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Compile Data Set for Download or QSAR

Found 4557 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret '   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50331094
PNG
(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O
Show InChI InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
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1.5n/an/an/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin)


J Med Chem 58: 3672-81 (2015)


Article DOI: 10.1021/jm501464c
BindingDB Entry DOI: 10.7270/Q2RR2106
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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18n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to RET (unknown origin)


Eur J Med Chem 82: 139-51 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.051
BindingDB Entry DOI: 10.7270/Q2F1918D
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50198782
PNG
(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H25Cl2N5O/c1-17-15-18(24-21(27)5-4-6-22(24)28)16-23-25(17)30-26(32-31-23)29-19-7-9-20(10-8-19)34-14-13-33-11-2-3-12-33/h4-10,15-16H,2-3,11-14H2,1H3,(H,29,30,32)
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407n/an/an/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Ret


Bioorg Med Chem Lett 17: 602-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.006
BindingDB Entry DOI: 10.7270/Q29024MW
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of RET


J Med Chem 54: 2341-50 (2011)


Article DOI: 10.1021/jm101499u
BindingDB Entry DOI: 10.7270/Q2KH0NPW
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311705
PNG
(Ex. Cpd. 157)
Show SMILES CCC(O)CC#Cc1c(C(=O)Nc2ccc(COC)cc2)c2c(N)ncnc2n1C1(C)CC1
Show InChI InChI=1S/C25H29N5O3/c1-4-18(31)6-5-7-19-20(24(32)29-17-10-8-16(9-11-17)14-33-3)21-22(26)27-15-28-23(21)30(19)25(2)12-13-25/h8-11,15,18,31H,4,6,12-14H2,1-3H3,(H,29,32)(H2,26,27,28)
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n/an/a 0.100n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50300027
PNG
((S)-1-Acryloyl-N-[4-(3-chloro-2,4-difluorophenylam...)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3F)c2cc1NC(=O)[C@@H]1CCCN1C(=O)C=C
Show InChI InChI=1S/C25H24ClF2N5O4/c1-3-21(34)33-8-4-5-19(33)25(35)32-18-11-14-17(12-20(18)37-10-9-36-2)29-13-30-24(14)31-16-7-6-15(27)22(26)23(16)28/h3,6-7,11-13,19H,1,4-5,8-10H2,2H3,(H,32,35)(H,29,30,31)/t19-/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



Hanmi Research Center

Curated by ChEMBL


Assay Description
Inhibition of Ret


J Med Chem 52: 6880-8 (2009)


Article DOI: 10.1021/jm901146p
BindingDB Entry DOI: 10.7270/Q28W3DDJ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311639
PNG
(Ex. Cpd. 91)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cnc4cccnn34)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C27H24N8O2/c1-27(11-12-27)34-20(10-9-19-14-29-21-4-3-13-32-35(19)21)22(23-24(28)30-16-31-25(23)34)26(36)33-18-7-5-17(6-8-18)15-37-2/h3-8,13-14,16H,11-12,15H2,1-2H3,(H,33,36)(H2,28,30,31)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311679
PNG
(Ex. Cpd. 131)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC3(O)CCCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H29N5O3/c1-25(13-14-25)31-19(9-12-26(33)10-3-4-11-26)20(21-22(27)28-16-29-23(21)31)24(32)30-18-7-5-17(6-8-18)15-34-2/h5-8,16,33H,3-4,10-11,13-15H2,1-2H3,(H,30,32)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311622
PNG
(Ex. Cpd. 59)
Show SMILES CSCc1ccc(NC(=O)c2c(Br)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C19H20BrN5OS/c1-19(7-8-19)25-15(20)13(14-16(21)22-10-23-17(14)25)18(26)24-12-5-3-11(4-6-12)9-27-2/h3-6,10H,7-9H2,1-2H3,(H,24,26)(H2,21,22,23)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311600
PNG
(Ex. Cpd. 37)
Show SMILES CSCc1ccc(NC(=O)c2cn(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C19H21N5OS/c1-19(7-8-19)24-9-14(15-16(20)21-11-22-17(15)24)18(25)23-13-5-3-12(4-6-13)10-26-2/h3-6,9,11H,7-8,10H2,1-2H3,(H,23,25)(H2,20,21,22)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50345579
PNG
(5-((5-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl...)
Show SMILES CNC(=O)c1ncc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(c2)C(F)(F)F)n1C
Show InChI InChI=1S/C30H33F3N6O3/c1-20-4-5-22(16-21(20)7-9-25-18-35-27(37(25)3)29(42)34-2)28(41)36-24-8-6-23(26(17-24)30(31,32)33)19-39-12-10-38(11-13-39)14-15-40/h4-6,8,16-18,40H,10-15,19H2,1-3H3,(H,34,42)(H,36,41)
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n/an/a 0.200n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human RET using KKKSPGEYVNIEFG by Hotspot assay


