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Compile Data Set for Download or QSAR

Found 222 hits Enz. Inhib. hit(s) with Target = 'Retinol-binding protein 4 (RBP4)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026260
PNG
(CHEMBL3359024)
Show SMILES OC(=O)c1cnncc1NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C20H19F3N4O3/c21-20(22,23)16-4-2-1-3-14(16)11-5-12-9-27(10-13(12)6-11)19(30)26-17-8-25-24-7-15(17)18(28)29/h1-4,7-8,11-13H,5-6,9-10H2,(H,28,29)(H,24,26,30)/t11-,12-,13+
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n/an/a 0.121n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019040
PNG
(CHEMBL1230001)
Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
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n/an/a 0.155n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026258
PNG
(CHEMBL3359022)
Show SMILES OC(=O)c1cnccc1NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C21H20F3N3O3/c22-21(23,24)17-4-2-1-3-15(17)12-7-13-10-27(11-14(13)8-12)20(30)26-18-5-6-25-9-16(18)19(28)29/h1-6,9,12-14H,7-8,10-11H2,(H,28,29)(H,25,26,30)/t12-,13-,14+
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n/an/a 0.179n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026259
PNG
(CHEMBL3359023)
Show SMILES Cc1cc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)c2ccccc2C(F)(F)F)c(cn1)C(O)=O
Show InChI InChI=1/C22H22F3N3O3/c1-12-6-19(17(9-26-12)20(29)30)27-21(31)28-10-14-7-13(8-15(14)11-28)16-4-2-3-5-18(16)22(23,24)25/h2-6,9,13-15H,7-8,10-11H2,1H3,(H,29,30)(H,26,27,31)/t13-,14-,15+
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n/an/a 0.235n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026255
PNG
(CHEMBL3359017)
Show SMILES OC(=O)c1cc(F)ccc1NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H20F4N2O3/c23-15-5-6-19(17(9-15)20(29)30)27-21(31)28-10-13-7-12(8-14(13)11-28)16-3-1-2-4-18(16)22(24,25)26/h1-6,9,12-14H,7-8,10-11H2,(H,27,31)(H,29,30)/t12-,13-,14+
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n/an/a 0.285n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026253
PNG
(CHEMBL3359014)
Show SMILES OC(=O)c1ccccc1NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H21F3N2O3/c23-22(24,25)18-7-3-1-5-16(18)13-9-14-11-27(12-15(14)10-13)21(30)26-19-8-4-2-6-17(19)20(28)29/h1-8,13-15H,9-12H2,(H,26,30)(H,28,29)/t13-,14-,15+
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n/an/a 0.294n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026256
PNG
(CHEMBL3359019)
Show SMILES OC(=O)c1cc(Cl)ccc1NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H20ClF3N2O3/c23-15-5-6-19(17(9-15)20(29)30)27-21(31)28-10-13-7-12(8-14(13)11-28)16-3-1-2-4-18(16)22(24,25)26/h1-6,9,12-14H,7-8,10-11H2,(H,27,31)(H,29,30)/t12-,13-,14+
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n/an/a 0.340n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026254
PNG
(CHEMBL3359015)
Show SMILES OC(=O)c1ccccc1NC(=O)N1C[C@H]2CC(=C[C@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H19F3N2O3/c23-22(24,25)18-7-3-1-5-16(18)13-9-14-11-27(12-15(14)10-13)21(30)26-19-8-4-2-6-17(19)20(28)29/h1-9,14-15H,10-12H2,(H,26,30)(H,28,29)/t14-,15+/s2
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n/an/a 0.481n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026251
PNG
(CHEMBL3359005)
Show SMILES CN(CCOc1ccccc1C(C)(C)C)C(=O)Nc1ccccc1C(O)=O
Show InChI InChI=1S/C21H26N2O4/c1-21(2,3)16-10-6-8-12-18(16)27-14-13-23(4)20(26)22-17-11-7-5-9-15(17)19(24)25/h5-12H,13-14H2,1-4H3,(H,22,26)(H,24,25)
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n/an/a 0.554n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026244
PNG
(CHEMBL3359028)
Show SMILES OC(=O)[C@@H](NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)c1ccccc1
Show InChI InChI=1/C23H23F3N2O3/c24-23(25,26)19-9-5-4-8-18(19)15-10-16-12-28(13-17(16)11-15)22(31)27-20(21(29)30)14-6-2-1-3-7-14/h1-9,15-17,20H,10-13H2,(H,27,31)(H,29,30)/t15-,16-,17+,20-/s2
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n/an/a 0.829n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026257
PNG
(CHEMBL3359020)
Show SMILES CS(=O)(=O)c1ccc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)c2ccccc2C(F)(F)F)c(c1)C(O)=O
Show InChI InChI=1/C23H23F3N2O5S/c1-34(32,33)16-6-7-20(18(10-16)21(29)30)27-22(31)28-11-14-8-13(9-15(14)12-28)17-4-2-3-5-19(17)23(24,25)26/h2-7,10,13-15H,8-9,11-12H2,1H3,(H,27,31)(H,29,30)/t13-,14-,15+
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n/an/a 1.60n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026250
PNG
(CHEMBL3358470)
Show SMILES CN(CCOc1ccccc1C(F)(F)F)C(=O)Nc1ccccc1C(O)=O
Show InChI InChI=1S/C18H17F3N2O4/c1-23(17(26)22-14-8-4-2-6-12(14)16(24)25)10-11-27-15-9-5-3-7-13(15)18(19,20)21/h2-9H,10-11H2,1H3,(H,22,26)(H,24,25)
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n/an/a 2.70n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019064
PNG
(CHEMBL3288340)
Show SMILES FC(F)(F)c1ccccc1C1CCN(CC1)C(=O)c1nccs1
Show InChI InChI=1S/C16H15F3N2OS/c17-16(18,19)13-4-2-1-3-12(13)11-5-8-21(9-6-11)15(22)14-20-7-10-23-14/h1-4,7,10-11H,5-6,8-9H2
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026249
PNG
(CHEMBL3358466)
Show SMILES OC(=O)C(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C14H14F3NO3/c15-14(16,17)11-4-2-1-3-10(11)9-5-7-18(8-6-9)12(19)13(20)21/h1-4,9H,5-8H2,(H,20,21)
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n/an/a 3.10n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104147
PNG
(CHEMBL3593524)
Show SMILES Cc1cc(nc(n1)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)C(N)=O
Show InChI InChI=1/C20H21F3N4O/c1-11-6-17(18(24)28)26-19(25-11)27-9-13-7-12(8-14(13)10-27)15-4-2-3-5-16(15)20(21,22)23/h2-6,12-14H,7-10H2,1H3,(H2,24,28)/t12-,13-,14+
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n/an/a 3.30n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM135825
PNG
(US8853215, 3)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1c[nH]cn1
Show InChI InChI=1S/C18H24N4O/c1-18(2,3)14-6-4-5-7-16(14)21-8-10-22(11-9-21)17(23)15-12-19-13-20-15/h4-7,12-13H,8-11H2,1-3H3,(H,19,20)
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US Patent
n/an/a 3.80n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104159
PNG
(CHEMBL3594229)
Show SMILES COC(=O)c1cc(C)nc(n1)N1C[C@H]2CN(C[C@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C20H21F3N4O2/c1-12-7-16(18(28)29-2)25-19(24-12)27-10-13-8-26(9-14(13)11-27)17-6-4-3-5-15(17)20(21,22)23/h3-7,13-14H,8-11H2,1-2H3/t13-,14+
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n/an/a 3.90n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026248
PNG
(CHEMBL3358465)
Show SMILES FC(F)(F)c1ccccc1C1CCN(CC1)C(=O)Nc1ccccc1C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H24F3N3O4S/c27-26(28,29)22-12-6-4-10-20(22)18-14-16-32(17-15-18)25(34)30-23-13-7-5-11-21(23)24(33)31-37(35,36)19-8-2-1-3-9-19/h1-13,18H,14-17H2,(H,30,34)(H,31,33)
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n/an/a 3.90n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104179
PNG
(CHEMBL3594225)
Show SMILES COC(=O)c1cc(C)nc(n1)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H20F3N3O2/c1-12-11-16(17(26)27-2)24-18(23-12)25-9-7-13(8-10-25)14-5-3-4-6-15(14)19(20,21)22/h3-6,11,13H,7-10H2,1-2H3
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n/an/a 4.10n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM106687
PNG
(US8586571, 50)
Show SMILES CC(C)(C)c1ccccc1OC1CCN(CC1)C(=O)c1ccccn1
Show InChI InChI=1S/C21H26N2O2/c1-21(2,3)17-8-4-5-10-19(17)25-16-11-14-23(15-12-16)20(24)18-9-6-7-13-22-18/h4-10,13,16H,11-12,14-15H2,1-3H3
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US Patent
n/an/a 5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026242
PNG
(CHEMBL3359026)
Show SMILES C[C@H](NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)C(O)=O
Show InChI InChI=1/C18H21F3N2O3/c1-10(16(24)25)22-17(26)23-8-12-6-11(7-13(12)9-23)14-4-2-3-5-15(14)18(19,20)21/h2-5,10-13H,6-9H2,1H3,(H,22,26)(H,24,25)/t10-,11-,12-,13+/s2
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n/an/a 5.30n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026247
PNG
(CHEMBL3358464)
Show SMILES FC(F)(F)c1ccccc1C1CCN(CC1)C(=O)Nc1ccccc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C23H24F3N3O4S/c24-23(25,26)19-7-3-1-5-17(19)15-11-13-29(14-12-15)22(31)27-20-8-4-2-6-18(20)21(30)28-34(32,33)16-9-10-16/h1-8,15-16H,9-14H2,(H,27,31)(H,28,30)
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n/an/a 5.30n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104157
PNG
(CHEMBL3594231)
Show SMILES COC(=O)c1cc(C)nc(n1)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C21H22F3N3O2/c1-12-7-18(19(28)29-2)26-20(25-12)27-10-14-8-13(9-15(14)11-27)16-5-3-4-6-17(16)21(22,23)24/h3-7,13-15H,8-11H2,1-2H3/t13-,14-,15+
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n/an/a 6.30n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026246
PNG
(CHEMBL3358463)
Show SMILES CS(=O)(=O)NC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H22F3N3O4S/c1-32(30,31)26-19(28)16-7-3-5-9-18(16)25-20(29)27-12-10-14(11-13-27)15-6-2-4-8-17(15)21(22,23)24/h2-9,14H,10-13H2,1H3,(H,25,29)(H,26,28)
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n/an/a 6.80n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026241
PNG
(CHEMBL3359025)
Show SMILES OC(=O)CNC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C17H19F3N2O3/c18-17(19,20)14-4-2-1-3-13(14)10-5-11-8-22(9-12(11)6-10)16(25)21-7-15(23)24/h1-4,10-12H,5-9H2,(H,21,25)(H,23,24)/t10-,11-,12+
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n/an/a 6.80n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104146
PNG
(CHEMBL3593525)
Show SMILES Cc1cc(nc(n1)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)-c1nnn[nH]1
Show InChI InChI=1/C20H20F3N7/c1-11-6-17(18-26-28-29-27-18)25-19(24-11)30-9-13-7-12(8-14(13)10-30)15-4-2-3-5-16(15)20(21,22)23/h2-6,12-14H,7-10H2,1H3,(H,26,27,28,29)/t12-,13-,14+
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n/an/a 7.5n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026245
