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Compile Data Set for Download or QSAR

Found 205 hits Enz. Inhib. hit(s) with Target = 'Pyrimidinergic receptor P2Y4' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50268874
PNG
(CHEMBL499580 | Sodium 1-Amino-4-[3-(4,6-dichloro-[...)
Show SMILES Nc1c(cc(Nc2cc(Nc3nc(Cl)nc(Cl)n3)cc(c2)C(O)=O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C24H14Cl2N6O7S/c25-22-30-23(26)32-24(31-22)29-11-6-9(21(35)36)5-10(7-11)28-14-8-15(40(37,38)39)18(27)17-16(14)19(33)12-3-1-2-4-13(12)20(17)34/h1-8,28H,27H2,(H,35,36)(H,37,38,39)(H,29,30,31,32)/p-1
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PubMed
n/an/a 1.45E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50268725
PNG
(CHEMBL496030 | sodium 1-amino-4-(4-hydroxyphenylam...)
Show SMILES Nc1c(cc(Nc2ccc(O)cc2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C20H14N2O6S/c21-18-15(29(26,27)28)9-14(22-10-5-7-11(23)8-6-10)16-17(18)20(25)13-4-2-1-3-12(13)19(16)24/h1-9,22-23H,21H2,(H,26,27,28)/p-1
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n/an/a 2.22E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50268725
PNG
(CHEMBL496030 | sodium 1-amino-4-(4-hydroxyphenylam...)
Show SMILES Nc1c(cc(Nc2ccc(O)cc2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C20H14N2O6S/c21-18-15(29(26,27)28)9-14(22-10-5-7-11(23)8-6-10)16-17(18)20(25)13-4-2-1-3-12(13)19(16)24/h1-9,22-23H,21H2,(H,26,27,28)/p-1
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n/an/a 2.37E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50029031
PNG
(1-Amino-4-{4-[4-chloro-6-(3-sulfo-phenylamino)-[1,...)
Show SMILES Nc1c(cc(Nc2ccc(Nc3nc(Cl)nc(Nc4cccc(c4)S([O-])(=O)=O)n3)c(c2)S([O-])(=O)=O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C29H20ClN7O11S3/c30-27-35-28(33-13-4-3-5-15(10-13)49(40,41)42)37-29(36-27)34-18-9-8-14(11-20(18)50(43,44)45)32-19-12-21(51(46,47)48)24(31)23-22(19)25(38)16-6-1-2-7-17(16)26(23)39/h1-12,32H,31H2,(H,40,41,42)(H,43,44,45)(H,46,47,48)(H2,33,34,35,36,37)/p-3
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n/an/a 5.75E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced intracellular calcium mobilization b...


