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Found 7 hits Enz. Inhib. hit(s) with Target = 'Rho-kinase (ROCK II)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-kinase (ROCK II)


(Homo sapiens (human))
BDBM25472
PNG
(CHEMBL519123 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-d...)
Show SMILES O=C(Nc1ccc(cc1)-c1cn[nH]c1)C1COc2ccccc2O1
Show InChI InChI=1S/C18H15N3O3/c22-18(17-11-23-15-3-1-2-4-16(15)24-17)21-14-7-5-12(6-8-14)13-9-19-20-10-13/h1-10,17H,11H2,(H,19,20)(H,21,22)
PDB
MMDB

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem

Patents


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AffyNet 
Article
PubMed
n/an/a 1.5n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...


Citation and Details
More data for this
Ligand-Target Pair
Rho-kinase (ROCK II)


(Homo sapiens (human))
BDBM25474
PNG
(JMC516642 Compound 5 | N-{2-[2-(dimethylamino)etho...)
Show SMILES CN(C)CCOc1cc(ccc1NC(=O)C1COc2ccccc2O1)-c1cn[nH]c1
Show InChI InChI=1S/C22H24N4O4/c1-26(2)9-10-28-20-11-15(16-12-23-24-13-16)7-8-17(20)25-22(27)21-14-29-18-5-3-4-6-19(18)30-21/h3-8,11-13,21H,9-10,14H2,1-2H3,(H,23,24)(H,25,27)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 3.20n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...


Citation and Details
More data for this
Ligand-Target Pair
Rho-kinase (ROCK II)


(Homo sapiens (human))
BDBM25473
PNG
(N-[2-methoxy-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydr...)
Show SMILES COc1cc(ccc1NC(=O)C1COc2ccccc2O1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N3O4/c1-24-17-8-12(13-9-20-21-10-13)6-7-14(17)22-19(23)18-11-25-15-4-2-3-5-16(15)26-18/h2-10,18H,11H2,1H3,(H,20,21)(H,22,23)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 3.30n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...


Citation and Details
More data for this
Ligand-Target Pair
Rho-kinase (ROCK II)


(Homo sapiens (human))
BDBM25470
PNG
(N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]-2,3-dihydro-...)
Show SMILES O=C(Nc1nc(cs1)-c1ccncc1)C1COc2ccccc2O1
Show InChI InChI=1S/C17H13N3O3S/c21-16(15-9-22-13-3-1-2-4-14(13)23-15)20-17-19-12(10-24-17)11-5-7-18-8-6-11/h1-8,10,15H,9H2,(H,19,20,21)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 7.20n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...


Citation and Details
More data for this
Ligand-Target Pair
Rho-kinase (ROCK II)


(Homo sapiens (human))
BDBM25471
PNG
(N-[4-(pyridin-4-yl)phenyl]-2,3-dihydro-1,4-benzodi...)
Show SMILES O=C(Nc1ccc(cc1)-c1ccncc1)C1COc2ccccc2O1
Show InChI InChI=1S/C20H16N2O3/c23-20(19-13-24-17-3-1-2-4-18(17)25-19)22-16-7-5-14(6-8-16)15-9-11-21-12-10-15/h1-12,19H,13H2,(H,22,23)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 46n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...


Citation and Details
More data for this
Ligand-Target Pair
Rho-kinase (ROCK II)


(Homo sapiens (human))
BDBM25476
PNG
(N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...)
Show SMILES CN(C)CCOc1cc(ccc1NC(C)=O)-c1cn[nH]c1
Show InChI InChI=1S/C15H20N4O2/c1-11(20)18-14-5-4-12(13-9-16-17-10-13)8-15(14)21-7-6-19(2)3/h4-5,8-10H,6-7H2,1-3H3,(H,16,17)(H,18,20)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 760n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...


Citation and Details
More data for this
Ligand-Target Pair
Rho-kinase (ROCK II)


(Homo sapiens (human))
BDBM25475
PNG
(2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)ani...)
Show SMILES CN(C)CCOc1cc(ccc1N)-c1cn[nH]c1
Show InChI InChI=1S/C13H18N4O/c1-17(2)5-6-18-13-7-10(3-4-12(13)14)11-8-15-16-9-11/h3-4,7-9H,5-6,14H2,1-2H3,(H,15,16)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 920n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...


Citation and Details
More data for this
Ligand-Target Pair