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Found 29 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase Src (c-Src)' AND taxid = 9031   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234848
PNG
(US9353116, 5)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a 899n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234843
PNG
(US9353116, 3)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a 1.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234861
PNG
(US9353116, 20)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a 2.17E+3n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234845
PNG
(US9353116, 1)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a 2.32E+3n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234852
PNG
(US9353116, 10)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a 3.08E+3n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234849
PNG
(US9353116, 6)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234860
PNG
(US9353116, 19 | US9353116, Fig. 16, Compound 1)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234859
PNG
(US9353116, 18)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234858
PNG
(US9353116, 17)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234857
PNG
(US9353116, 16)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234856
PNG
(US9353116, 15)
PDB

GoogleScholar
AffyNet 
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AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234855
PNG
(US9353116, 14)
PDB

GoogleScholar
AffyNet 
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AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234844
PNG
(US9353116, 13)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234854
PNG
(US9353116, 12)
PDB

GoogleScholar
AffyNet 
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AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234846
PNG
(US9353116, 2)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234847
PNG
(US9353116, 4)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234850
PNG
(US9353116, 7)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234851
PNG
(US9353116, 8)
PDB

GoogleScholar
AffyNet 
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM50403061
PNG
(CHEMBL2216823 | US9353116, 9)
Show SMILES CC(C)n1nc(Cc2cccc(NS(=O)(=O)C=C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C17H20N6O2S/c1-4-26(24,25)22-13-7-5-6-12(8-13)9-14-15-16(18)19-10-20-17(15)23(21-14)11(2)3/h4-8,10-11,22H,1,9H2,2-3H3,(H2,18,19,20)
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PC cid
PC sid
UniChem
AffyNet 
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM234853
PNG
(US9353116, 11)
PDB

GoogleScholar
AffyNet 
PDB
UniChem
AffyNet 
PDB
n/an/a>5.00E+3n/an/an/an/an/an/a


TBA



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Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185671
PNG
(DAS-DFGO-II)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C30H31F3N8O3S/c1-18-6-7-22(37-27(43)20-4-3-5-21(14-20)30(31,32)33)15-23(18)38-28(44)24-17-34-29(45-24)39-25-16-26(36-19(2)35-25)41-10-8-40(9-11-41)12-13-42/h3-7,14-17,42H,8-13H2,1-2H3,(H,37,43)(H,38,44)(H,34,35,36,39)
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Article
PubMed
n/an/an/a 2.70n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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n/an/an/a 0.0700n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185672
PNG
(DAS-CHO-I)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2ccc(Oc3ccccc3)cc2)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C27H29N7O3S/c1-19-29-24(17-25(30-19)34-13-11-33(12-14-34)15-16-35)32-27-28-18-23(38-27)26(36)31-20-7-9-22(10-8-20)37-21-5-3-2-4-6-21/h2-10,17-18,35H,11-16H2,1H3,(H,31,36)(H,28,29,30,32)
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PubMed
n/an/an/a 15n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185670
PNG
(DAS-DFGO-I | N-(2-chloro-6-methylphenyl)-2-[[6-[4-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2cccc(NC(=O)c3cccc(c3)C(F)(F)F)c2)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C29H29F3N8O3S/c1-18-34-24(16-25(35-18)40-10-8-39(9-11-40)12-13-41)38-28-33-17-23(44-28)27(43)37-22-7-3-6-21(15-22)36-26(42)19-4-2-5-20(14-19)29(30,31)32/h2-7,14-17,41H,8-13H2,1H3,(H,36,42)(H,37,43)(H,33,34,35,38)
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PubMed
n/an/an/a 0.530n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM50322535
PNG
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
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PubMed
n/an/an/a 0.700n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against phospho...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185676
PNG
(DAS-DFGO-II-BODIPY)
Show SMILES Cc1cc(C)n2c1C=C1C=CC(CCC(=O)N3CCN(CC3)c3cc(Nc4ncc(s4)C(=O)Nc4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C)nc(C)n3)=[N+]1[B-]2(F)F
Show InChI InChI=1S/C42H40BF5N10O3S/c1-24-8-9-30(52-39(60)28-6-5-7-29(19-28)42(44,45)46)20-33(24)53-40(61)35-23-49-41(62-35)54-36-22-37(51-27(4)50-36)55-14-16-56(17-15-55)38(59)13-12-31-10-11-32-21-34-25(2)18-26(3)57(34)43(47,48)58(31)32/h5-11,18-23H,12-17H2,1-4H3,(H,52,60)(H,53,61)(H,49,50,51,54)
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PubMed
n/an/an/a 2.80n/an/an/an/an/a



Stony Brook University



Assay Description
Reaction volumes of 50 μL were used in 96-well plates. Buffer A (1, 34 μL; 100 mM Tris, pH 8, 10 mM MgCl2) was added to a single row, foll...


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Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185675
PNG
(DAS-BODIPY)
Show SMILES Cc1cc(C)n2c1C=C1C=CC(CCC(=O)N3CCN(CC3)c3cc(Nc4ncc(s4)C(=O)Nc4c(C)cccc4Cl)nc(C)n3)=[N+]1[B-]2(F)F
Show InChI InChI=1S/C34H35BClF2N9O2S/c1-20-6-5-7-26(36)32(20)43-33(49)28-19-39-34(50-28)42-29-18-30(41-23(4)40-29)44-12-14-45(15-13-44)31(48)11-10-24-8-9-25-17-27-21(2)16-22(3)46(27)35(37,38)47(24)25/h5-9,16-19H,10-15H2,1-4H3,(H,43,49)(H,39,40,41,42)
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PubMed
n/an/an/a 0.5n/an/an/an/an/a



Stony Brook University



Assay Description
Reaction volumes of 50 μL were used in 96-well plates. Buffer A (1, 34 μL; 100 mM Tris, pH 8, 10 mM MgCl2) was added to a single row, foll...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185674
PNG
(4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)ca...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1
Show InChI InChI=1S/C30H28FN7O3/c1-30(2,3)26-17-27(38(37-26)19-7-9-23-18(14-19)6-5-12-33-23)36-29(40)35-24-10-8-20(15-22(24)31)41-21-11-13-34-25(16-21)28(39)32-4/h5-17H,1-4H3,(H,32,39)(H2,35,36,40)
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n/an/an/a 11n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against phospho...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185673
PNG
(DAS-CHO-II)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2ccc(Oc3ccccc3)cc2C)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C28H31N7O3S/c1-19-16-22(38-21-6-4-3-5-7-21)8-9-23(19)32-27(37)24-18-29-28(39-24)33-25-17-26(31-20(2)30-25)35-12-10-34(11-13-35)14-15-36/h3-9,16-18,36H,10-15H2,1-2H3,(H,32,37)(H,29,30,31,33)
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n/an/an/a 1.70n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair