39)34-21-8-3-1-4-9-21/h1-6,8-11,13-14,20,22,26,35H,7,12,15-19H2,(H,34,39)/t26-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265580
PNG
((2S)-N,N-Dimethyl-2-{[4-({[5-(phenylsulfonyl)-2-(t...)
Show SMILES CN(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H31F3N4O6S2/c1-31(2)25(35)33-14-6-9-22(33)24(34)32-15-12-18(13-16-32)30-41(38,39)23-17-20(10-11-21(23)26(27,28)29)40(36,37)19-7-4-3-5-8-19/h3-5,7-8,10-11,17-18,22,30H,6,9,12-16H2,1-2H3/t22-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265581
PNG
(CHEMBL505036 | N-{1-[1-(Morpholin-4-ylcarbonyl)-L-...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)N1CCOCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H33F3N4O7S2/c29-28(30,31)23-9-8-22(43(38,39)21-5-2-1-3-6-21)19-25(23)44(40,41)32-20-10-13-33(14-11-20)26(36)24-7-4-12-35(24)27(37)34-15-17-42-18-16-34/h1-3,5-6,8-9,19-20,24,32H,4,7,10-18H2/t24-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265582
PNG
(CHEMBL496581 | N-[1-(1-Methyl-L-prolyl)piperidin-4...)
Show SMILES CN1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H28F3N3O5S2/c1-29-13-5-8-21(29)23(31)30-14-11-17(12-15-30)28-37(34,35)22-16-19(9-10-20(22)24(25,26)27)36(32,33)18-6-3-2-4-7-18/h2-4,6-7,9-10,16-17,21,28H,5,8,11-15H2,1H3/t21-/m0/s1
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n/an/an/an/a 230n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265583
PNG
(CHEMBL451431 | N-{1-[1-(3,3-Dimethylbutyl)-L-proly...)
Show SMILES CC(C)(C)CCN1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C29H38F3N3O5S2/c1-28(2,3)15-19-34-16-7-10-25(34)27(36)35-17-13-21(14-18-35)33-42(39,40)26-20-23(11-12-24(26)29(30,31)32)41(37,38)22-8-5-4-6-9-22/h4-6,8-9,11-12,20-21,25,33H,7,10,13-19H2,1-3H3/t25-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265480
PNG
(CHEMBL523726 | N-[1-(Morpholin-4-ylacetyl)piperidi...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCOCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H28F3N3O6S2/c25-24(26,27)21-7-6-20(37(32,33)19-4-2-1-3-5-19)16-22(21)38(34,35)28-18-8-10-30(11-9-18)23(31)17-29-12-14-36-15-13-29/h1-7,16,18,28H,8-15,17H2
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n/an/an/an/a 160n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265481
PNG
(5-(Phenylsulfonyl)-N-[1-(piperazin-1-ylacetyl)pipe...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H29F3N4O5S2/c25-24(26,27)21-7-6-20(37(33,34)19-4-2-1-3-5-19)16-22(21)38(35,36)29-18-8-12-31(13-9-18)23(32)17-30-14-10-28-11-15-30/h1-7,16,18,28-29H,8-15,17H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265499
PNG
(CHEMBL495534 | N-[1-(1H-Imidazol-1-ylacetyl)piperi...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)Cn1ccnc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H23F3N4O5S2/c24-23(25,26)20-7-6-19(36(32,33)18-4-2-1-3-5-18)14-21(20)37(34,35)28-17-8-11-30(12-9-17)22(31)15-29-13-10-27-16-29/h1-7,10,13-14,16-17,28H,8-9,11-12,15H2
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265500
PNG
((S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-43(39,40)24-18-21(11-12-22(24)28(29,30)31)42(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m0/s1
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n/an/an/an/a 60n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265501
PNG
((R)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluo...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-43(39,40)24-18-21(11-12-22(24)28(29,30)31)42(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m1/s1
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n/an/an/an/a 210n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265502
PNG
(CHEMBL504979 | tert-Butyl(5S)-2-oxo-5-{[4-({[5-(Ph...)
Show SMILES CC(C)(C)OC(=O)N1[C@@H](CCC1=O)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H32F3N3O8S2/c1-27(2,3)42-26(37)34-22(11-12-24(34)35)25(36)33-15-13-18(14-16-33)32-44(40,41)23-17-20(9-10-21(23)28(29,30)31)43(38,39)19-7-5-4-6-8-19/h4-10,17-18,22,32H,11-16H2,1-3H3/t22-/m0/s1
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n/an/an/an/a 90n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265503
PNG
((S)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H26F3N3O5S2/c24-23(25,26)19-9-8-18(35(31,32)17-5-2-1-3-6-17)15-21(19)36(33,34)28-16-10-13-29(14-11-16)22(30)20-7-4-12-27-20/h1-3,5-6,8-9,15-16,20,27-28H,4,7,10-14H2/t20-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265504
PNG
((R)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbony...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@H]1CCCN1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H26F3N3O5S2/c24-23(25,26)19-9-8-18(35(31,32)17-5-2-1-3-6-17)15-21(19)36(33,34)28-16-10-13-29(14-11-16)22(30)20-7-4-12-27-20/h1-3,5-6,8-9,15-16,20,27-28H,4,7,10-14H2/t20-/m1/s1
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n/an/an/an/a 710n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265505
PNG
(CHEMBL525899 | N-[1-(5-oxo-L-Prolyl)piperidin-4-yl...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCC(=O)N1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H24F3N3O6S2/c24-23(25,26)18-7-6-17(36(32,33)16-4-2-1-3-5-16)14-20(18)37(34,35)28-15-10-12-29(13-11-15)22(31)19-8-9-21(30)27-19/h1-7,14-15,19,28H,8-13H2,(H,27,30)/t19-/m0/s1
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n/an/an/an/a 240n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265584
PNG
(CHEMBL503281 | N-{1-[1-(Cyclohexylmethyl)-L-prolyl...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1CC1CCCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C30H38F3N3O5S2/c31-30(32,33)26-14-13-25(42(38,39)24-10-5-2-6-11-24)20-28(26)43(40,41)34-23-15-18-35(19-16-23)29(37)27-12-7-17-36(27)21-22-8-3-1-4-9-22/h2,5-6,10-11,13-14,20,22-23,27,34H,1,3-4,7-9,12,15-19,21H2/t27-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265585
PNG
(CHEMBL511077 | N-[1-(1-Benzyl-L-prolyl)piperidin-4...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1Cc1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C30H32F3N3O5S2/c31-30(32,33)26-14-13-25(42(38,39)24-10-5-2-6-11-24)20-28(26)43(40,41)34-23-15-18-35(19-16-23)29(37)27-12-7-17-36(27)21-22-8-3-1-4-9-22/h1-6,8-11,13-14,20,23,27,34H,7,12,15-19,21H2/t27-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50265467
PNG
(5-(Phenylsulfonyl)-N-piperidin-4-yl-2-(trifluorome...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2
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n/an/an/an/a 650n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294822
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES COc1cc(ccc1-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C26H21N3O4/c1-33-20-13-17(24(30)28-18-6-2-4-14-5-3-11-27-23(14)18)9-10-19(20)29-25(31)21-15-7-8-16(12-15)22(21)26(29)32/h2-11,13,15-16,31-32H,12H2,1H3,(H,28,30)/t15-,16+
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294823
PNG
(2-Chloro-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(C(=O)Nc2cccc3cccnc23)c(Cl)c1
Show InChI InChI=1S/C25H18ClN3O3/c26-18-12-16(29-24(31)20-14-6-7-15(11-14)21(20)25(29)32)8-9-17(18)23(30)28-19-5-1-3-13-4-2-10-27-22(13)19/h1-10,12,14-15,31-32H,11H2,(H,28,30)/t14-,15+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294824
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1cc(ccc1C(=O)Nc1cccc2cccnc12)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O
Show InChI InChI=1S/C26H21N3O3/c1-14-12-18(29-25(31)21-16-7-8-17(13-16)22(21)26(29)32)9-10-19(14)24(30)28-20-6-2-4-15-5-3-11-27-23(15)20/h2-12,16-17,31-32H,13H2,1H3,(H,28,30)/t16-,17+
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n/an/an/an/a 2.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294825
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES COc1cc(ccc1C(=O)Nc1cccc2cccnc12)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O
Show InChI InChI=1S/C26H21N3O4/c1-33-20-13-17(29-25(31)21-15-7-8-16(12-15)22(21)26(29)32)9-10-18(20)24(30)28-19-6-2-4-14-5-3-11-27-23(14)19/h2-11,13,15-16,31-32H,12H2,1H3,(H,28,30)/t15-,16+
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The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294826
PNG
(1-[4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(NC(=O)Nc2cccc3cccnc23)cc1
Show InChI InChI=1S/C25H20N4O3/c30-23-20-15-6-7-16(13-15)21(20)24(31)29(23)18-10-8-17(9-11-18)27-25(32)28-19-5-1-3-14-4-2-12-26-22(14)19/h1-12,15-16,30-31H,13H2,(H2,27,28,32)/t15-,16+
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294827
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES O=C(Nc1cccc2cccnc12)[C@H]1CC[C@@H](CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O
Show InChI InChI=1S/C25H25N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-7,12,15-18,20-21H,8-11,13H2,(H,27,29)/t15-,16-,17+,18-,20-,21+
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n/an/an/an/a 400n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294828
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccnc2c(NC(=O)[C@H]3CC[C@@H](CC3)N3C(=O)[C@H]4[C@@H]5C[C@@H](C=C5)[C@H]4C3=O)cccc12
Show InChI InChI=1S/C26H27N3O3/c1-14-11-12-27-23-19(14)3-2-4-20(23)28-24(30)15-7-9-18(10-8-15)29-25(31)21-16-5-6-17(13-16)22(21)26(29)32/h2-6,11-12,15-18,21-22H,7-10,13H2,1H3,(H,28,30)/t15-,16-,17+,18-,21-,22+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294829
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccc2cccnc2c1NC(=O)[C@H]1CC[C@@H](CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O
Show InChI InChI=1S/C26H27N3O3/c1-14-4-5-15-3-2-12-27-23(15)22(14)28-24(30)16-8-10-19(11-9-16)29-25(31)20-17-6-7-18(13-17)21(20)26(29)32/h2-7,12,16-21H,8-11,13H2,1H3,(H,28,30)/t16-,17-,18+,19-,20-,21+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294830
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES O=C(Nc1cccc2cccnc12)N1CCC(CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O
Show InChI InChI=1S/C24H24N4O3/c29-22-19-15-6-7-16(13-15)20(19)23(30)28(22)17-8-11-27(12-9-17)24(31)26-18-5-1-3-14-4-2-10-25-21(14)18/h1-7,10,15-17,19-20H,8-9,11-13H2,(H,26,31)/t15-,16+,19-,20+
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n/an/an/an/a 1.00E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294831
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES O=C(Nc1cccc2cccnc12)[C@H]1CC[C@H](CN2C(=O)[C@H]3[C@@H]4C[C@@H](C=C4)[C@H]3C2=O)CC1
Show InChI InChI=1S/C26H27N3O3/c30-24(28-20-5-1-3-16-4-2-12-27-23(16)20)17-8-6-15(7-9-17)14-29-25(31)21-18-10-11-19(13-18)22(21)26(29)32/h1-5,10-12,15,17-19,21-22H,6-9,13-14H2,(H,28,30)/t15-,17-,18-,19+,21-,22+
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294832
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccnc2c(NC(=O)[C@H]3CC[C@H](CN4C(=O)[C@H]5[C@@H]6C[C@@H](C=C6)[C@H]5C4=O)CC3)cccc12
Show InChI InChI=1S/C27H29N3O3/c1-15-11-12-28-24-20(15)3-2-4-21(24)29-25(31)17-7-5-16(6-8-17)14-30-26(32)22-18-9-10-19(13-18)23(22)27(30)33/h2-4,9-12,16-19,22-23H,5-8,13-14H2,1H3,(H,29,31)/t16-,17-,18-,19+,22-,23+
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294833
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccc2cccnc2c1NC(=O)[C@H]1CC[C@H](CN2C(=O)[C@H]3[C@@H]4C[C@@H](C=C4)[C@H]3C2=O)CC1
Show InChI InChI=1S/C27H29N3O3/c1-15-4-7-17-3-2-12-28-24(17)23(15)29-25(31)18-8-5-16(6-9-18)14-30-26(32)21-19-10-11-20(13-19)22(21)27(30)33/h2-4,7,10-12,16,18-22H,5-6,8-9,13-14H2,1H3,(H,29,31)/t16-,18-,19-,20+,21-,22+
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n/an/an/an/a 1.00E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294834
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES CN(C(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O)c1cccc2cccnc12
Show InChI InChI=1S/C26H21N3O3/c1-28(20-6-2-4-15-5-3-13-27-23(15)20)24(30)16-9-11-19(12-10-16)29-25(31)21-17-7-8-18(14-17)22(21)26(29)32/h2-13,17-18,31-32H,14H2,1H3/t17-,18+
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294835
PNG
(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,30-31H,13H2,(H,27,29)/t16-,17+
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n/an/an/an/a 5.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294836
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3CC[C@H](C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C25H21N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-5,8-12,16-17,30-31H,6-7,13H2,(H,27,29)/t16-,17+
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n/an/an/an/a 200n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294787
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Cc1ccc2cccnc2c1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O
Show InChI InChI=1S/C26H21N3O3/c1-14-4-5-15-3-2-12-27-23(15)22(14)28-24(30)16-8-10-19(11-9-16)29-25(31)20-17-6-7-18(13-17)21(20)26(29)32/h2-12,17-18,31-32H,13H2,1H3,(H,28,30)/t17-,18+
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n/an/an/an/a 800n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294788
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NC1CCCc2cccnc12
Show InChI InChI=1S/C25H23N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h2,4,6-12,16-17,19,30-31H,1,3,5,13H2,(H,27,29)/t16-,17+,19?
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n/an/an/an/a 1.00E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294789
PNG
(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES COc1ccccc1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O
Show InChI InChI=1S/C23H20N2O4/c1-29-18-5-3-2-4-17(18)24-21(26)13-8-10-16(11-9-13)25-22(27)19-14-6-7-15(12-14)20(19)23(25)28/h2-11,14-15,27-28H,12H2,1H3,(H,24,26)/t14-,15+
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n/an/an/an/a 1.00E+3n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens)
BDBM50294790
PNG
(4-((1R,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Show SMILES Oc1c2[C@@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C22H18N2O3/c25-20(23-16-4-2-1-3-5-16)13-8-10-17(11-9-13)24-21(26)18-14-6-7-15(12-14)19(18)22(24)27/h1-11,14-15,26-27H,12H2,(H,23,25)/t14-,15-/m0/s1
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n/an/an/an/a>2.50E+4n/an/an/an/a



The University of Texas Southwestern Medical Center at Dallas

Curated by ChEMBL


Assay Description
Inhibition of Wnt3 expressed in mouse L-cells assessed as inhibition of Wnt/catanin signaling pathway by luciferase reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
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