Bioorg Med Chem Lett 21: 3743-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.060
BindingDB Entry DOI: 10.7270/Q21G0MM8
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311717
PNG
(Ex. Cpd. 169)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCn3cccc3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H26N6O2/c1-26(11-12-26)32-20(6-5-15-31-13-3-4-14-31)21(22-23(27)28-17-29-24(22)32)25(33)30-19-9-7-18(8-10-19)16-34-2/h3-4,7-10,13-14,17H,11-12,15-16H2,1-2H3,(H,30,33)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311652
PNG
(Ex. Cpd. 104)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC(O)C3CC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C25H27N5O3/c1-25(11-12-25)30-18(9-10-19(31)16-5-6-16)20(21-22(26)27-14-28-23(21)30)24(32)29-17-7-3-15(4-8-17)13-33-2/h3-4,7-8,14,16,19,31H,5-6,11-13H2,1-2H3,(H,29,32)(H2,26,27,28)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311708
PNG
(Ex. Cpd. 160)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cn[nH]c3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C24H23N7O2/c1-24(9-10-24)31-18(8-5-16-11-28-29-12-16)19(20-21(25)26-14-27-22(20)31)23(32)30-17-6-3-15(4-7-17)13-33-2/h3-4,6-7,11-12,14H,9-10,13H2,1-2H3,(H,28,29)(H,30,32)(H2,25,26,27)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311707
PNG
(Ex. Cpd. 159)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cnc4ccoc4c3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C28H24N6O3/c1-28(10-11-28)34-21(8-5-18-13-22-20(30-14-18)9-12-37-22)23(24-25(29)31-16-32-26(24)34)27(35)33-19-6-3-17(4-7-19)15-36-2/h3-4,6-7,9,12-14,16H,10-11,15H2,1-2H3,(H,33,35)(H2,29,31,32)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311704
PNG
(Ex. Cpd. 156)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCC3NC(=O)NC3=O)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C25H25N7O4/c1-25(10-11-25)32-17(5-3-4-16-22(33)31-24(35)30-16)18(19-20(26)27-13-28-21(19)32)23(34)29-15-8-6-14(7-9-15)12-36-2/h6-9,13,16H,4,10-12H2,1-2H3,(H,29,34)(H2,26,27,28)(H2,30,31,33,35)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311660
PNG
(Ex. Cpd. 112)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC3CCC(=O)CC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C27H29N5O3/c1-27(13-14-27)32-21(12-7-17-5-10-20(33)11-6-17)22(23-24(28)29-16-30-25(23)32)26(34)31-19-8-3-18(4-9-19)15-35-2/h3-4,8-9,16-17H,5-6,10-11,13-15H2,1-2H3,(H,31,34)(H2,28,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311734
PNG
(Ex. Cpd. 186)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3ccncc3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H24N6O2/c1-26(11-12-26)32-20(8-5-17-9-13-28-14-10-17)21(22-23(27)29-16-30-24(22)32)25(33)31-19-6-3-18(4-7-19)15-34-2/h3-4,6-7,9-10,13-14,16H,11-12,15H2,1-2H3,(H,31,33)(H2,27,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311736
PNG
(Ex. Cpd. 188)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCC(C)O)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C24H27N5O3/c1-15(30)5-4-6-18-19(23(31)28-17-9-7-16(8-10-17)13-32-3)20-21(25)26-14-27-22(20)29(18)24(2)11-12-24/h7-10,14-15,30H,5,11-13H2,1-3H3,(H,28,31)(H2,25,26,27)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311643
PNG
(Ex. Cpd. 95)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C22H23N5O2/c1-4-5-16-17(21(28)26-15-8-6-14(7-9-15)12-29-3)18-19(23)24-13-25-20(18)27(16)22(2)10-11-22/h6-9,13H,10-12H2,1-3H3,(H,26,28)(H2,23,24,25)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311751
PNG
(Ex. Cpd. 205)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1F
Show InChI InChI=1S/C26H28FN5O3/c1-26(9-10-26)32-20(6-3-16-7-11-35-12-8-16)21(22-23(28)29-15-30-24(22)32)25(33)31-18-5-4-17(14-34-2)19(27)13-18/h4-5,13,15-16H,7-12,14H2,1-2H3,(H,31,33)(H2,28,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311651
PNG
(Ex. Cpd. 103)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCC3(O)CCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H29N5O3/c1-25(13-14-25)31-19(5-3-10-26(33)11-4-12-26)20(21-22(27)28-16-29-23(21)31)24(32)30-18-8-6-17(7-9-18)15-34-2/h6-9,16,33H,4,10-15H2,1-2H3,(H,30,32)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311673
PNG
(Ex. Cpd. 125)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCC3(O)COC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C25H27N5O4/c1-24(10-11-24)30-18(4-3-9-25(32)13-34-14-25)19(20-21(26)27-15-28-22(20)30)23(31)29-17-7-5-16(6-8-17)12-33-2/h5-8,15,32H,9-14H2,1-2H3,(H,29,31)(H2,26,27,28)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311691
PNG
(Ex. Cpd. 143)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCC3(O)CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C27H31N5O4/c1-26(10-11-26)32-20(4-3-9-27(34)12-14-36-15-13-27)21(22-23(28)29-17-30-24(22)32)25(33)31-19-7-5-18(6-8-19)16-35-2/h5-8,17,34H,9-16H2,1-2H3,(H,31,33)(H2,28,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311699
PNG
(Ex. Cpd. 151)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN3CCSCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H30N6O2S/c1-26(9-10-26)32-20(4-3-11-31-12-14-35-15-13-31)21(22-23(27)28-17-29-24(22)32)25(33)30-19-7-5-18(6-8-19)16-34-2/h5-8,17H,9-16H2,1-2H3,(H,30,33)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311700
PNG
(Ex. Cpd. 152)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCC3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C27H31N5O3/c1-27(12-13-27)32-21(5-3-4-18-10-14-35-15-11-18)22(23-24(28)29-17-30-25(23)32)26(33)31-20-8-6-19(7-9-20)16-34-2/h6-9,17-18H,4,10-16H2,1-2H3,(H,31,33)(H2,28,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311633
PNG
(Ex. Cpd. 85)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H30N6O3/c1-26(9-10-26)32-20(4-3-11-31-12-14-35-15-13-31)21(22-23(27)28-17-29-24(22)32)25(33)30-19-7-5-18(6-8-19)16-34-2/h5-8,17H,9-16H2,1-2H3,(H,30,33)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311634
PNG
(Ex. Cpd. 86)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCC(C)(C)O)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C25H29N5O3/c1-24(2,32)11-5-6-18-19(23(31)29-17-9-7-16(8-10-17)14-33-4)20-21(26)27-15-28-22(20)30(18)25(3)12-13-25/h7-10,15,32H,11-14H2,1-4H3,(H,29,31)(H2,26,27,28)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311635
PNG
(Ex. Cpd. 87)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H29N5O3/c1-26(11-12-26)31-20(8-5-17-9-13-34-14-10-17)21(22-23(27)28-16-29-24(22)31)25(32)30-19-6-3-18(4-7-19)15-33-2/h3-4,6-7,16-17H,9-15H2,1-2H3,(H,30,32)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311703
PNG
(Ex. Cpd. 155)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3ccc(N)nc3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H25N7O2/c1-26(11-12-26)33-19(9-5-16-6-10-20(27)29-13-16)21(22-23(28)30-15-31-24(22)33)25(34)32-18-7-3-17(4-8-18)14-35-2/h3-4,6-8,10,13,15H,11-12,14H2,1-2H3,(H2,27,29)(H,32,34)(H2,28,30,31)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311653
PNG
(Ex. Cpd. 105)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN3CCCCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C27H32N6O2/c1-27(12-13-27)33-21(7-6-16-32-14-4-3-5-15-32)22(23-24(28)29-18-30-25(23)33)26(34)31-20-10-8-19(9-11-20)17-35-2/h8-11,18H,3-5,12-17H2,1-2H3,(H,31,34)(H2,28,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311636
PNG
(Ex. Cpd. 88)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN3CCCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H30N6O2/c1-26(11-12-26)32-20(6-5-15-31-13-3-4-14-31)21(22-23(27)28-17-29-24(22)32)25(33)30-19-9-7-18(8-10-19)16-34-2/h7-10,17H,3-4,11-16H2,1-2H3,(H,30,33)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311638
PNG
(Ex. Cpd. 90)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cnn(C)c3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C25H25N7O2/c1-25(10-11-25)32-19(9-6-17-12-29-31(2)13-17)20(21-22(26)27-15-28-23(21)32)24(33)30-18-7-4-16(5-8-18)14-34-3/h4-5,7-8,12-13,15H,10-11,14H2,1-3H3,(H,30,33)(H2,26,27,28)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311618
PNG
(Ex. Cpd. 55)
Show SMILES COCc1ccc(NC(=O)c2c(Br)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C19H20BrN5O2/c1-19(7-8-19)25-15(20)13(14-16(21)22-10-23-17(14)25)18(26)24-12-5-3-11(4-6-12)9-27-2/h3-6,10H,7-9H2,1-2H3,(H,24,26)(H2,21,22,23)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311720
PNG
(Ex. Cpd. 172)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3ccccn3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H24N6O2/c1-26(12-13-26)32-20(11-10-18-5-3-4-14-28-18)21(22-23(27)29-16-30-24(22)32)25(33)31-19-8-6-17(7-9-19)15-34-2/h3-9,14,16H,12-13,15H2,1-2H3,(H,31,33)(H2,27,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311711
PNG
(Ex. Cpd. 163)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC(C)(C)n3cccc3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C28H30N6O2/c1-27(2,33-15-5-6-16-33)12-11-21-22(26(35)32-20-9-7-19(8-10-20)17-36-4)23-24(29)30-18-31-25(23)34(21)28(3)13-14-28/h5-10,15-16,18H,13-14,17H2,1-4H3,(H,32,35)(H2,29,30,31)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311743
PNG
(Ex. Cpd. 195)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cncc(c3)C#N)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C27H23N7O2/c1-27(9-10-27)34-21(8-5-18-11-19(12-28)14-30-13-18)22(23-24(29)31-16-32-25(23)34)26(35)33-20-6-3-17(4-7-20)15-36-2/h3-4,6-7,11,13-14,16H,9-10,15H2,1-2H3,(H,33,35)(H2,29,31,32)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311741
PNG
(Ex. Cpd. 193)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cncs3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C24H22N6O2S/c1-24(9-10-24)30-18(8-7-17-11-26-14-33-17)19(20-21(25)27-13-28-22(20)30)23(31)29-16-5-3-15(4-6-16)12-32-2/h3-6,11,13-14H,9-10,12H2,1-2H3,(H,29,31)(H2,25,27,28)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311739
PNG
(Ex. Cpd. 191)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cnc[nH]3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C24H23N7O2/c1-24(9-10-24)31-18(8-7-17-11-26-13-27-17)19(20-21(25)28-14-29-22(20)31)23(32)30-16-5-3-15(4-6-16)12-33-2/h3-6,11,13-14H,9-10,12H2,1-2H3,(H,26,27)(H,30,32)(H2,25,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311733
PNG
(Ex. Cpd. 185)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC3(O)CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H29N5O4/c1-25(9-10-25)31-19(7-8-26(33)11-13-35-14-12-26)20(21-22(27)28-16-29-23(21)31)24(32)30-18-5-3-17(4-6-18)15-34-2/h3-6,16,33H,9-15H2,1-2H3,(H,30,32)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311731
PNG
(Ex. Cpd. 183)
