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Compile Data Set for Download or QSAR

Found 40 hits Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein phosphatase gamma' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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2.50E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355649
PNG
(CHEMBL1910889)
Show SMILES COc1ccc(cc1C(O)=O)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H15Cl2NO6S3/c1-29-16-5-3-12(9-13(16)20(25)26)32(27,28)23-19(24)18-17(6-7-30-18)31-10-11-2-4-14(21)15(22)8-11/h2-9H,10H2,1H3,(H,23,24)(H,25,26)
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n/an/a 500n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355641
PNG
(CHEMBL1910968)
Show SMILES NCC(=O)Nc1cccc(c1)C#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C24H18Cl2N2O3S/c25-20-9-7-17(11-21(20)26)14-32-22-12-16(6-8-19(22)24(30)31)5-4-15-2-1-3-18(10-15)28-23(29)13-27/h1-3,6-12H,13-14,27H2,(H,28,29)(H,30,31)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50425806
PNG
(CHEMBL2316907)
Show SMILES OC(=O)c1cc2c(C#Cc3ccc(OC(F)(F)F)cc3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C24H13F3O5/c25-24(26,27)32-16-9-6-14(7-10-16)8-11-17-18-12-19(23(29)30)20(28)13-21(18)31-22(17)15-4-2-1-3-5-15/h1-7,9-10,12-13,28H,(H,29,30)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPgamma (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50054344
PNG
(CHEMBL3319356)
Show SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1
Show InChI InChI=1S/C28H20IN3O5S/c1-32-22-13-23(33)21(28(36)37)12-20(22)24(29)25(32)16-3-2-4-19(11-16)31-27(35)26(34)30-18-7-5-15(6-8-18)17-9-10-38-14-17/h2-14,33H,1H3,(H,30,34)(H,31,35)(H,36,37)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPgamma (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50425807
PNG
(CHEMBL2316902)
Show SMILES OC(=O)c1cc2c(C#Cc3cccc(c3)C(F)(F)F)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C24H13F3O4/c25-24(26,27)16-8-4-5-14(11-16)9-10-17-18-12-19(23(29)30)20(28)13-21(18)31-22(17)15-6-2-1-3-7-15/h1-8,11-13,28H,(H,29,30)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPgamma (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355643
PNG
(CHEMBL1910886)
Show SMILES CS(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H11Cl2NO3S3/c1-22(18,19)16-13(17)12-11(4-5-20-12)21-7-8-2-3-9(14)10(15)6-8/h2-6H,7H2,1H3,(H,16,17)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355638
PNG
(CHEMBL1910887)
Show SMILES Clc1ccc(CSc2ccsc2C(=O)NS(=O)(=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C18H13Cl2NO3S3/c19-14-7-6-12(10-15(14)20)11-26-16-8-9-25-17(16)18(22)21-27(23,24)13-4-2-1-3-5-13/h1-10H,11H2,(H,21,22)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355635
PNG
(CHEMBL1910882)
Show SMILES OC(=O)c1sccc1SCc1ccc(Br)c(Br)c1
Show InChI InChI=1S/C12H8Br2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355642
PNG
(CHEMBL1910888)
Show SMILES Nc1cccc(c1)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H14Cl2N2O3S3/c19-14-5-4-11(8-15(14)20)10-27-16-6-7-26-17(16)18(23)22-28(24,25)13-3-1-2-12(21)9-13/h1-9H,10,21H2,(H,22,23)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50436358
PNG
(CHEMBL2396718)
Show SMILES CCCNC(=O)COc1ccc(cc1)-c1oc2cc(O)c(cc2c1C#Cc1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant PTPgamma (unknown origin) using pNPP as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355650
PNG
(CHEMBL1910966)
Show SMILES OCCC#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C18H14Cl2O3S/c19-15-7-5-13(9-16(15)20)11-24-17-10-12(3-1-2-8-21)4-6-14(17)18(22)23/h4-7,9-10,21H,2,8,11H2,(H,22,23)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50425808
PNG
(CHEMBL2316906)
Show SMILES OC(=O)c1cc2c(C#Cc3cc(F)cc(F)c3)c(oc2cc1O)-c1ccccc1
Show InChI InChI=1S/C23H12F2O4/c24-15-8-13(9-16(25)10-15)6-7-17-18-11-19(23(27)28)20(26)12-21(18)29-22(17)14-4-2-1-3-5-14/h1-5,8-12,26H,(H,27,28)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of PTPgamma (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355646
PNG
(CHEMBL1910962)
Show SMILES COC(=O)c1cc(ccc1OC)S(=O)(=O)NC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H17Cl2NO6S3/c1-29-17-6-4-13(10-14(17)21(26)30-2)33(27,28)24-20(25)19-18(7-8-31-19)32-11-12-3-5-15(22)16(23)9-12/h3-10H,11H2,1-2H3,(H,24,25)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355634
PNG
(CHEMBL1910967)
Show SMILES Nc1cccc(c1)C#Cc1ccc(C(O)=O)c(SCc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C22H15Cl2NO2S/c23-19-9-7-16(11-20(19)24)13-28-21-12-15(6-8-18(21)22(26)27)5-4-14-2-1-3-17(25)10-14/h1-3,6-12H,13,25H2,(H,26,27)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355652
PNG
(CHEMBL1910963)
Show SMILES OC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H10Cl2O2S/c15-11-6-5-9(7-12(11)16)8-19-13-4-2-1-3-10(13)14(17)18/h1-7H,8H2,(H,17,18)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355644
PNG
(CHEMBL1910965)
Show SMILES OC(=O)c1ccc(Br)cc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H9BrCl2O2S/c15-9-2-3-10(14(18)19)13(6-9)20-7-8-1-4-11(16)12(17)5-8/h1-6H,7H2,(H,18,19)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355636
PNG
(CHEMBL1403981)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 1.28E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide by FRET ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50436357
PNG
(CHEMBL2396719)
Show SMILES OC(=O)c1cc2c(C#Cc3cccc(Cl)c3)c(oc2cc1O)-c1ccc(OCC(=O)NC2CC2)cc1
Show InChI InChI=1S/C28H20ClNO6/c29-18-3-1-2-16(12-18)4-11-21-22-13-23(28(33)34)24(31)14-25(22)36-27(21)17-5-9-20(10-6-17)35-15-26(32)30-19-7-8-19/h1-3,5-6,9-10,12-14,19,31H,7-8,15H2,(H,30,32)(H,33,34)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant PTPgamma (unknown origin) using pNPP as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355639
PNG
(CHEMBL1910879)
Show SMILES OC(=O)c1sccc1SCc1cccc(Cl)c1Cl
Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-3-1-2-7(10(8)14)6-18-9-4-5-17-11(9)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50112356
PNG
(CHEMBL3609373)
Show SMILES OS(=O)(=O)C(C(=O)Nc1ccc(NC(=O)C(=O)Nc2ccc(I)cc2)cc1)c1ccccc1
Show InChI InChI=1/C22H18IN3O6S/c23-15-6-8-16(9-7-15)25-21(28)22(29)26-18-12-10-17(11-13-18)24-20(27)19(33(30,31)32)14-4-2-1-3-5-14/h1-13,19H,(H,24,27)(H,25,28)(H,26,29)(H,30,31,32)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of phosphatase activity of human PTPgamma using pNPP as a substrate after 10 mins by spectrophotometer analysis


