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Compile Data Set for Download or QSAR

Found 79 hits Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein phosphatase beta (PTPβ)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50270587
PNG
(5-(3-Cyclohexyl-4'-fluoro-2'-trifluoromethyl-biphe...)
Show SMILES OC(=O)c1cc(on1)-c1ccc(cc1C1CCCCC1)-c1ccc(F)cc1C(F)(F)F
Show InChI InChI=1S/C23H19F4NO3/c24-15-7-9-16(19(11-15)23(25,26)27)14-6-8-17(21-12-20(22(29)30)28-31-21)18(10-14)13-4-2-1-3-5-13/h6-13H,1-5H2,(H,29,30)
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220n/an/an/an/an/an/an/an/a



Astex Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PtpB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118751
PNG
(6-(Oxalyl-amino)-1H-indole-7-carboxylic acid | 6-(...)
Show SMILES OC(=O)C(=O)Nc1ccc2cc[nH]c2c1C(O)=O
Show InChI InChI=1S/C11H8N2O5/c14-9(11(17)18)13-6-2-1-5-3-4-12-8(5)7(6)10(15)16/h1-4,12H,(H,13,14)(H,15,16)(H,17,18)
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3.60E+3n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118796
PNG
(6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID | 6-(...)
Show SMILES OC(=O)C(=O)Nc1cc2[nH]ccc2cc1C(O)=O
Show InChI InChI=1S/C11H8N2O5/c14-9(11(17)18)13-8-4-7-5(1-2-12-7)3-6(8)10(15)16/h1-4,12H,(H,13,14)(H,15,16)(H,17,18)
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6.00E+3n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118744
PNG
(2-(Oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran...)
Show SMILES OC(=O)C(=O)Nc1sc2COCCc2c1C(O)=O
Show InChI InChI=1S/C10H9NO6S/c12-7(10(15)16)11-8-6(9(13)14)4-1-2-17-3-5(4)18-8/h1-3H2,(H,11,12)(H,13,14)(H,15,16)
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1.10E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50299462
PNG
(2-(3-(dihydroxymethyl)naphthalen-2-ylamino)-2-oxoa...)
Show SMILES OC(O)c1cc2ccccc2cc1NC(=O)C(O)=O
Show InChI InChI=1S/C13H11NO5/c15-11(13(18)19)14-10-6-8-4-2-1-3-7(8)5-9(10)12(16)17/h1-6,12,16-17H,(H,14,15)(H,18,19)
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1.40E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118778
PNG
(5-iodo-2-(oxaloamino)benzoic acid | CHEMBL336908)
Show SMILES OC(=O)C(=O)Nc1ccc(I)cc1C(O)=O
Show InChI InChI=1S/C9H6INO5/c10-4-1-2-6(5(3-4)8(13)14)11-7(12)9(15)16/h1-3H,(H,11,12)(H,13,14)(H,15,16)
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1.70E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118749
PNG
(2-(Oxalyl-amino)-thiophene-3-carboxylic acid | 2-(...)
Show SMILES OC(=O)C(=O)Nc1sccc1C(O)=O
Show InChI InChI=1S/C7H5NO5S/c9-4(7(12)13)8-5-3(6(10)11)1-2-14-5/h1-2H,(H,8,9)(H,10,11)(H,12,13)
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1.80E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118762
PNG
(2-(Oxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thioph...)
Show SMILES OC(=O)C(=O)Nc1sc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C11H11NO5S/c13-8(11(16)17)12-9-7(10(14)15)5-3-1-2-4-6(5)18-9/h1-4H2,(H,12,13)(H,14,15)(H,16,17)
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1.90E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50299461
PNG
((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)
Show SMILES OC(=O)C(=O)Nc1sc2[C@H](COC3=NS(=O)(=O)c4ccccc34)OCCc2c1C(O)=O
Show InChI InChI=1S/C18H14N2O9S2/c21-14(18(24)25)19-16-12(17(22)23)9-5-6-28-10(13(9)30-16)7-29-15-8-3-1-2-4-11(8)31(26,27)20-15/h1-4,10H,5-7H2,(H,19,21)(H,22,23)(H,24,25)/t10-/m0/s1
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2.10E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50441456
PNG
(CHEMBL1369374)
Show SMILES OC(=O)c1nc2nc(Cl)c(Cl)nc2[nH]1
Show InChI InChI=1S/C6H2Cl2N4O2/c7-1-2(8)10-4-3(9-1)11-5(12-4)6(13)14/h(H,13,14)(H,9,10,11,12)
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2.60E+4n/an/an/an/an/an/an/an/a



Saint John's University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of human GST-tagged LMW-PTP-B expressed in Escherichia coli JM 109 cells using p-nitrophenyl phosphate as substrate after 1...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118789
PNG
(2-(oxaloamino)benzoic acid | CHEMBL139050)
Show SMILES OC(=O)C(=O)Nc1ccccc1C(O)=O
Show InChI InChI=1S/C9H7NO5/c11-7(9(14)15)10-6-4-2-1-3-5(6)8(12)13/h1-4H,(H,10,11)(H,12,13)(H,14,15)
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3.30E+4n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50441457
PNG
(CHEMBL1358072)
Show SMILES CC(=O)Nc1c(C)cc(OCC(O)=O)cc1C
Show InChI InChI=1S/C12H15NO4/c1-7-4-10(17-6-11(15)16)5-8(2)12(7)13-9(3)14/h4-5H,6H2,1-3H3,(H,13,14)(H,15,16)
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7.32E+4n/an/an/an/an/an/an/an/a



Saint John's University

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of human GST-tagged LMW-PTP-B expressed in Escherichia coli JM 109 cells using p-nitrophenyl phosphate as substrate after 1...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50312261
PNG
((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
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>1.00E+5n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of human PtpB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118779
PNG
(3-(Oxalyl-amino)-thiophene-2-carboxylic acid | 3-(...)
Show SMILES OC(=O)C(=O)Nc1ccsc1C(O)=O
Show InChI InChI=1S/C7H5NO5S/c9-5(7(12)13)8-3-1-2-14-4(3)6(10)11/h1-2H,(H,8,9)(H,10,11)(H,12,13)
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1.60E+5n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50118792
PNG
(2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]P...)
Show SMILES OC(=O)C(=O)Nc1sc2CNCCc2c1C(O)=O
Show InChI InChI=1S/C10H10N2O5S/c13-7(10(16)17)12-8-6(9(14)15)4-1-2-11-3-5(4)18-8/h11H,1-3H2,(H,12,13)(H,14,15)(H,16,17)
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5.60E+5n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRB


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50308835
PNG
(4-((S)-2-(4-ethylthiazol-2-yl)-2-((S)-2-(methoxyca...)
Show SMILES CCc1csc(n1)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)[C@H](CC(C)C)C(=O)OC
Show InChI InChI=1S/C21H29N3O6S2/c1-5-15-12-31-20(22-15)18(23-19(25)17(10-13(2)3)21(26)30-4)11-14-6-8-16(9-7-14)24-32(27,28)29/h6-9,12-13,17-18,24H,5,10-11H2,1-4H3,(H,23,25)(H,27,28,29)/t17-,18-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Incyte Corporation

