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Found 14 hits Enz. Inhib. hit(s) with Target = 'Receptor protein-tyrosine kinase erbB-2' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099960
PNG
((1-Benzyl-1H-indazol-5-yl)-(6,7-dimethoxy-quinazol...)
Show SMILES COc1cc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c2cc1OC
Show InChI InChI=1S/C24H21N5O2/c1-30-22-11-19-20(12-23(22)31-2)25-15-26-24(19)28-18-8-9-21-17(10-18)13-27-29(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)
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n/an/a 1n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099969
PNG
((2-Benzyl-1H-benzoimidazol-5-yl)-(6,7-dimethoxy-qu...)
Show SMILES COc1cc2ncnc(Nc3ccc4nc(Cc5ccccc5)[nH]c4c3)c2cc1OC
Show InChI InChI=1S/C24H21N5O2/c1-30-21-12-17-19(13-22(21)31-2)25-14-26-24(17)27-16-8-9-18-20(11-16)29-23(28-18)10-15-6-4-3-5-7-15/h3-9,11-14H,10H2,1-2H3,(H,28,29)(H,25,26,27)
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n/an/a 10n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099965
PNG
((1-Benzyl-1H-indazol-5-yl)-quinazolin-4-yl-amine |...)
Show SMILES C(c1ccccc1)n1ncc2cc(Nc3ncnc4ccccc34)ccc12
Show InChI InChI=1S/C22H17N5/c1-2-6-16(7-3-1)14-27-21-11-10-18(12-17(21)13-25-27)26-22-19-8-4-5-9-20(19)23-15-24-22/h1-13,15H,14H2,(H,23,24,26)
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n/an/a 10n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099971
PNG
(CHEMBL288557 | N*4*-(1-Benzyl-1H-indol-5-yl)-pyrid...)
Show SMILES Nc1cc2c(Nc3ccc4n(Cc5ccccc5)ccc4c3)ncnc2cn1
Show InChI InChI=1S/C22H18N6/c23-21-11-18-19(12-24-21)25-14-26-22(18)27-17-6-7-20-16(10-17)8-9-28(20)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H2,23,24)(H,25,26,27)
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n/an/a 26n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099966
PNG
(CHEMBL281006 | N*4*-(1-Benzyl-1H-indazol-5-yl)-pyr...)
Show SMILES Nc1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1
Show InChI InChI=1S/C21H17N7/c22-20-9-17-18(11-23-20)24-13-25-21(17)27-16-6-7-19-15(8-16)10-26-28(19)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H2,22,23)(H,24,25,27)
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n/an/a 27n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099968
PNG
(CHEMBL31653 | N*4*-(2-Benzyl-1H-benzoimidazol-5-yl...)
Show SMILES Nc1cc2c(Nc3ccc4nc(Cc5ccccc5)[nH]c4c3)ncnc2cn1
Show InChI InChI=1S/C21H17N7/c22-19-10-15-18(11-23-19)24-12-25-21(15)26-14-6-7-16-17(9-14)28-20(27-16)8-13-4-2-1-3-5-13/h1-7,9-12H,8H2,(H2,22,23)(H,27,28)(H,24,25,26)
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n/an/a 49n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099970
PNG
((1-Benzyl-1H-indol-5-yl)-(6,7-dimethoxy-quinazolin...)
Show SMILES COc1cc2ncnc(Nc3ccc4n(Cc5ccccc5)ccc4c3)c2cc1OC
Show InChI InChI=1S/C25H22N4O2/c1-30-23-13-20-21(14-24(23)31-2)26-16-27-25(20)28-19-8-9-22-18(12-19)10-11-29(22)15-17-6-4-3-5-7-17/h3-14,16H,15H2,1-2H3,(H,26,27,28)
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n/an/a 49n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099967
PNG
((1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine | C...)
Show SMILES C(c1ccccc1)n1ccc2cc(Nc3ncnc4ccccc34)ccc12
Show InChI InChI=1S/C23H18N4/c1-2-6-17(7-3-1)15-27-13-12-18-14-19(10-11-22(18)27)26-23-20-8-4-5-9-21(20)24-16-25-23/h1-14,16H,15H2,(H,24,25,26)
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n/an/a 90n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099961
PNG
((2-Benzyl-2H-indazol-5-yl)-(6,7-dimethoxy-quinazol...)
Show SMILES COc1cc2ncnc(Nc3ccc4nn(Cc5ccccc5)cc4c3)c2cc1OC
Show InChI InChI=1S/C24H21N5O2/c1-30-22-11-19-21(12-23(22)31-2)25-15-26-24(19)27-18-8-9-20-17(10-18)14-29(28-20)13-16-6-4-3-5-7-16/h3-12,14-15H,13H2,1-2H3,(H,25,26,27)
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n/an/a 290n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099963
PNG
(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Show SMILES CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1
Show InChI InChI=1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)
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n/an/a 390n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of erbB2 overexpressing Calu3 cell proliferation


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099963
PNG
(CHEMBL30432 | N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*...)
Show SMILES CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1
Show InChI InChI=1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)
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n/an/a 390n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of erbB2 overexpressing Calu3 cell proliferation


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099959
PNG
((2-Benzyl-1H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Show SMILES C(c1nc2ccc(Nc3ncnc4ccccc34)cc2[nH]1)c1ccccc1
Show InChI InChI=1S/C22H17N5/c1-2-6-15(7-3-1)12-21-26-19-11-10-16(13-20(19)27-21)25-22-17-8-4-5-9-18(17)23-14-24-22/h1-11,13-14H,12H2,(H,26,27)(H,23,24,25)
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n/an/a 560n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099962
PNG
((3-Benzyl-3H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Show SMILES C(c1ccccc1)n1cnc2ccc(Nc3ncnc4ccccc34)cc12
Show InChI InChI=1S/C22H17N5/c1-2-6-16(7-3-1)13-27-15-25-20-11-10-17(12-21(20)27)26-22-18-8-4-5-9-19(18)23-14-24-22/h1-12,14-15H,13H2,(H,23,24,26)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-2


(Rattus norvegicus)
BDBM50099964
PNG
((1-Benzyl-1H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Show SMILES C(c1ccccc1)n1cnc2cc(Nc3ncnc4ccccc34)ccc12
Show InChI InChI=1S/C22H17N5/c1-2-6-16(7-3-1)13-27-15-25-20-12-17(10-11-21(20)27)26-22-18-8-4-5-9-19(18)23-14-24-22/h1-12,14-15H,13H2,(H,23,24,26)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of rat Receptor protein-tyrosine kinase erbB2


Bioorg Med Chem Lett 11: 1401-5 (2001)

More data for this
Ligand-Target Pair