BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 76 hits Enz. Inhib. hit(s) with Target = 'RNase L' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RNase L


(Homo sapiens)
BDBM50085553
PNG
(CHEMBL214603 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(65-29)2-62-73(54,55)68-21-18(48)12(66-30(21)44-7-39-14-23(32)35-5-37-26(14)44)3-63-74(56,57)69-22-19(49)13(4-64-75(58,59)71-76(60,61)70-72(51,52)53)67-31(22)45-8-40-15-24(33)36-6-38-27(15)45/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.720n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
PubMed
n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells


J Med Chem 28: 1376-80 (1985)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RNase L


(Homo sapiens)
BDBM50085558
PNG
(CHEMBL402676 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(61-29)3-59-67(54,55)65-22-19(49)13(63-31(22)45-8-40-15-24(33)36-6-38-27(15)45)4-60-68(56,57)64-21-18(48)12(2-58-66(51,52)53)62-30(21)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.60n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085554
PNG
(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Similars

AffyNet 
MMDB
PubMed
n/an/a 7.30n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
PubMed
n/an/a 13n/an/an/an/an/an/a



National Institute of Diabetes and Digestive antd Kidney Diseases

Curated by ChEMBL


Assay Description
Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluated


Bioorg Med Chem Lett 10: 1357-60 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RNase L


(Homo sapiens)
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
PubMed
n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes


J Med Chem 28: 1376-80 (1985)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RNase L


(Homo sapiens)
BDBM50085556
PNG
(CHEMBL405496 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(19(49)13(67-31)4-64-75(58,59)71-76(60,61)70-72(51,52)53)69-74(56,57)63-3-12-18(48)21(30(66-12)45-8-40-15-24(33)36-6-38-27(15)45)68-73(54,55)62-2-11-17(47)20(50)29(65-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 24n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085555
PNG
(CHEMBL384725 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(18(48)12(62-31)2-58-66(51,52)53)65-68(56,57)60-4-13-19(49)21(30(63-13)45-8-40-15-24(33)36-6-38-27(15)45)64-67(54,55)59-3-11-17(47)20(50)29(61-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 57n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085559
PNG
(CHEMBL410213 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H46N15O25P5/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(67-31)4-64-75(56,57)70-23-20(50)14(68-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47)5-65-76(58,59)71-24-21(51)15(6-66-77(60,61)73-78(62,63)72-74(53,54)55)69-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 105n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50021104
PNG
((2'-5'(pAris)3)
Show SMILES Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O
Show InChI InChI=1S/C33H44N15O16P3/c34-28-19-31(40-7-37-28)46(10-43-19)16-1-13(22(49)25(16)52)5-61-66(56,57)64-27-18(48-12-45-21-30(36)39-9-42-33(21)48)3-15(24(27)51)6-62-67(58,59)63-26-17(2-14(23(26)50)4-60-65(53,54)55)47-11-44-20-29(35)38-8-41-32(20)47/h7-18,22-27,49-52H,1-6H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/p-4
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/a 210n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells


J Med Chem 28: 1376-80 (1985)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50366437
PNG
(CHEMBL608874)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27-,28-,29-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 1.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085557
PNG
(CHEMBL407239 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H44N15O19P3/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(63-31)5-61-69(56,57)67-24-21(51)15(65-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48)6-62-70(58,59)66-23-20(50)14(4-60-68(53,54)55)64-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 1.06E+3n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50021104
PNG
((2'-5'(pAris)3)
Show SMILES Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O
Show InChI InChI=1S/C33H44N15O16P3/c34-28-19-31(40-7-37-28)46(10-43-19)16-1-13(22(49)25(16)52)5-61-66(56,57)64-27-18(48-12-45-21-30(36)39-9-42-33(21)48)3-15(24(27)51)6-62-67(58,59)63-26-17(2-14(23(26)50)4-60-65(53,54)55)47-11-44-20-29(35)38-8-41-32(20)47/h7-18,22-27,49-52H,1-6H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/p-4
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes


J Med Chem 28: 1376-80 (1985)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50366438
PNG
(CHEMBL608875)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@@H]3n3cnc4c(N)ncnc34)O[C@@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27+,28+,29-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a>5.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50366436
PNG
(CHEMBL605454)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](COP(O)(=O)O[C@@H]3[C@@H](OP(O)(O)=O)O[C@@H]([C@@H]3O)n3cnc4c(N)ncnc34)O[C@@H]([C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-15(46)14(45)9(58-26)1-56-65(52,53)61-18-10(59-27(16(18)47)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)28(60-29(19)63-64(49,50)51)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17-,18-,19+,26?,27+,28+,29-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a>5.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085555
PNG
(CHEMBL384725 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(18(48)12(62-31)2-58-66(51,52)53)65-68(56,57)60-4-13-19(49)21(30(63-13)45-8-40-15-24(33)36-6-38-27(15)45)64-67(54,55)59-3-11-17(47)20(50)29(61-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 0.700n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085559
PNG
(CHEMBL410213 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H46N15O25P5/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(67-31)4-64-75(56,57)70-23-20(50)14(68-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47)5-65-76(58,59)71-24-21(51)15(6-66-77(60,61)73-78(62,63)72-74(53,54)55)69-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 4.60n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085553
PNG
(CHEMBL214603 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(65-29)2-62-73(54,55)68-21-18(48)12(66-30(21)44-7-39-14-23(32)35-5-37-26(14)44)3-63-74(56,57)69-22-19(49)13(4-64-75(58,59)71-76(60,61)70-72(51,52)53)67-31(22)45-8-40-15-24(33)36-6-38-27(15)45/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 0.300n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085554
PNG
(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Similars

AffyNet 
MMDB
PubMed
n/an/an/an/a 0.200n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)

More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50152834
PNG
(2''-5--oligoadenylate derivative | [(2R,3R,4R,5R)-...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)O[C@@H]2[C@H](O)[C@@H](COP([O-])(=O)O[C@@H]3[C@H](O)[C@@H](COP([O-])(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)([O-])=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C40H50N20O25P4/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(65)21(61)13(79-37)2-76-87(69,70)84-27-23(63)15(81-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-78-89(73,74)85-28-24(64)16(82-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-77-88(71,72)83-26-22(62)14(1-75-86(66,67)68)80-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-65H,1-4H2,(H,69,70)(H,71,72)(H,73,74)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,66,67,68)/p-4/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 9.70n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309127
PNG
(CHEMBL601939 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](CO)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)41-29(83-86(72,73)74-3-15-22(63)26(67)38(78-15)58-10-54-18-30(42)46-6-50-34(18)58)25(66)17(80-41)5-76-85(70,71)82-28-24(65)16(79-40(28)60-12-56-20-32(44)48-8-52-36(20)60)4-75-84(68,69)81-27-23(64)14(2-62)77-39(27)59-11-55-19-31(43)47-7-51-35(19)59/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>50n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309128
PNG
(CHEMBL591445 | {[(2R,3R,4R,5R)-4-[({[(2R,3S,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](CO)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C31H39N15O16P2/c1-10-43-16-25(34)37-7-40-28(16)46(10)29-20(51)17(48)12(59-29)3-56-63(52,53)62-22-19(50)13(60-31(22)45-9-42-15-24(33)36-6-39-27(15)45)4-57-64(54,55)61-21-18(49)11(2-47)58-30(21)44-8-41-14-23(32)35-5-38-26(14)44/h5-9,11-13,17-22,29-31,47-51H,2-4H2,1H3,(H,52,53)(H,54,55)(H2,32,35,38)(H2,33,36,39)(H2,34,37,40)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>50n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309129
