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Compile Data Set for Download or QSAR

Found 62 hits Enz. Inhib. hit(s) with Target = 'Rap guanine nucleotide exchange factor 4' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425531
PNG
(CHEMBL2313646)
Show SMILES Cc1cc(C)n(c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C15H19NO2S/c1-10-6-12(3)15(13(4)7-10)19(17,18)16-9-11(2)8-14(16)5/h6-9H,1-5H3
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n/an/a 300n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425555
PNG
(CHEMBL2313653)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
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n/an/a 400n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of EPAC2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425541
PNG
(CHEMBL2313637)
Show SMILES Cc1cc(C)c(Nc2cc(Cl)ccc2Cl)c(C)c1
Show InChI InChI=1S/C15H15Cl2N/c1-9-6-10(2)15(11(3)7-9)18-14-8-12(16)4-5-13(14)17/h4-8,18H,1-3H3
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n/an/a 400n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425539
PNG
(CHEMBL2313639)
Show SMILES CCc1cccn1S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C15H19NO2S/c1-5-14-7-6-8-16(14)19(17,18)15-12(3)9-11(2)10-13(15)4/h6-10H,5H2,1-4H3
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n/an/a 500n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425555
PNG
(CHEMBL2313653)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
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n/an/a 500n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011368
PNG
(CHEMBL3260989)
Show SMILES [I-].COCCC[n+]1c(C)csc1Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C17H24N2OS.HI/c1-12-9-13(2)16(14(3)10-12)18-17-19(7-6-8-20-5)15(4)11-21-17;/h9-11H,6-8H2,1-5H3;1H
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n/an/a 600n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of EPAC2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425554
PNG
(CHEMBL2313654)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)c1cc(C)c(C)cc1C
Show InChI InChI=1S/C18H22O2S/c1-11-7-15(5)18(16(6)8-11)21(19,20)17-10-13(3)12(2)9-14(17)4/h7-10H,1-6H3
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n/an/a 700n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425542
PNG
(CHEMBL2313636)
Show SMILES Cc1cc(C)c(Nc2cc(Cl)cc(Cl)c2)c(C)c1
Show InChI InChI=1S/C15H15Cl2N/c1-9-4-10(2)15(11(3)5-9)18-14-7-12(16)6-13(17)8-14/h4-8,18H,1-3H3
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n/an/a 900n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM89901
PNG
(1-(2,4,6-Trimethyl-benzenesulfonyl)-1H-indole | 1-...)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)n1ccc2ccccc12
Show InChI InChI=1S/C17H17NO2S/c1-12-10-13(2)17(14(3)11-12)21(19,20)18-9-8-15-6-4-5-7-16(15)18/h4-11H,1-3H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425532
PNG
(CHEMBL2313645)
Show SMILES CCc1cccn1S(=O)(=O)c1ccc(C)cc1C
Show InChI InChI=1S/C14H17NO2S/c1-4-13-6-5-9-15(13)18(16,17)14-8-7-11(2)10-12(14)3/h5-10H,4H2,1-3H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50326557
PNG
((E)-5-((2-hydroxynaphthalen-1-yl)diazenyl)naphthal...)