Show SMILES COCc1ccc(NC(=O)c2c(C#CC3CCN(C)CC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C27H32N6O2/c1-27(12-13-27)33-21(9-6-18-10-14-32(2)15-11-18)22(23-24(28)29-17-30-25(23)33)26(34)31-20-7-4-19(5-8-20)16-35-3/h4-5,7-8,17-18H,10-16H2,1-3H3,(H,31,34)(H2,28,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311730
PNG
(Ex. Cpd. 182)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cnn(C)c3C)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H27N7O2/c1-16-18(13-30-32(16)3)7-10-20-21(25(34)31-19-8-5-17(6-9-19)14-35-4)22-23(27)28-15-29-24(22)33(20)26(2)11-12-26/h5-6,8-9,13,15H,11-12,14H2,1-4H3,(H,31,34)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311586
PNG
(Ex. Cpd. 23)
Show SMILES CSCc1ccc(NC(=O)c2nn(c3ncnc(N)c23)C(C)(C)C)cc1
Show InChI InChI=1S/C18H22N6OS/c1-18(2,3)24-16-13(15(19)20-10-21-16)14(23-24)17(25)22-12-7-5-11(6-8-12)9-26-4/h5-8,10H,9H2,1-4H3,(H,22,25)(H2,19,20,21)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311752
PNG
(Ex. Cpd. 206)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN3CCOCC3)n(c3ncnc(N)c23)C2(C)CC2)cc1F
Show InChI InChI=1S/C26H29FN6O3/c1-26(7-8-26)33-20(4-3-9-32-10-12-36-13-11-32)21(22-23(28)29-16-30-24(22)33)25(34)31-18-6-5-17(15-35-2)19(27)14-18/h5-6,14,16H,7-13,15H2,1-2H3,(H,31,34)(H2,28,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311746
PNG
(Ex. Cpd. 198)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCN(C)C)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C24H28N6O2/c1-24(11-12-24)30-18(6-5-13-29(2)3)19(20-21(25)26-15-27-22(20)30)23(31)28-17-9-7-16(8-10-17)14-32-4/h7-10,15H,11-14H2,1-4H3,(H,28,31)(H2,25,26,27)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311658
PNG
(Ex. Cpd. 110)
Show SMILES COCc1ccc(NC(=O)c2c(C#CCO)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C22H23N5O3/c1-22(9-10-22)27-16(4-3-11-28)17(18-19(23)24-13-25-20(18)27)21(29)26-15-7-5-14(6-8-15)12-30-2/h5-8,13,28H,9-12H2,1-2H3,(H,26,29)(H2,23,24,25)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311641
PNG
(Ex. Cpd. 93)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cncn3C)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C25H25N7O2/c1-25(10-11-25)32-19(9-8-18-12-27-15-31(18)2)20(21-22(26)28-14-29-23(21)32)24(33)30-17-6-4-16(5-7-17)13-34-3/h4-7,12,14-15H,10-11,13H2,1-3H3,(H,30,33)(H2,26,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311642
PNG
(Ex. Cpd. 94)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cccnc3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H24N6O2/c1-26(11-12-26)32-20(10-7-17-4-3-13-28-14-17)21(22-23(27)29-16-30-24(22)32)25(33)31-19-8-5-18(6-9-19)15-34-2/h3-6,8-9,13-14,16H,11-12,15H2,1-2H3,(H,31,33)(H2,27,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311729
PNG
(Ex. Cpd. 181)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cn(C)nc3C)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C26H27N7O2/c1-16-18(13-32(3)31-16)7-10-20-21(25(34)30-19-8-5-17(6-9-19)14-35-4)22-23(27)28-15-29-24(22)33(20)26(2)11-12-26/h5-6,8-9,13,15H,11-12,14H2,1-4H3,(H,30,34)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM311744
PNG
(Ex. Cpd. 196)
Show SMILES COCc1ccc(NC(=O)c2c(C#Cc3cncnc3)n(c3ncnc(N)c23)C2(C)CC2)cc1
Show InChI InChI=1S/C25H23N7O2/c1-25(9-10-25)32-19(8-5-17-11-27-14-28-12-17)20(21-22(26)29-15-30-23(21)32)24(33)31-18-6-3-16(4-7-18)13-34-2/h3-4,6-7,11-12,14-15H,9-10,13H2,1-2H3,(H,31,33)(H2,26,29,30)
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...


US Patent US10155768 (2018)

More data for this
Ligand-Target Pair
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