PNG
(CHEMBL601938 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)38-26(67)22(63)15(78-38)3-74-84(68,69)82-28-24(65)17(80-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-76-86(72,73)83-29-25(66)16(79-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-75-85(70,71)81-27-23(64)14(2-62)77-39(27)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.5n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309130
PNG
(CHEMBL591446 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c1-13-57-21-33(45)49-9-53-37(21)61(13)38-26(66)22(62)14(80-38)3-77-88(70,71)85-28-24(64)16(82-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-79-90(74,75)86-29-25(65)17(83-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-78-89(72,73)84-27-23(63)15(2-76-87(67,68)69)81-39(27)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-66H,2-5H2,1H3,(H,70,71)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,67,68,69)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.5n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373170
PNG
(CHEMBL408340)
Show SMILES CCCCOC(=O)c1ccc(NC(=S)NC(NC(=O)CC)C(Cl)(Cl)Cl)cc1
Show InChI InChI=1S/C17H22Cl3N3O3S/c1-3-5-10-26-14(25)11-6-8-12(9-7-11)21-16(27)23-15(17(18,19)20)22-13(24)4-2/h6-9,15H,3-5,10H2,1-2H3,(H,22,24)(H2,21,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 9.00E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373171
PNG
(CHEMBL260229)
Show SMILES Cc1c(Cl)cccc1NC1=NC(=O)C(S1)=Cc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C17H12ClN3O3S/c1-10-13(18)3-2-4-14(10)19-17-20-16(22)15(25-17)9-11-5-7-12(8-6-11)21(23)24/h2-9H,1H3,(H,19,20,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/an/a 5.00E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373172
PNG
(C-6474572 | CHEMBL265438)
Show SMILES Oc1ccc(cc1)-c1nc2sc3CCCCc3c2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O2S/c19-10-7-5-9(6-8-10)14-17-15(20)13-11-3-1-2-4-12(11)21-16(13)18-14/h5-8,19H,1-4H2,(H,17,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.60E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373173
PNG
(CHEMBL410485)
Show SMILES CCOC(=O)C1C(=O)C(SC1=Nc1ccc(Cl)cc1)=Cc1cccc(O)c1
Show InChI InChI=1S/C20H16ClNO4S/c1-2-26-20(25)17-18(24)16(11-12-4-3-5-15(23)10-12)27-19(17)22-14-8-6-13(21)7-9-14/h3-11,17,23H,2H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 4.90E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373174
PNG
(C-6131864 | CHEMBL265469)
Show SMILES CC(=O)c1ccc(NC(=S)NC(NC(=O)Cc2ccccc2)C(Cl)(Cl)Cl)cc1
Show InChI InChI=1S/C19H18Cl3N3O2S/c1-12(26)14-7-9-15(10-8-14)23-18(28)25-17(19(20,21)22)24-16(27)11-13-5-3-2-4-6-13/h2-10,17H,11H2,1H3,(H,24,27)(H2,23,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 7.90E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373175
PNG
(C-5972155 | CHEMBL411931)
Show SMILES Cc1ccc(NC2=NC(=O)C(S2)=Cc2cccc(O)c2)c(Cl)c1
Show InChI InChI=1S/C17H13ClN2O2S/c1-10-5-6-14(13(18)7-10)19-17-20-16(22)15(23-17)9-11-3-2-4-12(21)8-11/h2-9,21H,1H3,(H,19,20,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 4.90E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373176
PNG
(C-5950331 | CHEMBL259633)
Show SMILES Oc1cccc(c1)-c1nc2sc3CCCCc3c2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O2S/c19-10-5-3-4-9(8-10)14-17-15(20)13-11-6-1-2-7-12(11)21-16(13)18-14/h3-5,8,19H,1-2,6-7H2,(H,17,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.20E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373166
PNG
(CHEMBL259819)
Show SMILES CCOC(=O)C1C(=O)C(SC1=Nc1ccccc1)=Cc1cccc(O)c1
Show InChI InChI=1S/C20H17NO4S/c1-2-25-20(24)17-18(23)16(12-13-7-6-10-15(22)11-13)26-19(17)21-14-8-4-3-5-9-14/h3-12,17,22H,2H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 1.80E+4n/an/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Displacement of 5'-phosphorylated, 2',5'-oligoadenylate from human recombinant RNase L assessed as decrease in resonance by surface plasma resonance