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50029031
PNG
(1-Amino-4-{4-[4-chloro-6-(3-sulfo-phenylamino)-[1,...)
Show SMILES Nc1c(cc(Nc2ccc(Nc3nc(Cl)nc(Nc4cccc(c4)S([O-])(=O)=O)n3)c(c2)S([O-])(=O)=O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C29H20ClN7O11S3/c30-27-35-28(33-13-4-3-5-15(10-13)49(40,41)42)37-29(36-27)34-18-9-8-14(11-20(18)50(43,44)45)32-19-12-21(51(46,47)48)24(31)23-22(19)25(38)16-6-1-2-7-17(16)26(23)39/h1-12,32H,31H2,(H,40,41,42)(H,43,44,45)(H,46,47,48)(H2,33,34,35,36,37)/p-3
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n/an/a 9.79E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50029031
PNG
(1-Amino-4-{4-[4-chloro-6-(3-sulfo-phenylamino)-[1,...)
Show SMILES Nc1c(cc(Nc2ccc(Nc3nc(Cl)nc(Nc4cccc(c4)S([O-])(=O)=O)n3)c(c2)S([O-])(=O)=O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C29H20ClN7O11S3/c30-27-35-28(33-13-4-3-5-15(10-13)49(40,41)42)37-29(36-27)34-18-9-8-14(11-20(18)50(43,44)45)32-19-12-21(51(46,47)48)24(31)23-22(19)25(38)16-6-1-2-7-17(16)26(23)39/h1-12,32H,31H2,(H,40,41,42)(H,43,44,45)(H,46,47,48)(H2,33,34,35,36,37)/p-3
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n/an/a 9.79E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50307836
PNG
(CHEMBL608559 | Sodium 1-Amino-4-(2-anthracenylamin...)
Show SMILES Nc1c2C(=O)c3ccccc3C(=O)c2c(Nc2ccc3cc4ccccc4cc3c2)cc1S([O-])(=O)=O
Show InChI InChI=1S/C28H18N2O5S/c29-26-23(36(33,34)35)14-22(24-25(26)28(32)21-8-4-3-7-20(21)27(24)31)30-19-10-9-17-11-15-5-1-2-6-16(15)12-18(17)13-19/h1-14,30H,29H2,(H,33,34,35)/p-1
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50307835
PNG
(CHEMBL590956 | Sodium 1-amino-4-[4-fluoro-2-carbox...)
Show SMILES Nc1c(cc(Nc2ccc(F)cc2C(O)=O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C21H13FN2O7S/c22-9-5-6-13(12(7-9)21(27)28)24-14-8-15(32(29,30)31)18(23)17-16(14)19(25)10-3-1-2-4-11(10)20(17)26/h1-8,24H,23H2,(H,27,28)(H,29,30,31)/p-1
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50336787
PNG
(CHEMBL445413 | sodium 1-amino-9,10-dioxo-4-(m-toly...)
Show SMILES Cc1cccc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)c1
Show InChI InChI=1S/C21H16N2O5S/c1-11-5-4-6-12(9-11)23-15-10-16(29(26,27)28)19(22)18-17(15)20(24)13-7-2-3-8-14(13)21(18)25/h2-10,23H,22H2,1H3,(H,26,27,28)/p-1
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50336782
PNG
(CHEMBL1672106 | Sodium 1-Amino-4-[4-(4,6-dihydroxy...)
Show SMILES Nc1c(cc(Nc2ccc(Nc3nc(=O)[nH]c(=O)[nH]3)cc2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C23H16N6O7S/c24-18-15(37(34,35)36)9-14(16-17(18)20(31)13-4-2-1-3-12(13)19(16)30)25-10-5-7-11(8-6-10)26-21-27-22(32)29-23(33)28-21/h1-9,25H,24H2,(H,34,35,36)(H3,26,27,28,29,32,33)/p-1
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50268876
PNG
(CHEMBL509572 | Disodium 1-amino-4-[4-(4-chloro-6-m...)
Show SMILES COc1nc(Cl)nc(Nc2ccc(Nc3cc(c(N)c4C(=O)c5ccccc5C(=O)c34)S([O-])(=O)=O)cc2S([O-])(=O)=O)n1
Show InChI InChI=1S/C24H17ClN6O9S2/c1-40-24-30-22(25)29-23(31-24)28-13-7-6-10(8-15(13)41(34,35)36)27-14-9-16(42(37,38)39)19(26)18-17(14)20(32)11-4-2-3-5-12(11)21(18)33/h2-9,27H,26H2,1H3,(H,34,35,36)(H,37,38,39)(H,28,29,30,31)/p-2
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50336796
PNG
(CHEMBL1672105 | Sodium 1-Amino-4-[3-(4,6-dichloro[...)
Show SMILES Nc1c(cc(Nc2cccc(Nc3nc(Cl)nc(Cl)n3)c2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C23H14Cl2N6O5S/c24-21-29-22(25)31-23(30-21)28-11-5-3-4-10(8-11)27-14-9-15(37(34,35)36)18(26)17-16(14)19(32)12-6-1-2-7-13(12)20(17)33/h1-9,27H,26H2,(H,34,35,36)(H,28,29,30,31)/p-1
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50268875
PNG
(CHEMBL496401 | Sodium 1-amino-4-[4-(4,6-dichloro-[...)
Show SMILES Nc1c(cc(Nc2ccc(Nc3nc(Cl)nc(Cl)n3)cc2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C23H14Cl2N6O5S/c24-21-29-22(25)31-23(30-21)28-11-7-5-10(6-8-11)27-14-9-15(37(34,35)36)18(26)17-16(14)19(32)12-3-1-2-4-13(12)20(17)33/h1-9,27H,26H2,(H,34,35,36)(H,28,29,30,31)/p-1
