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Found 36 hits Enz. Inhib. hit(s) with Target = 'Rap guanine nucleotide exchange factor 4' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098793
PNG
(CHEMBL3593342)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N
Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+
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n/an/a 900n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098792
PNG
(CHEMBL3593343)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)c(F)c(F)c1)\C#N
Show InChI InChI=1S/C16H13F3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+
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n/an/a 1.10E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098713
PNG
(CHEMBL3593335)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(c1)C(F)(F)F)\C#N
Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-11-5-9(17(19,20)21)4-10(18)6-11/h4-7,23H,1-3H3/b24-13+
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n/an/a 1.60E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098719
PNG
(CHEMBL3593329)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N
Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+
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n/an/a 1.90E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098712
PNG
(CHEMBL3593336)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(Cl)c1)\C#N
Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+
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n/an/a 2.50E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098709
PNG
(CHEMBL3593338)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(F)c(Cl)c1)\C#N
Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-11(18)10(17)6-9/h4-7,20H,1-3H3/b21-13+
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n/an/a 2.70E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098748
PNG
(CHEMBL3593339)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(c1)C(F)(F)F)\C#N
Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6-,8+,9?,10?/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098718
PNG
(CHEMBL3593330)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(Cl)c1)\C#N
Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-10(17)11(18)6-9/h4-7,20H,1-3H3/b21-13+
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n/an/a 3.00E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098797
PNG
(CHEMBL3593471)
Show SMILES Clc1cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)cc(Cl)c1Cl
Show InChI InChI=1S/C18H15Cl3N4O2/c19-12-6-11(7-13(20)17(12)21)23-24-15(9-22)18(26)14-8-16(27-25-14)10-4-2-1-3-5-10/h6-8,10,23H,1-5H2/b24-15+
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n/an/a 3.50E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098794
PNG
(CHEMBL3593341)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(c(Cl)c1)C(F)(F)F)\C#N
Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-9-4-5-10(11(18)6-9)17(19,20)21/h4-7,23H,1-3H3/b24-13+
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n/an/a 3.60E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098710
PNG
(CHEMBL3593337)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(F)c1)\C#N
Show InChI InChI=1S/C16H14ClFN4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-10(17)11(18)6-9/h4-7,20H,1-3H3/b21-13+
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n/an/a 4.30E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098787
PNG
(CHEMBL3593468)
Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)c1
Show InChI InChI=1S/C18H16Cl2N4O2/c19-12-6-13(20)8-14(7-12)22-23-16(10-21)18(25)15-9-17(26-24-15)11-4-2-1-3-5-11/h6-9,11,22H,1-5H2/b23-16+
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n/an/a 4.80E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098714
PNG
(CHEMBL3593334)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(F)c1)\C#N
Show InChI InChI=1S/C16H14F2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+
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n/an/a 5.30E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098788
PNG
(CHEMBL3593467)
Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CC2)c1
Show InChI InChI=1S/C15H10Cl2N4O2/c16-9-3-10(17)5-11(4-9)19-20-13(7-18)15(22)12-6-14(23-21-12)8-1-2-8/h3-6,8,19H,1-2H2/b20-13+
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n/an/a 5.50E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098715
PNG
(CHEMBL3593333)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)cc(c1)C(F)(F)F)\C#N
Show InChI InChI=1S/C17H14F4N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-11-5-9(17(19,20)21)4-10(18)6-11/h4-7,23H,1-3H3/b24-13+
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n/an/a 5.80E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098716
PNG
(CHEMBL3593332)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)\C#N
Show InChI InChI=1S/C18H14F6N4O2/c1-16(2,3)14-7-12(28-30-14)15(29)13(8-25)27-26-11-5-9(17(19,20)21)4-10(6-11)18(22,23)24/h4-7,26H,1-3H3/b27-13+
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n/an/a 6.40E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098795
PNG
(CHEMBL3593340)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(F)c(F)c1)\C#N
Show InChI InChI=1S/C16H14F2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-9-4-5-10(17)11(18)6-9/h4-7,20H,1-3H3/b21-13+
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n/an/a 6.60E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098720
PNG
(CHEMBL3593328)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)ccc1Cl)\C#N
Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-6-9(17)4-5-10(11)18/h4-7,20H,1-3H3/b21-13+
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n/an/a 7.30E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098796