PNG
(CHEMBL3359029)
Show SMILES OC(=O)[C@H](NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)c1ccccc1
Show InChI InChI=1/C23H23F3N2O3/c24-23(25,26)19-9-5-4-8-18(19)15-10-16-12-28(13-17(16)11-15)22(31)27-20(21(29)30)14-6-2-1-3-7-14/h1-9,15-17,20H,10-13H2,(H,27,31)(H,29,30)/t15-,16-,17+,20-/s2
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n/an/a 8.30n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026252
PNG
(CHEMBL3359011)
Show SMILES OC(=O)c1ccccc1NC(=O)N1CC(C1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)14-7-3-1-5-12(14)11-9-23(10-11)17(26)22-15-8-4-2-6-13(15)16(24)25/h1-8,11H,9-10H2,(H,22,26)(H,24,25)
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n/an/a 8.40n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026243
PNG
(CHEMBL3359027)
Show SMILES C[C@@H](NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)C(O)=O
Show InChI InChI=1/C18H21F3N2O3/c1-10(16(24)25)22-17(26)23-8-12-6-11(7-13(12)9-23)14-4-2-3-5-15(14)18(19,20)21/h2-5,10-13H,6-9H2,1H3,(H,22,26)(H,24,25)/t10-,11-,12-,13+/s2
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n/an/a 9.20n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104154
PNG
(CHEMBL3594234)
Show SMILES OC(=O)c1cc(nc(n1)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C20H17F6N3O2/c21-19(22,23)14-4-2-1-3-13(14)10-5-11-8-29(9-12(11)6-10)18-27-15(17(30)31)7-16(28-18)20(24,25)26/h1-4,7,10-12H,5-6,8-9H2,(H,30,31)/t10-,11-,12+
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n/an/a 9.60n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104177
PNG
(CHEMBL3594227)
Show SMILES COC(=O)c1cc(C)nc(n1)N1CCN(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C18H19F3N4O2/c1-12-11-14(16(26)27-2)23-17(22-12)25-9-7-24(8-10-25)15-6-4-3-5-13(15)18(19,20)21/h3-6,11H,7-10H2,1-2H3
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n/an/a 9.70n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM106685
PNG
(US8586571, 17)
Show SMILES CC(C)(C)c1ccccc1SC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H22N2OS/c1-19(2,3)15-8-4-5-10-17(15)23-14-12-21(13-14)18(22)16-9-6-7-11-20-16/h4-11,14H,12-13H2,1-3H3
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US Patent
n/an/a 10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM106694
PNG
(US8586571, 207)
Show SMILES CC(C)(C)c1cc(Cl)ccc1OCC1CN(C1)C(=O)C(O)=O
Show InChI InChI=1S/C16H20ClNO4/c1-16(2,3)12-6-11(17)4-5-13(12)22-9-10-7-18(8-10)14(19)15(20)21/h4-6,10H,7-9H2,1-3H3,(H,20,21)
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US Patent
n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104153
PNG
(CHEMBL3594235)
Show SMILES COc1cc(nc(n1)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)C(O)=O
Show InChI InChI=1/C20H20F3N3O3/c1-29-17-8-16(18(27)28)24-19(25-17)26-9-12-6-11(7-13(12)10-26)14-4-2-3-5-15(14)20(21,22)23/h2-5,8,11-13H,6-7,9-10H2,1H3,(H,27,28)/t11-,12-,13+
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n/an/a 13n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104156
PNG
(CHEMBL3594232)
Show SMILES Cc1cc(nc(n1)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F)C(O)=O
Show InChI InChI=1/C20H20F3N3O2/c1-11-6-17(18(27)28)25-19(24-11)26-9-13-7-12(8-14(13)10-26)15-4-2-3-5-16(15)20(21,22)23/h2-6,12-14H,7-10H2,1H3,(H,27,28)/t12-,13-,14+
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n/an/a 13n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019040
PNG
(CHEMBL1230001)
Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
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n/an/a 14n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104192
PNG
(CHEMBL3593526)
Show SMILES Cc1cc(nc(c1)C(O)=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C21H21F3N2O2/c1-12-6-18(20(27)28)25-19(7-12)26-10-14-8-13(9-15(14)11-26)16-4-2-3-5-17(16)21(22,23)24/h2-7,13-15H,8-11H2,1H3,(H,27,28)/t13-,14-,15+
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n/an/a 14n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019040
PNG
(CHEMBL1230001)
Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
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n/an/a 15n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019040
PNG
(CHEMBL1230001)
Show SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
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n/an/a 15n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Displacement of [3H]retinol from biotinylated human RBP4 by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM135836
PNG
(US8853215, 59)
Show SMILES CC(C)(C)c1ccccc1N1CCN(CC1)C(=O)c1nc[nH]n1
Show InChI InChI=1S/C17H23N5O/c1-17(2,3)13-6-4-5-7-14(13)21-8-10-22(11-9-21)16(23)15-18-12-19-20-15/h4-7,12H,8-11H2,1-3H3,(H,18,19,20)
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US Patent
n/an/a 15n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Streptavidin (20 ul) (10 ug/ml Streptavidin type II (Wako Pure Chemical Industries, Ltd.), 10 mM Tris-HCl (pH 7.5), 10 mM NaCl) was added to a 384 we...


US Patent US8853215 (2014)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM106691
PNG
(US8586571, 164)
Show SMILES CC(C)(C)c1cc(Cl)ccc1OC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H21ClN2O2/c1-19(2,3)15-10-13(20)7-8-17(15)24-14-11-22(12-14)18(23)16-6-4-5-9-21-16/h4-10,14H,11-12H2,1-3H3
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US Patent
n/an/a 15n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019043
PNG
(CHEMBL3288142)
Show SMILES COc1ccc(Cl)cc1NC(=O)N1CCN(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H19ClF3N3O2/c1-28-17-7-6-13(20)12-15(17)24-18(27)26-10-8-25(9-11-26)16-5-3-2-4-14(16)19(21,22)23/h2-7,12H,8-11H2,1H3,(H,24,27)
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019044
PNG
(CHEMBL3288337)
Show SMILES Cn1cnc(c1)C(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O/c1-22-10-15(21-11-22)16(24)23-8-6-12(7-9-23)13-4-2-3-5-14(13)17(18,19)20/h2-5,10-12H,6-9H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019039
PNG
(CHEMBL3288342)
Show SMILES COC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H21F3N2O3/c1-29-19(27)16-7-3-5-9-18(16)25-20(28)26-12-10-14(11-13-26)15-6-2-4-8-17(15)21(22,23)24/h2-9,14H,10-13H2,1H3,(H,25,28)
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50026258
PNG
(CHEMBL3359022)
Show SMILES OC(=O)c1cnccc1NC(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C21H20F3N3O3/c22-21(23,24)17-4-2-1-3-15(17)12-7-13-10-27(11-14(13)8-12)20(30)26-18-5-6-25-9-16(18)19(28)29/h1-6,9,12-14H,7-8,10-11H2,(H,28,29)(H,25,26,30)/t12-,13-,14+
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n/an/a 19n/an/an/an/an/an/a



Albany Molecular Research

Curated by ChEMBL


Assay Description
Displacement of [3H]retinol from biotinylated human RBP4 by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM106681
PNG
(US8586571, 6)
Show SMILES CC(C)(C)c1cc(F)ccc1OC1CN(C1)C(=O)c1ccccn1
Show InChI InChI=1S/C19H21FN2O2/c1-19(2,3)15-10-13(20)7-8-17(15)24-14-11-22(12-14)18(23)16-6-4-5-9-21-16/h4-10,14H,11-12H2,1-3H3
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US Patent
n/an/a 20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM106688
PNG
(US8586571, 80)
Show SMILES CC(C)(C)c1cc(F)ccc1OC1CN(C1)C(=O)CCC(O)=O
Show InChI InChI=1S/C17H22FNO4/c1-17(2,3)13-8-11(18)4-5-14(13)23-12-9-19(10-12)15(20)6-7-16(21)22/h4-5,8,12H,6-7,9-10H2,1-3H3,(H,21,22)
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US Patent
n/an/a 20n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50104155
PNG
(CHEMBL3594233)
Show SMILES OC(=O)c1ccnc(n1)N1C[C@@H]2C[C@@H](C[C@@H]2C1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C19H18F3N3O2/c20-19(21,22)15-4-2-1-3-14(15)11-7-12-9-25(10-13(12)8-11)18-23-6-5-16(24-18)17(26)27/h1-6,11-13H,7-10H2,(H,26,27)/t11-,12-,13+
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n/an/a 21n/an/an/an/an/an/a



Columbia University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assay


J Med Chem 58: 5863-88 (2015)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM106690
PNG
(US8586571, 143)
Show SMILES CC(C)(C)c1cc(F)ccc1OCC1CN(C1)C(=O)CC(O)=O
Show InChI InChI=1S/C17H22FNO4/c1-17(2,3)13-6-12(18)4-5-14(13)23-10-11-8-19(9-11)15(20)7-16(21)22/h4-6,11H,7-10H2,1-3H3,(H,21,22)
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US Patent
n/an/a 23n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The action of the compound of the present invention to inhibit binding of RBP4 and retinol and TTR was evaluated using the Retinol-RBP4-TTR ELISA (hu...


US Patent US8586571 (2013)

More data for this
Ligand-Target Pair
Retinol-binding protein 4 (RBP4)


(Homo sapiens (Human))
BDBM50019045
PNG
(CHEMBL3288331)
Show SMILES COc1ccc(Cl)cc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H20ClF3N2O2/c1-28-18-7-6-14(21)12-17(18)25-19(27)26-10-8-13(9-11-26)15-4-2-3-5-16(15)20(22,23)24/h2-7,12-13H,8-11H2,1H3,(H,25,27)
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n/an/a 23n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
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