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50336781
PNG
(CHEMBL1672104 | Disodium 1-Amino-4-[3-(4,6-dichlor...)
Show SMILES Nc1c(cc(Nc2ccc(c(Nc3nc(Cl)nc(Cl)n3)c2)S([O-])(=O)=O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C23H14Cl2N6O8S2/c24-21-29-22(25)31-23(30-21)28-12-7-9(5-6-14(12)40(34,35)36)27-13-8-15(41(37,38)39)18(26)17-16(13)19(32)10-3-1-2-4-11(10)20(17)33/h1-8,27H,26H2,(H,34,35,36)(H,37,38,39)(H,28,29,30,31)/p-2
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50336768
PNG
(CHEMBL1671995 | sodium 1-amino-4-(3-methoxyphenyla...)
Show SMILES COc1cccc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)c1
Show InChI InChI=1S/C21H16N2O6S/c1-29-12-6-4-5-11(9-12)23-15-10-16(30(26,27)28)19(22)18-17(15)20(24)13-7-2-3-8-14(13)21(18)25/h2-10,23H,22H2,1H3,(H,26,27,28)/p-1
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50336801
PNG
(CHEMBL1672100 | Sodium1-Amino-4-(3-benzylphenylami...)
Show SMILES Nc1c(cc(Nc2cccc(Cc3ccccc3)c2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C27H20N2O5S/c28-25-22(35(32,33)34)15-21(23-24(25)27(31)20-12-5-4-11-19(20)26(23)30)29-18-10-6-9-17(14-18)13-16-7-2-1-3-8-16/h1-12,14-15,29H,13,28H2,(H,32,33,34)/p-1
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50268574
PNG
(CHEMBL498423 | Sodium 1-Amino-4-(1-naphthylamino)-...)
Show SMILES Nc1c2C(=O)c3ccccc3C(=O)c2c(Nc2cccc3ccccc23)cc1S([O-])(=O)=O
Show InChI InChI=1S/C24H16N2O5S/c25-22-19(32(29,30)31)12-18(26-17-11-5-7-13-6-1-2-8-14(13)17)20-21(22)24(28)16-10-4-3-9-15(16)23(20)27/h1-12,26H,25H2,(H,29,30,31)/p-1
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n/an/a 1.01E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50227020
PNG
(CHEMBL271672 | sodium 1-amino-4-(3-chlorophenylami...)
Show SMILES Nc1c(cc(Nc2cccc(Cl)c2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C20H13ClN2O5S/c21-10-4-3-5-11(8-10)23-14-9-15(29(26,27)28)18(22)17-16(14)19(24)12-6-1-2-7-13(12)20(17)25/h1-9,23H,22H2,(H,26,27,28)/p-1
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n/an/a 2.18E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50227032
PNG
(CHEMBL256057 | acid blue 25 | sodium 1-amino-9,10-...)
Show SMILES Nc1c2C(=O)c3ccccc3C(=O)c2c(Nc2ccccc2)cc1S([O-])(=O)=O
Show InChI InChI=1S/C20H14N2O5S/c21-18-15(28(25,26)27)10-14(22-11-6-2-1-3-7-11)16-17(18)20(24)13-9-5-4-8-12(13)19(16)23/h1-10,22H,21H2,(H,25,26,27)/p-1
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n/an/a 2.58E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50227032
PNG
(CHEMBL256057 | acid blue 25 | sodium 1-amino-9,10-...)
Show SMILES Nc1c2C(=O)c3ccccc3C(=O)c2c(Nc2ccccc2)cc1S([O-])(=O)=O
Show InChI InChI=1S/C20H14N2O5S/c21-18-15(28(25,26)27)10-14(22-11-6-2-1-3-7-11)16-17(18)20(24)13-9-5-4-8-12(13)19(16)23/h1-10,22H,21H2,(H,25,26,27)/p-1
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n/an/a 2.58E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity against human P2Y4 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50336767
PNG
(CHEMBL257495 | PSB-716 | sodium 1-amino-4-(2-metho...)
Show SMILES COc1ccccc1Nc1cc(c(N)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C21H16N2O6S/c1-29-15-9-5-4-8-13(15)23-14-10-16(30(26,27)28)19(22)18-17(14)20(24)11-6-2-3-7-12(11)21(18)25/h2-10,23H,22H2,1H3,(H,26,27,28)/p-1
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50262422
PNG
(CHEMBL477339 | sodium (E)-4-((3-formyl-4-hydroxy-5...)
Show SMILES Cc1cc(N=Nc2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(COP([O-])([O-])=O)c(C=O)c1O
Show InChI InChI=1S/C15H15N2O12PS2/c1-8-4-13(11(7-29-30(20,21)22)10(6-18)15(8)19)17-16-12-3-2-9(31(23,24)25)5-14(12)32(26,27)28/h2-6,19H,7H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28)/p-4
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n/an/a 7.30E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced intracellular calcium mobilization b...


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50336799
PNG
(5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
Show InChI InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
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n/an/an/an/a>1.00E+5n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)


J Med Chem 45: 4057-93 (2002)

More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM85043
PNG
(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Show SMILES Cc1nc(N=Nc2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O
Show InChI InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)


J Med Chem 45: 4057-93 (2002)

More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 2.50E+3n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)


J Med Chem 45: 4057-93 (2002)

More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50118229
PNG
(CHEMBL129841 | MRS 2179)
Show SMILES CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1
Show InChI InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)


J Med Chem 45: 4057-93 (2002)

More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50366480
PNG
(ADENOSINE TRIPHOSPHATE | ATP)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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n/an/an/an/a 4.30E+4n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)


J Med Chem 45: 4057-93 (2002)

More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50194161
PNG
((2R,3R,5S)-1-(5-(diphosphoryloxymethyl)-3-hydroxyt...)
Show SMILES O[C@@H]1C[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H14N2O11P2/c12-6-3-5(4-20-24(18,19)22-23(15,16)17)21-8(6)11-2-1-7(13)10-9(11)14/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1
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n/an/an/an/a 3.10E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y4 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199190
PNG
(3-METHYLURIDINE-5'-MONOPHOSHATE | 3-methyl-1-beta-...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H15N2O9P/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(21-9)4-20-22(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199174
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H19N2O10P/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(29-16)9-28-30(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199193
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H22N2O19P4/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)23)16-15(36-39(24,25)26)14(22)12(35-16)9-34-41(30,31)38-42(32,33)37-40(27,28)29/h1-7,12,14-16,22H,8-9H2,(H,30,31)(H,32,33)(H2,24,25,26)(H2,27,28,29)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199182
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H19N2O9P/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(23-11)5-22-24(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 1.77E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199179
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H15N2O9P/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(21-9)3-20-22(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199173
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H13BrN2O12P2/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(23-8)2-22-26(20,21)24-25(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 7.20E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199180
PNG
(1-(BETA-D-RIBOFURANOSYL)-2-THIO-URACIL-5'-PHOSPHAT...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H13N2O8PS/c12-5-1-2-11(9(21)10-5)8-7(14)6(13)4(19-8)3-18-20(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,10,12,21)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199178
PNG
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Show SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O
Show InChI InChI=1S/C9H13N2O10P/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(21-8)2-20-22(17,18)19/h1,3,6-8,13-15H,2H2,(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199183
PNG
(3-methyl-1-beta-D-ribofuranosylpyrimidine-2,4-dion...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H17N2O15P3/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(25-9)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 2.92E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199187
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]3OP(O)(=O)O[C@@H]23)c(=O)[nH]1
Show InChI InChI=1S/C12H20N2O17P4/c1-2-3-6-4-8(15)14(12(16)13-6)11-10-9(28-34(22,23)29-10)7(27-11)5-26-33(20,21)31-35(24,25)30-32(17,18)19/h4,7,9-11H,2-3,5H2,1H3,(H,13,16)(H,20,21)(H,22,23)(H,24,25)(H2,17,18,19)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199177
PNG
(3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H21N2O16P3/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(33-16)9-32-37(28,29)35-38(30,31)34-36(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H,30,31)(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199189
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H17N2O15P3/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199175
PNG
(6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES Cc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C10H16N2O12P2/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(23-9)3-22-26(20,21)24-25(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199186
PNG
(5-bromouridine-5'-uridylic acid (1,1-dichloro-1-ph...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H14BrCl2N2O14P3/c11-3-1-15(9(19)14-7(3)18)8-6(17)5(16)4(28-8)2-27-32(25,26)29-31(23,24)10(12,13)30(20,21)22/h1,4-6,8,16-17H,2H2,(H,23,24)(H,25,26)(H,14,18,19)(H2,20,21,22)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 3.99E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199172
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H21N2O15P3/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(27-11)5-26-31(22,23)29-32(24,25)28-30(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H,22,23)(H,24,25)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199188
PNG
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O16P3/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,3,6-8,13-15H,2H2,(H,20,21)(H,22,23)(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199192
PNG
(((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyr...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H14BrN2O15P3/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a 3.46E+3n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199191
PNG
(((2R,3S,4R,5R)-5-(2,4-dioxo-3-(2-oxo-2-phenylethyl...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1ccc(=O)n(CC(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C17H20N2O13P2/c20-11(10-4-2-1-3-5-10)8-19-13(21)6-7-18(17(19)24)16-15(23)14(22)12(31-16)9-30-34(28,29)32-33(25,26)27/h1-7,12,14-16,22-23H,8-9H2,(H,28,29)(H2,25,26,27)/t12-,14-,15-,16-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199181
PNG
(6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-...)
Show SMILES CCCc1cc(=O)n([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Show InChI InChI=1S/C12H20N2O12P2/c1-2-3-6-4-8(15)14(12(18)13-6)11-10(17)9(16)7(25-11)5-24-28(22,23)26-27(19,20)21/h4,7,9-11,16-17H,2-3,5H2,1H3,(H,13,18)(H,22,23)(H2,19,20,21)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50194162
PNG
(3-methyl-1-beta-D-ribofuranosylpyrimidine-2,4-dion...)
Show SMILES Cn1c(=O)ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c1=O
Show InChI InChI=1S/C10H16N2O12P2/c1-11-6(13)2-3-12(10(11)16)9-8(15)7(14)5(23-9)4-22-26(20,21)24-25(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
Pyrimidinergic receptor P2Y4


(Homo sapiens)
BDBM50199184
PNG
(5-BROMO-URIDINE-5'-MONOPHOSPHATE | 5-bromo-1-beta-...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Show InChI InChI=1S/C9H12BrN2O9P/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(21-8)2-20-22(17,18)19/h1,4-6,8,13-14H,2H2,(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


Citation and Details
More data for this
Ligand-Target Pair
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