PNG
(CHEMBL3593470)
Show SMILES Clc1cc(N\N=C(/C#N)C(=O)c2cc(on2)C2CC2)cc(Cl)c1Cl
Show InChI InChI=1S/C15H9Cl3N4O2/c16-9-3-8(4-10(17)14(9)18)20-21-12(6-19)15(23)11-5-13(24-22-11)7-1-2-7/h3-5,7,20H,1-2H2/b21-12+
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n/an/a 8.80E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
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n/an/a 8.90E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098789
PNG
(CHEMBL3593465)
Show SMILES Clc1cccc(N\N=C(/C#N)C(=O)c2cc(on2)C2CCCCC2)c1
Show InChI InChI=1S/C18H17ClN4O2/c19-13-7-4-8-14(9-13)21-22-16(11-20)18(24)15-10-17(25-23-15)12-5-2-1-3-6-12/h4,7-10,12,21H,1-3,5-6H2/b22-16+
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n/an/a 1.13E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098725
PNG
(CHEMBL3594321)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(c1)C(F)(F)F)\C#N
Show InChI InChI=1S/C17H15F3N4O2/c1-16(2,3)14-8-12(24-26-14)15(25)13(9-21)23-22-11-6-4-5-10(7-11)17(18,19)20/h4-8,22H,1-3H3/b23-13+
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n/an/a 1.19E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098727
PNG
(CHEMBL3594319)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Br)c1)\C#N
Show InChI InChI=1S/C16H15BrN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
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n/an/a 1.40E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098791
PNG
(CHEMBL3593344)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1c(Cl)cc(Cl)cc1Cl)\C#N
Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)21-22-14-9(18)4-8(17)5-10(14)19/h4-6,22H,1-3H3/b21-12+
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n/an/a 1.90E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098798
PNG
(CHEMBL3593480)
Show SMILES Cc1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N
Show InChI InChI=1S/C13H8Cl2N4O2/c1-7-2-11(19-21-7)13(20)12(6-16)18-17-10-4-8(14)3-9(15)5-10/h2-5,17H,1H3/b18-12+
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n/an/a 2.23E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098726
PNG
(CHEMBL3594320)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(F)c1)\C#N
Show InChI InChI=1S/C16H15FN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
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n/an/a 2.24E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098721
PNG
(CHEMBL3593327)
Show SMILES Cc1cccc(N\N=C(/C#N)C(=O)c2cc(on2)C(C)(C)C)c1
Show InChI InChI=1S/C17H18N4O2/c1-11-6-5-7-12(8-11)19-20-14(10-18)16(22)13-9-15(23-21-13)17(2,3)4/h5-9,19H,1-4H3/b20-14+
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n/an/a 2.51E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098728
PNG
(CHEMBL3594318)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)cc1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-10(17)5-7-11/h4-8,19H,1-3H3/b20-13+
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n/an/a 2.65E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098786
PNG
(CHEMBL3593469)
Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)-c2ccccc2)c1
Show InChI InChI=1S/C18H10Cl2N4O2/c19-12-6-13(20)8-14(7-12)22-23-16(10-21)18(25)15-9-17(26-24-15)11-4-2-1-3-5-11/h1-9,22H/b23-16+
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n/an/a 2.80E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098729
PNG
(CHEMBL3594317)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccccc1Cl)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-7-5-4-6-10(11)17/h4-8,19H,1-3H3/b20-13+
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n/an/a 2.83E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098724
PNG
(CHEMBL3594322)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(c1)[N+]([O-])=O)\C#N
Show InChI InChI=1S/C16H15N5O4/c1-16(2,3)14-8-12(20-25-14)15(22)13(9-17)19-18-10-5-4-6-11(7-10)21(23)24/h4-8,18H,1-3H3/b19-13+
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n/an/a 3.13E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098717
PNG
(CHEMBL3593331)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1Cl)\C#N
Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)13-7-11(22-24-13)15(23)12(8-19)21-20-10-6-4-5-9(17)14(10)18/h4-7,20H,1-3H3/b21-12+
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n/an/a 3.56E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098730
PNG
(CHEMBL3594316)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1ccccc1)\C#N
Show InChI InChI=1S/C16H16N4O2/c1-16(2,3)14-9-12(20-22-14)15(21)13(10-17)19-18-11-7-5-4-6-8-11/h4-9,18H,1-3H3/b19-13+
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n/an/a 5.98E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098790
PNG
(CHEMBL3593346)
Show SMILES Clc1cccc(N\N=C(/C#N)C(=O)c2cc(on2)C2CC2)c1
Show InChI InChI=1S/C15H11ClN4O2/c16-10-2-1-3-11(6-10)18-19-13(8-17)15(21)12-7-14(22-20-12)9-4-5-9/h1-3,6-7,9,18H,4-5H2/b19-13+
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n/an/a 6.00E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098722
PNG
(CHEMBL3593323)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(c1)C#N)\C#N
Show InChI InChI=1S/C17H15N5O2/c1-17(2,3)15-8-13(22-24-15)16(23)14(10-19)21-20-12-6-4-5-11(7-12)9-18/h4-8,20H,1-3H3/b21-14+
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n/an/a 6.78E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50098723
PNG
(CHEMBL3594323)
Show SMILES CCOC(=O)c1cccc(N\N=C(/C#N)C(=O)c2cc(on2)C(C)(C)C)c1
Show InChI InChI=1S/C19H20N4O4/c1-5-26-18(25)12-7-6-8-13(9-12)21-22-15(11-20)17(24)14-10-16(27-23-14)19(2,3)4/h6-10,21H,5H2,1-4H3/b22-15+
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n/an/a 7.14E+4n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair