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Found 6 hits Enz. Inhib. hit(s) with Target = 'Reverse transcriptase' AND taxid = 11709   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Reverse transcriptase


(Human immunodeficiency virus 2)
BDBM33411
PNG
(hydroxytropolone, 3)
Show SMILES CC(C)c1ccc(O)c(=O)c(O)c1
Show InChI InChI=1S/C10H12O3/c1-6(2)7-3-4-8(11)10(13)9(12)5-7/h3-6H,1-2H3,(H2,11,12,13)
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Article
PubMed
n/an/a 250n/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Inhibition of RNase H activity of HIV-2 reverse transcriptase


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Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 2)
BDBM1434
PNG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
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Article
PubMed
n/an/a 4.20E+3n/an/an/an/a7.837



University of Jordan



Assay Description
The reverse transcriptase inhibitory activity of compound was evaluated by a non-radioactive colorimetric assay method. This procedure uses RT to sy...


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More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 2)
BDBM82099
PNG
(NCI Code, 14129)
Show SMILES CCCCCCc1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C13H20N4O2/c1-4-5-6-7-8-9-14-10-11(15-9)16(2)13(19)17(3)12(10)18/h4-8H2,1-3H3,(H,14,15)
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n/an/a 1.89E+4n/an/an/an/a7.837



University of Jordan



Assay Description
The reverse transcriptase inhibitory activity of compound was evaluated by a non-radioactive colorimetric assay method. This procedure uses RT to sy...


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More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 2)
BDBM82100
PNG
(NCI Code, 6050)
Show SMILES CCCCN(CCCC)C(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C15H21Cl2NO/c1-3-5-9-18(10-6-4-2)15(19)13-8-7-12(16)11-14(13)17/h7-8,11H,3-6,9-10H2,1-2H3
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n/an/a 3.13E+4n/an/an/an/a7.837



University of Jordan



Assay Description
The reverse transcriptase inhibitory activity of compound was evaluated by a non-radioactive colorimetric assay method. This procedure uses RT to sy...


Citation and Details
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 2)
BDBM82101
PNG
(NCI Code, 4179)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2O3S/c1-9-2-5-11(6-3-9)19(16,17)18-13-7-4-10(14)8-12(13)15/h2-8H,1H3
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n/an/a 8.71E+4n/an/an/an/a7.837



University of Jordan



Assay Description
The reverse transcriptase inhibitory activity of compound was evaluated by a non-radioactive colorimetric assay method. This procedure uses RT to sy...


Citation and Details
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 2)
BDBM82102
PNG
(NCI Code, 6927)
Show SMILES CCCC(=O)Oc1ccc(cc1Br)C(C)(C)C
Show InChI InChI=1S/C14H19BrO2/c1-5-6-13(16)17-12-8-7-10(9-11(12)15)14(2,3)4/h7-9H,5-6H2,1-4H3
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PubMed
n/an/a 3.35E+5n/an/an/an/a7.837



University of Jordan



Assay Description
The reverse transcriptase inhibitory activity of compound was evaluated by a non-radioactive colorimetric assay method. This procedure uses RT to sy...


Citation and Details
More data for this
Ligand-Target Pair