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373176
PNG
(C-5950331 | CHEMBL259633)
Show SMILES Oc1cccc(c1)-c1nc2sc3CCCCc3c2c(=O)[nH]1
Show InChI InChI=1S/C16H14N2O2S/c19-10-5-3-4-9(8-10)14-17-15(20)13-11-6-1-2-7-12(11)21-16(13)18-14/h3-5,8,19H,1-2,6-7H2,(H,17,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 1.20E+4n/an/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Displacement of 5'-phosphorylated, 2',5'-oligoadenylate from human recombinant RNase L assessed as decrease in resonance by surface plasma resonance


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373177
PNG
(CHEMBL404038)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 0.0400n/an/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant recombinant RNase L


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373177
PNG
(CHEMBL404038)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.5n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373177
PNG
(CHEMBL404038)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 0.220n/an/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Displacement of 5'-phosphorylated, 2',5'-oligoadenylate from human recombinant RNase L assessed as decrease in resonance by surface plasma resonance


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373168
PNG
(C-5947495 | CHEMBL261864)
Show SMILES COc1ccc(Cl)cc1NC(=O)c1cc2c(C)nn(-c3ccccc3)c2s1
Show InChI InChI=1S/C20H16ClN3O2S/c1-12-15-11-18(19(25)22-16-10-13(21)8-9-17(16)26-2)27-20(15)24(23-12)14-6-4-3-5-7-14/h3-11H,1-2H3,(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/an/a 4.80E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373169
PNG
(C-5142087 | CHEMBL259804)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1nc2sc3CCCCc3c2c(=O)[nH]1
Show InChI InChI=1S/C16H13N3O3S/c20-15-13-11-6-1-2-7-12(11)23-16(13)18-14(17-15)9-4-3-5-10(8-9)19(21)22/h3-5,8H,1-2,6-7H2,(H,17,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.20E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373166
PNG
(CHEMBL259819)
Show SMILES CCOC(=O)C1C(=O)C(SC1=Nc1ccccc1)=Cc1cccc(O)c1
Show InChI InChI=1S/C20H17NO4S/c1-2-25-20(24)17-18(23)16(12-13-7-6-10-15(22)11-13)26-19(17)21-14-8-4-3-5-9-14/h3-12,17,22H,2H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.60E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373167
PNG
(CHEMBL406556)
Show SMILES CCCCOC(=O)c1ccc(NC(=S)NC(NC(C)=O)C(Cl)(Cl)Cl)cc1
Show InChI InChI=1S/C16H20Cl3N3O3S/c1-3-4-9-25-13(24)11-5-7-12(8-6-11)21-15(26)22-14(16(17,18)19)20-10(2)23/h5-8,14H,3-4,9H2,1-2H3,(H,20,23)(H2,21,22,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 9.90E+4n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388145
PNG
(CHEMBL2057900)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COCP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)2-77-88(70,71)85-28-24(64)17(82-40(28)60-11-56-20-32(44)48-7-52-36(20)60)4-79-90(74,75)86-29-25(65)16(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)3-78-89(72,73)84-27-23(63)14(1-76-13-87(67,68)69)81-39(27)59-10-55-19-31(43)47-6-51-35(19)59/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,70,71)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,67,68,69)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 53n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388146
PNG
(CHEMBL2058766)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)14(80-38)1-76-13-87(67,68)84-27-23(63)16(82-39(27)59-10-55-19-31(43)47-6-51-35(19)59)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-24(64)15(2-77-88(69,70)71)81-40(28)60-11-56-20-32(44)48-7-52-36(20)60/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22+,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 4.20n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388147
PNG
(CHEMBL2058765)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)14(80-38)1-76-13-87(67,68)84-27-23(63)16(82-39(27)59-10-55-19-31(43)47-6-51-35(19)59)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-24(64)15(2-77-88(69,70)71)81-40(28)60-11-56-20-32(44)48-7-52-36(20)60/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26+,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 6.5n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388148
PNG
(CHEMBL2058764)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)14(80-38)1-76-13-87(67,68)84-27-23(63)16(82-39(27)59-10-55-19-31(43)47-6-51-35(19)59)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-24(64)15(2-77-88(69,70)71)81-40(28)60-11-56-20-32(44)48-7-52-36(20)60/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 15n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388149
PNG
(CHEMBL2058763)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](O)[C@@H](COCP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)17(83-39(27)59-10-55-19-31(43)47-6-51-35(19)59)4-79-90(74,75)86-29-25(65)16(2-77-88(69,70)71)82-41(29)61-12-57-21-33(45)49-8-53-37(21)61/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23+,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388150
PNG
(CHEMBL2058192)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@H]2[C@H](O)[C@@H](COCP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)17(83-39(27)59-10-55-19-31(43)47-6-51-35(19)59)4-79-90(74,75)86-29-25(65)16(2-77-88(69,70)71)82-41(29)61-12-57-21-33(45)49-8-53-37(21)61/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28+,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388151
PNG
(CHEMBL2058191)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COCP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)17(83-39(27)59-10-55-19-31(43)47-6-51-35(19)59)4-79-90(74,75)86-29-25(65)16(2-77-88(69,70)71)82-41(29)61-12-57-21-33(45)49-8-53-37(21)61/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 300n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388152
PNG
(CHEMBL2058190)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@@H](O)[C@@H](COCP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)16(2-77-88(69,70)71)82-39(27)59-10-55-19-31(43)47-6-51-35(19)59/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23+,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388153
PNG
(CHEMBL2058189)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@H]3[C@H](O)[C@@H](COCP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)16(2-77-88(69,70)71)82-39(27)59-10-55-19-31(43)47-6-51-35(19)59/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28+,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388154
PNG
(CHEMBL2058188)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COCP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)16(2-77-88(69,70)71)82-39(27)59-10-55-19-31(43)47-6-51-35(19)59/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 76 total )  |  Next  |  Last  >>
Jump to: