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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase Src (T338C/V323S)' AND taxid = 9031   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src (T338C/V323S)


(Gallus gallus (Chicken))
BDBM234844
PNG
(US9353116, 13)
Show SMILES CC(C)n1nc(Cc2cccc(c2)C(=O)CF)c2c(N)ncnc12
Show InChI InChI=1S/C17H18FN5O/c1-10(2)23-17-15(16(19)20-9-21-17)13(22-23)7-11-4-3-5-12(6-11)14(24)8-18/h3-6,9-10H,7-8H2,1-2H3,(H2,19,20,21)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 29n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...


US Patent US9353116 (2016)


BindingDB Entry DOI: 10.7270/Q2V123N7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (T338C/V323S)


(Gallus gallus (Chicken))
BDBM234843
PNG
(US9353116, 3)
Show SMILES CC(C)n1nc(-c2cccc(NS(=O)(=O)C=C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C16H18N6O2S/c1-4-25(23,24)21-12-7-5-6-11(8-12)14-13-15(17)18-9-19-16(13)22(20-14)10(2)3/h4-10,21H,1H2,2-3H3,(H2,17,18,19)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 131n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...


US Patent US9353116 (2016)


BindingDB Entry DOI: 10.7270/Q2V123N7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (T338C/V323S)


(Gallus gallus (Chicken))
BDBM50403061
PNG
(CHEMBL2216823 | US9353116, 9)
Show SMILES CC(C)n1nc(Cc2cccc(NS(=O)(=O)C=C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C17H20N6O2S/c1-4-26(24,25)22-13-7-5-6-12(8-13)9-14-15-16(18)19-10-20-17(15)23(21-14)11(2)3/h4-8,10-11,22H,1,9H2,2-3H3,(H2,18,19,20)
PDB

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a 424n/an/an/an/an/an/a



The Regents of the University of California

US Patent


Assay Description
In vitro kinase assays for c-Src variants were performed in 50 mM Tris (pH 8.0), 10 mM MgCl2 and 1 mg/mL BSA. When obtaining kinetic parameters (kcat...


US Patent US9353116 (2016)


BindingDB Entry DOI: 10.7270/Q2V123N7
More data for this
Ligand-Target Pair