Show SMILES Oc1ccc2ccccc2c1N=Nc1cccc2cc(ccc12)S(O)(=O)=O
Show InChI InChI=1S/C20H14N2O4S/c23-19-11-8-13-4-1-2-6-17(13)20(19)22-21-18-7-3-5-14-12-15(27(24,25)26)9-10-16(14)18/h1-12,23H,(H,24,25,26)
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425550
PNG
(CHEMBL2313658)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H18O3S/c1-11-9-12(2)16(13(3)10-11)20(17,18)15-7-5-14(19-4)6-8-15/h5-10H,1-4H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425525
PNG
(CHEMBL2313652)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)n1ccc2cccnc12
Show InChI InChI=1S/C16H16N2O2S/c1-11-9-12(2)15(13(3)10-11)21(19,20)18-8-6-14-5-4-7-17-16(14)18/h4-10H,1-3H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425543
PNG
(CHEMBL2313635)
Show SMILES Cc1ccc(Nc2c(C)cc(C)cc2C)cc1
Show InChI InChI=1S/C16H19N/c1-11-5-7-15(8-6-11)17-16-13(3)9-12(2)10-14(16)4/h5-10,17H,1-4H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011357
PNG
(CHEMBL3260988)
Show SMILES OC(O)=C\C=C1/C2=C(Oc3c(O)c(O)ccc13)C(=O)C(=O)C=C2
Show InChI InChI=1S/C16H10O7/c17-10-4-1-8-7(3-6-12(19)20)9-2-5-11(18)14(22)16(9)23-15(8)13(10)21/h1-6,17,19-21H/b7-3-
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425528
PNG
(CHEMBL2313649)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C16H16N2O2S/c1-11-9-12(2)16(13(3)10-11)21(19,20)18-8-6-14-15(18)5-4-7-17-14/h4-10H,1-3H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425538
PNG
(CHEMBL2313640)
Show SMILES CCc1cccn1S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C13H15NO2S/c1-3-12-5-4-10-14(12)17(15,16)13-8-6-11(2)7-9-13/h4-10H,3H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384273
PNG
(CHEMBL2030612)
Show SMILES Cc1ccc(C)c(CSc2nc(C3CC3)c(C#N)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H17N3OS/c1-10-3-4-11(2)13(7-10)9-22-17-19-15(12-5-6-12)14(8-18)16(21)20-17/h3-4,7,12H,5-6,9H2,1-2H3,(H,19,20,21)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425551
PNG
(CHEMBL2313657)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)c1ccc(I)cc1
Show InChI InChI=1S/C15H15IO2S/c1-10-8-11(2)15(12(3)9-10)19(17,18)14-6-4-13(16)5-7-14/h4-9H,1-3H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
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n/an/a 4.40E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at EPAC2 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activity


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425533
PNG
(CHEMBL2313644)
Show SMILES CCc1cccn1S(=O)(=O)c1cc(C)cc(C)c1
Show InChI InChI=1S/C14H17NO2S/c1-4-13-6-5-7-15(13)18(16,17)14-9-11(2)8-12(3)10-14/h5-10H,4H2,1-3H3
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425534
PNG
(CHEMBL2313643)
Show SMILES CCc1cccn1S(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C13H15NO2S/c1-3-12-8-6-10-14(12)17(15,16)13-9-5-4-7-11(13)2/h4-10H,3H2,1-2H3
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n/an/a 5.30E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384274
PNG
(CHEMBL2030613)
Show SMILES Cc1ccc(C)c(CSc2nc(C3CCCC3)c(C#N)c(=O)[nH]2)c1
Show InChI InChI=1S/C19H21N3OS/c1-12-7-8-13(2)15(9-12)11-24-19-21-17(14-5-3-4-6-14)16(10-20)18(23)22-19/h7-9,14H,3-6,11H2,1-2H3,(H,21,22,23)
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384268
PNG
(CHEMBL2030607)
Show SMILES Cc1cc(C)cc(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c1
Show InChI InChI=1S/C20H23N3OS/c1-13-8-14(2)10-15(9-13)12-25-20-22-18(16-6-4-3-5-7-16)17(11-21)19(24)23-20/h8-10,16H,3-7,12H2,1-2H3,(H,22,23,24)
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011358
PNG
(CHEMBL1372282)
Show SMILES FC(F)(F)C(=O)Nc1sc2c(c1C#N)c1ccccc1oc1c2c(=O)c2ccccc2c1=O
Show InChI InChI=1S/C23H9F3N2O4S/c24-23(25,26)22(31)28-21-13(9-27)15-12-7-3-4-8-14(12)32-19-16(20(15)33-21)17(29)10-5-1-2-6-11(10)18(19)30/h1-8H,(H,28,31)
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n/an/a 7.90E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425537
PNG
(CHEMBL2313641)
Show SMILES CCc1cccn1S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C13H15NO3S/c1-3-11-5-4-10-14(11)18(15,16)13-8-6-12(17-2)7-9-13/h4-10H,3H2,1-2H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425536
PNG
(CHEMBL2311560)
Show SMILES CCc1cccn1S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C12H12ClNO2S/c1-2-11-4-3-9-14(11)17(15,16)12-7-5-10(13)6-8-12/h3-9H,2H2,1H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384265
PNG
(CHEMBL2030452)
Show SMILES Cc1ccc(C)c(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c1
Show InChI InChI=1S/C20H23N3OS/c1-13-8-9-14(2)16(10-13)12-25-20-22-18(15-6-4-3-5-7-15)17(11-21)19(24)23-20/h8-10,15H,3-7,12H2,1-2H3,(H,22,23,24)
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n/an/a 8.40E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425527
PNG
(CHEMBL2313650)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)n1ccc2cnccc12
Show InChI InChI=1S/C16H16N2O2S/c1-11-8-12(2)16(13(3)9-11)21(19,20)18-7-5-14-10-17-6-4-15(14)18/h4-10H,1-3H3
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n/an/a 8.90E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
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n/an/a 9.00E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from EPAC2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425529
PNG
(CHEMBL2313648)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)n1ccc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C18H17NO4S/c1-11-8-12(2)17(13(3)9-11)24(22,23)19-7-6-14-10-15(18(20)21)4-5-16(14)19/h4-10H,1-3H3,(H,20,21)
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n/an/a 1.08E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384271
PNG
(CHEMBL2030610)
Show SMILES Cc1cc(C)c(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c(C)c1
Show InChI InChI=1S/C21H25N3OS/c1-13-9-14(2)18(15(3)10-13)12-26-21-23-19(16-7-5-4-6-8-16)17(11-22)20(25)24-21/h9-10,16H,4-8,12H2,1-3H3,(H,23,24,25)
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n/an/a 1.16E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425526
PNG
(CHEMBL2313651)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)n1ccc2ccncc12
Show InChI InChI=1S/C16H16N2O2S/c1-11-8-12(2)16(13(3)9-11)21(19,20)18-7-5-14-4-6-17-10-15(14)18/h4-10H,1-3H3
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n/an/a 1.26E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384272
PNG
(CHEMBL2030611)
Show SMILES CC(C)c1nc(SCc2cc(C)ccc2C)[nH]c(=O)c1C#N
Show InChI InChI=1S/C17H19N3OS/c1-10(2)15-14(8-18)16(21)20-17(19-15)22-9-13-7-11(3)5-6-12(13)4/h5-7,10H,9H2,1-4H3,(H,19,20,21)
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n/an/a 1.27E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425548
PNG
(4-(2,4,6-Trimethylbenzenesulfonyl)Phenol | CHEMBL2...)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)c1ccc(O)cc1
Show InChI InChI=1S/C15H16O3S/c1-10-8-11(2)15(12(3)9-10)19(17,18)14-6-4-13(16)5-7-14/h4-9,16H,1-3H3
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n/an/a 1.35E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384269
PNG
(CHEMBL2030608)
Show SMILES Cc1ccc(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c(C)c1
Show InChI InChI=1S/C20H23N3OS/c1-13-8-9-16(14(2)10-13)12-25-20-22-18(15-6-4-3-5-7-15)17(11-21)19(24)23-20/h8-10,15H,3-7,12H2,1-2H3,(H,22,23,24)
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n/an/a 1.57E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50294336
PNG
(5-amino-2-(4-aminophenylamino)benzenesulfonic acid...)
Show SMILES Nc1ccc(Nc2ccc(N)cc2S(O)(=O)=O)cc1
Show InChI InChI=1S/C12H13N3O3S/c13-8-1-4-10(5-2-8)15-11-6-3-9(14)7-12(11)19(16,17)18/h1-7,15H,13-14H2,(H,16,17,18)
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384270
PNG
(CHEMBL2030609)
Show SMILES O=c1[nH]c(SCc2ccccc2)nc(C2CCCCC2)c1C#N
Show InChI InChI=1S/C18H19N3OS/c19-11-15-16(14-9-5-2-6-10-14)20-18(21-17(15)22)23-12-13-7-3-1-4-8-13/h1,3-4,7-8,14H,2,5-6,9-10,12H2,(H,20,21,22)
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n/an/a 3.05E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384267
PNG
(CHEMBL2030606)
Show SMILES Cc1ccc(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)cc1
Show InChI InChI=1S/C19H21N3OS/c1-13-7-9-14(10-8-13)12-24-19-21-17(15-5-3-2-4-6-15)16(11-20)18(23)22-19/h7-10,15H,2-6,12H2,1H3,(H,21,22,23)
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n/an/a 3.87E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384264
PNG
(CHEMBL316966)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2CO[P@](O)(=O)O[C@H]2[C@H]1O
Show InChI InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384264
PNG
(CHEMBL316966)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2CO[P@](O)(=O)O[C@H]2[C@H]1O
Show InChI InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of EPAC2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384264
PNG
(CHEMBL316966)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2CO[P@](O)(=O)O[C@H]2[C@H]1O
Show InChI InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
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n/an/a 4.80E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384275
PNG
(CHEMBL2030614)
Show SMILES CN1CCC(CC1)c1nc(SCc2cc(C)ccc2C)[nH]c(=O)c1C#N
Show InChI InChI=1S/C20H24N4OS/c1-13-4-5-14(2)16(10-13)12-26-20-22-18(17(11-21)19(25)23-20)15-6-8-24(3)9-7-15/h4-5,10,15H,6-9,12H2,1-3H3,(H,22,23,25)
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n/an/a 1.27E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384263
PNG
(CHEMBL2030618)
Show SMILES OC(=O)CSc1nc(C2CCCCC2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C13H15N3O3S/c14-6-9-11(8-4-2-1-3-5-8)15-13(16-12(9)19)20-7-10(17)18/h8H,1-5,7H2,(H,17,18)(H,15,16,19)
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384266
PNG
(CHEMBL2030605)
Show SMILES O=c1[nH]c(=S)[nH]c(C2CCCCC2)c1C#N
Show InChI InChI=1S/C11H13N3OS/c12-6-8-9(7-4-2-1-3-5-7)13-11(16)14-10(8)15/h7H,1-5H2,(H2,13,14,15,16)
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425553
PNG
(CHEMBL2313655)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C20H26O2S/c1-5-6-7-8-18-9-11-19(12-10-18)23(21,22)20-16(3)13-15(2)14-17(20)4/h9-14H,5-8H2,1-4H3
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PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425552
PNG
(CHEMBL2313656)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C21H26O2S/c1-15-13-16(2)21(17(3)14-15)24(22,23)20-11-9-19(10-12-20)18-7-5-4-6-8-18/h9-14,18H,4-8H2,1-3H3
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PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425549
PNG
(CHEMBL2313659)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1
Show InChI InChI=1S/C20H18FNO2S/c1-13-10-14(2)20(15(3)11-13)25(23,24)18-7-4-16(5-8-18)17-6-9-19(21)22-12-17/h4-12H,1-3H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425547
PNG
(CHEMBL2313661)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)c1ccc(OC2CCCCC2)cc1
Show InChI InChI=1S/C21H26O3S/c1-15-13-16(2)21(17(3)14-15)25(22,23)20-11-9-19(10-12-20)24-18-7-5-4-6-8-18/h9-14,18H,4-8H2,1-3H3
PDB
MMDB

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UniProtKB/SwissProt

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PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


Citation and Details
More data for this
Ligand-Target Pair
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