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase beta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188792
PNG
(CHEMBL213750 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS(O)(=O)=O)cc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C19H22N2O10S2/c1-30-17(22)19(18(23)31-2,11-13-3-7-15(8-4-13)20-32(24,25)26)12-14-5-9-16(10-6-14)21-33(27,28)29/h3-10,20-21H,11-12H2,1-2H3,(H,24,25,26)(H,27,28,29)/p-1
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n/an/a 60n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188795
PNG
(CHEMBL386550 | ammonium N-{4-[2,2-bis(3-methyl-1,2...)
Show SMILES Cc1noc(n1)C(CCCc1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)c1nc(C)no1
Show InChI InChI=1S/C23H25N5O5S/c1-16-24-21(32-26-16)23(22-25-17(2)27-33-22,14-6-9-18-7-4-3-5-8-18)15-19-10-12-20(13-11-19)28-34(29,30)31/h3-5,7-8,10-13,28H,6,9,14-15H2,1-2H3,(H,29,30,31)/p-1
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n/an/a 70n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188775
PNG
(CHEMBL214192 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(CCCS(=O)(=O)c1nnnn1-c1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C22H25N5O9S2/c1-35-19(28)22(20(29)36-2,15-16-9-11-17(12-10-16)24-38(32,33)34)13-6-14-37(30,31)21-23-25-26-27(21)18-7-4-3-5-8-18/h3-5,7-12,24H,6,13-15H2,1-2H3,(H,32,33,34)/p-1
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n/an/a 80n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188791
PNG
(CHEMBL213732 | ammonium N-{4-[2,2-bis(3-methyl-1,2...)
Show SMILES Cc1noc(n1)C(Cc1ccc(NS(O)(=O)=O)cc1)(Cc1ccc(NS([O-])(=O)=O)cc1)c1nc(C)no1
Show InChI InChI=1S/C21H22N6O8S2/c1-13-22-19(34-24-13)21(20-23-14(2)25-35-20,11-15-3-7-17(8-4-15)26-36(28,29)30)12-16-5-9-18(10-6-16)27-37(31,32)33/h3-10,26-27H,11-12H2,1-2H3,(H,28,29,30)(H,31,32,33)/p-1
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n/an/a 80n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188801
PNG
(CHEMBL213620 | ammonium N-{4-[2-(2-{[(tert-butoxy)...)
Show SMILES CCOC(=O)C(CCNC(=O)OC(C)(C)C)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C20H30N2O9S/c1-6-30-17(24)20(16(23)29-5,11-12-21-18(25)31-19(2,3)4)13-14-7-9-15(10-8-14)22-32(26,27)28/h7-10,22H,6,11-13H2,1-5H3,(H,21,25)(H,26,27,28)/p-1
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n/an/a 90n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188797
PNG
(CHEMBL213802 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1cccc(NS(O)(=O)=O)c1)C(=O)OC
Show InChI InChI=1S/C19H22N2O10S2/c1-30-17(22)19(18(23)31-2,11-13-6-8-15(9-7-13)20-32(24,25)26)12-14-4-3-5-16(10-14)21-33(27,28)29/h3-10,20-21H,11-12H2,1-2H3,(H,24,25,26)(H,27,28,29)/p-1
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n/an/a 100n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM26613
PNG
((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Show SMILES OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H7O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-7H,(H,10,11);2*1H2;;/q;;;;+2/p-2/b7-6+;;;;
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n/an/a 100n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50388723
PNG
(CHEMBL2057662)
Show SMILES OC(=O)CCc1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H9O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-5H,6-7H2,(H,10,11);2*1H2;;/q;;;;+2/p-2
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n/an/a 100n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of PTP-beta receptor using para-nitrophenol as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50306213
PNG
(CHEMBL611318 | {[25,26,27,28-tetrahydroxy-11,17,23...)
Show SMILES Oc1c2cc(CP(O)(O)=O)cc1sc1cc(CP(O)(O)=O)cc(sc3cc(CP(O)(O)=O)cc(sc4cc(CP(O)(O)=O)cc(s2)c4O)c3O)c1O
Show InChI InChI=1S/C28H28O16P4S4/c29-25-17-1-13(9-45(33,34)35)2-18(25)50-21-5-15(11-47(39,40)41)6-22(27(21)31)52-24-8-16(12-48(42,43)44)7-23(28(24)32)51-20-4-14(10-46(36,37)38)3-19(49-17)26(20)30/h1-8,29-32H,9-12H2,(H2,33,34,35)(H2,36,37,38)(H2,39,40,41)(H2,42,43,44)
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n/an/a 130n/an/an/an/an/an/a



National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188781
PNG
(CHEMBL209527 | ammonium N-(4-{2-[(4-carboxyphenyl)...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1ccc(cc1)C(O)=O)C(=O)OC
Show InChI InChI=1S/C20H21NO9S/c1-29-18(24)20(19(25)30-2,11-13-3-7-15(8-4-13)17(22)23)12-14-5-9-16(10-6-14)21-31(26,27)28/h3-10,21H,11-12H2,1-2H3,(H,22,23)(H,26,27,28)/p-1
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n/an/a 140n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188780
PNG
(CHEMBL211786 | ammonium N-(4-{2-[3-(benzenesulfony...)
Show SMILES COC(=O)C(CCCS(=O)(=O)c1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C21H25NO9S2/c1-30-19(23)21(20(24)31-2,13-6-14-32(25,26)18-7-4-3-5-8-18)15-16-9-11-17(12-10-16)22-33(27,28)29/h3-5,7-12,22H,6,13-15H2,1-2H3,(H,27,28,29)/p-1
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n/an/a 150n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188784
PNG
(CHEMBL385251 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(CCCc1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C21H25NO7S/c1-28-19(23)21(20(24)29-2,14-6-9-16-7-4-3-5-8-16)15-17-10-12-18(13-11-17)22-30(25,26)27/h3-5,7-8,10-13,22H,6,9,14-15H2,1-2H3,(H,25,26,27)/p-1
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n/an/a 150n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188778
PNG
(CHEMBL213626 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(CCCSc1nnnn1-c1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C22H25N5O7S2/c1-33-19(28)22(20(29)34-2,15-16-9-11-17(12-10-16)24-36(30,31)32)13-6-14-35-21-23-25-26-27(21)18-7-4-3-5-8-18/h3-5,7-12,24H,6,13-15H2,1-2H3,(H,30,31,32)/p-1
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n/an/a 200n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188782
PNG
(CHEMBL384201 | ammonium N-{4-[3-(3-cyanophenyl)-2,...)
Show SMILES Cc1noc(n1)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1cccc(c1)C#N)c1nc(C)no1
Show InChI InChI=1S/C22H20N6O5S/c1-14-24-20(32-26-14)22(21-25-15(2)27-33-21,12-17-4-3-5-18(10-17)13-23)11-16-6-8-19(9-7-16)28-34(29,30)31/h3-10,28H,11-12H2,1-2H3,(H,29,30,31)/p-1
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n/an/a 210n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188779
PNG
(CHEMBL378423 | ammonium N-{4-[4-ethoxy-2,2-bis(met...)
Show SMILES CCOC(=O)CC(Cc1ccc(NS([O-])(=O)=O)cc1)(C(=O)OC)C(=O)OC
Show InChI InChI=1S/C16H21NO9S/c1-4-26-13(18)10-16(14(19)24-2,15(20)25-3)9-11-5-7-12(8-6-11)17-27(21,22)23/h5-8,17H,4,9-10H2,1-3H3,(H,21,22,23)/p-1
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n/an/a 230n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188783
PNG
(CHEMBL213226 | ammonium N-{4-[3-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(CC(Cc2ccc(NS([O-])(=O)=O)cc2)(c2nc(C)no2)c2nc(C)no2)c1
Show InChI InChI=1S/C22H23N5O6S/c1-14-23-20(32-25-14)22(21-24-15(2)26-33-21,13-17-5-4-6-19(11-17)31-3)12-16-7-9-18(10-8-16)27-34(28,29)30/h4-11,27H,12-13H2,1-3H3,(H,28,29,30)/p-1
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n/an/a 230n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188798
PNG
(CHEMBL385818 | ammonium N-(4-{2-[(benzyloxy)methyl...)
Show SMILES COC(=O)C(COCc1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C20H23NO8S/c1-27-18(22)20(19(23)28-2,14-29-13-16-6-4-3-5-7-16)12-15-8-10-17(11-9-15)21-30(24,25)26/h3-11,21H,12-14H2,1-2H3,(H,24,25,26)/p-1
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n/an/a 270n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188794
PNG
(CHEMBL380374 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)c1cccc(CC(Cc2ccc(NS([O-])(=O)=O)cc2)(C(=O)OC)C(=O)OC)c1
Show InChI InChI=1S/C21H23NO9S/c1-29-18(23)16-6-4-5-15(11-16)13-21(19(24)30-2,20(25)31-3)12-14-7-9-17(10-8-14)22-32(26,27)28/h4-11,22H,12-13H2,1-3H3,(H,26,27,28)/p-1
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n/an/a 290n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188793
PNG
(CHEMBL209957 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1cccc(c1)S(N)(=O)=O)C(=O)OC
Show InChI InChI=1S/C19H22N2O9S2/c1-29-17(22)19(18(23)30-2,12-14-4-3-5-16(10-14)31(20,24)25)11-13-6-8-15(9-7-13)21-32(26,27)28/h3-10,21H,11-12H2,1-2H3,(H2,20,24,25)(H,26,27,28)/p-1
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n/an/a 300n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188776
PNG
(4-(2-benzyl-3-methoxy-2-(methoxycarbonyl)-3-oxopro...)
Show SMILES COC(=O)C(Cc1ccccc1)(Cc1ccc(NS(O)(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C19H21NO7S/c1-26-17(21)19(18(22)27-2,12-14-6-4-3-5-7-14)13-15-8-10-16(11-9-15)20-28(23,24)25/h3-11,20H,12-13H2,1-2H3,(H,23,24,25)
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n/an/a 320n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188796
PNG
(CHEMBL213728 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1cccc(OC)c1)C(=O)OC
Show InChI InChI=1S/C20H23NO8S/c1-27-17-6-4-5-15(11-17)13-20(18(22)28-2,19(23)29-3)12-14-7-9-16(10-8-14)21-30(24,25)26/h4-11,21H,12-13H2,1-3H3,(H,24,25,26)/p-1
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n/an/a 330n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188785
PNG
(CHEMBL209955 | ammonium N-{4-[3-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(CC(Cc2ccc(NS([O-])(=O)=O)cc2)(c2nc(C)no2)c2nc(C)no2)cc1
Show InChI InChI=1S/C22H23N5O6S/c1-14-23-20(32-25-14)22(21-24-15(2)26-33-21,13-17-6-10-19(31-3)11-7-17)12-16-4-8-18(9-5-16)27-34(28,29)30/h4-11,27H,12-13H2,1-3H3,(H,28,29,30)/p-1
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n/an/a 340n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188786
PNG
(CHEMBL213826 | ammonium N-{4-[6-methoxy-2,2-bis(me...)
Show SMILES COC(=O)CCCC(Cc1ccc(NS([O-])(=O)=O)cc1)(C(=O)OC)C(=O)OC
Show InChI InChI=1S/C17H23NO9S/c1-25-14(19)5-4-10-17(15(20)26-2,16(21)27-3)11-12-6-8-13(9-7-12)18-28(22,23)24/h6-9,18H,4-5,10-11H2,1-3H3,(H,22,23,24)/p-1
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n/an/a 380n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188799
PNG
(CHEMBL213727 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1ccc(OC)cc1)C(=O)OC
Show InChI InChI=1S/C20H23NO8S/c1-27-17-10-6-15(7-11-17)13-20(18(22)28-2,19(23)29-3)12-14-4-8-16(9-5-14)21-30(24,25)26/h4-11,21H,12-13H2,1-3H3,(H,24,25,26)/p-1
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n/an/a 390n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50214527
PNG
(4-((5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazoli...)
Show SMILES OC(=O)c1ccc(CN2C(=O)S\C(=C/c3ccc(OCc4ccccc4)cc3)C2=O)cc1
Show InChI InChI=1S/C25H19NO5S/c27-23-22(32-25(30)26(23)15-18-6-10-20(11-7-18)24(28)29)14-17-8-12-21(13-9-17)31-16-19-4-2-1-3-5-19/h1-14H,15-16H2,(H,28,29)/b22-14-
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n/an/a 400n/an/an/an/an/an/a



Universit£ di Messina

Curated by ChEMBL


Assay Description
Inhibition of human protein-tyrosine phosphatase beta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188777
PNG
(CHEMBL213452 | ammonium N-[4-(2-{[(benzyloxy)carbo...)
Show SMILES CCOC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(NC(=O)OCc1ccccc1)C(=O)OC
Show InChI InChI=1S/C21H24N2O9S/c1-3-31-19(25)21(18(24)30-2,22-20(26)32-14-16-7-5-4-6-8-16)13-15-9-11-17(12-10-15)23-33(27,28)29/h4-12,23H,3,13-14H2,1-2H3,(H,22,26)(H,27,28,29)/p-1
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n/an/a 400n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188800
PNG
(CHEMBL386657 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)c1ccc(CC(Cc2ccc(NS([O-])(=O)=O)cc2)(C(=O)OC)C(=O)OC)cc1
Show InChI InChI=1S/C21H23NO9S/c1-29-18(23)16-8-4-14(5-9-16)12-21(19(24)30-2,20(25)31-3)13-15-6-10-17(11-7-15)22-32(26,27)28/h4-11,22H,12-13H2,1-3H3,(H,26,27,28)/p-1
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n/an/a 410n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188788
PNG
(CHEMBL214241 | ammonium N-{4-[2-(3-methanesulfonyl...)
Show SMILES COC(=O)C(CCCS(C)(=O)=O)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C16H23NO9S2/c1-25-14(18)16(15(19)26-2,9-4-10-27(3,20)21)11-12-5-7-13(8-6-12)17-28(22,23)24/h5-8,17H,4,9-11H2,1-3H3,(H,22,23,24)/p-1
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n/an/a 420n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188789
PNG
(CHEMBL378337 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(Cc1ccc(cc1)S(N)(=O)=O)C(=O)OC
Show InChI InChI=1S/C19H22N2O9S2/c1-29-17(22)19(18(23)30-2,12-14-5-9-16(10-6-14)31(20,24)25)11-13-3-7-15(8-4-13)21-32(26,27)28/h3-10,21H,11-12H2,1-2H3,(H2,20,24,25)(H,26,27,28)/p-1
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n/an/a 430n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188802
PNG
(CHEMBL210180 | ammonium N-[4-(2-{[(tert-butoxy)car...)
Show SMILES CCOC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(NC(=O)OC(C)(C)C)C(=O)OC
Show InChI InChI=1S/C18H26N2O9S/c1-6-28-15(22)18(14(21)27-5,19-16(23)29-17(2,3)4)11-12-7-9-13(10-8-12)20-30(24,25)26/h7-10,20H,6,11H2,1-5H3,(H,19,23)(H,24,25,26)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50436358
PNG
(CHEMBL2396718)
Show SMILES CCCNC(=O)COc1ccc(cc1)-c1oc2cc(O)c(cc2c1C#Cc1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34)
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n/an/a 470n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant PTPbeta (unknown origin) using pNPP as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50079855
PNG
((R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)Oc1c(Br)cc(cc1Br)-c1c2c3ccccc3oc2c(Br)c2ccccc12
Show InChI InChI=1S/C31H19Br3O4/c32-22-15-18(16-23(33)29(22)38-25(31(35)36)14-17-8-2-1-3-9-17)26-19-10-4-5-11-20(19)28(34)30-27(26)21-12-6-7-13-24(21)37-30/h1-13,15-16,25H,14H2,(H,35,36)/t25-/m1/s1
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested in vitro for the inhibitory activity against Protein-tyrosine phosphatase beta (SH-PTP1) (human PTPases.)


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50188787
PNG
(CHEMBL213594 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(Cc1ccncc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C18H20N2O7S/c1-26-16(21)18(17(22)27-2,12-14-7-9-19-10-8-14)11-13-3-5-15(6-4-13)20-28(23,24)25/h3-10,20H,11-12H2,1-2H3,(H,23,24,25)/p-1
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Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of HPTPbeta


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase beta (PTPβ)


(Homo sapiens (Human))
BDBM50079856
PNG
(CHEMBL108721 | [2,6-Dibromo-4-(6-bromo-benzo[b]nap...)
Show SMILES OC(=O)COc1c(Br)cc(cc1Br)-c1c2c(sc3ccccc23)c(Br)c2ccccc12
Show InChI InChI=1S/C24H13Br3O3S/c25-16-9-12(10-17(26)23(16)30-11-19(28)29)20-13-5-1-2-6-14(13)22(27)24-21(20)15-7-3-4-8-18(15)31-24/h1-10H,11H2,(H,28,29)
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested in vitro for the inhibitory activity against Protein-tyrosine phosphatase beta (SH-PTP1) (human PTPases.)


Citation and Details
More data for this
Ligand-Target Pair
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