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Found 9 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase Src (c-Src)' AND taxid = 9031   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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PubMed
n/an/an/a 0.0700n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185670
PNG
(DAS-DFGO-I | N-(2-chloro-6-methylphenyl)-2-[[6-[4-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2cccc(NC(=O)c3cccc(c3)C(F)(F)F)c2)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C29H29F3N8O3S/c1-18-34-24(16-25(35-18)40-10-8-39(9-11-40)12-13-41)38-28-33-17-23(44-28)27(43)37-22-7-3-6-21(15-22)36-26(42)19-4-2-5-20(14-19)29(30,31)32/h2-7,14-17,41H,8-13H2,1H3,(H,36,42)(H,37,43)(H,33,34,35,38)
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PubMed
n/an/an/a 0.530n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185671
PNG
(DAS-DFGO-II)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C30H31F3N8O3S/c1-18-6-7-22(37-27(43)20-4-3-5-21(14-20)30(31,32)33)15-23(18)38-28(44)24-17-34-29(45-24)39-25-16-26(36-19(2)35-25)41-10-8-40(9-11-41)12-13-42/h3-7,14-17,42H,8-13H2,1-2H3,(H,37,43)(H,38,44)(H,34,35,36,39)
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n/an/an/a 2.70n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185672
PNG
(DAS-CHO-I)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2ccc(Oc3ccccc3)cc2)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C27H29N7O3S/c1-19-29-24(17-25(30-19)34-13-11-33(12-14-34)15-16-35)32-27-28-18-23(38-27)26(36)31-20-7-9-22(10-8-20)37-21-5-3-2-4-6-21/h2-10,17-18,35H,11-16H2,1H3,(H,31,36)(H,28,29,30,32)
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n/an/an/a 15n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185676
PNG
(DAS-DFGO-II-BODIPY)
Show SMILES Cc1cc(C)n2c1C=C1C=CC(CCC(=O)N3CCN(CC3)c3cc(Nc4ncc(s4)C(=O)Nc4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C)nc(C)n3)=[N+]1[B-]2(F)F
Show InChI InChI=1S/C42H40BF5N10O3S/c1-24-8-9-30(52-39(60)28-6-5-7-29(19-28)42(44,45)46)20-33(24)53-40(61)35-23-49-41(62-35)54-36-22-37(51-27(4)50-36)55-14-16-56(17-15-55)38(59)13-12-31-10-11-32-21-34-25(2)18-26(3)57(34)43(47,48)58(31)32/h5-11,18-23H,12-17H2,1-4H3,(H,52,60)(H,53,61)(H,49,50,51,54)
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n/an/an/a 2.80n/an/an/an/an/a



Stony Brook University



Assay Description
Reaction volumes of 50 μL were used in 96-well plates. Buffer A (1, 34 μL; 100 mM Tris, pH 8, 10 mM MgCl2) was added to a single row, foll...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM50322535
PNG
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
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PC sid
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Article
PubMed
n/an/an/a 0.700n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against phospho...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185674
PNG
(4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)ca...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1
Show InChI InChI=1S/C30H28FN7O3/c1-30(2,3)26-17-27(38(37-26)19-7-9-23-18(14-19)6-5-12-33-23)36-29(40)35-24-10-8-20(15-22(24)31)41-21-11-13-34-25(16-21)28(39)32-4/h5-17H,1-4H3,(H,32,39)(H2,35,36,40)
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n/an/an/a 11n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against phospho...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185675
PNG
(DAS-BODIPY)
Show SMILES Cc1cc(C)n2c1C=C1C=CC(CCC(=O)N3CCN(CC3)c3cc(Nc4ncc(s4)C(=O)Nc4c(C)cccc4Cl)nc(C)n3)=[N+]1[B-]2(F)F
Show InChI InChI=1S/C34H35BClF2N9O2S/c1-20-6-5-7-26(36)32(20)43-33(49)28-19-39-34(50-28)42-29-18-30(41-23(4)40-29)44-12-14-45(15-13-44)31(48)11-10-24-8-9-25-17-27-21(2)16-22(3)46(27)35(37,38)47(24)25/h5-9,16-19H,10-15H2,1-4H3,(H,43,49)(H,39,40,41,42)
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n/an/an/a 0.5n/an/an/an/an/a



Stony Brook University



Assay Description
Reaction volumes of 50 μL were used in 96-well plates. Buffer A (1, 34 μL; 100 mM Tris, pH 8, 10 mM MgCl2) was added to a single row, foll...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (c-Src)


(Gallus gallus (Chicken))
BDBM185673
PNG
(DAS-CHO-II)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2ccc(Oc3ccccc3)cc2C)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C28H31N7O3S/c1-19-16-22(38-21-6-4-3-5-7-21)8-9-23(19)32-27(37)24-18-29-28(39-24)33-25-17-26(31-20(2)30-25)35-12-10-34(11-13-35)14-15-36/h3-9,16-18,36H,10-15H2,1-2H3,(H,32,37)(H,29,30,31,33)
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n/an/an/a 1.70n/an/an/an/an/a



Stony Brook University



Assay Description
Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...


Citation and Details
More data for this
Ligand-Target Pair