ACS Med Chem Lett 6: 782-6 (2015)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50112358
PNG
(CHEMBL3609374)
Show SMILES OS(=O)(=O)C(C(=O)Nc1ccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccccc2)cc1)c1ccccc1
Show InChI InChI=1/C28H23N3O6S/c32-26(25(38(35,36)37)21-9-5-2-6-10-21)29-23-15-17-24(18-16-23)31-28(34)27(33)30-22-13-11-20(12-14-22)19-7-3-1-4-8-19/h1-18,25H,(H,29,32)(H,30,33)(H,31,34)(H,35,36,37)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of phosphatase activity of human PTPgamma using pNPP as a substrate after 10 mins by spectrophotometer analysis


ACS Med Chem Lett 6: 782-6 (2015)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50112357
PNG
(CHEMBL3609375)
Show SMILES CC(C)c1ccc(NC(=O)C(=O)Nc2ccc(NC(=O)C(c3ccccc3)S(O)(=O)=O)cc2)cc1
Show InChI InChI=1/C25H25N3O6S/c1-16(2)17-8-10-19(11-9-17)27-24(30)25(31)28-21-14-12-20(13-15-21)26-23(29)22(35(32,33)34)18-6-4-3-5-7-18/h3-16,22H,1-2H3,(H,26,29)(H,27,30)(H,28,31)(H,32,33,34)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of phosphatase activity of human PTPgamma using pNPP as a substrate after 10 mins by spectrophotometer analysis


ACS Med Chem Lett 6: 782-6 (2015)

More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50087856
PNG
(CHEMBL3426913)
Show SMILES CCCCC(Oc1cc(O)c(cc1C#Cc1ccccc1OC(F)(F)F)C(O)=O)C(=O)NC1CCCCC1
Show InChI InChI=1/C28H30F3NO6/c1-2-3-12-24(26(34)32-20-10-5-4-6-11-20)37-25-17-22(33)21(27(35)36)16-19(25)15-14-18-9-7-8-13-23(18)38-28(29,30)31/h7-9,13,16-17,20,24,33H,2-6,10-12H2,1H3,(H,32,34)(H,35,36)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Inhibition of PTPgamma (unknown origin) using pNPP as substrate at pH 7 at 25 degC by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355654
PNG
(CHEMBL1910964)
Show SMILES CS(=O)(=O)NC(=O)c1ccccc1SCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H13Cl2NO3S2/c1-23(20,21)18-15(19)11-4-2-3-5-14(11)22-9-10-6-7-12(16)13(17)8-10/h2-8H,9H2,1H3,(H,18,19)
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n/an/a 7.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355653
PNG
(CHEMBL1910878)
Show SMILES OC(=O)c1sccc1SCc1cccc(Cl)c1
Show InChI InChI=1S/C12H9ClO2S2/c13-9-3-1-2-8(6-9)7-17-10-4-5-16-11(10)12(14)15/h1-6H,7H2,(H,14,15)
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n/an/a 8.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355640
PNG
(CHEMBL1910877)
Show SMILES OC(=O)c1sccc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C12H9ClO2S2/c13-9-3-1-8(2-4-9)7-17-10-5-6-16-11(10)12(14)15/h1-6H,7H2,(H,14,15)
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n/an/a 8.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50188784
PNG
(CHEMBL385251 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Show SMILES COC(=O)C(CCCc1ccccc1)(Cc1ccc(NS([O-])(=O)=O)cc1)C(=O)OC
Show InChI InChI=1S/C21H25NO7S/c1-28-19(23)21(20(24)29-2,14-6-9-16-7-4-3-5-8-16)15-17-10-12-18(13-11-17)22-30(25,26)27/h3-5,7-8,10-13,22H,6,9,14-15H2,1-2H3,(H,25,26,27)/p-1
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n/an/a 9.30E+4n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PTP gamma


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355633
PNG
(CHEMBL1910969)
Show SMILES OC(=O)c1ccc(cc1SCc1ccc(Cl)c(Cl)c1)C#Cc1cccc(Cl)c1
Show InChI InChI=1S/C22H13Cl3O2S/c23-17-3-1-2-14(10-17)4-5-15-6-8-18(22(26)27)21(12-15)28-13-16-7-9-19(24)20(25)11-16/h1-3,6-12H,13H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355645
PNG
(CHEMBL1910880)
Show SMILES Cc1ccc(CSc2ccsc2C(O)=O)cc1C
Show InChI InChI=1S/C14H14O2S2/c1-9-3-4-11(7-10(9)2)8-18-12-5-6-17-13(12)14(15)16/h3-7H,8H2,1-2H3,(H,15,16)
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n/an/a 1.10E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355637
PNG
(CHEMBL1910885)
Show SMILES OC(=O)c1sccc1S(=O)(=O)Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O4S2/c13-8-2-1-7(5-9(8)14)6-20(17,18)10-3-4-19-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355647
PNG
(CHEMBL1910876)
Show SMILES OC(=O)c1sccc1SCc1ccccc1
Show InChI InChI=1S/C12H10O2S2/c13-12(14)11-10(6-7-15-11)16-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,14)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355655
PNG
(CHEMBL1910883)
Show SMILES OC(=O)c1sccc1OCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H8Cl2O3S/c13-8-2-1-7(5-9(8)14)6-17-10-3-4-18-11(10)12(15)16/h1-5H,6H2,(H,15,16)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355648
PNG
(CHEMBL1910881)
Show SMILES OC(=O)c1sccc1SCc1ccc2ccccc2c1
Show InChI InChI=1S/C16H12O2S2/c17-16(18)15-14(7-8-19-15)20-10-11-5-6-12-3-1-2-4-13(12)9-11/h1-9H,10H2,(H,17,18)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50355651
PNG
(CHEMBL1910884)
Show SMILES OC(=O)c1sccc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H9Cl2NO2S/c13-8-2-1-7(5-9(8)14)6-15-10-3-4-18-11(10)12(16)17/h1-5,15H,6H2,(H,16,17)
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n/an/a>1.20E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50188777
PNG
(CHEMBL213452 | ammonium N-[4-(2-{[(benzyloxy)carbo...)
Show SMILES CCOC(=O)C(Cc1ccc(NS([O-])(=O)=O)cc1)(NC(=O)OCc1ccccc1)C(=O)OC
Show InChI InChI=1S/C21H24N2O9S/c1-3-31-19(25)21(18(24)30-2,22-20(26)32-14-16-7-5-4-6-8-16)13-15-9-11-17(12-10-15)23-33(27,28)29/h4-12,23H,3,13-14H2,1-2H3,(H,22,26)(H,27,28,29)/p-1
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n/an/a 1.96E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PTP gamma


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50188779
PNG
(CHEMBL378423 | ammonium N-{4-[4-ethoxy-2,2-bis(met...)
Show SMILES CCOC(=O)CC(Cc1ccc(NS([O-])(=O)=O)cc1)(C(=O)OC)C(=O)OC
Show InChI InChI=1S/C16H21NO9S/c1-4-26-13(18)10-16(14(19)24-2,15(20)25-3)9-11-5-7-12(8-6-11)17-27(21,22)23/h5-8,17H,4,9-10H2,1-3H3,(H,21,22,23)/p-1
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n/an/a 2.00E+5n/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of PTP gamma


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase gamma


(Homo sapiens)
BDBM50420258
PNG
(CEFSULODIN)
Show SMILES NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)C(c2ccccc2)S(O)(=O)=O)C3=O)C(O)=O)cc1
Show InChI InChI=1S/C22H20N4O8S2/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34)/p+1/t15-,17?,21-/m1/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of phosphatase activity of human PTPgamma using pNPP as a substrate after 10 mins by spectrophotometer analysis


ACS Med Chem Lett 6: 782-6 (2015)

More data for this
Ligand-Target Pair